Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders_West China Medical Journal

Authors：

LI Xianghong , LI Jie , LI Yajuan ,  YUAN Huaihong

Department of Nephrology and Institute of Kidney Diseases, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

YUAN Huaihong, Email: yuanhuaihong@wchscu.cn

Keywords：

Maintenance hemodialysis; grip strength; subjective cognitive decline; influencing factor

DOI：

10.7507/1002-0179.202406084

Video：

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Objective To investigate the correlation between grip strength and subjective cognitive decline (SCD) in maintenance hemodialysis (MHD) patients of different genders. Methods Patients who underwent outpatient MHD in the Wenjiang Hemodialysis Unit, Department of Nephrology, West China Hospital, Sichuan University between March and June 2024 were selected as the research subjects. Multiple linear regression analysis was used to explore the relationship between grip strength and SCD in MHD patients of different genders. Results A total of 171 patients were investigated, with 76 in the non-SCD group and 95 in the SCD group. The results of multiple linear regression analysis showed that educational level (P=0.039), nutritional status (P=0.026), and grip strength (P=0.042) were the influencing factors of SCD in male MHD patients. Work status (P=0.001) and nutritional status (P=0.011) were the influencing factors of SCD in female MHD patients. Conclusions Educational level, nutritional status, and grip strength are influencing factors of SCD in male MHD patients. Work status and nutritional status are influencing factors of SCD in female MHD patients. Grip strength may serve as an indicator for evaluating SCD in male MHD patients.

Citation： LI Xianghong, LI Jie, LI Yajuan, YUAN Huaihong. Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders. West China Medical Journal, 2024, 39(7): 1096-1101. doi: 10.7507/1002-0179.202406084 Copy

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2.	O’Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis, 2016, 67(6): 925-935.
3.	Kalirao P, Pederson S, Foley RN, et al. Cognitive impairment in peritoneal dialysis patients. Am J Kidney Dis, 2011, 57(4): 612-620.
4.	San A, Hiremagalur B, Muircroft W, et al. Screening of cognitive impairment in the dialysis population: a scoping review. Dement Geriatr Cogn Disord, 2017, 44(3/4): 182-195.
5.	Kallenberg MH, Kleinveld HA, Dekker FW, et al. Functional and cognitive impairment, frailty, and adverse health outcomes in older patients reaching ESRD-a systematic review. Clin J Am Soc Nephrol, 2016, 11(9): 1624-1639.
6.	van Zwieten A, Wong G, Ruospo M, et al. Associations of cognitive function and education level with all-cause mortality in adults on hemodialysis: findings from the COGNITIVE-HD study. Am J Kidney Dis, 2019, 74(4): 452-462.
7.	張雷, 范占芳, 張作鵬, 等. 阿爾茲海默癥發病機制及相關治療藥物的研究進展. 中國藥物化學雜志, 2021, 31(6): 438-446, 469.
8.	Burns JM, Johnson DK, Watts A, et al. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol, 2010, 67(4): 428-433.
9.	Leong DP, Teo KK, Rangarajan S, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 2015, 386(9990): 266-273.
10.	Cui M, Zhang S, Liu Y, et al. Grip strength and the risk of cognitive decline and dementia: a systematic review and meta-analysis of longitudinal cohort studies. Front Aging Neurosci, 2021, 13: 625551.
11.	董雅勤, 王為強. 社區老年人群主觀認知下降與握力的相關性研究. 中華全科醫學, 2022, 20(8): 1363-1366, 1426.
12.	Detsky AS, McLaughlin JR, Baker JP, et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr, 1987, 11(1): 8-13.
13.	Kopple JD. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis, 2001, 37(Suppl 2): S66-S70.
14.	郝立曉, 邢悅, 賈建國, 等. 英文版主觀認知下降問卷 21 的漢化研究. 中國全科醫學, 2021, 24(18): 2349-2354.
15.	Gifford KA, Liu D, Romano R 3rd, et al. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst), 2015, 1(4): 429-439.
16.	張波, 胡益, 孫若琳, 等. 握力與主觀認知下降在不同性別老年人群中的相關性分析. 中國實用神經疾病雜志, 2023, 26(12): 1532-1536.
17.	宋銀華, 劉玉雙, 楊青, 等. 老年人主觀認知下降與慢性病共病的相關性分析. 中國全科醫學, 2023, 26(10): 1241-1249.
18.	Wen C, Hu H, Ou YN, et al. Risk factors for subjective cognitive decline: the CABLE study. Transl Psychiatry, 2021, 11(1): 576.
19.	顧懷聰, 王為強, 董雅勤. 社區老年人群主觀認知下降的影響因素分析. 中國醫藥導報, 2023, 20(26): 55-59, 99.
20.	Reuben R, Karkaby L, McNamee C, et al. Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?. Climacteric, 2021, 24(4): 321-332.
21.	Liu Y, Lachman ME. Education and cognition in middle age and later life: the mediating role of physical and cognitive activity. J Gerontol B Psychol Sci Soc Sci, 2020, 75(7): e93-e104.
22.	遲晨汝, 陳夢奇, 楊丹, 等. 維持性血液透析病人認知功能障礙影響因素及干預的研究進展. 全科護理, 2023, 21(14): 1920-1924.
23.	常曉東, 薛痕, 肖峰, 等. 維持性血液透析患者認知功能障礙影響因素及與血清 Klotho 蛋白的相關性分析. 國際精神病學雜志, 2021, 48(5): 901-904.
24.	歐琴琴, 查艷. 維持性血液透析患者營養不良與認知損害的研究進展. 中華腎臟病雜志, 2022, 38(11): 1006-1010.
25.	胡美玲, 羅棉, 覃勛, 等. 維持性血液透析患者握力與營養指標的相關性. 廣東醫學, 2019, 40(11): 1589-1593.
26.	Sharma R, Agrawal S, Saxena A, et al. Association of IL-6, IL-10, and TNF-α gene polymorphism with malnutrition inflammation syndrome and survival among end stage renal disease patients. J Interferon Cytokine Res, 2013, 33(7): 384-391.
27.	Mantzorou M, Vadikolias K, Pavlidou E, et al. Nutritional status is associated with the degree of cognitive impairment and depressive symptoms in a Greek elderly population. Nutr Neurosci, 2020, 23(3): 201-209.
28.	Doorduijn AS, Visser M, van de Rest O, et al. Associations of AD biomarkers and cognitive performance with nutritional status: the NUDAD project. Nutrients, 2019, 11(5): 1161.
29.	Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol, 2015, 11(3): 157-165.
30.	宋雅云. 中老年人認知功能與握力的相關性研究——基于 CHARLS 數據. 中華養生保健, 2022, 40(19): 1-5.
31.	楊佳佳, 程光文, 李正宏, 等. 老年人握力與認知功能的關聯性. 中華老年醫學雜志, 2022, 41(2): 206-210.
32.	Shaughnessy KA, Hackney KJ, Clark BC, et al. A narrative review of handgrip strength and cognitive functioning: bringing a new characteristic to muscle memory. J Alzheimers Dis, 2020, 73(4): 1265-1278.
33.	Chen ST, Siddarth P, Ercoli LM, et al. Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups. PLoS One, 2014, 9(6): e98630.

1. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
2. O’Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis, 2016, 67(6): 925-935.
3. Kalirao P, Pederson S, Foley RN, et al. Cognitive impairment in peritoneal dialysis patients. Am J Kidney Dis, 2011, 57(4): 612-620.
4. San A, Hiremagalur B, Muircroft W, et al. Screening of cognitive impairment in the dialysis population: a scoping review. Dement Geriatr Cogn Disord, 2017, 44(3/4): 182-195.
5. Kallenberg MH, Kleinveld HA, Dekker FW, et al. Functional and cognitive impairment, frailty, and adverse health outcomes in older patients reaching ESRD-a systematic review. Clin J Am Soc Nephrol, 2016, 11(9): 1624-1639.
6. van Zwieten A, Wong G, Ruospo M, et al. Associations of cognitive function and education level with all-cause mortality in adults on hemodialysis: findings from the COGNITIVE-HD study. Am J Kidney Dis, 2019, 74(4): 452-462.
7. 張雷, 范占芳, 張作鵬, 等. 阿爾茲海默癥發病機制及相關治療藥物的研究進展. 中國藥物化學雜志, 2021, 31(6): 438-446, 469.
8. Burns JM, Johnson DK, Watts A, et al. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol, 2010, 67(4): 428-433.
9. Leong DP, Teo KK, Rangarajan S, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 2015, 386(9990): 266-273.
10. Cui M, Zhang S, Liu Y, et al. Grip strength and the risk of cognitive decline and dementia: a systematic review and meta-analysis of longitudinal cohort studies. Front Aging Neurosci, 2021, 13: 625551.
11. 董雅勤, 王為強. 社區老年人群主觀認知下降與握力的相關性研究. 中華全科醫學, 2022, 20(8): 1363-1366, 1426.
12. Detsky AS, McLaughlin JR, Baker JP, et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr, 1987, 11(1): 8-13.
13. Kopple JD. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis, 2001, 37(Suppl 2): S66-S70.
14. 郝立曉, 邢悅, 賈建國, 等. 英文版主觀認知下降問卷 21 的漢化研究. 中國全科醫學, 2021, 24(18): 2349-2354.
15. Gifford KA, Liu D, Romano R 3rd, et al. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst), 2015, 1(4): 429-439.
16. 張波, 胡益, 孫若琳, 等. 握力與主觀認知下降在不同性別老年人群中的相關性分析. 中國實用神經疾病雜志, 2023, 26(12): 1532-1536.
17. 宋銀華, 劉玉雙, 楊青, 等. 老年人主觀認知下降與慢性病共病的相關性分析. 中國全科醫學, 2023, 26(10): 1241-1249.
18. Wen C, Hu H, Ou YN, et al. Risk factors for subjective cognitive decline: the CABLE study. Transl Psychiatry, 2021, 11(1): 576.
19. 顧懷聰, 王為強, 董雅勤. 社區老年人群主觀認知下降的影響因素分析. 中國醫藥導報, 2023, 20(26): 55-59, 99.
20. Reuben R, Karkaby L, McNamee C, et al. Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?. Climacteric, 2021, 24(4): 321-332.
21. Liu Y, Lachman ME. Education and cognition in middle age and later life: the mediating role of physical and cognitive activity. J Gerontol B Psychol Sci Soc Sci, 2020, 75(7): e93-e104.
22. 遲晨汝, 陳夢奇, 楊丹, 等. 維持性血液透析病人認知功能障礙影響因素及干預的研究進展. 全科護理, 2023, 21(14): 1920-1924.
23. 常曉東, 薛痕, 肖峰, 等. 維持性血液透析患者認知功能障礙影響因素及與血清 Klotho 蛋白的相關性分析. 國際精神病學雜志, 2021, 48(5): 901-904.
24. 歐琴琴, 查艷. 維持性血液透析患者營養不良與認知損害的研究進展. 中華腎臟病雜志, 2022, 38(11): 1006-1010.
25. 胡美玲, 羅棉, 覃勛, 等. 維持性血液透析患者握力與營養指標的相關性. 廣東醫學, 2019, 40(11): 1589-1593.
26. Sharma R, Agrawal S, Saxena A, et al. Association of IL-6, IL-10, and TNF-α gene polymorphism with malnutrition inflammation syndrome and survival among end stage renal disease patients. J Interferon Cytokine Res, 2013, 33(7): 384-391.
27. Mantzorou M, Vadikolias K, Pavlidou E, et al. Nutritional status is associated with the degree of cognitive impairment and depressive symptoms in a Greek elderly population. Nutr Neurosci, 2020, 23(3): 201-209.
28. Doorduijn AS, Visser M, van de Rest O, et al. Associations of AD biomarkers and cognitive performance with nutritional status: the NUDAD project. Nutrients, 2019, 11(5): 1161.
29. Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol, 2015, 11(3): 157-165.
30. 宋雅云. 中老年人認知功能與握力的相關性研究——基于 CHARLS 數據. 中華養生保健, 2022, 40(19): 1-5.
31. 楊佳佳, 程光文, 李正宏, 等. 老年人握力與認知功能的關聯性. 中華老年醫學雜志, 2022, 41(2): 206-210.
32. Shaughnessy KA, Hackney KJ, Clark BC, et al. A narrative review of handgrip strength and cognitive functioning: bringing a new characteristic to muscle memory. J Alzheimers Dis, 2020, 73(4): 1265-1278.
33. Chen ST, Siddarth P, Ercoli LM, et al. Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups. PLoS One, 2014, 9(6): e98630.

West China Medical Journal

Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders

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