Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis_West China Medical Journal

Authors：

ZENG Hui ¹ , WANG Guiyan ² ,  LIU Jian ² , LIU Binwei ²

1. Department of Medical Examination Center, the First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P. R. China;
2. Department of General Surgery, the First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P. R. China;

Corresponding?author：

LIU Jian, Email: haijian56480476@163.com

Keywords：

Abdominal infection; sepsis; soluble triggering receptor expressed on myeloid cell-1; cyclooxygenase-2; condition; prognosis

DOI：

10.7507/1002-0179.202304045

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Objective To study the diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) and cyclooxygenase-2 (COX-2) in abdominal infection-caused sepsis. Methods A total of 170 patients with abdominal infection treated in the First Hospital of Qinhuangdao between January 2019 and March 2022 were retrospectively selected and divided into sepsis group (n=76) and non-sepsis group (n=94) according to whether they were combined with abdominal infection-caused sepsis. In addition, 80 healthy people in the same period were selected as the control group. The levels of serum sTREM-1 and COX-2 in the three groups were detected and the differences were compared. The laboratory indexes, including white blood cell count, high-sensitivity C-reactive protein, and procalcitonin of patients with abdominal infection-caused sepsis were detected. The Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation System Ⅱ and prognosis (survival or death) of patients with abdominal infection-caused sepsis were evaluated. The correlations of serum sTREM-1 and COX-2 with the severity of sepsis were analyzed, and the diagnostic and prognostic value of sTREM-1 and COX-2 in abdominal infection-caused sepsis was assessed. Results The levels of serum sTREM-1 and COX-2 in the sepsis group were higher than those in the control group and the non-sepsis group (P<0.05). The levels of serum sTREM-1 and COX-2 in the sepsis group were positively correlated with white blood cell count, high-sensitivity C-reactive protein, procalcitonin, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation System Ⅱ score (P<0.05). The serum levels of sTREM-1 and COX-2 of patients who died during hospitalization in the sepsis group were higher than those of the surviving patients. The areas under the receiver operating characteristic curves of the serum sTREM-1 and COX-2 levels for diagnosing sepsis caused by abdominal infection were 0.814 [95% confidence interval (CI) (0.746, 0.882), P<0.001] and 0.848 [95%CI (0.788, 0.905), P<0.001], respectively, with critical values of 1.879 pg/mL and 18.75 ng/mL, respectively, and those for predicting the prognosis of patients with sepsis caused by abdominal infection were 0.775 [95%CI (0.659, 0.890), P<0.001] and 0.784 [95%CI (0.679, 0.889), P<0.001], respectively, with critical values of 2.283 pg/mL and 23.02 ng/mL, respectively (P<0.05). Conclusion The serum levels of sTREM-1 and COX-2 have certain value in the diagnosis and prognosis prediction of abdominal infection-caused sepsis.

Citation： ZENG Hui, WANG Guiyan, LIU Jian, LIU Binwei. Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis. West China Medical Journal, 2023, 38(11): 1709-1713. doi: 10.7507/1002-0179.202304045 Copy

1.	Blot S, Antonelli M, Arvaniti K, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med, 2019, 45(12): 1703-1717.
2.	Chou EH, Mann S, Hsu TC, et al. Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study. PLoS One, 2020, 15(1): e0227752.
3.	況剛, 陳勇, 魏旭升, 等. 24 h LCR、SOFA 評分及 SAPSⅡ評分在腹腔感染致膿毒癥患者預后評估中的作用. 湖南師范大學學報(醫學版), 2020, 17(1): 26-29.
4.	Qu Z, Zhu Y, Wang M, et al. Prognosis and risk factors of sepsis patients in Chinese ICUs: a retrospective analysis of a cohort database. Shock, 2021, 56(6): 921-926.
5.	Dadkhah A, Fatemi F, Rasooli A, et al. Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 2018, 56(1): 495-504.
6.	劉勝蕊, 史曉峰, 王兵, 等. 腹腔感染性膿毒癥可溶性髓樣細胞觸發受體(sTREM-1)與 Janus 激酶-信號轉導和轉錄激活因子(JAK/STAT)通路的關系. 中華急診醫學雜志, 2016, 25(3): 314-319.
7.	李瑞萍, 宋偉. 血漿 sTREM-1、sFLT-1 及 APACHEⅡ評分對重癥肺炎患者預后評估價值. 國際呼吸雜志, 2018, 38(13): 968-971.
8.	Verma AK, Pandey AK, Singh A, et al. Increased serum levels of matrix-metalloproteinase-9, cyclo-oxygenase-2 and prostaglandin E-2 in patients with chronic obstructive pulmonary disease (COPD). Indian J Clin Biochem, 2022, 37(2): 169-177.
9.	中華醫學會外科學分會外科感染與重癥醫學學組, 中國醫師協會外科醫師分會腸瘺外科醫師專業委員會. 中國腹腔感染診治指南(2019 版). 中國實用外科雜志, 2020, 40(1): 1-16.
10.	中國醫師協會急診醫師分會, 中國研究型醫院學會休克與膿毒癥專業委員會. 中國膿毒癥/膿毒性休克急診治療指南(2018). 中國急救醫學, 2018, 38(9): 741-756.
11.	魏鋒, 洪志敏, 董海濤, 等. ICU 重度膿毒癥的流行病學特點及預后影響因素的分析. 中華醫院感染學雜志, 2018, 28(10): 1469-1471, 1484.
12.	陶麗麗, 張振輝, 張瑞昌, 等. 綜合 ICU 內腹腔感染相關性膿毒癥患者的臨床特征分析. 國際醫藥衛生導報, 2018, 24(23): 3604-3606.
13.	Wang L, Chen Q, Yu Q, et al. ITREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis. Inflamm Res, 2021, 70(9): 971-980.
14.	Wang X, Luo B, Lu Y, et al. The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. Cell Tissue Res, 2018, 374(1): 137-148.
15.	Gon?alves RM, Delgobo M, Agnes JP, et al. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Cancer Lett, 2021, 1(502): 44-57.
16.	Xie Y, Li X, Lv D, et al. TREM-1 amplifies trophoblastic inflammation via activating NF-κB pathway during preeclampsia. Placenta, 2021, 115: 97-105.
17.	Tang J, Dong Q, Tang J, et al. Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway. Biochem Biophys Res Commun, 2017, 482(4): 1240-1245.
18.	Joung EJ, Cao L, Lee B, et al. Sargahydroquinoic acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells. Inflammation, 2021, 44(5): 2120-2131.

1. Blot S, Antonelli M, Arvaniti K, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med, 2019, 45(12): 1703-1717.
2. Chou EH, Mann S, Hsu TC, et al. Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study. PLoS One, 2020, 15(1): e0227752.
3. 況剛, 陳勇, 魏旭升, 等. 24 h LCR、SOFA 評分及 SAPSⅡ評分在腹腔感染致膿毒癥患者預后評估中的作用. 湖南師范大學學報(醫學版), 2020, 17(1): 26-29.
4. Qu Z, Zhu Y, Wang M, et al. Prognosis and risk factors of sepsis patients in Chinese ICUs: a retrospective analysis of a cohort database. Shock, 2021, 56(6): 921-926.
5. Dadkhah A, Fatemi F, Rasooli A, et al. Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 2018, 56(1): 495-504.
6. 劉勝蕊, 史曉峰, 王兵, 等. 腹腔感染性膿毒癥可溶性髓樣細胞觸發受體(sTREM-1)與 Janus 激酶-信號轉導和轉錄激活因子(JAK/STAT)通路的關系. 中華急診醫學雜志, 2016, 25(3): 314-319.
7. 李瑞萍, 宋偉. 血漿 sTREM-1、sFLT-1 及 APACHEⅡ評分對重癥肺炎患者預后評估價值. 國際呼吸雜志, 2018, 38(13): 968-971.
8. Verma AK, Pandey AK, Singh A, et al. Increased serum levels of matrix-metalloproteinase-9, cyclo-oxygenase-2 and prostaglandin E-2 in patients with chronic obstructive pulmonary disease (COPD). Indian J Clin Biochem, 2022, 37(2): 169-177.
9. 中華醫學會外科學分會外科感染與重癥醫學學組, 中國醫師協會外科醫師分會腸瘺外科醫師專業委員會. 中國腹腔感染診治指南(2019 版). 中國實用外科雜志, 2020, 40(1): 1-16.
10. 中國醫師協會急診醫師分會, 中國研究型醫院學會休克與膿毒癥專業委員會. 中國膿毒癥/膿毒性休克急診治療指南(2018). 中國急救醫學, 2018, 38(9): 741-756.
11. 魏鋒, 洪志敏, 董海濤, 等. ICU 重度膿毒癥的流行病學特點及預后影響因素的分析. 中華醫院感染學雜志, 2018, 28(10): 1469-1471, 1484.
12. 陶麗麗, 張振輝, 張瑞昌, 等. 綜合 ICU 內腹腔感染相關性膿毒癥患者的臨床特征分析. 國際醫藥衛生導報, 2018, 24(23): 3604-3606.
13. Wang L, Chen Q, Yu Q, et al. ITREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis. Inflamm Res, 2021, 70(9): 971-980.
14. Wang X, Luo B, Lu Y, et al. The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. Cell Tissue Res, 2018, 374(1): 137-148.
15. Gon?alves RM, Delgobo M, Agnes JP, et al. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Cancer Lett, 2021, 1(502): 44-57.
16. Xie Y, Li X, Lv D, et al. TREM-1 amplifies trophoblastic inflammation via activating NF-κB pathway during preeclampsia. Placenta, 2021, 115: 97-105.
17. Tang J, Dong Q, Tang J, et al. Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway. Biochem Biophys Res Commun, 2017, 482(4): 1240-1245.
18. Joung EJ, Cao L, Lee B, et al. Sargahydroquinoic acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells. Inflammation, 2021, 44(5): 2120-2131.

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Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis

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