Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YAN Xin’an , YAO Xiangyu ^△ ,  FANG Yue , LIANG Yu , YANG Yun , HUANG Fuguo

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding?author：

FANG Yue, Email: fangyue1968@163.com

Keywords：

Nickel-titanium memory alloy; tibial plateau fracture; Beagle dog; biomechanics

DOI：

10.7507/1002-1892.201807024

Video：

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ObjectiveTo evaluate the effect of nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture by biomechanical testing. MethodsSixteen healthy 12-month-old Beagle dogs were randomly divided into 4 group, 4 dogs in each group. The dogs were used to establish the tibial plateau collapse fracture model in groups A, B, and C. Then, the nickel-titanium three-dimensional memory alloy mesh combined with autologous bone (the fibula cortical bone particles), the artificial bone (nano-hydroxyapatite), and autologous fibula cortical bone particles were implanted to repair the bone defects within 4 hours after modeling in groups A, B, and C, respectively; and the plate and screws were fixed outside the bone defects. The dogs were not treated in group D, as normal control. At 5 months after operation, all animals were sacrificed and the tibial specimens were harvested and observed visually. The destructive axial compression experiments were carried out by the biomechanical testing machine. The displacement and the maximum failure load were recorded and the axial stiffness was calculated. ResultsAll animals stayed alive after operation, and all incisions healed. After 1-3 days of operation, the animals could stand and move, and no obvious limb deformity was found. The articular surfaces of the tibial plateau specimens were completely smooth at 5 months after operation. No obvious articular surface collapse was observed. The displacement and maximum failure load of specimens in groups A and D were significantly higher than those in groups B and C (P<0.05). But no significant difference was found between groups A and D and between groups B and C (P>0.05). ConclusionThe nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for subarticular bone defect of tibial plateau in dogs has good biomechanical properties at 5 months after operation, and has better axial stiffness when compared with the artificial bone and autologous bone graft.

Citation： YAN Xin’an, YAO Xiangyu, FANG Yue, LIANG Yu, YANG Yun, HUANG Fuguo. Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(12): 1549-1553. doi: 10.7507/1002-1892.201807024 Copy

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2.	Lachiewicz PF, Funcik T. Factors influencing the results of open reduction and internal fixation of tibial plateau fractures. Clin Orthop Relat Res, 1990, (259): 210-215.
3.	Hsu CJ, Chang WN, Wong CY. Surgical treatment of tibial plateau fracture in elderly patients. Arch Orthop Trauma Surg, 2001, 121(1-2): 67-70.
4.	Tscherne H, Lobenhoffer P. Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res, 1993, (292): 87-100.
5.	McNamara IR, Smith TO, Shepherd KL, et al. Surgical fixation methods for tibial plateau fractures. Cochrane Database Syst Rev, 2015, (9): CD009679.
6.	Heikkil? JT, Kukkonen J, Aho AJ, et al. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: a prospective, randomized 1 year follow-up study. J Mater Sci Mater Med, 2011, 22(4): 1073-1080.
7.	晏兆魁, 梁羽, 方躍, 等. 鎳鈦三維記憶合金網復合自體骨治療犬脛骨平臺塌陷骨折模型生物力學試驗. 中國修復重建外科雜志, 2018, 32(6): 722-725.
8.	Wheeler DL, Cross AR, Eschbach EJ, et al. Grafting of massive tibial subchondral bone defects in a caprine model using beta-tricalcium phosphate versus autograft. J Orthop Trauma, 2005, 19(2): 85-91.
9.	王巖, 譯. 坎貝爾骨科手術學. 11 版. 北京: 人民軍醫出版社, 2009: 2472-2485.
10.	Morrison JB. Bioengineering analysis of force actions transmitted by the knee joint. Bio Med, 1968, 3: 164-170.
11.	Larsson S, Hannink G. Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments. Injury, 2011, 42(Suppl 2): S30-S34.
12.	Cornell CN. Osteoconductive materials and their role as substitutes for autogenous bone grafts. Orthop Clin North Am, 1999, 30(4): 591-598.
13.	Goff T, Kanakaris NK, Giannoudis PV. Use of bone graft substitutes in the management of tibial plateau fractures. Injury, 2013, 44(Suppl 1): S86-S94.
14.	Sevcikova J, Pavkova Goldbergova M. Biocompatibility of NiTi alloys in the cell behaviour. Biometals, 2017, 30(2): 163-169.
15.	Li Y, Wang F, Hu P, et al. Feasibility of shape-memory Ni/Ti alloy wire containing tube elevators for transcrestal detaching maxillary sinus mucosa: Ex vivo study. Cell Physiol Biochem, 2016, 40(5): 944-952.
16.	王成健, 孟增東, 張玉勤, 等. 鎳鈦形狀記憶合金的生物相容性研究進展. 生物骨科材料與臨床研究, 2016, 13(1): 65-68, 72.
17.	林斌, 王巖, 趙衛東, 等. 鎳鈦記憶合金網球治療股骨頭缺血性壞死的生物力學及三維有限元分析. 中國矯形外科雜志, 2003, 11(15): 1059-1062.
18.	趙定麟, 張文明. 形狀記憶合金椎間關節用于頸椎病前路減壓術. 中華外科雜志, 1984, 22(7): 410-412.
19.	呂曉華, 陳根元, 曲國欣, 等. 鎳鈦形態記憶合金環抱器與重建鋼板置入內固定治療尺橈骨中段骨折的比較. 中國組織工程研究與臨床康復, 2010, 14(52): 9827-9830.
20.	劉欣偉, 王攀峰, 付青格, 等. 動力髖螺釘結合記憶合金弓齒釘治療股骨粗隆下 SeinsheimerⅤ型粉碎性骨折. 中國骨傷, 2010, 23(4): 288-290.
21.	Liu X, Xu S, Zhang C, et al. Application of a shape-memory alloy internal fixator for treatment of acetabular fractures with a follow-up of two to nine years in China. Int Orthop, 2010, 34(7): 1033-1040.
22.	Su JC, Liu XW, Yu BQ, et al. Shape memory Ni-Ti alloy swan-like bone connector for treatment of humeral shaft nonunion. Int Orthop, 2010, 34(3): 369-375.

1. Elsoe R, Larsen P, Nielsen NP, et al. Population-based epidemiology of tibial plateau fractures. Orthopedics, 2015, 38(9): e780-e786.
2. Lachiewicz PF, Funcik T. Factors influencing the results of open reduction and internal fixation of tibial plateau fractures. Clin Orthop Relat Res, 1990, (259): 210-215.
3. Hsu CJ, Chang WN, Wong CY. Surgical treatment of tibial plateau fracture in elderly patients. Arch Orthop Trauma Surg, 2001, 121(1-2): 67-70.
4. Tscherne H, Lobenhoffer P. Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res, 1993, (292): 87-100.
5. McNamara IR, Smith TO, Shepherd KL, et al. Surgical fixation methods for tibial plateau fractures. Cochrane Database Syst Rev, 2015, (9): CD009679.
6. Heikkil? JT, Kukkonen J, Aho AJ, et al. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: a prospective, randomized 1 year follow-up study. J Mater Sci Mater Med, 2011, 22(4): 1073-1080.
7. 晏兆魁, 梁羽, 方躍, 等. 鎳鈦三維記憶合金網復合自體骨治療犬脛骨平臺塌陷骨折模型生物力學試驗. 中國修復重建外科雜志, 2018, 32(6): 722-725.
8. Wheeler DL, Cross AR, Eschbach EJ, et al. Grafting of massive tibial subchondral bone defects in a caprine model using beta-tricalcium phosphate versus autograft. J Orthop Trauma, 2005, 19(2): 85-91.
9. 王巖, 譯. 坎貝爾骨科手術學. 11 版. 北京: 人民軍醫出版社, 2009: 2472-2485.
10. Morrison JB. Bioengineering analysis of force actions transmitted by the knee joint. Bio Med, 1968, 3: 164-170.
11. Larsson S, Hannink G. Injectable bone-graft substitutes: current products, their characteristics and indications, and new developments. Injury, 2011, 42(Suppl 2): S30-S34.
12. Cornell CN. Osteoconductive materials and their role as substitutes for autogenous bone grafts. Orthop Clin North Am, 1999, 30(4): 591-598.
13. Goff T, Kanakaris NK, Giannoudis PV. Use of bone graft substitutes in the management of tibial plateau fractures. Injury, 2013, 44(Suppl 1): S86-S94.
14. Sevcikova J, Pavkova Goldbergova M. Biocompatibility of NiTi alloys in the cell behaviour. Biometals, 2017, 30(2): 163-169.
15. Li Y, Wang F, Hu P, et al. Feasibility of shape-memory Ni/Ti alloy wire containing tube elevators for transcrestal detaching maxillary sinus mucosa: Ex vivo study. Cell Physiol Biochem, 2016, 40(5): 944-952.
16. 王成健, 孟增東, 張玉勤, 等. 鎳鈦形狀記憶合金的生物相容性研究進展. 生物骨科材料與臨床研究, 2016, 13(1): 65-68, 72.
17. 林斌, 王巖, 趙衛東, 等. 鎳鈦記憶合金網球治療股骨頭缺血性壞死的生物力學及三維有限元分析. 中國矯形外科雜志, 2003, 11(15): 1059-1062.
18. 趙定麟, 張文明. 形狀記憶合金椎間關節用于頸椎病前路減壓術. 中華外科雜志, 1984, 22(7): 410-412.
19. 呂曉華, 陳根元, 曲國欣, 等. 鎳鈦形態記憶合金環抱器與重建鋼板置入內固定治療尺橈骨中段骨折的比較. 中國組織工程研究與臨床康復, 2010, 14(52): 9827-9830.
20. 劉欣偉, 王攀峰, 付青格, 等. 動力髖螺釘結合記憶合金弓齒釘治療股骨粗隆下 SeinsheimerⅤ型粉碎性骨折. 中國骨傷, 2010, 23(4): 288-290.
21. Liu X, Xu S, Zhang C, et al. Application of a shape-memory alloy internal fixator for treatment of acetabular fractures with a follow-up of two to nine years in China. Int Orthop, 2010, 34(7): 1033-1040.
22. Su JC, Liu XW, Yu BQ, et al. Shape memory Ni-Ti alloy swan-like bone connector for treatment of humeral shaft nonunion. Int Orthop, 2010, 34(3): 369-375.

Chinese Journal of Reparative and Reconstructive Surgery

Biomechanical study on nickel-titanium three-dimensional memory alloy mesh combined with autologous bone for living model of canine tibial plateau collapse fracture

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