Research progress on venous thromboembolism in patients with cerebral hemorrhage_West China Medical Journal

Authors：

YE Hongmin ,  GAN Xiuni

Department of Nursing, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P. R. China;

Corresponding?author：

GAN Xiuni, Email: 300650@cqmu.edu.cn

Keywords：

Cerebral hemorrhage; venous thromboembolism; risk factors; assessment tools; literature review

DOI：

10.7507/1002-0179.202407084

Video：

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Abstract Full text Figures/Tables Video References Cited by

Cerebral hemorrhage is a common clinical critical disease, and venous thromboembolism is one of its common complications. How to diagnose and treat venous thromboembolism early is still the main problem in the management of patients with cerebral hemorrhage. This article reviews the concept, pathogenesis, risk factors, evaluation tools, prevention and treatment of venous thromboembolism in patients with cerebral hemorrhage. Suggestions are put forward on the development of evaluation tools and improvement of prevention and treatment, in order to provide reference for clinical management and related research of patients with cerebral hemorrhage complicated with venous thromboembolism.

Citation： YE Hongmin, GAN Xiuni. Research progress on venous thromboembolism in patients with cerebral hemorrhage. West China Medical Journal, 2024, 39(12): 1958-1963. doi: 10.7507/1002-0179.202407084 Copy

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1. Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am, 2012, 30(3): 771-794.
2. Naidech AM. Intracranial hemorrhage. Am J Respir Crit Care Med, 2011, 184(9): 998-1006.
3. 中華醫學會神經病學分會, 中華醫學會神經病學分會腦血管病學組. 中國腦出血診治指南(2019). 中華神經科雜志, 2019, 52(12): 994-1005.
4. 何菁, 王芳, 熊璐璐, 等. 腦卒中并發靜脈血栓栓塞癥的發生情況及危險因素分析. 四川大學學報(醫學版), 2023, 54(3): 638-641.
5. 張萍. 神經重癥患者危重病情的精準量化評估. 武漢: 華中科技大學, 2018.
6. Liu S, Wang Y, Gao B, et al. A nomogram for predicting venous thromboembolism in critically ill patients with primary intracerebral hemorrhage. World Neurosurg, 2022, 157: e301-e307.
7. Chu Q, Liao L, Wei W, et al. Venous thromboembolism in ICU patients with intracerebral hemorrhage: risk factors and the prognosis after anticoagulation therapy. Int J Gen Med, 2021, 14: 5397-5404.
8. 杜偉, 周輝, 魏新亭. AHA/ASA《自發性腦出血診療指南(2022 版)》解讀. 中華神經醫學雜志, 2023, 22(3): 217-221.
9. Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke Vasc Neurol, 2017, 2(1): 21-29.
10. van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol, 2010, 9(2): 167-176.
11. 中華醫學會呼吸病學分會肺栓塞與肺血管病學組, 中國醫師協會呼吸醫師分會肺栓塞與肺血管病工作委員會, 全國肺栓塞與肺血管病防治協作組. 肺血栓栓塞癥診治與預防指南. 中華醫學雜志, 2018, 98(14): 1060-1087.
12. 倪瑩瑩, 王首紅, 宋為群, 等. 神經重癥康復中國專家共識(下). 中國康復醫學雜志, 2018, 33(3): 264-268.
13. 中華醫學會重癥醫學分會. 重癥監護病房患者深靜脈血栓形成預防指南. 中國危重病急救醫學, 2009, 21(9): 514-517.
14. 陳穎. 危重癥患者下肢深靜脈血栓影響因素分析及風險預測模型構建. 青島: 青島大學, 2021.
15. 宮蓓蕾, 許啟霞, 龐穎穎, 等. 靜脈血栓栓塞癥患者臨床特征: 10 年 177 例病例分析. 中華危重病急救醫學, 2019, 31(4): 453-457.
16. Malone PC, Agutter PS. The aetiology of deep venous thrombosis. QJM, 2006, 99(9): 581-593.
17. 高亮, 陳宋育. 美國神經重癥學會預防神經重癥患者靜脈血栓栓塞指南的解讀. 中華神經創傷外科電子雜志, 2016, 2(5): 261-270.
18. 袁春艷, 彭衛平, 鄧娟娟. 腦出血老年患者術后發生靜脈血栓栓塞的危險因素. 吉林醫學, 2023, 44(7): 1985-1987.
19. Dong C, Li Y, Ma Z. Venous thromboembolism after spontaneous intracerebral hemorrhage and the status quo of anticoagulation in this population: a retrospective casecontrol study from a tertiary hospital in China. Clin Neurol Neurosurg, 2023, 231: 107839.
20. Miao L, Shi J, Yu H, et al. Studies on atrial fibrillation and venous thromboembolism in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer. J Am Heart Assoc, 2023, 12(17): e029810.
21. Melmed KR, Boehme A, Ironside N, et al. Respiratory and blood stream infections are associated with subsequent venous thromboembolism after primary intracerebral hemorrhage. Neurocrit Care, 2021, 34(1): 85-91.
22. 王榮榮, 周乾宇, 郭園麗, 等. 腦卒中患者靜脈血栓栓塞癥風險預測模型的構建及驗證. 中華疾病控制雜志, 2023, 27(10): 1161-1166.
23. 石瓊婭, 周立宇, 張嬌, 等. 預測老年自發性腦出血患者深靜脈血栓——基于 MIMIC-Ⅳ數據庫回顧性分析. 臨床神經外科雜志, 2023, 20(3): 327-331.
24. Koch V, Biener M, Müller-Hennessen M, et al. Diagnostic performance of D-dimer in predicting venous thromboembolism and acute aortic dissection. Eur Heart J Acute Cardiovasc Care, 2021, 10(5): 559-566.
25. Wolberg AS, Sang Y. Fibrinogen and factor XIII in venous thrombosis and thrombus stability. Arterioscler Thromb Vasc Biol, 2022, 42(8): 931-941.
26. Ding J, Yue X, Tian X, et al. Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis. Thromb J, 2023, 21(1): 82.
27. Wang G, Zhao W, Zhao Z, et al. Leukocyte as an independent predictor of lower-extremity deep venous thrombosis in elderly patients with primary intracerebral hemorrhage. Frontiers in Neurol, 2022, 13: 899849.
28. Spasi? I, Ubavi? M, ?umarac Z, et al. Influence of lipid metabolism disorders on venous thrombosis risk. J Med Biochem, 2021, 40(3): 245-251.
29. Ren W, Huang Q, Fan K, et al. Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke. Nutr Metab Cardiovasc Dis, 2021, 31(9): 2700-2706.
30. 湯廳均, 張翔, 耿保偉, 等. 腦出血術后下肢深靜脈血栓形成的臨床特點及危險因素. 血管與腔內血管外科雜志, 2023, 9(2): 250-253, 256.
31. Kelly J, Hunt BJ, Lewis RR, et al. Dehydration and venous thromboembolism after acute stroke. QJM, 2004, 97(5): 293-296.
32. 張紅玲, 許佑冬, 劉正東. 急性腦出血患者 ICU 期間下肢深靜脈血栓發生的危險因素分析. 中華神經醫學雜志, 2020, 19(5): 488-492.
33. 林鴻輝, 田原卿. 腦出血患者在 ICU 期間下肢深靜脈血栓形成的影響因素及中西醫結合預防策略. 黑龍江醫藥, 2023, 36(3): 607-610.
34. Hallan DR, Simion C, Rizk E. Early versus late tracheostomy in spontaneous intracerebral hemorrhage. Cureus, 2022, 14(4): e24059.
35. 郝廣志, 董玉書, 張冰瑩, 等. 基于 LASSO-logistic 回歸構建腦出血術后下肢靜脈血栓的風險預測模型. 中華神經外科疾病研究雜志, 2024, 18(4): 1-6.
36. Benincasa G, Costa D, Infante T, et al. Interplay between genetics and epigenetics in modulating the risk of venous thromboembolism: a new challenge for personalized therapy. Thromb Res, 2019, 177: 145-153.
37. 姚漪婷. 靜脈血栓栓塞癥遺傳特征分析. 廣州: 廣州醫科大學, 2023.
38. 周佳, 嚴靜, 李莉. 重癥醫學科患者深靜脈血栓形成預防現狀的研究進展. 中華重癥醫學電子雜志(網絡版), 2020, 6(3): 314-317.
39. Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon, 2005, 51(2/3): 70-78.
40. 周鑫飛, 嚴靜. 靜脈血栓栓塞癥風險評估模型在重癥監護室中的應用. 心腦血管病防治, 2022, 22(6): 66-70.
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