Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage_West China Medical Journal

Authors：

WANG Jiuji ¹ ,  GUO Hongmin ¹ , ZHAO Haiyang ² , YANG Jinfei ³ , ZHANG Jiangtao ³

1. Emergency Department, Chengde Central Hospital, Chengde, Hebei 067000, P. R. China;
2. Department of Orthopedics for Severe Trauma, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P. R. China;
3. Department of Neurology, Chengde Central Hospital, Chengde, Hebei 067000, P. R. China;

Corresponding?author：

GUO Hongmin, Email: wpnla8@163.com

Keywords：

miR-141-3p; miR-130a; miR-29a-3p; miR-210; non-traumatic cerebral hemorrhage; early neurological deterioration; value of prediction

DOI：

10.7507/1002-0179.202301007

Video：

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Objective To analyze the value of serum levels of miR-141-3p, miR-130a, miR-29a-3p, and miR-210 in predicting early neurological deterioration (END) in non-traumatic intracerebral hemorrhage. Methods The patients with non-traumatic cerebral hemorrhage who met the selection criteria and were admitted to Chengde Central Hospital between February 2021 and October 2022 were prospectively selected by convenience sampling method. The serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels upon admission and the occurrence of neurological deterioration within 24 h were collected, and the patients were divided into a deterioration group and a non-deterioration group according to whether neurological deterioration occurred. The correlation of serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels with the END of non-traumatic intracerebral hemorrhage and their predictive value to the END of non-traumatic intracerebral hemorrhage were analyzed. Results A total of 235 patient were enrolled. Of the 235 patients, 45 (19.1%) showed neurological deterioration and 190 (80.9%) showed no neurological deterioration. The levels of miR-141-3p and miR-29a-3p in the deteriorating group were significantly lower than those in the non-deteriorating group [(1.11±0.32) vs. (1.76±0.51) ng/mL, P<0.001; (1.19±0.31) vs. (1.71±0.51) ng/mL, P<0.001], and the levels of miR-130a and miR-210 were significantly higher than those in the non-deteriorating group [(5.13±1.11) vs. (3.82±1.03) ng/mL, P<0.001; (3.96±0.76) vs. (2.78±0.50) ng/mL, P<0.001]. Multivariate logistic regression analysis showed that serum miR-141-3p and miR-29a-3p levels were protective factors for the occurrence of END in non-traumatic intracerebral hemorrhage patients [odds ratio (OR)=0.513, 95% confidence interval (CI) (0.330, 0.798), P=0.003; OR=0.582, 95%CI (0.380, 0.893), P=0.013], and serum miR-130a and miR-210 levels were independent risk factors for that [OR=2.046, 95%CI (1.222, 3.426), P=0.007; OR=2.377, 95%CI (1.219, 4.638), P=0.011]. The area under the receiver operating characteristic curve was 0.857 [95%CI (0.760, 0.954)] in predicting the END of non-traumatic intracerebral hemorrhage by the combined probability of the serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 levels obtained by logistic regression, and the sensitivity was 86.7%, the specificity was 94.7%, the positive predictive value was 79.6%, and the negative predictive value was 96.8% according to the cut-off value of the prediction probability of the combined test. Conclusion The combined detection of serum miR-141-3p, miR-130a, miR-29a-3p, and miR-210 has a high predictive value in the occurrence of END in non-traumatic intracerebral hemorrhage patients.

Citation： WANG Jiuji, GUO Hongmin, ZHAO Haiyang, YANG Jinfei, ZHANG Jiangtao. Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage. West China Medical Journal, 2023, 38(5): 704-709. doi: 10.7507/1002-0179.202301007 Copy

1.	Ponamgi SP, Ward R, DeSimone CV, et al. High mortality rates among patients with non-traumatic intracerebral hemorrhage and atrial fibrillation on antithrombotic therapy are independent of the presence of cerebral amyloid angiopathy: insights from a population-based study. J Am Heart Assoc, 2020, 9(15): e016893.
2.	Sallinen H, Putaala J, Strbian D. Triggering factors in non-traumatic intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(8): 104921.
3.	Jiang Q, Wang Y, Shi X. Propofol inhibits neurogenesis of rat neural stem cells by upregulating microRNA-141-3p. Stem Cells Dev, 2017, 26(3): 189-196.
4.	Zhang CY, Ren XM, Li HB, et al. Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4890-4897.
5.	Gao XZ, Zhang ZX, Han GL. miR-29a-3p enhances the viability of rat neuronal cells that injured by oxygen-glucose deprivation/reoxygenation treatment through targeting TNFRSF1A and regulating NF-κB signaling pathway. J Stroke Cerebrovasc Dis, 2020, 29(11): 105210.
6.	李光波, 王新港, 張旭偉. 自發性腦出血患者血清 microRNA-130a、microRNA-210 表達水平及與早期神經功能惡化的關系. 中國現代醫學雜志, 2022, 32(8): 79-84.
7.	婉玲, 于瀛, 黃清海. 自發性腦出血診療指南-美國心臟協會/美國卒中協會的健康職業者指南. 中國腦血管病雜志, 2015(9): 490-504.
8.	中華醫學會神經外科學分會, 中國醫師協會急診醫師分會, 國家衛生和計劃生育委員會腦卒中篩查與防治工程委員會. 自發性腦出血診斷治療中國多學科專家共識. 中華急診醫學雜志, 2015, 24(12): 1319-1323.
9.	Elmegiri M, Koivunen RJ, Tatlisumak T, et al. MRI characterization of non-traumatic intracerebral hemorrhage in young adults. Front Neurol, 2020, 11: 558680.
10.	孫婷婷, 張強. 自發性腦出血早期神經功能惡化的預后因素分析. 卒中與神經疾病, 2020, 27(3): 355-358.
11.	Loggini A, Ammar FE, Awad IA, et al. Temporal evolution and outcomes of non-traumatic intracerebral hemorrhage in hospitalized patients. J Stroke Cerebrovasc Dis, 2021, 30(3): 105584.
12.	Khatri GD, Sarikaya B, Cross NM, et al. The role of imaging in the management of non-traumatic subarachnoid hemorrhage: a practical review. Emerg Radiol, 2021, 28(4): 797-808.
13.	黃四妹, 儲照虎, 胡文杰, 等. 外泌體 microRNA 在腦出血中的研究進展. 卒中與神經疾病, 2020, 27(6): 844-846.
14.	Kim CK, Pak TR. miRNA degradation in the mammalian brain. Am J Physiol Cell Physiol, 2020, 319(4): C624-C629.
15.	王瑞麗, 李曄. 《顱腦損傷康復》出版: 血清 miRNA 標志物檢測對顱腦損傷修復情況預測研究. 介入放射學雜志, 2022, 31(4): 后插 6.
16.	Lim Y, Beane-Ebel JE, Tanaka Y, et al. Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. Transl Psychiatry, 2021, 11(1): 504.
17.	張亮, 張鳳岐, 鄭貴超, 等. 血清 miRNA 的表達對急性腦出血患者神經功能重建的指導價值. 臨床血液學雜志, 2020, 33(12): 835-839.
18.	Yu M, Tian T, Zhang J, et al. miR-141-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting ZEB2. J Clin Neurosci, 2022, 99: 253-260.
19.	臧雪風, 史明語, 王禮玲. 高血壓性腦出血患者血清 miR-141-3p、miR-29a-3p 水平變化及臨床意義. 山東醫藥, 2022, 62(4): 16-21.

1. Ponamgi SP, Ward R, DeSimone CV, et al. High mortality rates among patients with non-traumatic intracerebral hemorrhage and atrial fibrillation on antithrombotic therapy are independent of the presence of cerebral amyloid angiopathy: insights from a population-based study. J Am Heart Assoc, 2020, 9(15): e016893.
2. Sallinen H, Putaala J, Strbian D. Triggering factors in non-traumatic intracerebral hemorrhage. J Stroke Cerebrovasc Dis, 2020, 29(8): 104921.
3. Jiang Q, Wang Y, Shi X. Propofol inhibits neurogenesis of rat neural stem cells by upregulating microRNA-141-3p. Stem Cells Dev, 2017, 26(3): 189-196.
4. Zhang CY, Ren XM, Li HB, et al. Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4890-4897.
5. Gao XZ, Zhang ZX, Han GL. miR-29a-3p enhances the viability of rat neuronal cells that injured by oxygen-glucose deprivation/reoxygenation treatment through targeting TNFRSF1A and regulating NF-κB signaling pathway. J Stroke Cerebrovasc Dis, 2020, 29(11): 105210.
6. 李光波, 王新港, 張旭偉. 自發性腦出血患者血清 microRNA-130a、microRNA-210 表達水平及與早期神經功能惡化的關系. 中國現代醫學雜志, 2022, 32(8): 79-84.
7. 婉玲, 于瀛, 黃清海. 自發性腦出血診療指南-美國心臟協會/美國卒中協會的健康職業者指南. 中國腦血管病雜志, 2015(9): 490-504.
8. 中華醫學會神經外科學分會, 中國醫師協會急診醫師分會, 國家衛生和計劃生育委員會腦卒中篩查與防治工程委員會. 自發性腦出血診斷治療中國多學科專家共識. 中華急診醫學雜志, 2015, 24(12): 1319-1323.
9. Elmegiri M, Koivunen RJ, Tatlisumak T, et al. MRI characterization of non-traumatic intracerebral hemorrhage in young adults. Front Neurol, 2020, 11: 558680.
10. 孫婷婷, 張強. 自發性腦出血早期神經功能惡化的預后因素分析. 卒中與神經疾病, 2020, 27(3): 355-358.
11. Loggini A, Ammar FE, Awad IA, et al. Temporal evolution and outcomes of non-traumatic intracerebral hemorrhage in hospitalized patients. J Stroke Cerebrovasc Dis, 2021, 30(3): 105584.
12. Khatri GD, Sarikaya B, Cross NM, et al. The role of imaging in the management of non-traumatic subarachnoid hemorrhage: a practical review. Emerg Radiol, 2021, 28(4): 797-808.
13. 黃四妹, 儲照虎, 胡文杰, 等. 外泌體 microRNA 在腦出血中的研究進展. 卒中與神經疾病, 2020, 27(6): 844-846.
14. Kim CK, Pak TR. miRNA degradation in the mammalian brain. Am J Physiol Cell Physiol, 2020, 319(4): C624-C629.
15. 王瑞麗, 李曄. 《顱腦損傷康復》出版: 血清 miRNA 標志物檢測對顱腦損傷修復情況預測研究. 介入放射學雜志, 2022, 31(4): 后插 6.
16. Lim Y, Beane-Ebel JE, Tanaka Y, et al. Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. Transl Psychiatry, 2021, 11(1): 504.
17. 張亮, 張鳳岐, 鄭貴超, 等. 血清 miRNA 的表達對急性腦出血患者神經功能重建的指導價值. 臨床血液學雜志, 2020, 33(12): 835-839.
18. Yu M, Tian T, Zhang J, et al. miR-141-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting ZEB2. J Clin Neurosci, 2022, 99: 253-260.
19. 臧雪風, 史明語, 王禮玲. 高血壓性腦出血患者血清 miR-141-3p、miR-29a-3p 水平變化及臨床意義. 山東醫藥, 2022, 62(4): 16-21.

West China Medical Journal

Value of serum microRNAs in predicting early neurological deterioration of non-traumatic cerebral hemorrhage

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