Current status and influencing factors of salivation in patients with orotracheal cannula_West China Medical Journal

Authors：

DU Jinlei ¹ , NIE Chencong ¹ ,  LEI Ling ¹ , ZHAO Hongxiang ¹ , ZHANG Qiyu ² , YE Qun ³ , PENG Gutao ⁴ , CHEN Zhimei ⁵ , ZHANG Shangshu ⁶

1. Department of Intensive Care Medicine, Zigong Fourth People’s Hospital, Zigong, Sichuan 643000, P. R. China;
2. School of Nursing, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
3. Department of Critical Care Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P. R. China;
4. Department of Neurosurgery, the Affiliated Fuling Hospital of Chongqing University, Chongqing 408000, P. R. China;
5. Department of Critical Care Medicine, the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550000, P. R. China;
6. Department of Critical Care Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P. R. China;

Corresponding?author：

LEI Ling, Email: 837024980@qq.com

Keywords：

Tracheal intubation; salivation; occurrence status; influencing factor

DOI：

10.7507/1002-0179.202312058

Video：

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Objective To investigate the current situation of salivation in patients with orotracheal cannula, and to systematically analyze its influencing factors. Methods Patients who underwent tracheal intubation treatment in 47 tertiary comprehensive medical institutions were selected between October 10th and 20th, 2023. A cross-sectional survey method was used to conduct an online survey of the patient’s salivation status. The patients were divided into the salivation group and no-salivation group. Results A total of 565 questionnaires were collected and 561 were valid, with an effective recovery rate of 99%. Among 561 patients, 284 were males (50.62%) and 277 were females (49.38%), with an age of (59.80±10.96) years; 159 cases of salivation occurred, with a total static saliva flow rate of (7.21±3.15) mL and the incidence of salivation was 28.34% (159/561). There were statistically significant differences in age, education level, body mass index, primary disease, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days, intubation depth, intubation process, sedation and/or analgesia days, and enteral nutrition treatment between the two groups (P<0.05). There was no statistically significant difference in other indicators between the two groups (P>0.05). The results of multivariate logistic regression analysis showed that body mass index, neurological diseases, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days and intubation process were independent risk factors for salivation in patients with oral catheterization. Conclusion The incidence of salivation in patients with orotracheal cannula is 28.34%, which is directly related to body mass index, neurological diseases, number of concurrent functional impairments, concurrent oral diseases, smoking, intubation days and intubation process.

Citation： DU Jinlei, NIE Chencong, LEI Ling, ZHAO Hongxiang, ZHANG Qiyu, YE Qun, PENG Gutao, CHEN Zhimei, ZHANG Shangshu. Current status and influencing factors of salivation in patients with orotracheal cannula. West China Medical Journal, 2024, 39(6): 913-919. doi: 10.7507/1002-0179.202312058 Copy

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13.	Ladwig KH, Schriever SC, Atasoy S, et al. Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-age study. Sci Rep, 2020, 10(1): 14321.
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15.	苗久旺, 苗久旺. 藥理學. 北京: 中國醫藥科技出版社, 2022.
16.	吳振波, 陳虹宇, 彭瀟, 等. 氯氮平治療精神分裂癥期間流涎的影響因素. 中國藥物與臨床, 2022, 22(7): 618-621.
17.	孔艷玲, 張少波. 胞磷膽堿鈉注射液致流涎 1 例. 中國藥物警戒, 2017, 14(9): 569, 571.
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1. Yoshimura J, Yamakawa K, Ohta Y, et al. Effect of Gram stain-guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia: the GRACE-vap randomized clinical trial. JAMA Netw Open, 2022, 5(4): e226136.
2. 趙順杰, 白莎, 王恬, 等. 肌萎縮側索硬化患者流涎癥評估方法的研究進展. 護理學報, 2022, 29(19): 25-29.
3. Verhoeff MC, Koutris M, Vries R, et al. Salivation in Parkinson’s disease: a scoping review. Gerodontology, 2023, 40(1): 26-38.
4. Subra M, Dezi M, Bigay J, et al. VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites. Dev Cell, 2023, 58(2): 121-138.
5. Shrimpton AJ, O’Farrell G, Howes HM, et al. A quantitative evaluation of aerosol generation during awake tracheal intubation. Anaesthesia, 2023, 78(5): 587-597.
6. 杜金磊, 聶臣聰, 雷玲, 等. 基于信息化平臺對機械通氣患者聲門下分泌物精準化管理方案的探索研究. 山西醫藥雜志, 2022, 51(1): 92-97.
7. 楊和金. 觀察針刺聯合口腔感覺運動療法治療小兒腦性癱瘓流涎癥療效. 保健醫學研究與實踐, 2021, 18(S1): 4-6.
8. 肖王靜, 王萬勝, 彭玲, 等. 超聲引導下注射 A 型肉毒毒素治療腦卒中后流涎癥 1 例報道及文獻復習. 實用老年醫學, 2023, 37(1): 104-106.
9. 王紅梅, BOSOMTWE Samuel, 杜金磊, 等. 經口氣管插管患者流涎癥影響因素和干預措施的研究進展. 中華全科醫學, 2021, 19(12): 2102-2105.
10. 王松靈, 竇慧昕, 秦力錚, 等. 流唾癥的病因、診斷與治療. 口腔疾病防治, 2019, 27(8): 477-484.
11. 歐平花, 李翠, 蘇華, 等. 口腔疾病規范化診治方案. 長沙: 中南大學出版社, 2022.
12. Du J, Chengcong N, Wu X. Volume-based subglottic secretion drainage: a randomized controlled trial. Ann Med Surg (Lond), 2024, 86(3): 1426-1432.
13. Ladwig KH, Schriever SC, Atasoy S, et al. Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-age study. Sci Rep, 2020, 10(1): 14321.
14. Naeem F, Reid J, Bailey M, et al. Pharmacological interventions for sialorrhoea in people with Parkinson’s disease: a systematic review and meta-analysis. Mov Disord Clin Pract, 2023, 10(4): 558-568.
15. 苗久旺, 苗久旺. 藥理學. 北京: 中國醫藥科技出版社, 2022.
16. 吳振波, 陳虹宇, 彭瀟, 等. 氯氮平治療精神分裂癥期間流涎的影響因素. 中國藥物與臨床, 2022, 22(7): 618-621.
17. 孔艷玲, 張少波. 胞磷膽堿鈉注射液致流涎 1 例. 中國藥物警戒, 2017, 14(9): 569, 571.
18. Proctor GB, Shaalan AM. Disease-induced changes in salivary gland function and the composition of saliva. J Dent Res, 2021, 100(11): 1201-1209.
19. Yoon NY, Yun I, Park YS, et al. Associations between environmental tobacco smoke exposure and oral health symptoms in adolescents. BMC Oral Health, 2022, 22(1): 397.
20. Ahonen H, Neher M, Fransson EI, et al. Views on oral health determinants as described by persons with continuous positive airway pressure-treated obstructive sleep apnoea: a qualitative study. BMC Oral Health, 2023, 23(1): 407.
21. 唐莉, 李敏, 姚倩. 經口氣管插管病人口腔黏膜壓力性損傷護理的研究進展. 護理研究, 2023, 37(20): 3682-3686.

West China Medical Journal

Current status and influencing factors of salivation in patients with orotracheal cannula

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