Objective  To detect human papilloma virus (HPV) typing in wart tissue of patients with condyloma acuminatum (CA) in Sichuan, understand the characteristics of CA, HPV infection and subtype distribution, and provide theoretical basis for formulating prevention and control strategy and further screening cervical malignant lesions. Methods  HPV typing was performed in patients diagnosed with CA between January 1, 2018 and December 31, 2023 in the Department of Dermatology & Venereology of West China Hospital of Sichuan University by polymerase chain reaction capillary electrophoresis fragment analysis. The overall positive rate of HPV infection, distribution of HPV subtypes and infection characteristics were analyzed and calculated. The positive rate of HPV in different sex, age, and immune status were analyzed. Results  A total of 1 741 patients were included. Among them, there were 1 527 cases of pure CA and 214 cases of CA with immune deficiency; 1 264 cases were HPV positive, with a positivity rate of 72.60%. The overall positive rate of HPV in male patients was higher than that in female patients [76.83% (713/928) vs. 67.77% (551/813); χ²=17.875, P<0.001]; 1155 cases of low-risk HPV infection were detected; the low-risk subtypes with the highest positivity rates were HPV type 6 [690 cases (39.63%)] and HPV type 11 [456 cases (26.19%)]. Among the 1 264 HPV-positive patients, 773 patients were infected with a single HPV subtype, and 491 patients were infected with multiple HPV subtypes. Among the 1 155 patients infected with low-risk HPV, 357 patients (30.91%) were co-infected with high-risk HPV, of whom 79 patients (6.84%) were co-infected with HPV16 and/or HPV18. Among the 214 CA patients with immune deficiency, females were more than males (135 vs. 79 cases; χ²=26.322, P<0.001). Among the 1 527 patients with simple CA, males were more than females (849 vs. 678 cases; χ²=20.927, P<0.001). There was no statistically significant difference in the HPV infection rate, double or more type infection rate, or combined high-risk HPV infection rate in CA patients with immunosuppression compared with that in simple CA patients (P>0.05). Conclusion  The results of HPV infection analysis in CA patients in Sichuan area emphasize the necessity of HPV typing detection in CA patients, which not only helps to monitor the efficacy and recurrence of positive patients after treatment, but also can detect patients with high-risk HPV co-infection, providing theoretical basis for further screening and prevention and control of cervical cancer and other HPV-related diseases in these patients.

Citation： ZHONG Huiyu, LIU Tangyuheng, WU Lijuan, WANG Minjin, SONG Xingbo. Detection and analysis of human papilloma virus genotyping in tissue of patients with condyloma acuminatum in Sichuan. West China Medical Journal, 2025, 40(8): 1210-1216. doi: 10.7507/1002-0179.202406131 Copy

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