PRELIMINARY STUDY ON EFFECT OF FEMORAL TUNNEL ANGLE ON FEMORAL TUNNEL AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION IN RABBITS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 ZOUGuoyao , SONGEnhong , LIZhang

Department of Spinal and Osteopathy Surgery, Affiliated Hospital, Guilin Medical College, Guilin Guangxi, 541001, P. R. China;

Corresponding?author：

ZOUGuoyao, Email: zhouguoyao2000@aliyun.com

Keywords：

Anterior cruciate ligament reconstruction; Femoral tunnel; Tumor necrosis factor α; Maximum load

DOI：

10.7507/1002-1892.20150037

Video：

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Objective To investigate the effect of the femoral tunnel angle on the femoral tunnel after anterior cruciate ligament (ACL) reconstruction in rabbits. Methods Fifty-four healthy 4-5 months old rabbits (weighing, 1.8-2.3 kg, male or female) were randomly divided into 3 groups (n=18). The ACL reconstruction models of the right knee were established in 3 experimental groups using its Achilles tendons, and the left knee served as the control group. On the coronal position, the angle between the femoral tunnel and the femoral shaft axis was 30°, 45°, and 60°. The level of tumor necrosis factor α (TNF-α) in the synovial fluid at 1, 2, and 4 weeks, the maximum load of the ligament and the rate of bone tunnel enlargement at 4, 8, and 12 weeks were detected. Results The level of TNF-α significantly increased, and the maximum load of the ligament significantly decreased in the 3 experimental groups when compared with ones in the control group (P<0.05), but no significant difference was found among 3 experimental groups (P>0.05). The bone tunnel enlargement was observed in 3 experimental groups at each time point and reached the peak at 4 weeks, but no significant difference was shown among 3 groups (P>0.05). Conclusion The 30-60° angle between the femoral tunnel and the femoral shaft axis in the coronal position has no significant effect on the femoral tunnel enlargement after ACL reconstruction in rabbits.

Citation： ZOUGuoyao, SONGEnhong, LIZhang. PRELIMINARY STUDY ON EFFECT OF FEMORAL TUNNEL ANGLE ON FEMORAL TUNNEL AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION IN RABBITS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(2): 171-174. doi: 10.7507/1002-1892.20150037 Copy

1.	Lee Y S, Lee SW, Nam SW, et al. Analysis of tunnel widening after double-bundle ACL reconstruction. Knee Surg Sports Traumatol Arthrosc, 2012, 20(11):2243-2250.
2.	Zhang C, Xu H, Li X, et al. Oblique femoral tunnel or oblique graft? A modified anteromedial portal technique to obtain vertical femoral tunnel and oblique graft in anatomic anterior cruciate ligament recon struction. Eur J Orthop Surg Traumatol, 2013, 23(4):731-735.
3.	劉慶鵬, 于連祥, 丁曉琳, 等. BMP加強型蠶絲人工韌帶重建兔ACL的實驗研究. 中國矯形外科雜志, 2013, 21(8):799-807.
4.	Mather RC, Koenig L, Kocher MS, et al. Societal and economic impact of anterior cruciate ligament tears. J Bone Joint Surg (Am), 2013, 95(19):1751-1759.
5.	張偉, 孫磊. 保留與切除殘跡前交叉韌帶重建關節液滲入骨隧道的實驗比較. 中國骨與關節損傷雜志, 2012, 27(7):608-610.
6.	安明, 劉金, 馮晶晶, 等. 骨保護素對骨-腱愈合促進作用的研究. 中日友好醫院學報, 2013, 27(6):346-348.
7.	Webster KE, Chiu JJ, Feller JA. Impact of measurement error in the analysis of bone tunnel enlargement after anterior cruciate ligament reconstruction. Am J Sports Med, 2005, 33(11):1680-1687.
8.	高加智, 孫磊. 保留殘跡對骨隧道封閉前交叉韌帶重建移植物關節內愈合的影響. 中國矯形外科雜志, 2013, 21(18):1877-1881.
9.	張健, 姜鑫, 張洪亮. 自體富血小板血漿對兔前交叉韌帶重建后腱骨愈合組織學影響. 遼寧醫學院學報, 2013, 34(2):23-26.
10.	Sun L, Zhou X, Wu B, et al. Inhibitory effect of synovial fluid on tendon-to-bone healing:an experimental study in rabbits. Arthroscopy, 2012, 28(9):1297-1305.
11.	Darabos N, Haspl M, Moser C, et al. Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc, 2011, 19 Suppl 1:S36-46.
12.	孫正明, 凌鳴, 馮偉樓, 等. 負壓對兔前交叉韌帶重建術后腱-骨界面血管化影響的研究. 山西醫科大學學報, 2013, 44(7):523-526.
13.	Zysk SP, Fraunberger P, Veihelmann A, et al. Tunnel enlargement and changes in synovial fluid cytokine profile following anterior cruciate ligament reconstruction with patellar tendon and hamstring tendon autografts. Knee Surg Sports Traumatol Arthrosc, 2004, 12(2):98-103.
14.	孫磊, 吳波, 田敏, 等. 兔保留與切除殘跡前交叉韌帶重建生物力學的比較.中華關節外科雜志(電子版), 2013, 7(1):81-85.
15.	Li X, Snedeker JG. Wired silk architectures provide a biomimetic ACL tissue engineering scaffold. J Mech Behav Biomed Mater, 2013, 22:30-40.
16.	張文友, 賀健康, 李翔, 等. 基于3-D打印技術的韌帶-骨復合支架制造與體內植入研究. 中國修復重建外科雜志, 2014, 28(3):314-317.
17.	Lovric V, Ledger M, Goldberg J, et al. The effects of low-intensity pulsed ultrasound on tendon-bone healing in a transosseous equivalent sheep rotator cuff model. Knee Surg Sports Traumatol Arthrosc, 2013, 21(2):466-475.
18.	Lee YS, Han SH, Kim JH. A biomechanical comparison of tibial back side fixation between suspensory and expansion mechanisms in trans-tibial posterior cruciate ligament reconstruction. Knee, 2012, 19(1):55-59.
19.	Lim JK, Hui J, Li L, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy, 2004, 20(9):899-910.
20.	He P, Sahoo S, Ng KS, et al. Enhanced osteoinductivity and osteoconductivity through hydroxyapatite coating of silk-based tissue-engineered ligament scaffold. J Biomed Mater Res A, 2013, 101(2):555-566.
21.	Rodeo SA, Kawamura S, Kim HJ, et al. Tendon healing in a bone tunnel differs at the tunnel entrance versus the tunnel exit:all effect of graft-tunnel motion? Am J Spots Med, 2006, 34 (11):1790-1800.
22.	項群, 王四清, 殷俊, 等. 重建后交叉韌帶股骨側"銳角效應"的相關研究. 中國骨與關節外科, 2013, 6(1):47-49.
23.	沈光思, 徐又佳, 周海斌, 等. 前交叉韌帶重建術股骨隧道角度與隧道壁承受應力關系的研究. 臨床骨科雜志, 2008, 11(5):469-472.

1. Lee Y S, Lee SW, Nam SW, et al. Analysis of tunnel widening after double-bundle ACL reconstruction. Knee Surg Sports Traumatol Arthrosc, 2012, 20(11):2243-2250.
2. Zhang C, Xu H, Li X, et al. Oblique femoral tunnel or oblique graft? A modified anteromedial portal technique to obtain vertical femoral tunnel and oblique graft in anatomic anterior cruciate ligament recon struction. Eur J Orthop Surg Traumatol, 2013, 23(4):731-735.
3. 劉慶鵬, 于連祥, 丁曉琳, 等. BMP加強型蠶絲人工韌帶重建兔ACL的實驗研究. 中國矯形外科雜志, 2013, 21(8):799-807.
4. Mather RC, Koenig L, Kocher MS, et al. Societal and economic impact of anterior cruciate ligament tears. J Bone Joint Surg (Am), 2013, 95(19):1751-1759.
5. 張偉, 孫磊. 保留與切除殘跡前交叉韌帶重建關節液滲入骨隧道的實驗比較. 中國骨與關節損傷雜志, 2012, 27(7):608-610.
6. 安明, 劉金, 馮晶晶, 等. 骨保護素對骨-腱愈合促進作用的研究. 中日友好醫院學報, 2013, 27(6):346-348.
7. Webster KE, Chiu JJ, Feller JA. Impact of measurement error in the analysis of bone tunnel enlargement after anterior cruciate ligament reconstruction. Am J Sports Med, 2005, 33(11):1680-1687.
8. 高加智, 孫磊. 保留殘跡對骨隧道封閉前交叉韌帶重建移植物關節內愈合的影響. 中國矯形外科雜志, 2013, 21(18):1877-1881.
9. 張健, 姜鑫, 張洪亮. 自體富血小板血漿對兔前交叉韌帶重建后腱骨愈合組織學影響. 遼寧醫學院學報, 2013, 34(2):23-26.
10. Sun L, Zhou X, Wu B, et al. Inhibitory effect of synovial fluid on tendon-to-bone healing:an experimental study in rabbits. Arthroscopy, 2012, 28(9):1297-1305.
11. Darabos N, Haspl M, Moser C, et al. Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc, 2011, 19 Suppl 1:S36-46.
12. 孫正明, 凌鳴, 馮偉樓, 等. 負壓對兔前交叉韌帶重建術后腱-骨界面血管化影響的研究. 山西醫科大學學報, 2013, 44(7):523-526.
13. Zysk SP, Fraunberger P, Veihelmann A, et al. Tunnel enlargement and changes in synovial fluid cytokine profile following anterior cruciate ligament reconstruction with patellar tendon and hamstring tendon autografts. Knee Surg Sports Traumatol Arthrosc, 2004, 12(2):98-103.
14. 孫磊, 吳波, 田敏, 等. 兔保留與切除殘跡前交叉韌帶重建生物力學的比較.中華關節外科雜志(電子版), 2013, 7(1):81-85.
15. Li X, Snedeker JG. Wired silk architectures provide a biomimetic ACL tissue engineering scaffold. J Mech Behav Biomed Mater, 2013, 22:30-40.
16. 張文友, 賀健康, 李翔, 等. 基于3-D打印技術的韌帶-骨復合支架制造與體內植入研究. 中國修復重建外科雜志, 2014, 28(3):314-317.
17. Lovric V, Ledger M, Goldberg J, et al. The effects of low-intensity pulsed ultrasound on tendon-bone healing in a transosseous equivalent sheep rotator cuff model. Knee Surg Sports Traumatol Arthrosc, 2013, 21(2):466-475.
18. Lee YS, Han SH, Kim JH. A biomechanical comparison of tibial back side fixation between suspensory and expansion mechanisms in trans-tibial posterior cruciate ligament reconstruction. Knee, 2012, 19(1):55-59.
19. Lim JK, Hui J, Li L, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy, 2004, 20(9):899-910.
20. He P, Sahoo S, Ng KS, et al. Enhanced osteoinductivity and osteoconductivity through hydroxyapatite coating of silk-based tissue-engineered ligament scaffold. J Biomed Mater Res A, 2013, 101(2):555-566.
21. Rodeo SA, Kawamura S, Kim HJ, et al. Tendon healing in a bone tunnel differs at the tunnel entrance versus the tunnel exit:all effect of graft-tunnel motion? Am J Spots Med, 2006, 34 (11):1790-1800.
22. 項群, 王四清, 殷俊, 等. 重建后交叉韌帶股骨側"銳角效應"的相關研究. 中國骨與關節外科, 2013, 6(1):47-49.
23. 沈光思, 徐又佳, 周海斌, 等. 前交叉韌帶重建術股骨隧道角度與隧道壁承受應力關系的研究. 臨床骨科雜志, 2008, 11(5):469-472.

Chinese Journal of Reparative and Reconstructive Surgery

PRELIMINARY STUDY ON EFFECT OF FEMORAL TUNNEL ANGLE ON FEMORAL TUNNEL AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION IN RABBITS

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