Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients_West China Medical Journal

Authors：

HE Maoxin ¹ ,  YUAN Huaihong ¹ , YANG Yujie ¹ , YU Shaobin ² , FU Ping ²

1. Department of Nephrology, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Nephrology / Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

YUAN Huaihong, Email: yuanhuaihong@wchscu.cn

Keywords：

Maintenance hemodialysis; sarcopenia; frailty

DOI：

10.7507/1002-0179.202202025

Video：

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Abstract Full text Figures/Tables Video References Cited by

The incidence of sarcopenia and frailty in maintenance hemodialysis patients are high, and there are often comorbidities, which easily lead to more complications, thus increasing the hospitalization rate and reducing the quality of life of patients. This article reviews the definition, physiological mechanism, incidence and diagnosis, relationship and treatment strategies of sarcopenia and frailty in maintenance hemodialysis patients, in order to better prevent and intervene the occurrence of sarcopenia and frailty and provide a reference for prevention and treatment.

Citation： HE Maoxin, YUAN Huaihong, YANG Yujie, YU Shaobin, FU Ping. Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients. West China Medical Journal, 2022, 37(11): 1720-1725. doi: 10.7507/1002-0179.202202025 Copy

1.	吳芳, 王福詡, 周紅衛. 維持性血液透析患者蛋白質能量消耗臨床研究進展. 中國血液凈化, 2019, 18(2): 127-130.
2.	Garcia-Canton C, Rodenas A, Lopez-Aperador C, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail, 2019, 41(1): 567-575.
3.	Yoneki K, Kitagawa J, Hoshi K, et al. Association between frailty and bone loss in patients undergoing maintenance hemodialysis. J Bone Miner Metab, 2019, 37(1): 81-89.
4.	Yadla M, John JP, Mummadi M. A study of clinical assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme. Saudi J Kidney Dis Transpl, 2017, 28(1): 15-22.
5.	López-Montes A, Martínez-Villaescusa M, Pérez-Rodríguez A, et al. Frailty, physical function and affective status in elderly patients on hemodialysis. Arch Gerontol Geriatr, 2020, 87: 103976.
6.	杜蘭玉, 胡霞, 王向弘, 等. 380 例維持性血液透析患者衰弱現狀及其對預后的影響. 護理學報, 2018, 25(20): 37-41.
7.	陳管潔, 張海林, 尹麗霞, 等. 維持性血液透析患者認知功能障礙與衰弱的相關性. 護理學雜志, 2021, 36(6): 27-31.
8.	Ren H, Gong D, Jia F, et al. Sarcopenia in patients undergoing maintenance hemodialysis: incidence rate, risk factors and its effect on survival risk. Ren Fail, 2016, 38(3): 364-371.
9.	Lamarca F, Carrero JJ, Rodrigues JC, et al. Prevalence of sarcopenia in elderly maintenance hemodialysis patients: the impact of different diagnostic criteria. J Nutr Health Aging, 2014, 18(7): 710-717.
10.	董志娟, 張海林. 維持性血液透析患者肌少癥發生的危險因素分析. 護理學雜志, 2018, 33(9): 20-24.
11.	李蘭, 溫賢秀, 夏琪, 等. 維持性血液透析患者肌少癥患病率的 meta 分析. 現代預防醫學, 2021, 48(22): 4214-4218.
12.	江山秀. 維持性血液透析患者衰弱風險預測模型的構建. 湖州: 湖州師范學院, 2022.
13.	Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
14.	Yoowannakul S, Tangvoraphonkchai K, Vongsanim S, et al. Differences in the prevalence of sarcopenia in haemodialysis patients: the effects of gender and ethnicity. J Hum Nutr Diet, 2018, 31(5): 689-696.
15.	Giglio J, Kamimura MA, Lamarca F, et al. Association of sarcopenia with nutritional parameters, quality of life, hospitalization, and mortality rates of elderly patients on hemodialysis. J Ren Nutr, 2018, 28(3): 197-207.
16.	Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet, 2013, 381(9868): 752-762.
17.	Kutner NG, Zhang R, Allman RM, et al. Correlates of ADL difficulty in a large hemodialysis cohort. Hemodial Int, 2014, 18(1): 70-77.
18.	Bao Y, Dalrymple L, Chertow GM, et al. Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med, 2012, 172(14): 1071-1077.
19.	García-Prat L, Martínez-Vicente M, Perdiguero E, et al. Autophagy maintains stemness by preventing senescence. Nature, 2016, 529(7584): 37-42.
20.	Noce A, Bocedi A, Campo M, et al. A pilot study of a natural food supplement as new possible therapeutic approach in chronic kidney disease patients. Pharmaceuticals (Basel), 2020, 13(7): 148.
21.	Romani A, Bernini R, Noce A, et al. Potential beneficial effects of extra virgin olive oils characterized by high content in minor polar compounds in nephropathic patients: a pilot study. Molecules, 2020, 25(20): 4757.
22.	Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr, 2007, 86(3): 633-638.
23.	Raj DS, Sun Y, Tzamaloukas AH. Hypercatabolism in dialysis patients. Curr Opin Nephrol Hypertens, 2008, 17(6): 589-594.
24.	Sun DF, Chen Y, Rabkin R. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Kidney Int, 2006, 70(3): 453-459.
25.	Deleaval P, Luaire B, Laffay P, et al. Short-term effects of branched-chain amino acids-enriched dialysis fluid on branched-chain amino acids plasma level and mass balance: a randomized cross-over study. J Ren Nutr, 2020, 30(1): 61-68.
26.	Mitch WE, Price SR. Mechanisms activated by kidney disease and the loss of muscle mass. Am J Kidney Dis, 2001, 38(6): 1337-1342.
27.	Kalantar-Zadeh K, Kopple JD, Deepak S, et al. Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr, 2002, 12(1): 17-31.
28.	Roshanravan B, Gamboa J, Wilund K. Exercise and CKD: skeletal muscle dysfunction and practical application of exercise to prevent and treat physical impairments in CKD. Am J Kidney Dis, 2017, 69(6): 837-852.
29.	Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156.
30.	GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
31.	Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol, 2020, 16(5): 251.
32.	朱亞杰. 老年維持性血液透析患者衰弱相關因素及規律腳踏車運動的干預效果評價. 延安: 延安大學, 2022.
33.	Lee SW, Lee A, Yu MY, et al. Is frailty a modifiable risk factor of future adverse outcomes in elderly patients with incident end-stage renal disease?. J Korean Med Sci, 2017, 32(11): 1800-1806.
34.	Lee HJ, Son YJ. Prevalence and associated factors of frailty and mortality in patients with end-stage renal disease undergoing hemodialysis: a systematic review and meta-analysis. Int J Environ Res Public Health, 2021, 18(7): 3471.
35.	吳淑琳, 宋潔, 肖萍, 等. 維持性血液透析患者衰弱發生率及影響因素的系統評價. 中華護理教育, 2021, 18(4): 352-357.
36.	Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
37.	Nitta K, Tsuchiya K. Recent advances in the pathophysiology and management of protein-energy wasting in chronic kidney disease. Ren Replace Ther, 2016, 2(1): 1-12.
38.	蔡康琴, 李偉, 王莉, 等. 血液透析患者衰弱現狀的調查研究. 護理學雜志, 2019, 34(11): 24-27.
39.	葉麗欽, 周瑩, 張海林, 等. 維持性血液透析患者衰弱及其表型對生活質量的影響研究. 中華護理雜志, 2018, 53(9): 1072-1077.
40.	Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.e2.
41.	Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
42.	韓君, 王君俏, 謝博欽, 等. Fried 衰弱表型和 FRAIL 量表及埃德蒙頓衰弱評估量表在社區高齡老年人衰弱篩查中一致性和適用性的比較研究. 中國全科醫學, 2021, 24(21): 2669-2675.
43.	Ensrud KE, Ewing SK, Cawthon PM, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc, 2009, 57(3): 492-498.
44.	Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: a consensus on definition from an international expert group. Injury, 2018, 49(3): 505-510.
45.	武力, 鄭燕蓉, 柴源. 老年住院患者衰弱程度與肌肉減少癥嚴重程度的相關性分析. 現代醫學, 2020, 48(5): 647-651.
46.	Delgado C, Doyle JW, Johansen KL. Association of frailty with body composition among patients on hemodialysis. J Ren Nutr, 2013, 23(5): 356-362.
47.	宋良晨, 蔡曉燕, 敖強國, 等. 衰弱對老年男性慢性腎臟病患者發生肌少癥的影響. 中華老年心腦血管病雜志, 2020, 22(3): 249-252.
48.	Gielen E, Beckwée D, Delaere A, et al. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Nutr Rev, 2021, 79(2): 121-147.
49.	翟婉春, 吳樹敏, 黃海群. 運動訓練對改善維持性血液透析患者衰弱癥的研究進展. 中國保健營養, 2021, 31(9): 8-9.
50.	董欣, 莫懿晗, 王秀華, 等. 抗阻運動對老年肌少癥危險人群肌肉量、肌力和活動能力的影響. 中國護理管理, 2021, 21(8): 1190-1195.
51.	Kirkman DL, Mullins P, Junglee NA, et al. Anabolic exercise in haemodialysis patients: a randomised controlled pilot study. J Cachexia Sarcopenia Muscle, 2014, 5(3): 199-207.
52.	Abdala R, Elena Del Valle E, Negri AL, et al. Sarcopenia in hemodialysis patients from Buenos Aires, Argentina. Osteoporos Sarcopenia, 2021, 7(2): 75-80.
53.	孫超, 侯莉明, 簡偉明, 等. 我國 60 歲以上老年人群肌少癥患病率及相關因素調查. 中華老年醫學雜志, 2021, 40(8): 981-986.
54.	Stockton KA, Mengersen K, Paratz JD, et al. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int, 2011, 22(3): 859-871.
55.	Lin YL, Chen SY, Lai YH, et al. Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients. BMC Nephrol, 2019, 20(1): 54.
56.	Rolland Y, Onder G, Morley JE, et al. Current and future pharmacologic treatment of sarcopenia. Clin Geriatr Med, 2011, 27(3): 423-447.

1. 吳芳, 王福詡, 周紅衛. 維持性血液透析患者蛋白質能量消耗臨床研究進展. 中國血液凈化, 2019, 18(2): 127-130.
2. Garcia-Canton C, Rodenas A, Lopez-Aperador C, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail, 2019, 41(1): 567-575.
3. Yoneki K, Kitagawa J, Hoshi K, et al. Association between frailty and bone loss in patients undergoing maintenance hemodialysis. J Bone Miner Metab, 2019, 37(1): 81-89.
4. Yadla M, John JP, Mummadi M. A study of clinical assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme. Saudi J Kidney Dis Transpl, 2017, 28(1): 15-22.
5. López-Montes A, Martínez-Villaescusa M, Pérez-Rodríguez A, et al. Frailty, physical function and affective status in elderly patients on hemodialysis. Arch Gerontol Geriatr, 2020, 87: 103976.
6. 杜蘭玉, 胡霞, 王向弘, 等. 380 例維持性血液透析患者衰弱現狀及其對預后的影響. 護理學報, 2018, 25(20): 37-41.
7. 陳管潔, 張海林, 尹麗霞, 等. 維持性血液透析患者認知功能障礙與衰弱的相關性. 護理學雜志, 2021, 36(6): 27-31.
8. Ren H, Gong D, Jia F, et al. Sarcopenia in patients undergoing maintenance hemodialysis: incidence rate, risk factors and its effect on survival risk. Ren Fail, 2016, 38(3): 364-371.
9. Lamarca F, Carrero JJ, Rodrigues JC, et al. Prevalence of sarcopenia in elderly maintenance hemodialysis patients: the impact of different diagnostic criteria. J Nutr Health Aging, 2014, 18(7): 710-717.
10. 董志娟, 張海林. 維持性血液透析患者肌少癥發生的危險因素分析. 護理學雜志, 2018, 33(9): 20-24.
11. 李蘭, 溫賢秀, 夏琪, 等. 維持性血液透析患者肌少癥患病率的 meta 分析. 現代預防醫學, 2021, 48(22): 4214-4218.
12. 江山秀. 維持性血液透析患者衰弱風險預測模型的構建. 湖州: 湖州師范學院, 2022.
13. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
14. Yoowannakul S, Tangvoraphonkchai K, Vongsanim S, et al. Differences in the prevalence of sarcopenia in haemodialysis patients: the effects of gender and ethnicity. J Hum Nutr Diet, 2018, 31(5): 689-696.
15. Giglio J, Kamimura MA, Lamarca F, et al. Association of sarcopenia with nutritional parameters, quality of life, hospitalization, and mortality rates of elderly patients on hemodialysis. J Ren Nutr, 2018, 28(3): 197-207.
16. Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet, 2013, 381(9868): 752-762.
17. Kutner NG, Zhang R, Allman RM, et al. Correlates of ADL difficulty in a large hemodialysis cohort. Hemodial Int, 2014, 18(1): 70-77.
18. Bao Y, Dalrymple L, Chertow GM, et al. Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med, 2012, 172(14): 1071-1077.
19. García-Prat L, Martínez-Vicente M, Perdiguero E, et al. Autophagy maintains stemness by preventing senescence. Nature, 2016, 529(7584): 37-42.
20. Noce A, Bocedi A, Campo M, et al. A pilot study of a natural food supplement as new possible therapeutic approach in chronic kidney disease patients. Pharmaceuticals (Basel), 2020, 13(7): 148.
21. Romani A, Bernini R, Noce A, et al. Potential beneficial effects of extra virgin olive oils characterized by high content in minor polar compounds in nephropathic patients: a pilot study. Molecules, 2020, 25(20): 4757.
22. Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr, 2007, 86(3): 633-638.
23. Raj DS, Sun Y, Tzamaloukas AH. Hypercatabolism in dialysis patients. Curr Opin Nephrol Hypertens, 2008, 17(6): 589-594.
24. Sun DF, Chen Y, Rabkin R. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Kidney Int, 2006, 70(3): 453-459.
25. Deleaval P, Luaire B, Laffay P, et al. Short-term effects of branched-chain amino acids-enriched dialysis fluid on branched-chain amino acids plasma level and mass balance: a randomized cross-over study. J Ren Nutr, 2020, 30(1): 61-68.
26. Mitch WE, Price SR. Mechanisms activated by kidney disease and the loss of muscle mass. Am J Kidney Dis, 2001, 38(6): 1337-1342.
27. Kalantar-Zadeh K, Kopple JD, Deepak S, et al. Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr, 2002, 12(1): 17-31.
28. Roshanravan B, Gamboa J, Wilund K. Exercise and CKD: skeletal muscle dysfunction and practical application of exercise to prevent and treat physical impairments in CKD. Am J Kidney Dis, 2017, 69(6): 837-852.
29. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156.
30. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
31. Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol, 2020, 16(5): 251.
32. 朱亞杰. 老年維持性血液透析患者衰弱相關因素及規律腳踏車運動的干預效果評價. 延安: 延安大學, 2022.
33. Lee SW, Lee A, Yu MY, et al. Is frailty a modifiable risk factor of future adverse outcomes in elderly patients with incident end-stage renal disease?. J Korean Med Sci, 2017, 32(11): 1800-1806.
34. Lee HJ, Son YJ. Prevalence and associated factors of frailty and mortality in patients with end-stage renal disease undergoing hemodialysis: a systematic review and meta-analysis. Int J Environ Res Public Health, 2021, 18(7): 3471.
35. 吳淑琳, 宋潔, 肖萍, 等. 維持性血液透析患者衰弱發生率及影響因素的系統評價. 中華護理教育, 2021, 18(4): 352-357.
36. Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
37. Nitta K, Tsuchiya K. Recent advances in the pathophysiology and management of protein-energy wasting in chronic kidney disease. Ren Replace Ther, 2016, 2(1): 1-12.
38. 蔡康琴, 李偉, 王莉, 等. 血液透析患者衰弱現狀的調查研究. 護理學雜志, 2019, 34(11): 24-27.
39. 葉麗欽, 周瑩, 張海林, 等. 維持性血液透析患者衰弱及其表型對生活質量的影響研究. 中華護理雜志, 2018, 53(9): 1072-1077.
40. Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.e2.
41. Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
42. 韓君, 王君俏, 謝博欽, 等. Fried 衰弱表型和 FRAIL 量表及埃德蒙頓衰弱評估量表在社區高齡老年人衰弱篩查中一致性和適用性的比較研究. 中國全科醫學, 2021, 24(21): 2669-2675.
43. Ensrud KE, Ewing SK, Cawthon PM, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc, 2009, 57(3): 492-498.
44. Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: a consensus on definition from an international expert group. Injury, 2018, 49(3): 505-510.
45. 武力, 鄭燕蓉, 柴源. 老年住院患者衰弱程度與肌肉減少癥嚴重程度的相關性分析. 現代醫學, 2020, 48(5): 647-651.
46. Delgado C, Doyle JW, Johansen KL. Association of frailty with body composition among patients on hemodialysis. J Ren Nutr, 2013, 23(5): 356-362.
47. 宋良晨, 蔡曉燕, 敖強國, 等. 衰弱對老年男性慢性腎臟病患者發生肌少癥的影響. 中華老年心腦血管病雜志, 2020, 22(3): 249-252.
48. Gielen E, Beckwée D, Delaere A, et al. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Nutr Rev, 2021, 79(2): 121-147.
49. 翟婉春, 吳樹敏, 黃海群. 運動訓練對改善維持性血液透析患者衰弱癥的研究進展. 中國保健營養, 2021, 31(9): 8-9.
50. 董欣, 莫懿晗, 王秀華, 等. 抗阻運動對老年肌少癥危險人群肌肉量、肌力和活動能力的影響. 中國護理管理, 2021, 21(8): 1190-1195.
51. Kirkman DL, Mullins P, Junglee NA, et al. Anabolic exercise in haemodialysis patients: a randomised controlled pilot study. J Cachexia Sarcopenia Muscle, 2014, 5(3): 199-207.
52. Abdala R, Elena Del Valle E, Negri AL, et al. Sarcopenia in hemodialysis patients from Buenos Aires, Argentina. Osteoporos Sarcopenia, 2021, 7(2): 75-80.
53. 孫超, 侯莉明, 簡偉明, 等. 我國 60 歲以上老年人群肌少癥患病率及相關因素調查. 中華老年醫學雜志, 2021, 40(8): 981-986.
54. Stockton KA, Mengersen K, Paratz JD, et al. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int, 2011, 22(3): 859-871.
55. Lin YL, Chen SY, Lai YH, et al. Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients. BMC Nephrol, 2019, 20(1): 54.
56. Rolland Y, Onder G, Morley JE, et al. Current and future pharmacologic treatment of sarcopenia. Clin Geriatr Med, 2011, 27(3): 423-447.

West China Medical Journal

Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients

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