Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital_West China Medical Journal

Authors：

JI Dandan ¹ , HU Bijie ² , GAO Xiaodong ³ , ZHENG Zheng ¹ ,  YUAN Zheng ¹

1. Nursing Department, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
2. Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
3. Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;

Corresponding?author：

YUAN Zheng, Email: yuan.zheng@zs-hospital.sh.cn

Keywords：

β-lactam antibiotics; skin test; multi-center; allergy

DOI：

10.7507/1002-0179.202401074

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the status of nurses’ cognition of skin test for β-lactam antibiotics in tertiary hospitals in China and its influencing factors. Methods The nurses in the eastern and western regions were selected by stratified sampling and convenient sampling between March and May 2023. A multi-center survey was conducted with the help of the questionnaire star platform using the “Questionnaire on the Cognitive Status of β-lactam Antibiotics Skin Test” developed by the “Guidelines for β-lactam Antibiotics Skin Test (2021 Edition)” issued by the National Health Commission of the reference country. Results A total of 89 tertiary hospitals were surveyed. Among them, there were 27 in the eastern regions and 62 in the western regions; There were 64 comprehensive hospitals and 25 specialized hospitals. A total of 4 241 nurses were included. Among them, 4 151 were females and 90 were males. The scores of nurses’ cognition of skin test of β-lactam antibiotics were (61.47±16.27). The survey results showed that the accuracy rate ranges from 15.52% to 88.98%. Only no routine skin test before cephalosporin administration, judgment of skin test results, and infusion device replacement after allergy were greater than 80%. The results of the logistic regression analysis showed that the nurses with professional titles and antimicrobial management training in the past 2 years were independent influencing factors of nurses’ cognition of skin test of β-lactam antibiotics (P<0.001). Conclusions At present, nurses in tertiary hospitals in China still have insufficient knowledge of skin test of β-lactam antibiotics. It is suggested that hospitals should form corresponding hospital skin test of β-lactam antibiotics standards in combination with guidelines and strengthen training for nurses in this regard, so as to improve nurses’ correct cognition and implementation of skin test of β-lactam antibiotics.

Citation： JI Dandan, HU Bijie, GAO Xiaodong, ZHENG Zheng, YUAN Zheng. Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital. West China Medical Journal, 2024, 39(3): 455-460. doi: 10.7507/1002-0179.202401074 Copy

1.	何艷, 章登政, 付偉, 等. 湖北省內醫療機構β-內酰胺類抗菌藥物皮膚試驗現狀調查分析. 中國醫院藥學雜志, 2020, 40(18): 1937-1941, 1991.
2.	趙昕, 張海霞, 程青, 等. β-內酰胺類抗菌藥物皮試的國內現狀調查. 兒科藥學雜志, 2018, 24(11): 30-34.
3.	許錦英, 盛雪鶴, 劉孟雪, 等. 皖南地區 18 所公立醫院β-內酰胺類抗菌藥物皮膚過敏試驗現狀分析. 安徽醫藥, 2017, 21(5): 943-947.
4.	中華人民共和國國家衛生健康委員會. β內酰胺類抗菌藥物皮膚試驗指導原則(2021 年版). 中國實用鄉村醫生雜志, 2021, 28(5): 1-4.
5.	許譯尹, 余霞霞, 張學麗, 等. 《β-內酰胺類抗菌藥物皮膚試驗指導原則(2021 年版)》醫療機構執行情況調研分析. 中國抗生素雜志, 2023, 48(10): 1177-1182.
6.	Kelley TL. The selection of upper and lower groups for the validation of test items. J Educ Psychology, 1939, 30(1): 17-24.
7.	陳敏, 黃敏, 鄧蘭蘭. 某市青霉素及頭孢類抗菌藥物皮膚過敏試驗現狀調查研究. 中國藥業, 2016, 25(5): 4-6.
8.	中華預防醫學會過敏病預防與控制專業委員會預防食物藥物過敏學組. 藥物過敏診斷和預防方案中國專家共識. 中華預防醫學雜志, 2022, 56(6): 682-706.
9.	Torres MJ, Romano A, Celik G, et al. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy, 2017, 7: 7.
10.	蔣子涵, 肖浩, 孟娟. 華西醫院住院患者“青霉素過敏史”相關問卷調查. 中華臨床免疫和變態反應雜志, 2022, 16(6): 589-594.
11.	張筱璇, 湯智慧, 朱曼, 等. 國內部分醫院β-內酰胺類抗生素皮膚試驗現狀調查分析. 藥物流行病學雜志, 2018, 27(1): 33-37.
12.	鄒鶴娟, 李穎, 呂娟麗, 等. 全國醫療機構頭孢菌素皮試現狀分析. 中國感染與化療雜志, 2023, 23(1): 14-19.
13.	Blumenthal KG, Kuper K, Schulz LT, et al. Association between penicillin allergy documentation and antibiotic use. JAMA Intern Med, 2020, 180(8): 1120-1122.
14.	Oliver WD, Heil EL, Thom KA, et al. Allergy profile should be updated after uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy. J Allergy Clin Immunol Pract, 2017, 5(1): 184-186.
15.	趙紅福. 外科護士參與抗菌藥物管理知信行現狀調查. 當代護士(上旬刊), 2022, 29(9): 146-149.
16.	Berger RE, Singh HK, Loo AS, et al. Improving antibiotic stewardship for inpatients with reported beta-lactam allergies and limited access to penicillin skin testing. Jt Comm J Qual Patient Saf, 2022, 48(3): 147-153.
17.	Barbaud A, Weinborn M, Garvey LH, et al. Intradermal tests with drugs: an approach to standardization. Front Med (Lausanne), 2020, 7: 156.
18.	King EA, Challa S, Curtin P, et al. Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol, 2016, 117(1): 67-71.

1. 何艷, 章登政, 付偉, 等. 湖北省內醫療機構β-內酰胺類抗菌藥物皮膚試驗現狀調查分析. 中國醫院藥學雜志, 2020, 40(18): 1937-1941, 1991.
2. 趙昕, 張海霞, 程青, 等. β-內酰胺類抗菌藥物皮試的國內現狀調查. 兒科藥學雜志, 2018, 24(11): 30-34.
3. 許錦英, 盛雪鶴, 劉孟雪, 等. 皖南地區 18 所公立醫院β-內酰胺類抗菌藥物皮膚過敏試驗現狀分析. 安徽醫藥, 2017, 21(5): 943-947.
4. 中華人民共和國國家衛生健康委員會. β內酰胺類抗菌藥物皮膚試驗指導原則(2021 年版). 中國實用鄉村醫生雜志, 2021, 28(5): 1-4.
5. 許譯尹, 余霞霞, 張學麗, 等. 《β-內酰胺類抗菌藥物皮膚試驗指導原則(2021 年版)》醫療機構執行情況調研分析. 中國抗生素雜志, 2023, 48(10): 1177-1182.
6. Kelley TL. The selection of upper and lower groups for the validation of test items. J Educ Psychology, 1939, 30(1): 17-24.
7. 陳敏, 黃敏, 鄧蘭蘭. 某市青霉素及頭孢類抗菌藥物皮膚過敏試驗現狀調查研究. 中國藥業, 2016, 25(5): 4-6.
8. 中華預防醫學會過敏病預防與控制專業委員會預防食物藥物過敏學組. 藥物過敏診斷和預防方案中國專家共識. 中華預防醫學雜志, 2022, 56(6): 682-706.
9. Torres MJ, Romano A, Celik G, et al. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy, 2017, 7: 7.
10. 蔣子涵, 肖浩, 孟娟. 華西醫院住院患者“青霉素過敏史”相關問卷調查. 中華臨床免疫和變態反應雜志, 2022, 16(6): 589-594.
11. 張筱璇, 湯智慧, 朱曼, 等. 國內部分醫院β-內酰胺類抗生素皮膚試驗現狀調查分析. 藥物流行病學雜志, 2018, 27(1): 33-37.
12. 鄒鶴娟, 李穎, 呂娟麗, 等. 全國醫療機構頭孢菌素皮試現狀分析. 中國感染與化療雜志, 2023, 23(1): 14-19.
13. Blumenthal KG, Kuper K, Schulz LT, et al. Association between penicillin allergy documentation and antibiotic use. JAMA Intern Med, 2020, 180(8): 1120-1122.
14. Oliver WD, Heil EL, Thom KA, et al. Allergy profile should be updated after uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy. J Allergy Clin Immunol Pract, 2017, 5(1): 184-186.
15. 趙紅福. 外科護士參與抗菌藥物管理知信行現狀調查. 當代護士(上旬刊), 2022, 29(9): 146-149.
16. Berger RE, Singh HK, Loo AS, et al. Improving antibiotic stewardship for inpatients with reported beta-lactam allergies and limited access to penicillin skin testing. Jt Comm J Qual Patient Saf, 2022, 48(3): 147-153.
17. Barbaud A, Weinborn M, Garvey LH, et al. Intradermal tests with drugs: an approach to standardization. Front Med (Lausanne), 2020, 7: 156.
18. King EA, Challa S, Curtin P, et al. Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol, 2016, 117(1): 67-71.

West China Medical Journal

Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content