DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANGDan ,  RENLiling

School of Stomatology, Lanzhou University, Lanzhou Gansu, 730000, P. R. China;

Corresponding?author：

RENLiling, Email: renlil@lzu.edu.cn

Keywords：

Tissue engineering; Hypoxia-inducible factor 1α; Osteogenesis; Angiogenesis

DOI：

10.7507/1002-1892.20160100

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the development and applications of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Method The literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α plays a key role in angiogenic-osteogenic coupling, and as an upstream regulator, HIF-1α can regulate the expressions of its target genes related with angiogenesis and osteogenesis. In addition, HIF-1α not only can control and improve the angiogenesis, but also has important significance in proliferation and differentiation of seed cells, especially stem cells, which is the foundation for bone healing. Conclusions With the development of tissue engineering technology, the problems in the applications of HIF-1α, such as the effective dose of targeting controlled-release, pro-inflammatory effect, and carcinogenicity, will be explored and solved in the future, so it can be used better in clinical.

Citation： ZHANGDan, RENLiling. DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(4): 504-508. doi: 10.7507/1002-1892.20160100 Copy

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2.	Semenza GL. Hypoxia-Inducible factors in physiology and medicine. Cell, 2012, 148(3) :399-408.
3.	王彥梅, 鄒多宏, 何家才. HIF-1在骨缺損修復中的作用. 口腔醫學研究, 2014, 30(2) :183-185.
4.	Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev, 2013, 27(1) :41-53.
5.	Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care (New Rochelle), 2014, 3(5) :390-399.
6.	Niyaz M, Gürp?nar ?A, Oktar GL, et al. Effect of VEGF and MSCs on vascular regeneration in a trauma model in rats. Wound Repair Regen, 2015, 23(2) :262-267.
7.	鄒多宏, 黃遠亮. 低氧誘導因子-1α的研究進展. 國際口腔醫學雜志, 2010, 37(3) :320-323.
8.	Han Y, Kuang SZ, Gomer A, et al. Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of vascular endothelial growth factor receptors in an ARNT-dependent manner. Stem Cells, 2010, 28(4) :799-809.
9.	Bluteau G, Julien M, Magne D, et al. VEGF and VEGF receptors are differentially expressed in chondrocytes. Bone, 2007, 40(3) :568-576.
10.	Carmeliet P. Angiogenesis in health and disease. Nat Med, 2003, 9(6) :653-660.
11.	Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep, 2011, 9(2) :46-52.
12.	朱勛兵, 周建生, 肖玉周, 等. 低氧誘導因子-1α在長骨發育中的表達研究. 中國骨傷, 2009, 22(8) :599-601.
13.	張鵬, 王越, 王文良, 等. 骨形成耦連血管生成中HIF-1α作用. 武警后勤學院學報(醫學版), 2012, 21(8) :654-657.
14.	徐林, 柏小金, 駱旭東, 等. 大鼠股骨骨折合并腦外傷時HIF-1α及Cbfα1的血清表達及意義. 臨床和實驗醫學雜志, 2014, 13(9) :689-692.
15.	金小嵐, 郎紅梅, 萬勇, 等. 不同氧濃度對骨髓基質細胞向成骨細胞分化的影響. 中國病理生理雜志, 2010, 26(5) :982-986.
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23.	亓云龍, 張睿, 李紅喜, 等. TGF-β2在低氧條件下誘導骨髓基質干細胞向軟骨細胞分化的研究. 現代生物醫學進展, 2014, 14(14) :2632-2635.
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34.	Peng J, Lai ZG, Fang ZL, et al. Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis. PLoS One, 2014, 9(11) :e112744.
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1. 黃姣. 低氧微環境對骨髓間充質干細胞成骨分化影響的研究. 重慶:重慶醫科大學, 2012.
2. Semenza GL. Hypoxia-Inducible factors in physiology and medicine. Cell, 2012, 148(3) :399-408.
3. 王彥梅, 鄒多宏, 何家才. HIF-1在骨缺損修復中的作用. 口腔醫學研究, 2014, 30(2) :183-185.
4. Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev, 2013, 27(1) :41-53.
5. Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care (New Rochelle), 2014, 3(5) :390-399.
6. Niyaz M, Gürp?nar ?A, Oktar GL, et al. Effect of VEGF and MSCs on vascular regeneration in a trauma model in rats. Wound Repair Regen, 2015, 23(2) :262-267.
7. 鄒多宏, 黃遠亮. 低氧誘導因子-1α的研究進展. 國際口腔醫學雜志, 2010, 37(3) :320-323.
8. Han Y, Kuang SZ, Gomer A, et al. Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of vascular endothelial growth factor receptors in an ARNT-dependent manner. Stem Cells, 2010, 28(4) :799-809.
9. Bluteau G, Julien M, Magne D, et al. VEGF and VEGF receptors are differentially expressed in chondrocytes. Bone, 2007, 40(3) :568-576.
10. Carmeliet P. Angiogenesis in health and disease. Nat Med, 2003, 9(6) :653-660.
11. Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep, 2011, 9(2) :46-52.
12. 朱勛兵, 周建生, 肖玉周, 等. 低氧誘導因子-1α在長骨發育中的表達研究. 中國骨傷, 2009, 22(8) :599-601.
13. 張鵬, 王越, 王文良, 等. 骨形成耦連血管生成中HIF-1α作用. 武警后勤學院學報(醫學版), 2012, 21(8) :654-657.
14. 徐林, 柏小金, 駱旭東, 等. 大鼠股骨骨折合并腦外傷時HIF-1α及Cbfα1的血清表達及意義. 臨床和實驗醫學雜志, 2014, 13(9) :689-692.
15. 金小嵐, 郎紅梅, 萬勇, 等. 不同氧濃度對骨髓基質細胞向成骨細胞分化的影響. 中國病理生理雜志, 2010, 26(5) :982-986.
16. 劉曉東, 鄧廉夫, 王君, 等. 低氧誘導因子-1α對成骨細胞功能的調控作用. 上海交通大學學報(醫學版), 2007, 27(3) :298-302.
17. Riddle RC, Khatri R, Schipani E, et al. Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling. J Mol Med (Berl), 2009, 87(6) :583-590.
18. Rankin EB, Wu C, Khatri R, et al. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell, 2012, 149(1) :63-74.
19. 周年. HIF-1α對BMP2誘導干細胞成軟骨、成骨分化的影響的研究. 重慶:重慶醫科大學, 2014.
20. 孔令擘. IGF-1表達載體轉染兔骨髓間充質干細胞體外成骨的實驗研究. 西安:第四軍醫大學, 2009.
21. 薛鵬. IGF1對BMSCs向成骨細胞分化的影響和機制研究. 石家莊:河北醫科大學, 2014.
22. 孫鑫, 侯玉東. 轉化生長因子β超家族在修復骨缺損方面的應用研究. 口腔醫學研究, 2014, 30(1) :85-88.
23. 亓云龍, 張睿, 李紅喜, 等. TGF-β2在低氧條件下誘導骨髓基質干細胞向軟骨細胞分化的研究. 現代生物醫學進展, 2014, 14(14) :2632-2635.
24. 胡寧. 缺氧誘導因子-1α增強骨形態發生蛋白-9介導的間充質干細胞成骨分化及其機制研究. 重慶:重慶醫科大學, 2012.
25. Lord-Dufour S, Copland IB, Levros LC Jr, et al. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha:Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells, 2009, 27(3) :489-497.
26. 孔宏亮, 孫洪波, 宋麗杰, 等. 缺氧誘導因子-1α過表達對骨髓間充質干細胞缺氧時生存能力的影響. 中國普外基礎與臨床雜志, 2011, 18(3) :261-266.
27. Liu J, Hao H, Huang H, et al. Hypoxia regulates the therapeutic potential of mesenchymal stem cells through enhanced autophagy. Int J Low Extrem Wounds, 2015, 14(1) :63-72.
28. Yew TL, Huang TF, Ma HL, et al. Scale-up of MSC under hypoxic conditions for allogeneic transplantation and enhancing bony regeneration in a rabbit calvarial defect model. J Orthop Res, 2012, 30(8) :1213-1220.
29. Hill P, Shukla D, Tran MG, et al. Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemiareperfusion injury. J Am Soc Nephrol, 2008, 19(1) :39-46.
30. Eckle T, K?hler D, Lehmann R, et al. Hypoxia-inducible factor-1 is central to cardioprotection:a new paradigm for ischemic preconditioning. Circulation, 2008, 118(2) :166-175.
31. Cummins EP, Seeballuck F, Keely SJ, et al. Th hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology, 2008, 134(1) :156-165.
32. Safran M, Kim WY, O'Connell F, et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity:assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A, 2006, 103(1) :105-110.
33. 張磊, 趙學凌, 李彪, 等. 二甲基乙二酰基甘氨酸促進骨髓間充質干細胞成骨分化. 中國骨質疏松雜志, 2012, 18(11) :1048-1053.
34. Peng J, Lai ZG, Fang ZL, et al. Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis. PLoS One, 2014, 9(11) :e112744.
35. 劉麗珍. 缺氧與缺氧模擬劑對間充質干細胞的動員作用及機理研究. 杭州:浙江大學, 2012.
36. 侯躍龍, 李彤, 張臣, 等. CoCl2缺氧處理對臍帶間充質干細胞促血管生長因子表達的影響. 心臟雜志, 2011, 23(1) :59-64.
37. 李文迪. 氯化鈷在BMSCs修復HIBD認知功能中的作用. 重慶:重慶醫科大學, 2013.
38. Hou Z, Nie C, Si Z, et al. Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia. Diabetes Res Clin Prac, 2013, 101(1) :62-71.
39. Schofild CJ, Ratcliff PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol, 2004, 5(5) :343-354.
40. Azevedo MM, Jell G, O'Donnell MD, et al. Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration. J Mater Chem, 2010, 20(40) :8854-8864.
41. Azevedo MM, Tsigkou O, Nair R, et al. Hypoxia inducible factor-stabilizing bioactive glasses for directing mesenchymal stem cell behavior. Tissue Eng Part A, 2015, 21(1-2) :382-389.
42. Wu C, Zhou Y, Fan W, et al. Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials, 2012, 33(7) :2076-2085.
43. Quinlan E, Partap S, Azevedo MM, et al. Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair. Biomaterials, 2015, 52:358-366.
44. Wu C, Zhou Y, Chang J, et al. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater, 2013, 9(11) :9159-9168.
45. 鄒多宏, 吳軼群, 張秀麗, 等. HIF-1α促進BMSCs成骨及成血管作用的體內外研究. 中國口腔頜面外科雜志, 2012, 10(6) :441-453.
46. Ding H, Gao YS, Hu C, et al. HIF-1α transgenic bone marrow cells can promote tissue repair in cases of corticosteroid-induced osteonecrosis of the femoral head in rabbits. PLoS One, 2013, 8(5) :e63628.
47. 張勁娥, 王淑紅, 張忻, 等. 低氧誘導因子1α慢病毒載體轉染骨髓間充質干細胞的成骨基因表達. 中國組織工程研究, 2014, 18(1) :57-62.
48. Zou D, Zhang Z, He J, et al. Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold. Biomaterials, 2011, 32(36) :9707-9718.
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Chinese Journal of Reparative and Reconstructive Surgery

DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS

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