Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu_West China Medical Journal

Authors：

LI Shuhua ^1,2 , LIAO Hongyan ¹ , MA Li ³ , ZHAO Guojiang ² ,  HE Dongmei ⁴ , KANG Xin ⁴ , YANG Lixi ⁵ , DAI Qin ⁶

1. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Laboratory Medicine, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
3. West China School of Nursing / Institute of Hospital Management / Outpatient Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. Emergency Department, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
5. Department of Obstetrics, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
6. Department of Ophthalmology, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;

Corresponding?author：

HE Dongmei, Email: li370782178@163.com

Keywords：

The elderly; platelet-related parameters; reference interval

DOI：

10.7507/1002-0179.202210211

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Objective To establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District, Chengdu. Methods From November 1st to December 31st 2021, elderly individuals aged between 60 and 80 years were selected from the Longquanyi branch of a natural population cohort study initiated by West China Hospital of Sichuan University in 2021. Complete blood cell analysis was performed to obtain the platelet-related parameters. IBM SPSS Statistics 25 software was used to analyze the data and establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District. Results A total of 1938 reference individuals were selected by inclusion and exclusion criteria, and finally 1669 reference individuals, including 665 males and 1004 females, were included to establish the reference intervals after excluding outliers. The reference range of blood platelet count was (95.03-301.32)×10⁹/L for elderly men and (112.13-320.75)×10⁹/L for elderly women, respectively. The reference range of mean platelet volume was 8.97-13.80 fL for elderly men and 9.10-13.90 fL for elderly women, respectively. The reference range of plateletcrit was 0.13%-0.30% for elderly men and 0.14%-0.32% for elderly women, respectively. The reference range of platelet distribution width was 15.80-16.90 for elderly men and 15.70-16.90 for elderly women, respectively. Conclusion It is of practical significance to establish platelet-related parameters in the elderly in local region.

Citation： LI Shuhua, LIAO Hongyan, MA Li, ZHAO Guojiang, HE Dongmei, KANG Xin, YANG Lixi, DAI Qin. Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu. West China Medical Journal, 2024, 39(4): 599-603. doi: 10.7507/1002-0179.202210211 Copy

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1. 衛生部臨床檢驗標準專業委員會. 血細胞分析參考區間: WS/T 405-2012. 北京: 中國標準出版社, 2012.
2. 黃燕, 張玨, 張文霞, 等. 上海地區 29 614 例健康成人血小板相關參數分析. 臨床輸血與檢驗, 2021, 23(4): 506-510.
3. 丁寧, 王琳. 血小板參數參考區間的建立與分析. 臨床血液學雜志, 2018, 31(6): 467-470.
4. 江虹, 陳思, 蔡力力, 等. 中國老年健康人群血常規檢測結果多中心調查. 中華檢驗醫學雜志, 2021, 44(1): 25-31.
5. 叢玉隆, 金大鳴, 王鴻利, 等. 中國人群血小板各項參數的調查分析. 中華檢驗醫學雜志, 2004, 27(6): 35-37.
6. 衛生部臨床檢驗標準專業委員會. 臨床實驗室檢驗項目參考區間的制定: WS/T 402-2012. 北京: 中國標準出版社, 2012.
7. 王鑫, 趙琴, 鄧肇達, 等. 老年類風濕性關節炎治療進展. 中國骨傷, 2017, 30(6): 576-580.
8. Berman S, Bucher J, Koyfman A, et al. Emergent complications of rheumatoid arthritis. J Emerg Med, 2018, 55(5): 647-658.
9. 楊仲岳, 陳曉梅, 石亞妹, 等. 中性粒細胞/淋巴細胞、血小板/淋巴細胞比值在類風濕關節炎中的研究進展. 中華醫學雜志, 2020, 100(47): 3818-3820.
10. 胡盛壽. 中國心血管健康與疾病報告(2019). 北京: 科學出版社, 2020: 142-150.
11. Bia?as AJ, Siewiera K, Wata?a C, et al. Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs - a pilot study. Int J Chron Obstruct Pulmon Dis, 2018, 13: 3707-3717.
12. Ibrahim H, Schutt RC, Hannawi B, et al. Association of immature platelets with adverse cardiovascular outcomes. J Am Coll Cardiol, 2014, 64(20): 2122-2129.
13. 韓良富, 卞曉潔, 潘赟, 等. 血小板參數在急性心肌梗死臨床評估中的作用. 中華急診醫學雜志, 2016, 25(3): 349-355.
14. 耿子悅, 許雪丹, 王秋紅, 等. 不同血壓水平人群中血小板參數與新發腦卒中發生風險的關聯性研究. 中華流行病學雜志, 2021, 42(9): 1580-1585.
15. 李欣明. 腦梗死患者免疫狀態和血小板參數及活化指標的變化分析. 國際醫藥衛生導報, 2017, 23(15): 2394-2396.
16. 牟嚴艷, 葉中慧, 林梅珍, 等. 糖尿病流行病學研究進展. 糖尿病新世界, 2019, 22(4): 196-198.
17. Przygodzki T, Luzak B, Kassassir H, et al. Diabetes and hyperglycemia affect platelet GPIIIa expression. effects on adhesion potential of blood platelets from diabetic patients under in vitro flow conditions. Int J Mol Sci, 2020, 21(9): 3222.
18. 程亞琦, 尚進, 趙占正. 血小板壓積對糖尿病進展至糖尿病腎病的預測效能. 中國實用醫刊, 2020, 47(8): 5-8.
19. 張藝凡, 蘇倍倍, 靳津, 等. MLR、MPV 與 2 型糖尿病患者腎小管損傷的相關性研究. 醫學研究雜志, 2022, 51(6): 72-77.
20. 李子安, 阿祥仁, 馮建明, 等. 西寧市 8876 名健康漢族成人靜脈血血小板相關參數參考值范圍研究. 檢驗醫學, 2012, 27(8): 681-683.

West China Medical Journal

Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu

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