APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

QINMian ¹ ,  LIUYaxiong ¹ , HEJiankang ¹ , WANGLing ¹ , LIANQin ¹ , LIDichen ¹ , JINZhongmin ^1,2 , HESanhu ³ , LIGang ³ , LIUYanpu ⁴ , WANGZhen ⁵

1. State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an Shaanxi, 710049, P. R. China;
2. Institute of Medical and Biological Engineering, Leeds University, UK;
3. Department of Maxillofacial Surgery, School of Stomatology, Xi'an Jiaotong University;
4. Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University;
5. Department of Orthopedics, Xijing Hospital, the Fourth Military Medical University;

Corresponding?author：

LIUYaxiong, Email: yaxiongliu@mail.xjtu.edu.cn

Keywords：

Three-dimensional printing technique; Individualized medical treatment; Medical implant; Clinical application

DOI：

10.7507/1002-1892.20140065

Video：

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Objective To summarize the latest research development of the application of digital design and three-dimensional (3-D) printing technique on individualized medical treatment. Methods Recent research data and clinical literature about the application of digital design and 3-D printing technique on individualized medical treatment in Xi'an Jiaotong University and its cooperation unit were summarized, reviewed, and analyzed. Results Digital design and 3-D printing technique can design and manufacture individualized implant based on the patient's specific disease conditions. And the implant can satisfy the needs of specific shape and function of the patient, reducing dependence on the level of experience required for the doctor. So 3-D printing technique get more and more recognition of the surgeon on the individualized repair of human tissue. Xi'an Jiaotong University is the first unit to develop the commercial 3-D printer and conduct depth research on the design and manufacture of individualized medical implant. And complete technological processes and quality standards of product have been developed. Conclusion The individualized medical implant manufactured by 3-D printing technique can not only achieve personalized match but also meet the functional requirements and aesthetic requirements of patients. In addition, the individualized medical implant has the advantages of accurate positioning, stable connection, and high strength. So 3-D printing technique has broad prospects in the manufacture and application of individualized implant.

Citation： QINMian, LIUYaxiong, HEJiankang, WANGLing, LIANQin, LIDichen, JINZhongmin, HESanhu, LIGang, LIUYanpu, WANGZhen. APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(3): 286-291. doi: 10.7507/1002-1892.20140065 Copy

1.	劉葳, 李滌塵, 周麗斌, 等. 定制化柔性下頜骨鈦替代物的有限元優化分析及動物試驗. 機械工程學報, 2010, 46(5):133-138.
2.	王金濤, 劉美娟, 苗雷英, 等. 下頜骨缺損修復新進展. 吉林大學學報:醫學版, 2005, 31(6):973-976.
3.	邱蔚六. 口腔頜面修復重建外科近況. 中國修復重建外科雜志, 2006, 20(4):339-343.
4.	Giannatsis J, Dedoussis V. Additive fabrication technologies applied to medicine and health care:a review. Int J Adv Manuf Technol, 2009, 40:116-127.
5.	龔振宇, 劉彥普, 周樹夏, 等. 基于反求工程和快速原型的下頜骨缺損的修復. 中華口腔醫學雜志, 2004, 39(1):9-11.
6.	Singare S, Dichen L, Bingheng L, et al. Design and fabrication of custom mandible titanium tray based on rapid prototyping. Med Eng Phys, 2004, 26(8):671-676.
7.	Singare S, Yaxiong L, Dichen L, et al. Fabrication of customized maxillo-facial prosthesis using computer-aided design and rapid prototyping techniques. Rapid Prototyping Journal, 2006, 12(4):206-213.
8.	王千, 劉亞雄, 杜如坤, 等. 利用布爾運算的定制化下頜骨替代物設計方法. 西安交通大學學報, 2009, 43(1):43-46.
9.	楊海歐, 林鑫, 陳靜, 等. 激光成形制備生物醫用鈦合金材料研究進展. 鑄造技術, 2011, 32(10):1431-1434.
10.	劉輝, 楊冠軍, 于振濤, 等. 生物醫用多孔鈦合金材料的制備. 鈦工業進展, 2010, 27(1):9-15.
11.	Ducan RL, Turner CH. Mechanotransduction and the functional response of bone tomechanical strain. Calcif Tissue Int, 1995, 57(5):344-358.
12.	劉亞雄, 王千, 賀健康, 等. 定制化鈦合金假體光固化快速鑄造工藝精度研究. 機械工程學報, 2013, 網絡版:http://www.cnki.net/kcms/detail/11.2187.TH.20131009.1408.021.html.
13.	張安峰, 李滌塵, 盧秉恒. 激光直接金屬快速成形技術的研究進展. 兵器材科科學與工程, 2007, 30(5):68-73.
14.	李伯瓊. 多孔鈦的孔隙特征和力學性能的研究. 大連:大連交通大學, 2005.
15.	Liu Yaxiong, Li Dichen, Lu Bingheng, et al. The customized mandible substitute based on rapid prototyping. Rapid Prototyping Journal, 2003, 9(3):167-174.
16.	劉亞雄, 李滌塵, 盧秉恒, 等. 快速原型在口腔頜面修復中的應用(1)——下頜骨替代物的原位設計. 實用口腔醫學雜志, 2002, 18(5):395-397.
17.	劉亞雄, 李滌塵, 盧秉恒, 等. 快速原型在口腔頜面修復中的應用(2)——下頜骨替代物的個性化制造. 實用口腔醫學雜志, 2003, 19(5):408-410.
18.	He J, Li D, Lu B, et al. Custom fabrication of composite tibial hemi-knee joint combining CAD/CAE/CAM techniques. Proc Inst Mech Eng H, 2006, 220(8):823-830.
19.	張虎, 李滌塵, 孫明林, 等. 定制化單側膝關節假體設計與快速制造方法研究. 北京生物醫學工程, 2003, 22(4):266-268, 273.
20.	鄭淑賢, 趙萬華, 盧秉恒. 殘肢與接受腔的三維建模及力學分析. 中國康復, 2006, 21(1):52-54.

1. 劉葳, 李滌塵, 周麗斌, 等. 定制化柔性下頜骨鈦替代物的有限元優化分析及動物試驗. 機械工程學報, 2010, 46(5):133-138.
2. 王金濤, 劉美娟, 苗雷英, 等. 下頜骨缺損修復新進展. 吉林大學學報:醫學版, 2005, 31(6):973-976.
3. 邱蔚六. 口腔頜面修復重建外科近況. 中國修復重建外科雜志, 2006, 20(4):339-343.
4. Giannatsis J, Dedoussis V. Additive fabrication technologies applied to medicine and health care:a review. Int J Adv Manuf Technol, 2009, 40:116-127.
5. 龔振宇, 劉彥普, 周樹夏, 等. 基于反求工程和快速原型的下頜骨缺損的修復. 中華口腔醫學雜志, 2004, 39(1):9-11.
6. Singare S, Dichen L, Bingheng L, et al. Design and fabrication of custom mandible titanium tray based on rapid prototyping. Med Eng Phys, 2004, 26(8):671-676.
7. Singare S, Yaxiong L, Dichen L, et al. Fabrication of customized maxillo-facial prosthesis using computer-aided design and rapid prototyping techniques. Rapid Prototyping Journal, 2006, 12(4):206-213.
8. 王千, 劉亞雄, 杜如坤, 等. 利用布爾運算的定制化下頜骨替代物設計方法. 西安交通大學學報, 2009, 43(1):43-46.
9. 楊海歐, 林鑫, 陳靜, 等. 激光成形制備生物醫用鈦合金材料研究進展. 鑄造技術, 2011, 32(10):1431-1434.
10. 劉輝, 楊冠軍, 于振濤, 等. 生物醫用多孔鈦合金材料的制備. 鈦工業進展, 2010, 27(1):9-15.
11. Ducan RL, Turner CH. Mechanotransduction and the functional response of bone tomechanical strain. Calcif Tissue Int, 1995, 57(5):344-358.
12. 劉亞雄, 王千, 賀健康, 等. 定制化鈦合金假體光固化快速鑄造工藝精度研究. 機械工程學報, 2013, 網絡版:http://www.cnki.net/kcms/detail/11.2187.TH.20131009.1408.021.html.
13. 張安峰, 李滌塵, 盧秉恒. 激光直接金屬快速成形技術的研究進展. 兵器材科科學與工程, 2007, 30(5):68-73.
14. 李伯瓊. 多孔鈦的孔隙特征和力學性能的研究. 大連:大連交通大學, 2005.
15. Liu Yaxiong, Li Dichen, Lu Bingheng, et al. The customized mandible substitute based on rapid prototyping. Rapid Prototyping Journal, 2003, 9(3):167-174.
16. 劉亞雄, 李滌塵, 盧秉恒, 等. 快速原型在口腔頜面修復中的應用(1)——下頜骨替代物的原位設計. 實用口腔醫學雜志, 2002, 18(5):395-397.
17. 劉亞雄, 李滌塵, 盧秉恒, 等. 快速原型在口腔頜面修復中的應用(2)——下頜骨替代物的個性化制造. 實用口腔醫學雜志, 2003, 19(5):408-410.
18. He J, Li D, Lu B, et al. Custom fabrication of composite tibial hemi-knee joint combining CAD/CAE/CAM techniques. Proc Inst Mech Eng H, 2006, 220(8):823-830.
19. 張虎, 李滌塵, 孫明林, 等. 定制化單側膝關節假體設計與快速制造方法研究. 北京生物醫學工程, 2003, 22(4):266-268, 273.
20. 鄭淑賢, 趙萬華, 盧秉恒. 殘肢與接受腔的三維建模及力學分析. 中國康復, 2006, 21(1):52-54.

Chinese Journal of Reparative and Reconstructive Surgery

APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT

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