- 1. Department of Rehabilitation Medicine and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
- 2. Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan 610041, P. R. China;
HE Chengqi,
Email: hxkfhcq2015@126.com
Hypoxia and other factors are related to cognitive impairment. Hyperbaric oxygen therapy can improve tissue oxygen supply to improve brain hypoxia. Based on the basic principle of hyperbaric oxygen therapy, hyperbaric oxygen has been widely used in recent years for cognitive impairment caused by stroke, brain injury, neurodegenerative disease, neuroinflammatory disease and metabolic encephalopathy. This article will review the basic mechanism of hyperbaric oxygen, and summarize and discuss the improvement of hyperbaric oxygen therapy on cognitive and brain diseases, in order to provide relevant reference for clinical treatment.
Citation： REN Ling, HE Chengqi. Research progress of hyperbaric oxygen therapy in improving cognitive impairment. West China Medical Journal, 2023, 38(4): 597-602. doi: 10.7507/1002-0179.202203129 Copy
Copyright ? the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 1. Calvert JW, Cahill J, Zhang JH. Hyperbaric oxygen and cerebral physiology. Neurol Res, 2007, 29(2): 132-141.
- 2. Fu Q, Duan R, Sun Y, et al. Hyperbaric oxygen therapy for healthy aging: from mechanisms to therapeutics. Redox Biol, 2022, 53: 102352.
- 3. 中國醫師協會神經內科醫師分會腦與脊髓損害專業委員會. CO 中毒遲發性腦病診斷與治療中國專家共識. 中國神經免疫學和神經病學雜志, 2021, 28(3): 173-179.
- 4. 花蕓, 戎天藝, 陳贇, 等. 高壓氧與神經變性疾病的相關性. 中國實用神經疾病雜志, 2017, 20(21): 111-113.
- 5. Hadanny A, Rittblat M, Bitterman M, et al. Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis. Restor Neurol Neurosci, 2020, 38(1): 93-107.
- 6. 陳進, 彭智翔, 徐國平, 等. 高壓氧治療對顱腦損傷患者認知功能障礙的影響. 基層醫學論壇, 2021, 25(25): 3598-3600.
- 7. 張麗, 卞立, 陳煜, 等. 腦卒中后認知功能障礙的康復評估與治療進展. 中國康復, 2020, 35(12): 660-663.
- 8. Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients-randomized, prospective trial. PLoS One, 2013, 8(1): e53716.
- 9. Rosario ER, Kaplan SE, Khonsari S, et al. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int, 2018, 2018: 3172679.
- 10. Marcinkowska AB, Mankowska ND, Kot J, et al. Impact of hyperbaric oxygen therapy on cognitive functions: a systematic review. Neuropsychol Rev, 2022, 32(1): 99-126.
- 11. 史智超, 邱立軍, 陳強, 等. 高壓氧治療對急性缺血性腦卒中保護作用機制研究進展. 中國醫學物理學雜志, 2018, 35(4): 466-469.
- 12. 于秋紅, 郁軍超, 吉康祥, 等. 大劑量高壓氧對腦梗死大鼠細胞色素 C 及 caspase-3 的影響. 中國康復理論與實踐, 2016, 22(5): 540-543.
- 13. Mu J, Ostrowski RP, Soejima Y, et al. Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAO-induced ischemic brain injury. Neurobiol Dis, 2013, 51: 133-143.
- 14. Zhong X, Shan A, Xu J, et al. Hyperbaric oxygen for severe traumatic brain injury: a randomized trial. J Int Med Res, 2020, 48(10): 300060520939824.
- 15. Chen L, Li F, Gu D. Hyperbaric oxygen therapy for cerebral blood flow and electroencephalogram in patients with acute cerebral infarction: choice for therapeutic occasion. Neural Regen Res, 2007, 2(3): 171-174.
- 16. Yan Y, Zhang X, An X, et al. The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: from the bench to a starter?. Front Neurol, 2022, 13: 928802.
- 17. 阮俊勇. 急性低壓低氧環境下膜法氧氣機富氧干預對大鼠認知功能及海馬結構的影響. 西安: 空軍軍醫大學, 2019.
- 18. 周惠琴, 陳培峰, 周慧霞, 等. 銀杏達莫注射液聯合高壓氧治療血管性癡呆的效果及對氧化應激和腦血流動力學的影響. 解放軍醫藥雜志, 2021, 33(3): 108-111.
- 19. 郭大志, 齊亞南, 潘樹義. 高壓氧對輕度認知障礙的腦白質疏松癥患者的療效和安全性研究. 重慶醫學, 2020, 49(16): 2637-2641.
- 20. Helms A, Evans AW, Chu J, et al. Hyperbaric oxygen for neurologic indications-action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy & status migrainosus. Undersea Hyperb Med, 2011, 38(5): 309-319.
- 21. 徐玉振, 王茜, 單敏, 等. 高壓氧治療對阿爾茨海默病患者認知功能及血清 Humanin 水平的影響. 中華診斷學電子雜志, 2019, 7(2): 83-86.
- 22. 馮寶靜, 宋國亮, 張天麟, 等. 頭針聯合高壓氧治療高血壓腦出血臨床療效及對患者腦水腫、認知功能的影響. 河北中醫, 2020, 42(2): 264-269.
- 23. 張明明, 籍文強, 張瑛琪, 等. 高壓氧聯合早期運動治療一氧化碳中毒遲發性腦病的臨床研究. 現代中西醫結合雜志, 2021, 30(9): 996-998.
- 24. 秦抗洪. 高壓氧聯合重復經顱磁刺激對腦小血管病認知損害和抑郁癥狀的影響. 合肥: 安徽醫科大學, 2019.
- 25. Vila JF, Balcarce PE, Abiusi GR, et al. Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial. Undersea Hyperb Med, 2005, 32(5): 341-349.
- 26. Chen J, Zhang F, Zhao L, et al. Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer’s disease and amnestic mild cognitive impairment. Alzheimers Dement (N Y), 2020, 6(1): e12030.
- 27. Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res, 2019, 8(4): 181-184.
- 28. Xu Y, Wang Q, Qu Z, et al. Protective effect of hyperbaric oxygen therapy on cognitive function in patients with vascular dementia. Cell Transplant, 2019, 28(8): 1071-1075.
- 29. 茹凝玉, 李金聲, 王文嵐, 等. 高壓氧聯合凋亡信號調節激酶抑制劑 NQDI-1 對大鼠腦缺血半暗帶區神經細胞及血腦屏障通透性的保護作用. 中國急救醫學, 2021, 41(4): 347-352.
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