Correlation of <i>OPRM</i><i>1</i> A118G gene polymorphism with Eysenck personality type and pain sensitivity_West China Medical Journal

Authors：

YUAN Ling ¹ , DENG Xiaoli ² , ZHONG Jingyi ³ , HE Yunan ¹ ,  ZHONG Wu ¹

1. Department of Emergency Medicine, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;
2. Department of Pharmacy, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;
3. Medical Records and Statistics Department, Luzhou People’s Hospital, Luzhou, Sichuan 646000, P. R. China;

Corresponding?author：

ZHONG Wu, Email: zhongwu2876@sina.com

Keywords：

OPRM1 A118G gene; gene polymorphism; Eysenck personality type; pain sensitivity

DOI：

10.7507/1002-0179.202110118

Video：

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Objective To investigate the correlation between OPRM1 A118G gene polymorphism and Eysenck personality type and pain sensitivity. Methods The surgical patients who were transferred from Department of Emergency Medicine to Department of General Surgery of Luzhou People’s Hospital between January 2018 and December 2020 were selected. Before surgery, Eysenck Personality Questionnai (EPQ) was used to investigate the patient’s personality type, and the pain threshold and pain tolerance threshold were determined by electric stimulation instrument. The OPRM1 A118G genotype of peripheral venous blood was detected by polymerase chain reaction-restriction fragment length polymorphism analysis technique. Patients were divided into wild homozygous (A/A) group, mutant heterozygous (A/G) group and mutant homozygous (G/G) group according to the typing results. The general condition, pain sensitivity, EPQ score, difference of Eysenck personality type and correlation between Eysenck personality type and pain sensitivity were analyzed. Results A total of 356 patients were enrolled, including 174 in A/A group, 136 in A/G group and 46 in G/G group. The mutation rate of OPRM1 A118G gene was 32.00%. There were statistically significant differences in pain sensitivity (pain threshold, pain tolerance threshold) and scores of introverted and extraverted, neurotic and dissemble personality types among three groups (P<0.05). There were significant differences in introverted and extraverted and psychotic personality types among the three groups (P<0.05). There were significant differences in pain threshold and pain tolerance threshold among different introverted, extraverted and psychotropic personality types (P<0.05). Conclusion Both OPRM1 A118G gene polymorphism and Eysenck personality type have influence on pain sensitivity, and there is a correlation between them.

Citation： YUAN Ling, DENG Xiaoli, ZHONG Jingyi, HE Yunan, ZHONG Wu. Correlation of OPRM1 A118G gene polymorphism with Eysenck personality type and pain sensitivity. West China Medical Journal, 2022, 37(2): 237-241. doi: 10.7507/1002-0179.202110118 Copy

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2.	Matic M, Simons SH, van Lingen RA, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics, 2014, 15(10): 1287-1295.
3.	徐靜, 馮黎陽, 邱英, 等. 直腸癌患者人格特征、應對方式與術前焦慮狀況的相關性研究. 解放軍預防醫學雜志, 2019, 37(5): 161-162, 165.
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5.	胡慧君, 常志明, 李曉蕾, 等. 下頜第三磨牙拔除患者疼痛、焦慮情況與人格特點的相關性分析. 中國口腔頜面外科雜志, 2020, 18(6): 508-511.
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7.	陳思, 劉瞾宇, 曾毅, 等. OPRM1 A118G 多態性對喉癌患者術后舒芬太尼靜脈自控鎮痛效果的影響. 西部醫學, 2018, 30(11): 1589-1592.
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10.	伍小英, 魯婧婧, 張晉昕, 等. 兩兩比較的 Bonferroni 法. 循證醫學, 2006, 6(6): 361-363, 374.
11.	Zhang W, Yuan JJ, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanal intravenous analgesia. Minerva Anestesiol, 2011, 77(1): 33-39.
12.	Shi CM, Wang DX, Chen KS, et al. Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery. Chin Med J (Engl), 2010, 123(8): 993-999.
13.	Van Rompaey B, Elseviers MM, Schuurmans MJ, et al. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care, 2009, 13(3): R77.
14.	Inouye SK. Delirium in older persons. N Engl J Med, 2006, 354(11): 1157-1165.
15.	Gallinat J, M?ller H, Moser RL, et al. Postoperative delirium: risk factors, prophylaxis and treatment. Anaesthesist, 1999, 48(8): 507-518.
16.	錢銘怡, 武國城, 朱榮春, 等. 艾森克人格問卷簡式量表中國版(EPQ-RSC)的修訂. 心理學報, 2000, 32(3): 317-323.
17.	鄭麗, 陳銘晟, 王璐, 等. 艾森克人格因素對頜骨囊腫開窗減壓術后應用塞制器患者牙科焦慮癥和疼痛的影響研究. 口腔醫學研究, 2017, 33(9): 978-981.
18.	譚靈, 黃學平, 付禹堯, 等. OPRM1 A118G 基因多態性對創傷患者疼痛治療效果的影響. 中國醫學前沿雜志(電子版), 2020, 12(12): 72-75.
19.	王偉, 黃文鋒, 栗村瑞. OPRM1 118G 基因多態性對剖宮產鞘內注射嗎啡術后鎮痛的影響. 西部醫學, 2020, 32(12): 1841-1844.
20.	林濤, 李祥奎, 宋俊梅, 等. OPRM1 118A/G 基因多態性與癌痛患者羥考酮劑量相關性. 中華醫學遺傳學雜志, 2018, 35(6): 887-890.
21.	陸彥霓, 湯曉青, 沈麗達. OPRM1 (A118G) 基因多態性對阿片類藥物鎮痛效應影響的研究進展. 現代腫瘤醫學, 2018, 26(9): 1477-1480.
22.	Stamer UM, Stüber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol, 2007, 20(5): 478-484.

1. Victoria G. Pain care. Nurs Care North Am, 1994, 29(3): 534-544.
2. Matic M, Simons SH, van Lingen RA, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics, 2014, 15(10): 1287-1295.
3. 徐靜, 馮黎陽, 邱英, 等. 直腸癌患者人格特征、應對方式與術前焦慮狀況的相關性研究. 解放軍預防醫學雜志, 2019, 37(5): 161-162, 165.
4. 張慶, 陳文靜, 馬龍, 等. 艾森克人格因素對正畸中植入微種植體支抗患者焦慮癥和疼痛的影響研究. 口腔醫學, 2015, 35(8): 644-648.
5. 胡慧君, 常志明, 李曉蕾, 等. 下頜第三磨牙拔除患者疼痛、焦慮情況與人格特點的相關性分析. 中國口腔頜面外科雜志, 2020, 18(6): 508-511.
6. 李琳. 腹腔鏡子宮切除術患者術前焦慮對術后疼痛的影響. 太原: 山西醫科大學, 2020.
7. 陳思, 劉瞾宇, 曾毅, 等. OPRM1 A118G 多態性對喉癌患者術后舒芬太尼靜脈自控鎮痛效果的影響. 西部醫學, 2018, 30(11): 1589-1592.
8. 龔耀先. 修訂艾森克個性問卷手冊. 長沙: 湖南醫學院, 1986.
9. 王中玉. COMTvall58 met 和 OPRM1 A118G 基因多態性對國人電刺激疼痛敏感性和術前焦慮的影響. 鄭州: 鄭州大學, 2012.
10. 伍小英, 魯婧婧, 張晉昕, 等. 兩兩比較的 Bonferroni 法. 循證醫學, 2006, 6(6): 361-363, 374.
11. Zhang W, Yuan JJ, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanal intravenous analgesia. Minerva Anestesiol, 2011, 77(1): 33-39.
12. Shi CM, Wang DX, Chen KS, et al. Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery. Chin Med J (Engl), 2010, 123(8): 993-999.
13. Van Rompaey B, Elseviers MM, Schuurmans MJ, et al. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care, 2009, 13(3): R77.
14. Inouye SK. Delirium in older persons. N Engl J Med, 2006, 354(11): 1157-1165.
15. Gallinat J, M?ller H, Moser RL, et al. Postoperative delirium: risk factors, prophylaxis and treatment. Anaesthesist, 1999, 48(8): 507-518.
16. 錢銘怡, 武國城, 朱榮春, 等. 艾森克人格問卷簡式量表中國版(EPQ-RSC)的修訂. 心理學報, 2000, 32(3): 317-323.
17. 鄭麗, 陳銘晟, 王璐, 等. 艾森克人格因素對頜骨囊腫開窗減壓術后應用塞制器患者牙科焦慮癥和疼痛的影響研究. 口腔醫學研究, 2017, 33(9): 978-981.
18. 譚靈, 黃學平, 付禹堯, 等. OPRM1 A118G 基因多態性對創傷患者疼痛治療效果的影響. 中國醫學前沿雜志(電子版), 2020, 12(12): 72-75.
19. 王偉, 黃文鋒, 栗村瑞. OPRM1 118G 基因多態性對剖宮產鞘內注射嗎啡術后鎮痛的影響. 西部醫學, 2020, 32(12): 1841-1844.
20. 林濤, 李祥奎, 宋俊梅, 等. OPRM1 118A/G 基因多態性與癌痛患者羥考酮劑量相關性. 中華醫學遺傳學雜志, 2018, 35(6): 887-890.
21. 陸彥霓, 湯曉青, 沈麗達. OPRM1 (A118G) 基因多態性對阿片類藥物鎮痛效應影響的研究進展. 現代腫瘤醫學, 2018, 26(9): 1477-1480.
22. Stamer UM, Stüber F. Genetic factors in pain and its treatment. Curr Opin Anaesthesiol, 2007, 20(5): 478-484.

West China Medical Journal

Correlation of OPRM1 A118G gene polymorphism with Eysenck personality type and pain sensitivity

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