Research progress in influencing factors of fatigue symptoms in patients with inflammatory bowel disease_West China Medical Journal

Authors：

QIAN Lin ¹ , LIU Yajun ¹ ,  WU Jing ²

1. Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, P. R. China;
2. Department of Traditional Chinese Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical College / Institutes of Chinese Medicine, Nanjing University / Drum Tower Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210008, P. R. China;

Corresponding?author：

WU Jing, Email: wujing@njucm.edu.cn

Keywords：

Inflammatory bowel disease; fatigue; inflammation; psychological disorder; metabolomics

DOI：

10.7507/1002-0179.202303125

Video：

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Abstract Full text Figures/Tables Video References Cited by

Inflammatory bowel disease (IBD) is characterized by recurrent abdominal pain, diarrhea, and mucopurulent bloody stools as its main clinical manifestations. In recent years, its parenteral manifestations have received increasing attention. Fatigue, as one of the extraintestinal manifestations of IBD, affects the quality of life of patients, and results in considerable distress for patients. The influencing factors of fatigue symptoms in IBD patients include inflammation, psychological comorbidities, sleep disorders, anemia, micronutrient deficiency, changes in microbiota, and metabolomics. The pathogenesis is currently unclear and may be related to disorders in tryptophan metabolism. This article will review the influencing factors and pathogenesis of fatigue symptoms in IBD patients, aiming to provide a basis for the prevention and treatment of IBD fatigue.

Citation： QIAN Lin, LIU Yajun, WU Jing. Research progress in influencing factors of fatigue symptoms in patients with inflammatory bowel disease. West China Medical Journal, 2023, 38(11): 1760-1765. doi: 10.7507/1002-0179.202303125 Copy

1.	中華醫學會消化病學分會炎癥性腸病學組. 炎癥性腸病診斷與治療的共識意見(2018 年·北京). 中國實用內科雜志, 2018, 38(9): 796-813.
2.	秦有, 龐鳳舜, 蔡北源, 等. 慢性疲勞綜合征定義及診斷標準的變遷. 中國中西醫結合雜志, 2009, 29(10): 946-948.
3.	Su Y, Cochrane BB, Yu SY, et al. Fatigue in community-dwelling older adults: a review of definitions, measures, and related factors. Geriatr Nurs, 2022, 43: 266-279.
4.	D’Silva A, Fox DE, Nasser Y, et al. Prevalence and risk factors for fatigue in adults with inflammatory bowel disease: a systematic review with meta-analysis. Clin Gastroenterol Hepatol, 2022, 20(5): 995-1009. e7.
5.	Borren NZ, van der Woude CJ, Ananthakrishnan AN. Fatigue in IBD: epidemiology, pathophysiology and management. Nat Rev Gastroenterol Hepatol, 2019, 16(4): 247-259.
6.	McGing JJ, Radford SJ, Francis ST, et al. Review article: the aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Aliment Pharmacol Ther, 2021, 54(4): 368-387.
7.	Bisgaard TH, Allin KH, Keefer L, et al. Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment. Nat Rev Gastroenterol Hepatol, 2022, 19(11): 717-726.
8.	Bager P, Hvas CL, Rud CL, et al. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease. Aliment Pharmacol Ther, 2021, 53(1): 79-86.
9.	Jones K, Kimble R, Baker K, et al. Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): a systematic review and meta-analysis. PLoS One, 2022, 17(12): e0278480.
10.	Nguyen TLL, Huynh DTN, Jin Y, et al. Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway. Arch Pharm Res, 2021, 44(2): 241-252.
11.	Tasson L, Zingone F, Barberio B, et al. Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases. Sci Rep, 2021, 11(1): 15251.
12.	Thomann AK, Wüstenberg T, Wirbel J, et al. Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics. BMC Med, 2022, 20(1): 366.
13.	張培培, 張佳佳, 崔鵬, 等. 靜止期炎性腸病患者糞便微生物群和 TNF-α及 IL-6 與疲勞感的相關性. 新疆醫科大學學報, 2021, 44(2): 220-223.
14.	Vogelaar L, de Haar C, Aerts BR, et al. Fatigue in patients with inflammatory bowel disease is associated with distinct differences in immune parameters. Clin Exp Gastroenterol, 2017, 10: 83-90.
15.	Villoria A, García V, Dosal A, et al. Fatigue in out-patients with inflammatory bowel disease: prevalence and predictive factors. PLoS One, 2017, 12(7): e0181435.
16.	Borren NZ, Plichta D, Joshi AD, et al. Alterations in fecal microbiomes and serum metabolomes of fatigued patients with quiescent inflammatory bowel diseases. Clin Gastroenterol Hepatol, 2021, 19(3): 519-527. e5.
17.	Bourgonje AR, Wichers SJ, Hu S, et al. Proteomic analyses do not reveal subclinical inflammation in fatigued patients with clinically quiescent inflammatory bowel disease. Sci Rep, 2022, 12(1): 14581.
18.	Miaskowski C. Future directions in symptom cluster research. Semin Oncol Nurs, 2016, 32(4): 405-415.
19.	Emerson C, Barhoun P, Olive L, et al. A systematic review of psychological treatments to manage fatigue in patients with inflammatory bowel disease. J Psychosom Res, 2021, 147: 110524.
20.	Lee HH, Gweon TG, Kang SG, et al. Assessment of fatigue and associated factors in patients with inflammatory bowel disease: a questionnaire-based study. J Clin Med, 2023, 12(9): 3116.
21.	李仲賢, 符文彬, 張嘉諭, 等. 整合針灸療法對慢性疲勞綜合征患者抑郁及焦慮狀態的影響. 廣州中醫藥大學學報, 2022, 39(5): 1084-1089.
22.	Gong SS, Fan YH, Lv B, et al. Fatigue in patients with inflammatory bowel disease in Eastern China. World J Gastroenterol, 2021, 27(11): 1076-1089.
23.	Vogelaar L, van't Spijker A, van Tilburg AJ, et al. Determinants of fatigue in Crohn’s disease patients. Eur J Gastroenterol Hepatol, 2013, 25(2): 246-251.
24.	李慶, 劉祥彥, 鐘焱. 化療對乳腺癌患者疲勞、焦慮抑郁和生活質量的影響研究. 醫學理論與實踐, 2022, 35(8): 1276-1279, 1298.
25.	Davis SP, Chen DG, Crane PB, et al. Influencing factors of inflammatory bowel disease-fatigue: a path analysis model. Nurs Res, 2021, 70(4): 256-265.
26.	Chrobak AA, Nowakowski J, Zwolińska-Wcis?o M, et al. Associations between chronotype, sleep disturbances and seasonality with fatigue and inflammatory bowel disease symptoms. Chronobiol Int, 2018, 35(8): 1142-1152.
27.	Chavarría C, Casanova MJ, Chaparro M, et al. Prevalence and factors associated with fatigue in patients with inflammatory bowel disease: a multicentre study. J Crohns Colitis, 2019, 13(8): 996-1002.
28.	Graff LA, Vincent N, Walker JR, et al. A population-based study of fatigue and sleep difficulties in inflammatory bowel disease. Inflamm Bowel Dis, 2011, 17(9): 1882-1889.
29.	Ranjbaran Z, Keefer L, Farhadi A, et al. Impact of sleep disturbances in inflammatory bowel disease. J Gastroenterol Hepatol, 2007, 22(11): 1748-1753.
30.	Amiot A, Chaibi S, Bouhnik Y, et al. Prevalence and determinants of fatigue in patients with ibd: a cross-sectional survey from the GETAID. J Crohns Colitis, 2023, 17(9): 1418-1425.
31.	Barnes A, Spizzo P, Bampton P, et al. Examining the influence of inflammatory bowel disease medications on sleep quality. JGH Open, 2023, 7(3): 190-196.
32.	Meier-Ewert HK, Ridker PM, Rifai N, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol, 2004, 43(4): 678-683.
33.	Shearer WT, Reuben JM, Mullington JM, et al. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol, 2001, 107(1): 165-170.
34.	Hodges S, Guler S, Sacca V, et al. Associations among acute and chronic musculoskeletal pain, sleep duration, and C-reactive protein (CRP): a cross-sectional study of the UK biobank dataset. Sleep Med, 2023, 101: 393-400.
35.	李華玉, 時蕭寒, 張新蕊, 等. 203 例膠質瘤患者睡眠障礙與炎癥細胞因子的關聯分析. 山東大學學報(醫學版), 2022, 60(12): 26-30, 38.
36.	鄧介華, 溫艷, 林文. 腦卒中并發睡眠障礙患者血清細胞因子及神經遞質表達的變化研究. 世界睡眠醫學雜志, 2019, 6(3): 269-271.
37.	Loveikyte R, Boer M, van der Meulen CN, et al. Anemia and iron deficiency in outpatients with inflammatory bowel disease: ubiquitous yet suboptimally managed. J Clin Med, 2022, 11(22): 6843.
38.	Bergamaschi G, Castiglione F, D'Incà R, et al. Prevalence, pathogenesis and management of anemia in inflammatory bowel disease: an IG-IBD multicenter, prospective, and observational study. Inflamm Bowel Dis, 2023, 29(1): 76-84.
39.	Jelsness-J?rgensen LP, Bernklev T, Henriksen M, et al. Chronic fatigue is more prevalent in patients with inflammatory bowel disease than in healthy controls. Inflamm Bowel Dis, 2011, 17(7): 1564-1572.
40.	Xu F, Hu J, Yang Q, et al. Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study. BMC Gastroenterol, 2022, 22(1): 281.
41.	Mahadea D, Adamczewska E, Ratajczak AE, et al. Iron deficiency anemia in inflammatory bowel diseases-a narrative review. Nutrients, 2021, 13(11): 4008.
42.	K?nig P, Jimenez K, Saletu-Zyhlarz G, et al. Iron deficiency, depression, and fatigue in inflammatory bowel diseases. Z Gastroenterol, 2020, 58(12): 1191-1200.
43.	Goldenberg BA, Graff LA, Clara I, et al. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease?. Am J Gastroenterol, 2013, 108(9): 1392-1397.
44.	Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr, 2015, 102(6): 1585-1594.
45.	Maggini S, óvári V, Ferreres Giménez I, et al. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. Nutr Hosp, 2021, 38(2): 3-8.
46.	Ward MG, Kariyawasam VC, Mogan SB, et al. Prevalence and risk factors for functional vitamin B12 deficiency in patients with Crohn’s disease. Inflamm Bowel Dis, 2015, 21(12): 2839-2847.
47.	Fyfe JC, Madsen M, H?jrup P, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood, 2004, 103(5): 1573-1579.
48.	Huijts M, Duits A, Staals J, et al. Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. PLoS One, 2012, 7(1): e30519.
49.	Frigstad SO, H?ivik M, Jahnsen J, et al. Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scand J Gastroenterol, 2017, 52(1): 100-106.
50.	Kabbani TA, Koutroubakis IE, Schoen RE, et al. Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year longitudinal study. Am J Gastroenterol, 2016, 111(5): 712-719.
51.	Torki M, Gholamrezaei A, Mirbagher L, et al. Vitamin D deficiency associated with disease activity in patients with inflammatory bowel diseases. Dig Dis Sci, 2015, 60(10): 3085-3091.
52.	Ulitsky A, Ananthakrishnan AN, Naik A, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr, 2011, 35(3): 308-316.
53.	Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab, 2007, 92(6): 2058-2065.
54.	周靜, 李婭, 張佳琳, 等. 潰瘍性結腸炎相關性疲勞的影響因素分析. 河南醫學研究, 2019, 28(20): 3659-3662.
55.	Frigstad SO, H?ivik ML, Jahnsen J, et al. Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World J Gastroenterol, 2018, 24(29): 3293-3301.
56.	Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut, 2016, 65(2): 330-339.
57.	Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology, 2008, 134(2): 577-594.
58.	Salminen S, Von Wright A, Morelli L, et al. Demonstration of safety of probiotics -- a review. Int J Food Microbiol, 1998, 44(1/2): 93-106.
59.	Rastall RA, Gibson GR, Gill HS, et al. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: an overview of enabling science and potential applications. FEMS Microbiol Ecol, 2005, 52(2): 145-152.
60.	Li Y, Li J, Xu F, et al. Gut microbiota as a potential target for developing anti-fatigue foods. Crit Rev Food Sci Nutr, 2023, 63(18): 3065-3080.
61.	Luo C, Wei X, Song J, et al. Interactions between gut microbiota and polyphenols: new insights into the treatment of fatigue. Molecules, 2022, 27(21): 7377.
62.	Lv Z, Liu R, Su K, et al. Acupuncture ameliorates breast cancer-related fatigue by regulating the gut microbiota-gut-brain axis. Front Endocrinol (Lausanne), 2022, 13: 921119.
63.	Yamashita M. Potential Role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit. Int J Tryptophan Res, 2020, 13: 1178646920936279.
64.	Comai S, Bertazzo A, Brughera M, et al. Tryptophan in health and disease. Adv Clin Chem, 2020, 95: 165-218.
65.	Oliver SG, Winson MK, Kell DB, et al. Systematic functional analysis of the yeast genome. Trends Biotechnol, 1998, 16(9): 373-378.
66.	Buergel T, Steinfeldt J, Ruyoga G, et al. Simultaneous prediction of risk for multiple common diseases using metabolomics. Nat Med, 2022, 28(11): 2265-2266.
67.	Acworth I, Nicholass J, Morgan B, et al. Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines. Biochem Biophys Res Commun, 1986, 137(1): 149-153.
68.	Lanser L, Kink P, Egger EM, et al. Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer. Front Immunol, 2020, 11: 249.
69.	Horta D, Moreno-Torres M, Ramírez-Lázaro MJ, et al. Analysis of the association between fatigue and the plasma lipidomic profile of inflammatory bowel disease patients. J Proteome Res, 2021, 20(1): 381-392.
70.	陳森. “柔筋益髓”推拿法治療慢性疲勞綜合征的代謝組學探索. 鄭州: 河南中醫藥大學, 2022.
71.	池愛平, 張楊, 康亦姜, 等. 五味子多糖對慢性疲勞綜合征大鼠治療效果與代謝機制研究. 中國藥學雜志, 2017, 52(5): 391-397.
72.	郭新明, 吳麗君, 孫卓, 等. 疲勞運動大鼠骨骼肌代謝組學研究. 天津體育學院學報, 2021, 36(3): 354-359, 372.
73.	劉洋, 彭玉清, 葛辛, 等. 健脾益腎法對慢性疲勞綜合征患者自由基代謝的影響. 北京中醫藥, 2019, 38(2): 140-142.
74.	Pekow J. Fatigue in inflammatory bowel disease: a common complaint with few answers. Gastroenterology, 2022, 163(5): 1164-1165.
75.	Chen W, Xu Y, Li ZH, et al. Serum metabolic alterations in peritoneal dialysis patients with excessive daytime sleepiness. Ren Fail, 2023, 45(1): 2190815.
76.	Lai W, Huang Z, Li S, et al. Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response. Int Immunopharmacol, 2023, 117: 109840.
77.	Truyens M, Lobatón T, Ferrante M, et al. Effect of 5-hydroxytryptophan on fatigue in quiescent inflammatory bowel disease: a randomized controlled trial. Gastroenterology, 2022, 163(5): 1294-1305. e3.
78.	朱國苗, 房敏, 孫武權, 等. 慢性疲勞綜合征的發病機制與椎拿干預研究進展. 上海中醫藥雜志, 2006, 40(11): 74-76.

1. 中華醫學會消化病學分會炎癥性腸病學組. 炎癥性腸病診斷與治療的共識意見(2018 年·北京). 中國實用內科雜志, 2018, 38(9): 796-813.
2. 秦有, 龐鳳舜, 蔡北源, 等. 慢性疲勞綜合征定義及診斷標準的變遷. 中國中西醫結合雜志, 2009, 29(10): 946-948.
3. Su Y, Cochrane BB, Yu SY, et al. Fatigue in community-dwelling older adults: a review of definitions, measures, and related factors. Geriatr Nurs, 2022, 43: 266-279.
4. D’Silva A, Fox DE, Nasser Y, et al. Prevalence and risk factors for fatigue in adults with inflammatory bowel disease: a systematic review with meta-analysis. Clin Gastroenterol Hepatol, 2022, 20(5): 995-1009. e7.
5. Borren NZ, van der Woude CJ, Ananthakrishnan AN. Fatigue in IBD: epidemiology, pathophysiology and management. Nat Rev Gastroenterol Hepatol, 2019, 16(4): 247-259.
6. McGing JJ, Radford SJ, Francis ST, et al. Review article: the aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Aliment Pharmacol Ther, 2021, 54(4): 368-387.
7. Bisgaard TH, Allin KH, Keefer L, et al. Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment. Nat Rev Gastroenterol Hepatol, 2022, 19(11): 717-726.
8. Bager P, Hvas CL, Rud CL, et al. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease. Aliment Pharmacol Ther, 2021, 53(1): 79-86.
9. Jones K, Kimble R, Baker K, et al. Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): a systematic review and meta-analysis. PLoS One, 2022, 17(12): e0278480.
10. Nguyen TLL, Huynh DTN, Jin Y, et al. Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway. Arch Pharm Res, 2021, 44(2): 241-252.
11. Tasson L, Zingone F, Barberio B, et al. Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases. Sci Rep, 2021, 11(1): 15251.
12. Thomann AK, Wüstenberg T, Wirbel J, et al. Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics. BMC Med, 2022, 20(1): 366.
13. 張培培, 張佳佳, 崔鵬, 等. 靜止期炎性腸病患者糞便微生物群和 TNF-α及 IL-6 與疲勞感的相關性. 新疆醫科大學學報, 2021, 44(2): 220-223.
14. Vogelaar L, de Haar C, Aerts BR, et al. Fatigue in patients with inflammatory bowel disease is associated with distinct differences in immune parameters. Clin Exp Gastroenterol, 2017, 10: 83-90.
15. Villoria A, García V, Dosal A, et al. Fatigue in out-patients with inflammatory bowel disease: prevalence and predictive factors. PLoS One, 2017, 12(7): e0181435.
16. Borren NZ, Plichta D, Joshi AD, et al. Alterations in fecal microbiomes and serum metabolomes of fatigued patients with quiescent inflammatory bowel diseases. Clin Gastroenterol Hepatol, 2021, 19(3): 519-527. e5.
17. Bourgonje AR, Wichers SJ, Hu S, et al. Proteomic analyses do not reveal subclinical inflammation in fatigued patients with clinically quiescent inflammatory bowel disease. Sci Rep, 2022, 12(1): 14581.
18. Miaskowski C. Future directions in symptom cluster research. Semin Oncol Nurs, 2016, 32(4): 405-415.
19. Emerson C, Barhoun P, Olive L, et al. A systematic review of psychological treatments to manage fatigue in patients with inflammatory bowel disease. J Psychosom Res, 2021, 147: 110524.
20. Lee HH, Gweon TG, Kang SG, et al. Assessment of fatigue and associated factors in patients with inflammatory bowel disease: a questionnaire-based study. J Clin Med, 2023, 12(9): 3116.
21. 李仲賢, 符文彬, 張嘉諭, 等. 整合針灸療法對慢性疲勞綜合征患者抑郁及焦慮狀態的影響. 廣州中醫藥大學學報, 2022, 39(5): 1084-1089.
22. Gong SS, Fan YH, Lv B, et al. Fatigue in patients with inflammatory bowel disease in Eastern China. World J Gastroenterol, 2021, 27(11): 1076-1089.
23. Vogelaar L, van't Spijker A, van Tilburg AJ, et al. Determinants of fatigue in Crohn’s disease patients. Eur J Gastroenterol Hepatol, 2013, 25(2): 246-251.
24. 李慶, 劉祥彥, 鐘焱. 化療對乳腺癌患者疲勞、焦慮抑郁和生活質量的影響研究. 醫學理論與實踐, 2022, 35(8): 1276-1279, 1298.
25. Davis SP, Chen DG, Crane PB, et al. Influencing factors of inflammatory bowel disease-fatigue: a path analysis model. Nurs Res, 2021, 70(4): 256-265.
26. Chrobak AA, Nowakowski J, Zwolińska-Wcis?o M, et al. Associations between chronotype, sleep disturbances and seasonality with fatigue and inflammatory bowel disease symptoms. Chronobiol Int, 2018, 35(8): 1142-1152.
27. Chavarría C, Casanova MJ, Chaparro M, et al. Prevalence and factors associated with fatigue in patients with inflammatory bowel disease: a multicentre study. J Crohns Colitis, 2019, 13(8): 996-1002.
28. Graff LA, Vincent N, Walker JR, et al. A population-based study of fatigue and sleep difficulties in inflammatory bowel disease. Inflamm Bowel Dis, 2011, 17(9): 1882-1889.
29. Ranjbaran Z, Keefer L, Farhadi A, et al. Impact of sleep disturbances in inflammatory bowel disease. J Gastroenterol Hepatol, 2007, 22(11): 1748-1753.
30. Amiot A, Chaibi S, Bouhnik Y, et al. Prevalence and determinants of fatigue in patients with ibd: a cross-sectional survey from the GETAID. J Crohns Colitis, 2023, 17(9): 1418-1425.
31. Barnes A, Spizzo P, Bampton P, et al. Examining the influence of inflammatory bowel disease medications on sleep quality. JGH Open, 2023, 7(3): 190-196.
32. Meier-Ewert HK, Ridker PM, Rifai N, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol, 2004, 43(4): 678-683.
33. Shearer WT, Reuben JM, Mullington JM, et al. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol, 2001, 107(1): 165-170.
34. Hodges S, Guler S, Sacca V, et al. Associations among acute and chronic musculoskeletal pain, sleep duration, and C-reactive protein (CRP): a cross-sectional study of the UK biobank dataset. Sleep Med, 2023, 101: 393-400.
35. 李華玉, 時蕭寒, 張新蕊, 等. 203 例膠質瘤患者睡眠障礙與炎癥細胞因子的關聯分析. 山東大學學報(醫學版), 2022, 60(12): 26-30, 38.
36. 鄧介華, 溫艷, 林文. 腦卒中并發睡眠障礙患者血清細胞因子及神經遞質表達的變化研究. 世界睡眠醫學雜志, 2019, 6(3): 269-271.
37. Loveikyte R, Boer M, van der Meulen CN, et al. Anemia and iron deficiency in outpatients with inflammatory bowel disease: ubiquitous yet suboptimally managed. J Clin Med, 2022, 11(22): 6843.
38. Bergamaschi G, Castiglione F, D'Incà R, et al. Prevalence, pathogenesis and management of anemia in inflammatory bowel disease: an IG-IBD multicenter, prospective, and observational study. Inflamm Bowel Dis, 2023, 29(1): 76-84.
39. Jelsness-J?rgensen LP, Bernklev T, Henriksen M, et al. Chronic fatigue is more prevalent in patients with inflammatory bowel disease than in healthy controls. Inflamm Bowel Dis, 2011, 17(7): 1564-1572.
40. Xu F, Hu J, Yang Q, et al. Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study. BMC Gastroenterol, 2022, 22(1): 281.
41. Mahadea D, Adamczewska E, Ratajczak AE, et al. Iron deficiency anemia in inflammatory bowel diseases-a narrative review. Nutrients, 2021, 13(11): 4008.
42. K?nig P, Jimenez K, Saletu-Zyhlarz G, et al. Iron deficiency, depression, and fatigue in inflammatory bowel diseases. Z Gastroenterol, 2020, 58(12): 1191-1200.
43. Goldenberg BA, Graff LA, Clara I, et al. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease?. Am J Gastroenterol, 2013, 108(9): 1392-1397.
44. Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr, 2015, 102(6): 1585-1594.
45. Maggini S, óvári V, Ferreres Giménez I, et al. Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing. Nutr Hosp, 2021, 38(2): 3-8.
46. Ward MG, Kariyawasam VC, Mogan SB, et al. Prevalence and risk factors for functional vitamin B12 deficiency in patients with Crohn’s disease. Inflamm Bowel Dis, 2015, 21(12): 2839-2847.
47. Fyfe JC, Madsen M, H?jrup P, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood, 2004, 103(5): 1573-1579.
48. Huijts M, Duits A, Staals J, et al. Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. PLoS One, 2012, 7(1): e30519.
49. Frigstad SO, H?ivik M, Jahnsen J, et al. Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scand J Gastroenterol, 2017, 52(1): 100-106.
50. Kabbani TA, Koutroubakis IE, Schoen RE, et al. Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year longitudinal study. Am J Gastroenterol, 2016, 111(5): 712-719.
51. Torki M, Gholamrezaei A, Mirbagher L, et al. Vitamin D deficiency associated with disease activity in patients with inflammatory bowel diseases. Dig Dis Sci, 2015, 60(10): 3085-3091.
52. Ulitsky A, Ananthakrishnan AN, Naik A, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr, 2011, 35(3): 308-316.
53. Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab, 2007, 92(6): 2058-2065.
54. 周靜, 李婭, 張佳琳, 等. 潰瘍性結腸炎相關性疲勞的影響因素分析. 河南醫學研究, 2019, 28(20): 3659-3662.
55. Frigstad SO, H?ivik ML, Jahnsen J, et al. Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World J Gastroenterol, 2018, 24(29): 3293-3301.
56. Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut, 2016, 65(2): 330-339.
57. Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology, 2008, 134(2): 577-594.
58. Salminen S, Von Wright A, Morelli L, et al. Demonstration of safety of probiotics -- a review. Int J Food Microbiol, 1998, 44(1/2): 93-106.
59. Rastall RA, Gibson GR, Gill HS, et al. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: an overview of enabling science and potential applications. FEMS Microbiol Ecol, 2005, 52(2): 145-152.
60. Li Y, Li J, Xu F, et al. Gut microbiota as a potential target for developing anti-fatigue foods. Crit Rev Food Sci Nutr, 2023, 63(18): 3065-3080.
61. Luo C, Wei X, Song J, et al. Interactions between gut microbiota and polyphenols: new insights into the treatment of fatigue. Molecules, 2022, 27(21): 7377.
62. Lv Z, Liu R, Su K, et al. Acupuncture ameliorates breast cancer-related fatigue by regulating the gut microbiota-gut-brain axis. Front Endocrinol (Lausanne), 2022, 13: 921119.
63. Yamashita M. Potential Role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit. Int J Tryptophan Res, 2020, 13: 1178646920936279.
64. Comai S, Bertazzo A, Brughera M, et al. Tryptophan in health and disease. Adv Clin Chem, 2020, 95: 165-218.
65. Oliver SG, Winson MK, Kell DB, et al. Systematic functional analysis of the yeast genome. Trends Biotechnol, 1998, 16(9): 373-378.
66. Buergel T, Steinfeldt J, Ruyoga G, et al. Simultaneous prediction of risk for multiple common diseases using metabolomics. Nat Med, 2022, 28(11): 2265-2266.
67. Acworth I, Nicholass J, Morgan B, et al. Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines. Biochem Biophys Res Commun, 1986, 137(1): 149-153.
68. Lanser L, Kink P, Egger EM, et al. Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer. Front Immunol, 2020, 11: 249.
69. Horta D, Moreno-Torres M, Ramírez-Lázaro MJ, et al. Analysis of the association between fatigue and the plasma lipidomic profile of inflammatory bowel disease patients. J Proteome Res, 2021, 20(1): 381-392.
70. 陳森. “柔筋益髓”推拿法治療慢性疲勞綜合征的代謝組學探索. 鄭州: 河南中醫藥大學, 2022.
71. 池愛平, 張楊, 康亦姜, 等. 五味子多糖對慢性疲勞綜合征大鼠治療效果與代謝機制研究. 中國藥學雜志, 2017, 52(5): 391-397.
72. 郭新明, 吳麗君, 孫卓, 等. 疲勞運動大鼠骨骼肌代謝組學研究. 天津體育學院學報, 2021, 36(3): 354-359, 372.
73. 劉洋, 彭玉清, 葛辛, 等. 健脾益腎法對慢性疲勞綜合征患者自由基代謝的影響. 北京中醫藥, 2019, 38(2): 140-142.
74. Pekow J. Fatigue in inflammatory bowel disease: a common complaint with few answers. Gastroenterology, 2022, 163(5): 1164-1165.
75. Chen W, Xu Y, Li ZH, et al. Serum metabolic alterations in peritoneal dialysis patients with excessive daytime sleepiness. Ren Fail, 2023, 45(1): 2190815.
76. Lai W, Huang Z, Li S, et al. Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response. Int Immunopharmacol, 2023, 117: 109840.
77. Truyens M, Lobatón T, Ferrante M, et al. Effect of 5-hydroxytryptophan on fatigue in quiescent inflammatory bowel disease: a randomized controlled trial. Gastroenterology, 2022, 163(5): 1294-1305. e3.
78. 朱國苗, 房敏, 孫武權, 等. 慢性疲勞綜合征的發病機制與椎拿干預研究進展. 上海中醫藥雜志, 2006, 40(11): 74-76.

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