Research progress of hyperbaric oxygen therapy for cognitive impairment in cerebral small vessel disease_West China Medical Journal

Authors：

QU Zhixuan ,  ZENG Xianrong

Department of Neurology, Medical School of University of Electronic Science and Technology of China, Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610000, P. R. China;

Corresponding?author：

ZENG Xianrong, Email: 570574804@qq.com

Keywords：

Cerebral small vessel disease; hyperbaric oxygen therapy; cognitive impairment; hypoxia; mechanism

DOI：

10.7507/1002-0179.202404127

Video：

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Abstract Full text Figures/Tables Video References Cited by

Cerebral small vessel disease refers to a series of clinical, imaging, and pathological syndromes caused by various factors affecting small blood vessels in the brain. Cognitive impairment is one of the most common complications of cerebral small vessel disease. Current researches have found that cognitive impairment is related to various factors such as hypoxia. Hyperbaric oxygen therapy can achieve certain therapeutic effects by improving hypoxia. This article reviews the pathogenesis of cerebral small vessel disease, biomarkers of cerebral small vessel disease, research progress on hyperbaric oxygen therapy for cognitive impairment, and focuses on the research progress of hyperbaric oxygen therapy for mild cognitive impairment and dementia, providing more references for clinical treatment.

Citation： QU Zhixuan, ZENG Xianrong. Research progress of hyperbaric oxygen therapy for cognitive impairment in cerebral small vessel disease. West China Medical Journal, 2024, 39(7): 1151-1155. doi: 10.7507/1002-0179.202404127 Copy

1.	Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol, 2019, 18(7): 684-696.
2.	徐培麗, 楊一帆, 胡楠, 等. 腦小血管病與認知功能障礙相關性研究進展. 遼寧中醫藥大學學報, 2024, 26(3): 56-60.
3.	鄭金萍, 謝樂, 方銳, 等. 腦小血管病生物標志物的研究進展. 世界科學技術-中醫藥現代化, 2021, 23(12): 4398-4405.
4.	Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol, 2010, 9(7): 689-701.
5.	Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
6.	Brisset M, Boutouyrie P, Pico F, et al. Large-vessel correlates of cerebral small-vessel disease. Neurology, 2013, 80(7): 662-669.
7.	Nezu T, Hosomi N, Aoki S, et al. Endothelial dysfunction is associated with the severity of cerebral small vessel disease. Hypertens Res, 2015, 38(4): 291-297.
8.	Rajani RM, Quick S, Ruigrok SR, et al. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 2018, 10(448): eaam9507.
9.	Li Y, Li M, Zhang X, et al. Higher blood-brain barrier permeability is associated with higher white matter hyperintensities burden. J Neurol, 2017, 264(7): 1474-1481.
10.	Zhang CE, Wong SM, Uiterwijk R, et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav, 2019, 13(2): 389-395.
11.	郝棟, 李孟文, 孔艷妮, 等. 腦小血管病患者血清 Hcy、VEGF 水平及意義. 神經損傷與功能重建, 2020, 15(7): 423-424.
12.	張微微. 腦小血管病的新進展. 中華腦血管病雜志(電子版), 2008, 2(4): 272-277.
13.	Shoamanesh A, Preis SR, Beiser AS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology, 2015, 84(8): 825-832.
14.	張貴強. 腦小血管病患者血漿血管內皮生長因子水平的變化及意義. 中國實用神經疾病雜志, 2018, 21(14): 1547-1551.
15.	王瑾, 趙建華, 劉昊, 等. 腦小血管病患者血清 VEGF 水平與腦白質高信號、認知功能障礙的相關性研究. 中華行為醫學與腦科學雜志, 2022, 31(4): 333-340.
16.	何昕, 鄧建中, 黃曉宇. 腦小血管病患者認知損害程度與高同型半胱氨酸及 hs-CRP 的相關性. 中國實用神經疾病雜志, 2017, 20(1): 59-61.
17.	黃淑云, 盧健聰, 章成國, 等. 血漿同型半胱氨酸水平與非高血壓腦小血管病患者腦白質病變關系的研究. 中國老年保健醫學, 2018, 16(4): 26-28.
18.	任玲, 何成奇. 高壓氧治療改善認知功能障礙的研究進展. 華西醫學, 2023, 38(4): 597-602.
19.	Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 2017, 11: 25.
20.	Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med, 2002, 32(11): 1050-1060.
21.	Schottlender N, Gottfried I, Ashery U. Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress. Biomolecules, 2021, 11(12): 1827.
22.	Thom SR, Milovanova TN, Yang M, et al. Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen, 2011, 19(2): 149-161.
23.	王曉莉, 楊于嘉, 謝岷, 等. 高壓氧治療促進 HIBD 新生大鼠內源性神經干細胞的遷移與分化. 中國當代兒科雜志, 2009, 11(9): 749-752.
24.	周磊, 應英, 范茂丹, 等. 高壓氧治療對慢性腦缺血大鼠認知功能的影響及其作用機制. 中國卒中雜志, 2020, 15(8): 836-841.
25.	Hu HQ, Shu MQ, Xue F, et al. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiol Behav, 2018, 195: 1-8.
26.	Gottfried I, Schottlender N, Ashery U. Hyperbaric oxygen treatment-from mechanisms to cognitive improvement. Biomolecules, 2021, 11(10): 1520.
27.	韓曉云, 解力, 李永安. 高壓氧治療腦小血管病患者對血清 hs-CRP、同型半胱氨酸水平及認知、抑郁相關指標的影響分析. 世界復合醫學, 2023, 9(3): 153-155, 159.
28.	陳丹娜, 盧曉航, 陳曉潔, 等. 高壓氧聯合丁苯酞治療腦梗死的效果及對血同型半胱氨酸的影響. 中國醫藥科學, 2022, 12(8): 147-150.
29.	姜如海. 高壓氧治療對腦小血管病患者血清急性時相反應蛋白及認知相關指標的影響研究. 中國醫學創新, 2021, 18(22): 106-109.
30.	冼曉琪, 楊杰華, 區大明, 等. 心理干預聯合高壓氧對腦小血管病患者抑郁癥狀及認知功能的影響. 實用醫技雜志, 2015(9): 922-925.
31.	楊杰華, 冼曉琪, 區大明, 等. 高壓氧聯合重復經顱磁刺激對腦小血管病伴抑郁患者軀體癥狀及認知功能的療效研究. 中國康復醫學雜志, 2015, 30(4): 362-365.
32.	秦艷霞, 劉再高, 鄭杰, 等. 腦復康方聯合高壓氧治療腦小血管病致認知功能障礙療效及對血清 VEGF、BDNF、hs-CRP 的影響. 現代中西醫結合雜志, 2018, 27(19): 2099-2102.
33.	楊杰華, 冼曉琪, 區大明, 等. 高壓氧對腦小血管病大鼠學習記憶功能及腦源性神經生長因子、乙酰膽堿表達的影響. 中華物理醫學與康復雜志, 2014, 36(7): 508-511.
34.	羅增媛, 李俊, 胡結林, 等. “智三針”聯合高壓氧對腦梗死后血管性認知障礙患者認知功能及日常生活活動能力的影響. 中國當代醫藥, 2024, 31(3): 92-95.
35.	邊亞禮, 楊艷雙, 鞏江華. 高壓氧聯合丁苯肽及艾地苯醌治療血管性癡呆的療效及對氧化應激、認知功能的影響. 中華航海醫學與高氣壓醫學雜志, 2024, 31(1): 55-58.
36.	江玉英. 高壓氧聯合有氧運動治療老年輕度血管性癡呆的療效觀察. 中國標準化, 2022(8): 200-202.
37.	蔣芳況, 王楊, 王麗, 等. 高壓氧聯合有氧運動治療老年輕度血管性癡呆的療效觀察. 國際老年醫學雜志, 2021, 42(5): 275-278.
38.	武衛周, 員麗娜, 田晉梅, 等. 養血清腦顆粒聯合高壓氧治療血管性癡呆的臨床研究. 武警后勤學院學報(醫學版), 2020, 29(1): 25-28.
39.	劉莉莉, 陳艷芳, 王曉宇. 高壓氧聯合銀杏葉提取物治療老年血管性癡呆療效觀察. 新鄉醫學院學報, 2024, 41(5): 477-481.
40.	陳克龍, 宋成城, 陳凌. 益氣活血法在腦小血管病認知障礙患者中的臨床應用. 中華全科醫學, 2023, 21(10): 1767-1769.
41.	石磊, 陳寧寧, 郭亞培, 等. 冬凌草甲素對腦小血管病大鼠認知功能及PERK/CHOP信號通路的影響. 中國藥師, 2022, 25(6): 949-954, 980.

1. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol, 2019, 18(7): 684-696.
2. 徐培麗, 楊一帆, 胡楠, 等. 腦小血管病與認知功能障礙相關性研究進展. 遼寧中醫藥大學學報, 2024, 26(3): 56-60.
3. 鄭金萍, 謝樂, 方銳, 等. 腦小血管病生物標志物的研究進展. 世界科學技術-中醫藥現代化, 2021, 23(12): 4398-4405.
4. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol, 2010, 9(7): 689-701.
5. Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
6. Brisset M, Boutouyrie P, Pico F, et al. Large-vessel correlates of cerebral small-vessel disease. Neurology, 2013, 80(7): 662-669.
7. Nezu T, Hosomi N, Aoki S, et al. Endothelial dysfunction is associated with the severity of cerebral small vessel disease. Hypertens Res, 2015, 38(4): 291-297.
8. Rajani RM, Quick S, Ruigrok SR, et al. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 2018, 10(448): eaam9507.
9. Li Y, Li M, Zhang X, et al. Higher blood-brain barrier permeability is associated with higher white matter hyperintensities burden. J Neurol, 2017, 264(7): 1474-1481.
10. Zhang CE, Wong SM, Uiterwijk R, et al. Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging Behav, 2019, 13(2): 389-395.
11. 郝棟, 李孟文, 孔艷妮, 等. 腦小血管病患者血清 Hcy、VEGF 水平及意義. 神經損傷與功能重建, 2020, 15(7): 423-424.
12. 張微微. 腦小血管病的新進展. 中華腦血管病雜志(電子版), 2008, 2(4): 272-277.
13. Shoamanesh A, Preis SR, Beiser AS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology, 2015, 84(8): 825-832.
14. 張貴強. 腦小血管病患者血漿血管內皮生長因子水平的變化及意義. 中國實用神經疾病雜志, 2018, 21(14): 1547-1551.
15. 王瑾, 趙建華, 劉昊, 等. 腦小血管病患者血清 VEGF 水平與腦白質高信號、認知功能障礙的相關性研究. 中華行為醫學與腦科學雜志, 2022, 31(4): 333-340.
16. 何昕, 鄧建中, 黃曉宇. 腦小血管病患者認知損害程度與高同型半胱氨酸及 hs-CRP 的相關性. 中國實用神經疾病雜志, 2017, 20(1): 59-61.
17. 黃淑云, 盧健聰, 章成國, 等. 血漿同型半胱氨酸水平與非高血壓腦小血管病患者腦白質病變關系的研究. 中國老年保健醫學, 2018, 16(4): 26-28.
18. 任玲, 何成奇. 高壓氧治療改善認知功能障礙的研究進展. 華西醫學, 2023, 38(4): 597-602.
19. Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci, 2017, 11: 25.
20. Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med, 2002, 32(11): 1050-1060.
21. Schottlender N, Gottfried I, Ashery U. Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress. Biomolecules, 2021, 11(12): 1827.
22. Thom SR, Milovanova TN, Yang M, et al. Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen, 2011, 19(2): 149-161.
23. 王曉莉, 楊于嘉, 謝岷, 等. 高壓氧治療促進 HIBD 新生大鼠內源性神經干細胞的遷移與分化. 中國當代兒科雜志, 2009, 11(9): 749-752.
24. 周磊, 應英, 范茂丹, 等. 高壓氧治療對慢性腦缺血大鼠認知功能的影響及其作用機制. 中國卒中雜志, 2020, 15(8): 836-841.
25. Hu HQ, Shu MQ, Xue F, et al. Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. Physiol Behav, 2018, 195: 1-8.
26. Gottfried I, Schottlender N, Ashery U. Hyperbaric oxygen treatment-from mechanisms to cognitive improvement. Biomolecules, 2021, 11(10): 1520.
27. 韓曉云, 解力, 李永安. 高壓氧治療腦小血管病患者對血清 hs-CRP、同型半胱氨酸水平及認知、抑郁相關指標的影響分析. 世界復合醫學, 2023, 9(3): 153-155, 159.
28. 陳丹娜, 盧曉航, 陳曉潔, 等. 高壓氧聯合丁苯酞治療腦梗死的效果及對血同型半胱氨酸的影響. 中國醫藥科學, 2022, 12(8): 147-150.
29. 姜如海. 高壓氧治療對腦小血管病患者血清急性時相反應蛋白及認知相關指標的影響研究. 中國醫學創新, 2021, 18(22): 106-109.
30. 冼曉琪, 楊杰華, 區大明, 等. 心理干預聯合高壓氧對腦小血管病患者抑郁癥狀及認知功能的影響. 實用醫技雜志, 2015(9): 922-925.
31. 楊杰華, 冼曉琪, 區大明, 等. 高壓氧聯合重復經顱磁刺激對腦小血管病伴抑郁患者軀體癥狀及認知功能的療效研究. 中國康復醫學雜志, 2015, 30(4): 362-365.
32. 秦艷霞, 劉再高, 鄭杰, 等. 腦復康方聯合高壓氧治療腦小血管病致認知功能障礙療效及對血清 VEGF、BDNF、hs-CRP 的影響. 現代中西醫結合雜志, 2018, 27(19): 2099-2102.
33. 楊杰華, 冼曉琪, 區大明, 等. 高壓氧對腦小血管病大鼠學習記憶功能及腦源性神經生長因子、乙酰膽堿表達的影響. 中華物理醫學與康復雜志, 2014, 36(7): 508-511.
34. 羅增媛, 李俊, 胡結林, 等. “智三針”聯合高壓氧對腦梗死后血管性認知障礙患者認知功能及日常生活活動能力的影響. 中國當代醫藥, 2024, 31(3): 92-95.
35. 邊亞禮, 楊艷雙, 鞏江華. 高壓氧聯合丁苯肽及艾地苯醌治療血管性癡呆的療效及對氧化應激、認知功能的影響. 中華航海醫學與高氣壓醫學雜志, 2024, 31(1): 55-58.
36. 江玉英. 高壓氧聯合有氧運動治療老年輕度血管性癡呆的療效觀察. 中國標準化, 2022(8): 200-202.
37. 蔣芳況, 王楊, 王麗, 等. 高壓氧聯合有氧運動治療老年輕度血管性癡呆的療效觀察. 國際老年醫學雜志, 2021, 42(5): 275-278.
38. 武衛周, 員麗娜, 田晉梅, 等. 養血清腦顆粒聯合高壓氧治療血管性癡呆的臨床研究. 武警后勤學院學報(醫學版), 2020, 29(1): 25-28.
39. 劉莉莉, 陳艷芳, 王曉宇. 高壓氧聯合銀杏葉提取物治療老年血管性癡呆療效觀察. 新鄉醫學院學報, 2024, 41(5): 477-481.
40. 陳克龍, 宋成城, 陳凌. 益氣活血法在腦小血管病認知障礙患者中的臨床應用. 中華全科醫學, 2023, 21(10): 1767-1769.
41. 石磊, 陳寧寧, 郭亞培, 等. 冬凌草甲素對腦小血管病大鼠認知功能及PERK/CHOP信號通路的影響. 中國藥師, 2022, 25(6): 949-954, 980.

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