Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sj?gren syndrome based on VOSviewer software_West China Medical Journal

Authors：

GONG Bei ,  SU Li ,  SUN Ding

Department of Rheumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China;

Corresponding?author：

SU Li, Email: suli2002@vip.sina.com; SUN Ding, Email: denny.sunding@gmail.com

Keywords：

Systemic lupus erythematosus; Sj?gren syndrome; law of drug use; VOSviewer; traditional Chinese medicine; data mining

DOI：

10.7507/1002-0179.202302159

Video：

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Objective To discuss the rules of using traditional Chinese medicine (TCM) to treat systemic lupus erythematosus (SLE) and Sj?gren syndrome (SS). Methods The TCM prescriptions for patients with SLE or SS treated at the Department of Rheumatology of Longhua Hospital, Shanghai University of Traditional Chinese Medicine between January 2013 and July 2021 were collected. The prescriptions collected were broken down and analyzed for frequencies of the efficacies, properties, flavors and meridian tropisms of drugs in the prescriptions. The correlation and clustering analysis was performed in VOSviewer software. Results The medication information of 3689 cases of inpatients was included, from which 69167 pieces of data of using TCM prescriptions were extracted. The top 20 high-frequency drugs for treating SLE patients were mainly drugs for promoting blood circulation and removing blood stasis, qi-tonifying drugs, and drugs for heat clearing and detoxicating, which were mostly sweet, bitter or acrid in flavor, cold, warm or neutral in properties, and of the spleen, liver or stomach meridian. The drugs could be seperated into 3 clusters, the blue cluster mainly included qi-tonifying drugs, blood-tonifying drugs, and drugs for promoting blood circulation and removing blood stasis; the green cluster mainly included drugs for heat clearing and drugs for promoting blood circulation and removing blood stasis; and the red cluster mainly consisted of drugs for promoting blood circulation and removing blood stasis, drugs for inducing diuresis and alleviating edema, drugs for dispelling wind-heat, and digestant drugs. The top 20 high-frequency drugs for treating SS patients were mainly drugs for promoting blood circulation and removing blood stasis, qi-tonifying drugs, and drugs for inducing diuresis and alleviating edema, which were mostly sweet, bitter or acrid in flavor, slightly cold, cold or warm in properties, and of the spleen, stomach or liver meridian. The drugs could be seperated into 2 clusters, the green cluster mainly consisted of yin-tonifying drugs, drugs for promoting blood circulation and removing blood stasis, and drugs for heat clearing; the red cluster mainly included qi-tonifying drugs, drugs for promoting blood circulation and removing blood stasis, and drugs for inducing diuresis and alleviating edema. Conclusions The medication for SLE is in line with the treatment principle of “supplementing qi and nourishing yin, detoxicating and removing stasis”; the medication for SS, on the other hand, agrees with the basic rule of “nourishing yin and clearing away heat, promoting body fluid to moisten dryness”. Both are based on the approach of strengthening the body resistance, which is in line with the diagnostic and treatment ideas of rheumatology department and may offer the ideas of TCM syndrome differentiation for clinical use of drugs and thereby guiding the current clinical practice.

Citation： GONG Bei, SU Li, SUN Ding. Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sj?gren syndrome based on VOSviewer software. West China Medical Journal, 2023, 38(6): 884-891. doi: 10.7507/1002-0179.202302159 Copy

1.	張蘭予, 王春濱, 于靜靜, 等. 系統性紅斑狼瘡重疊干燥綜合征合并肺部曲霉菌感染 1 例報告. 第二軍醫大學學報, 2014, 35(10): 1176-1177.
2.	徐愿, 羅靜, 韓曼, 等. 中醫藥治療風濕免疫領域臨床優勢病種的探討. 中國實驗方劑學雜志, 2022, 28(9): 198-204.
3.	王翎晟, 賀娟. 《黃帝內經》“正氣”概念內涵辨析. 北京中醫藥大學學報, 2020, 43(6): 469-474.
4.	陳明. 大數據可視化分析. 計算機教育, 2015, 13(5): 94-97.
5.	楊曄穎, 周珺, 茅建春, 等. 補腎活血膏方對強直性脊柱炎疾病活動影響研究. 中醫藥學報, 2021, 49(3): 34-38.
6.	顧軍花, 茅建春. 陳湘君運用扶正法治療強直性脊柱炎經驗擷菁. 上海中醫藥雜志, 2008, 42(3): 16-17.
7.	徐翔峰, 向珍蛹, 曲環汝, 等. 蘇勵辨治強直性脊柱炎經驗案 1 則. 上海中醫藥雜志, 2011, 45(4): 22-24.
8.	國家藥典委員會. 中華人民共和國藥典: 一部. 北京: 中國醫藥科技出版社, 2015.
9.	中華醫學會風濕病學分會. 系統性紅斑狼瘡診斷及治療指南. 中華風濕病學雜志, 2010, 14(5): 342-346.
10.	Feng Y, Yang M, Wu H, et al. The pathological role of B cells in systemic lupus erythematosus: from basic research to clinical. Autoimmunity, 2020, 53(2): 56-64.
11.	呂芹, 梁卡軍, 李凱, 等. 《金匱要略》陰陽毒證治發揮. 時珍國醫國藥, 2021, 32(9): 2218-2219.
12.	姚重華, 曲環汝. 蘇勵教授治療系統性紅斑狼瘡經驗介紹. 新中醫, 2009, 41(6): 10-11.
13.	陳薇薇, 蘇勵. 蘇勵從脾腎論治系統性紅斑狼瘡經驗. 上海中醫藥雜志, 2019, 53(6): 24-27.
14.	徐冬, 呂曉偉, 崔鵬, 等. 艾拉莫德與羥氯喹治療干燥綜合征患者療效及安全性比較. 疑難病雜志, 2017, 16(9): 915-918.
15.	徐洋, 高明利. 中西醫治療干燥綜合征概述. 實用中醫內科雜志, 2020, 34(4): 17-20.
16.	劉河間. 素問玄機原病式. 北京: 中國醫藥科技出版社, 2011: 47.
17.	李永明, 薛鸞. 養陰生津法為主治療干燥綜合征臨床進展. 中醫學報, 2019, 34(10): 2113-2118.
18.	曹佐媛, 周珺, 曲環汝. 干燥綜合征中醫證候研究進展. 上海中醫藥大學學報, 2014, 28(4): 103-105.
19.	王貴幫, 吳振起. 從“秋燥”探析清燥救肺湯制方特點. 中華中醫藥學刊, 2018, 36(1): 163-165.
20.	柳文, 張慶華, 郭圓. 陳湘君運用補陰法治療干燥綜合征經驗初探. 上海中醫藥雜志, 2015, 49(9): 1-2.
21.	羅雅文, 劉英. 劉英教授基于“伏毒學說”辨治干燥綜合征經驗. 中國醫藥導報, 2022, 19(3): 115-118.
22.	劉萍. 酸甘化陰配伍臨證應用規律探討. 中醫雜志, 2019, 60(11): 986-987.

1. 張蘭予, 王春濱, 于靜靜, 等. 系統性紅斑狼瘡重疊干燥綜合征合并肺部曲霉菌感染 1 例報告. 第二軍醫大學學報, 2014, 35(10): 1176-1177.
2. 徐愿, 羅靜, 韓曼, 等. 中醫藥治療風濕免疫領域臨床優勢病種的探討. 中國實驗方劑學雜志, 2022, 28(9): 198-204.
3. 王翎晟, 賀娟. 《黃帝內經》“正氣”概念內涵辨析. 北京中醫藥大學學報, 2020, 43(6): 469-474.
4. 陳明. 大數據可視化分析. 計算機教育, 2015, 13(5): 94-97.
5. 楊曄穎, 周珺, 茅建春, 等. 補腎活血膏方對強直性脊柱炎疾病活動影響研究. 中醫藥學報, 2021, 49(3): 34-38.
6. 顧軍花, 茅建春. 陳湘君運用扶正法治療強直性脊柱炎經驗擷菁. 上海中醫藥雜志, 2008, 42(3): 16-17.
7. 徐翔峰, 向珍蛹, 曲環汝, 等. 蘇勵辨治強直性脊柱炎經驗案 1 則. 上海中醫藥雜志, 2011, 45(4): 22-24.
8. 國家藥典委員會. 中華人民共和國藥典: 一部. 北京: 中國醫藥科技出版社, 2015.
9. 中華醫學會風濕病學分會. 系統性紅斑狼瘡診斷及治療指南. 中華風濕病學雜志, 2010, 14(5): 342-346.
10. Feng Y, Yang M, Wu H, et al. The pathological role of B cells in systemic lupus erythematosus: from basic research to clinical. Autoimmunity, 2020, 53(2): 56-64.
11. 呂芹, 梁卡軍, 李凱, 等. 《金匱要略》陰陽毒證治發揮. 時珍國醫國藥, 2021, 32(9): 2218-2219.
12. 姚重華, 曲環汝. 蘇勵教授治療系統性紅斑狼瘡經驗介紹. 新中醫, 2009, 41(6): 10-11.
13. 陳薇薇, 蘇勵. 蘇勵從脾腎論治系統性紅斑狼瘡經驗. 上海中醫藥雜志, 2019, 53(6): 24-27.
14. 徐冬, 呂曉偉, 崔鵬, 等. 艾拉莫德與羥氯喹治療干燥綜合征患者療效及安全性比較. 疑難病雜志, 2017, 16(9): 915-918.
15. 徐洋, 高明利. 中西醫治療干燥綜合征概述. 實用中醫內科雜志, 2020, 34(4): 17-20.
16. 劉河間. 素問玄機原病式. 北京: 中國醫藥科技出版社, 2011: 47.
17. 李永明, 薛鸞. 養陰生津法為主治療干燥綜合征臨床進展. 中醫學報, 2019, 34(10): 2113-2118.
18. 曹佐媛, 周珺, 曲環汝. 干燥綜合征中醫證候研究進展. 上海中醫藥大學學報, 2014, 28(4): 103-105.
19. 王貴幫, 吳振起. 從“秋燥”探析清燥救肺湯制方特點. 中華中醫藥學刊, 2018, 36(1): 163-165.
20. 柳文, 張慶華, 郭圓. 陳湘君運用補陰法治療干燥綜合征經驗初探. 上海中醫藥雜志, 2015, 49(9): 1-2.
21. 羅雅文, 劉英. 劉英教授基于“伏毒學說”辨治干燥綜合征經驗. 中國醫藥導報, 2022, 19(3): 115-118.
22. 劉萍. 酸甘化陰配伍臨證應用規律探討. 中醫雜志, 2019, 60(11): 986-987.

West China Medical Journal

Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sj?gren syndrome based on VOSviewer software

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