Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit_West China Medical Journal

Authors：

 CHEN Jing , ZHENG Xiaojia , LIAO Tianfen , XIANG Qian

1. Department of Healthcare-associated Infection Control Center, Sichuan Provincial People’s Hospital & Sichuan Academy of Medical Sciences, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

CHEN Jing, Email: cjlwy0217@163.com

Keywords：

Car accident injury; multidrug-resistant organism infection; risk factor

DOI：

10.7507/1002-0179.202401022

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Objective To investigate the risk factors of multidrug-resistant organism (MDRO) infection in patients with car accident injuries in intensive care unit (ICU), providing clinical guidance for reducing MDRO infection in car accident patients. Methods The clinical data of patients with car accident injuries in Sichuan Provincial People’s Hospital between January 1st 2019 and February 28th 2023 were collected, and the relevant data were analyzed retrospectively to explore the risk factors of MDRO infection. Results A total of 141 patients with car accident injuries were collected, of whom 30 had MDRO infection. The proportions of males (P=0.012), indwelling catheters (P=0.005), mechanical ventilation (P=0.001), length of hospital stay (P<0.001), and total treatment costs (P<0.001) in the infection group were higher than those in the non-infection group. Multiple logistic regression analysis showed that male [odds ratio (OR)=3.797, 95% confidence interval (CI) (1.174, 12.275), P=0.026], mechanical ventilation [OR=4.596, 95%CI (1.538, 13.734), P=0.006], and length of hospital stay≥20 d [OR=1.014, 95%CI (1.001, 1.028), P=0.037] were independent risk factors for MDRO infection in car accident patients. Conclusions Male, mechanical ventilation, and increased length of hospital stay are independent risk factors for MDRO infection in car accident patients. For such patients, the prevention and control measures of hospital infection should be strictly implemented to reduce the risk of infection.

Citation： CHEN Jing, ZHENG Xiaojia, LIAO Tianfen, XIANG Qian. Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit. West China Medical Journal, 2024, 39(3): 383-386. doi: 10.7507/1002-0179.202401022 Copy

1.	邵青青. 急診車禍傷病人的心理反應特點及對患者實施針對性護理的效果分析. 航空航天醫學雜志, 2022, 33(9): 1127-1130.
2.	鞏樹梅, 顏婷婷, 劉曉虹. 團體認知行為干預對意外創傷者創傷后成長的效果研究. 護理學雜志, 2015, 30(22): 74-77.
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4.	Seong H, Lee SK, Cheon JH, et al. Fecal microbiota transplantation for multidrug-resistant organism: efficacy and response prediction. J Infect, 2020, 81(5): 719-725.
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12.	衛生部辦公廳關于印發《多重耐藥菌醫院感染預防與控制技術指南(試行)》的通知. 中華人民共和國衛生部公報, 2011(2): 59-61.
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16.	Iwu CD, Patrick SM. An insight into the implementation of the global action plan on antimicrobial resistance in the WHO African region: a roadmap for action. Int J Antimicrob Agents, 2021, 58(4): 106411.
17.	楊修文, 崔俊昌, 趙進, 等. 碳青霉烯類耐藥肺炎克雷伯菌血流感染的臨床特征與死亡危險因素分析. 中國感染與化療雜志, 2018, 18(2): 142-149.
18.	林沛鈺, 王愛平. 急性髓系白血病患者誘導緩解化療期間癥狀與生活質量現狀及影響因素分析. 護士進修雜志, 2022, 37(12): 1136-1140.
19.	何怡蓓, 王文博, 譚積善, 等. 成都某三甲醫院多重耐藥菌的臨床分布特點及耐藥性分析. 現代生物醫學進展, 2022, 22(3): 500-505, 458.
20.	Wang RH, Wen WX, Jiang ZP, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol, 2023, 14: 1115031.

1. 邵青青. 急診車禍傷病人的心理反應特點及對患者實施針對性護理的效果分析. 航空航天醫學雜志, 2022, 33(9): 1127-1130.
2. 鞏樹梅, 顏婷婷, 劉曉虹. 團體認知行為干預對意外創傷者創傷后成長的效果研究. 護理學雜志, 2015, 30(22): 74-77.
3. 孫樂平, 繆麒, 王殿深, 等. AIS-ISS 評分在法醫病理學傷病關系分析中的應用. 中國法醫學雜志, 2019, 34(3): 218-221.
4. Seong H, Lee SK, Cheon JH, et al. Fecal microbiota transplantation for multidrug-resistant organism: efficacy and response prediction. J Infect, 2020, 81(5): 719-725.
5. Jean SS, Gould IM, Lee WS, et al. New drugs for multidrug-resistant Gram-negative organisms: time for stewardship. Drugs, 2019, 79(7): 705-714.
6. Deering RW, Whalen KE, Alvarez I, et al. Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii. J Antibiot (Tokyo), 2021, 74(6): 370-380.
7. 楊晉如, 劉丹, 談宜斌, 等. 重癥醫學科多重耐藥菌感染風險因素的網狀路徑分析. 中國感染控制雜志, 2020, 19(2): 148-154.
8. Tatarelli P, Mikulska M. Multidrug-resistant bacteria in hematology patients: emerging threats. Future Microbiol, 2016, 11: 767-780.
9. Kollef MH, Torres A, Shorr AF, et al. Nosocomial infection. Crit Care Med, 2021, 49(2): 169-187.
10. 劉濟, 方旭, 楊瀅, 等. 某醫院多重耐藥菌醫院感染特征及變化趨勢分析. 中國消毒學雜志, 2023, 40(10): 776-778.
11. 中華人民共和國衛生部. 醫院感染診斷標準(試行). 中華醫學雜志, 2001, 81(5): 61-67.
12. 衛生部辦公廳關于印發《多重耐藥菌醫院感染預防與控制技術指南(試行)》的通知. 中華人民共和國衛生部公報, 2011(2): 59-61.
13. 白偉, 張小華. 自體輸血與異體輸血在腹部手術患者中的應用時對凝血功能與血液流變學的影響. 血栓與止血學, 2020, 26(2): 252-254.
14. 汪璐璐, 劉安諾, 李惠萍, 等. 創傷后成長與創傷后應激障礙癥狀相關性的 meta 分析. 中國心理衛生雜志, 2016, 30(1): 23-28.
15. 吳擁軍. 神經外科術后病人創傷后成長與心理彈性及疾病感知的關系. 護理研究, 2015, 29(15): 1839-1842.
16. Iwu CD, Patrick SM. An insight into the implementation of the global action plan on antimicrobial resistance in the WHO African region: a roadmap for action. Int J Antimicrob Agents, 2021, 58(4): 106411.
17. 楊修文, 崔俊昌, 趙進, 等. 碳青霉烯類耐藥肺炎克雷伯菌血流感染的臨床特征與死亡危險因素分析. 中國感染與化療雜志, 2018, 18(2): 142-149.
18. 林沛鈺, 王愛平. 急性髓系白血病患者誘導緩解化療期間癥狀與生活質量現狀及影響因素分析. 護士進修雜志, 2022, 37(12): 1136-1140.
19. 何怡蓓, 王文博, 譚積善, 等. 成都某三甲醫院多重耐藥菌的臨床分布特點及耐藥性分析. 現代生物醫學進展, 2022, 22(3): 500-505, 458.
20. Wang RH, Wen WX, Jiang ZP, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol, 2023, 14: 1115031.

West China Medical Journal

Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit

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