RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YANGShuifa ,  YIYangyan

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding?author：

YIYangyan, Email: yyy0218@126.com

Keywords：

Tissue engineered adipose; Adipose-derived stem cells; Injectable scaffold; Repair and reconstruction

DOI：

10.7507/1002-1892.20150051

Video：

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Objective To review the research progress of constructing injectable tissue engineered adipose tissue by adipose-derived stem cells (ADSCs). Methods Recent literature about ADSCs composite three-dimensional scaffold to construct injectable tissue engineered adipose tissue is summarized, mainly on the characteristics of ADSCs, innovation of injectable scaffold, and methods to promote blood supply. Results ADSCs have a sufficient amount and powerful ability such as secretion, excellent compatibility with injectable scaffold, plus with methods of promoting blood supply, which can build forms of injectable tissue engineered adipose tissue. Conclusion In despite of many problems to be dealt with, ADSCs constructing injectable tissue engineered adipose tissue may provide a promising source for soft-tissue defect repair and plastic surgery.

Citation： YANGShuifa, YIYangyan. RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(2): 245-249. doi: 10.7507/1002-1892.20150051 Copy

1.	Chang Q, Lu F. A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold. Med Hypotheses, 2012, 79(2):267-270.
2.	Tanzi MC, Farè S. Adipose tissue engineering:state of the art, recent advances and innovative approaches. Expert Rev Med Devices, 2009, 6(5):533-551.
3.	Eto H, Kato H, Suga H, et al. The fate of adipocytes after nonvascularized fat grafting:evidence of early death and replacement of adipocytes. Plast Reconstr Surg, 2012, 129(5):1081-1092.
4.	Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue:implications for cell-based therapies. Tissue Eng, 2001, 7(2):211-228.
5.	Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science, 2008, 322(5901):583-586.
6.	Strem BM, Zhu M, Alfonso Z, et al. Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury. Cytotherapy, 2005, 7(3):282-291.
7.	Bianchi F, Maioli M, Leonardi E, et al. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant, 2013, 22(11):2063-2077.
8.	Li Q, Qi LJ, Guo ZK, et al. CD73⁺ adipose-derived mesenchymal stem cells possess higher potential to differentiate into cardiomyocytes in vitro. J Mol Histol, 2013, 44(4):411-422.
9.	Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun, 2005, 328(1):258-264.
10.	Yamamoto Y, Banas A, Murata S, et al. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J, 2008, 275(6):1260-1273.
11.	Kajiyama H, Hamazaki TS, Tokuhara M, et al. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol, 2010, 54(4):699-705.
12.	Zhu M, Zhou Z, Chen Y, et al. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg, 2010, 64(2):222-228.
13.	Hsiao ST, Lokmic Z, Peshavariya H, et al. Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. Stem Cells Dev, 2013, 22(10):1614-1623.
14.	付冰川, 高建華, 魯峰, 等. 新鮮分離的脂肪SVF細胞促進脂肪移植存活的實驗研究. 中華整形外科雜志, 2010, 26(4):289-294.
15.	Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant:a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5):1409-1424.
16.	Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
17.	Neuss S, Stainforth R, Salber J, et al. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant, 2008, 17(8):977-986.
18.	張云松, 高建華, 魯峰, 等. 人脂肪來源干細胞復合I型膠原支架構建工程化脂肪組織的實驗研究. 中華整形外科雜志, 2008, 24(5):385-389.
19.	Shaterian A, Borboa A, Sawada R, et al. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns, 2009, 35(6):811-817.
20.	Vashi AV, Abberton KM, Thomas GP, et al. Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix. Tissue Eng, 2006, 12(11):3035-3043.
21.	Verseijden F, Posthumus-van SS, van Neck JW, et al. Comparing scaffold-free and fibrin-based adipose-derived stromal cell constructs for adipose tissue engineering:an in vitro and in vivo study. Cell Transplant, 2012, 21(10):2283-2297.
22.	張云松, 高建華, 魯峰, 等. 人脂肪來源干細胞復合纖維蛋白膠構建可注射型工程化脂肪組織的實驗研究. 中華醫學雜志, 2008, 88(38):2705-2709.
23.	許兆峰, 高建華, 李劼, 等. 纖維蛋白膠與脂肪來源干細胞影響脂肪注射移植的實驗研究. 南方醫科大學學報, 2009, 29(5):1073-1075.
24.	Tan H, Ramirez CM, Miljkovic N, et al. Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering. Biomaterials, 2009, 30(36):6844-6853.
25.	Zheng L, Fan HS, Sun J, et al. Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study. J Biomed Mater Res A, 2010, 93(2):783-792.
26.	于文淵, 崔磊, 趙宇, 等. 人脂肪干細胞與聚L-谷氨酸/海藻酸鈉可注射水凝膠的生物相容性研究. 安徽醫科大學學報, 2012, 47(6):727-731.
27.	Wu I, Nahas Z, Kimmerling KA, et al. An injectable adipose matrix for soft-tissue reconstruction. Plast Reconstr Surg, 2012, 129(6):1247-1257.
28.	察鵬飛, 高建華, 陳陽, 等. 人細胞外基質支架聯合脂肪干細胞構建脂肪組織. 中華實驗外科雜志, 2012, 29(6):1085-1088.
29.	Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer:supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12 (12):3375-3382.
30.	Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy:efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9):1178-1185.
31.	Wei X, Li G, Yang X, et al. Effects of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse adipose-derived stem cells. Cell Prolif, 2013, 46(4):416-424.
32.	Wang B, Han J, Gao Y, et al. The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs. Neurosci Lett, 2007, 421(3):191-196.
33.	許海委, 徐寶山, 楊強,等. 細胞共培養法誘導兔脂肪來源干細胞向軟骨細胞分化的實驗研究. 中國修復重建外科雜志, 2013, 27(2):193-198.
34.	Stosich MS, Moioli EK, Wu JK, et al. Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape. Methods, 2009, 47(2):116-121.
35.	黎洪棉, 高建華, 吳濤, 等. 脂肪干細胞與外源性血管內皮生長因子及纖維蛋白膠復合物體內構建血管化組織工程脂肪. 中國組織工程研究與臨床康復, 2011, 15(40):7480-7484.
36.	楊波, 沈宏亮, 徐志飛, 等. 血管內皮細胞生長因子165基因轉染干細胞促進組織工程化脂肪的存活. 中國組織工程研究, 2012, 16(14):2534-2539.
37.	Taniyama Y, Morishita R, Aoki M, et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models:preclinical study for treatment of peripheral arterial disease. Gene Ther, 2001, 8(3):181-189.
38.	王有虎, 劉毅, 哈小琴, 等. 轉染肝細胞生長因子基因對移植顆粒脂肪新生血管形成的影響. 中華實驗外科雜志, 2008, 25(8):1079.
39.	黎洪棉, 柳大烈, 趙培冉, 等. 脂肪干細胞與自體富血小板血漿載體復合物體內構建血管化組織工程脂肪. 中國組織工程研究, 2012, 16(45):8424-8429.
40.	Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
41.	Adams WJ Jr. Discussion:Breast augmentation using preexpansion and autologous fat transplantation:a clinical radiographic study. Plast Reconstr Surg, 2011, 127(6):2453-2454.

1. Chang Q, Lu F. A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold. Med Hypotheses, 2012, 79(2):267-270.
2. Tanzi MC, Farè S. Adipose tissue engineering:state of the art, recent advances and innovative approaches. Expert Rev Med Devices, 2009, 6(5):533-551.
3. Eto H, Kato H, Suga H, et al. The fate of adipocytes after nonvascularized fat grafting:evidence of early death and replacement of adipocytes. Plast Reconstr Surg, 2012, 129(5):1081-1092.
4. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue:implications for cell-based therapies. Tissue Eng, 2001, 7(2):211-228.
5. Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science, 2008, 322(5901):583-586.
6. Strem BM, Zhu M, Alfonso Z, et al. Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury. Cytotherapy, 2005, 7(3):282-291.
7. Bianchi F, Maioli M, Leonardi E, et al. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant, 2013, 22(11):2063-2077.
8. Li Q, Qi LJ, Guo ZK, et al. CD73⁺ adipose-derived mesenchymal stem cells possess higher potential to differentiate into cardiomyocytes in vitro. J Mol Histol, 2013, 44(4):411-422.
9. Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun, 2005, 328(1):258-264.
10. Yamamoto Y, Banas A, Murata S, et al. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J, 2008, 275(6):1260-1273.
11. Kajiyama H, Hamazaki TS, Tokuhara M, et al. Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. Int J Dev Biol, 2010, 54(4):699-705.
12. Zhu M, Zhou Z, Chen Y, et al. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg, 2010, 64(2):222-228.
13. Hsiao ST, Lokmic Z, Peshavariya H, et al. Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. Stem Cells Dev, 2013, 22(10):1614-1623.
14. 付冰川, 高建華, 魯峰, 等. 新鮮分離的脂肪SVF細胞促進脂肪移植存活的實驗研究. 中華整形外科雜志, 2010, 26(4):289-294.
15. Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant:a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5):1409-1424.
16. Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
17. Neuss S, Stainforth R, Salber J, et al. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant, 2008, 17(8):977-986.
18. 張云松, 高建華, 魯峰, 等. 人脂肪來源干細胞復合I型膠原支架構建工程化脂肪組織的實驗研究. 中華整形外科雜志, 2008, 24(5):385-389.
19. Shaterian A, Borboa A, Sawada R, et al. Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing. Burns, 2009, 35(6):811-817.
20. Vashi AV, Abberton KM, Thomas GP, et al. Adipose tissue engineering based on the controlled release of fibroblast growth factor-2 in a collagen matrix. Tissue Eng, 2006, 12(11):3035-3043.
21. Verseijden F, Posthumus-van SS, van Neck JW, et al. Comparing scaffold-free and fibrin-based adipose-derived stromal cell constructs for adipose tissue engineering:an in vitro and in vivo study. Cell Transplant, 2012, 21(10):2283-2297.
22. 張云松, 高建華, 魯峰, 等. 人脂肪來源干細胞復合纖維蛋白膠構建可注射型工程化脂肪組織的實驗研究. 中華醫學雜志, 2008, 88(38):2705-2709.
23. 許兆峰, 高建華, 李劼, 等. 纖維蛋白膠與脂肪來源干細胞影響脂肪注射移植的實驗研究. 南方醫科大學學報, 2009, 29(5):1073-1075.
24. Tan H, Ramirez CM, Miljkovic N, et al. Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering. Biomaterials, 2009, 30(36):6844-6853.
25. Zheng L, Fan HS, Sun J, et al. Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study. J Biomed Mater Res A, 2010, 93(2):783-792.
26. 于文淵, 崔磊, 趙宇, 等. 人脂肪干細胞與聚L-谷氨酸/海藻酸鈉可注射水凝膠的生物相容性研究. 安徽醫科大學學報, 2012, 47(6):727-731.
27. Wu I, Nahas Z, Kimmerling KA, et al. An injectable adipose matrix for soft-tissue reconstruction. Plast Reconstr Surg, 2012, 129(6):1247-1257.
28. 察鵬飛, 高建華, 陳陽, 等. 人細胞外基質支架聯合脂肪干細胞構建脂肪組織. 中華實驗外科雜志, 2012, 29(6):1085-1088.
29. Matsumoto D, Sato K, Gonda K, et al. Cell-assisted lipotransfer:supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Eng, 2006, 12 (12):3375-3382.
30. Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy:efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 2008, 34(9):1178-1185.
31. Wei X, Li G, Yang X, et al. Effects of bone morphogenetic protein-4 (BMP-4) on adipocyte differentiation from mouse adipose-derived stem cells. Cell Prolif, 2013, 46(4):416-424.
32. Wang B, Han J, Gao Y, et al. The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs. Neurosci Lett, 2007, 421(3):191-196.
33. 許海委, 徐寶山, 楊強,等. 細胞共培養法誘導兔脂肪來源干細胞向軟骨細胞分化的實驗研究. 中國修復重建外科雜志, 2013, 27(2):193-198.
34. Stosich MS, Moioli EK, Wu JK, et al. Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape. Methods, 2009, 47(2):116-121.
35. 黎洪棉, 高建華, 吳濤, 等. 脂肪干細胞與外源性血管內皮生長因子及纖維蛋白膠復合物體內構建血管化組織工程脂肪. 中國組織工程研究與臨床康復, 2011, 15(40):7480-7484.
36. 楊波, 沈宏亮, 徐志飛, 等. 血管內皮細胞生長因子165基因轉染干細胞促進組織工程化脂肪的存活. 中國組織工程研究, 2012, 16(14):2534-2539.
37. Taniyama Y, Morishita R, Aoki M, et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models:preclinical study for treatment of peripheral arterial disease. Gene Ther, 2001, 8(3):181-189.
38. 王有虎, 劉毅, 哈小琴, 等. 轉染肝細胞生長因子基因對移植顆粒脂肪新生血管形成的影響. 中華實驗外科雜志, 2008, 25(8):1079.
39. 黎洪棉, 柳大烈, 趙培冉, 等. 脂肪干細胞與自體富血小板血漿載體復合物體內構建血管化組織工程脂肪. 中國組織工程研究, 2012, 16(45):8424-8429.
40. Mazzola RF, Cantarella G, Torretta S, et al. Autologous fat injection to face and neck:from soft tissue augmentation to regenerative medicine. Acta Otorhinolaryngol Ital, 2011, 31(2):59-69.
41. Adams WJ Jr. Discussion:Breast augmentation using preexpansion and autologous fat transplantation:a clinical radiographic study. Plast Reconstr Surg, 2011, 127(6):2453-2454.

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RESEARCH PROGRESS OF CONSTRUCTING INJECTABLE TISSUE ENGINEERED ADIPOSE TISSUE WITH ADIPOSE-DERIVED STEM CELLS

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