Regulation of cAMP receptor protein on siderophores-related virulence genes_West China Medical Journal

Authors：

BI Jiandie ,  DU Yan

Department of Laboratory Medicine, the First Affiliated Hospital of Kunming Medical University / Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunnan 650032, P. R. China;

Corresponding?author：

DU Yan, Email: duyan_m@139.com

Keywords：

cAMP receptor protein; Siderophores; Virulence genes

DOI：

10.7507/1002-0179.202006351

Video：

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As an essential trace element for most organisms, iron is an important cofactor for various enzymes that performs key reactions. Siderophore has been considered as an important virulence factor. The cAMP receptor protein is an integral regulator, directly or indirectly involved in the regulation of siderophores-related genes in some prokaryotes and eukaryotes. This paper briefly introduces the cAMP receptor protein, and reviews the regulation of cAMP receptor protein on siderophores-related virulence genes of Klebsiella pneumoniae, Yersinia pestis, Vibrio vulnificus and Cryptococcus neoformans, in order to lay a theoretical foundation for clarifying the regulation mechanism of cAMP receptor protein on siderophores and provide a reference for pathogenic bacteria virulence control and clinical prevention.

Citation： BI Jiandie, DU Yan. Regulation of cAMP receptor protein on siderophores-related virulence genes. West China Medical Journal, 2020, 35(8): 995-998. doi: 10.7507/1002-0179.202006351 Copy

1.	Lamb AL. Breaking a pathogen’s iron will: Inhibiting siderophore production as an antimicrobial strategy. Biochim Biophys Acta, 2015, 1854(8): 1054-1070.
2.	Kramer J, ?zkaya ?, Kümmerli R. Bacterial siderophores in community and host interactions. Nat Rev Microbiol, 2020, 18(3): 152-163.
3.	陳辭言, 杜艷. 高毒力肺炎克雷伯菌研究進展. 中華實驗和臨床感染病雜志(電子版), 2019, 13(2): 89-92.
4.	Ou Q, Fan J, Duan D, <italic>et al</italic>. Involvement of cAMP receptor protein in biofilm formation, fimbria production, capsular polysaccharide biosynthesis and lethality in mouse of <italic>Klebsiella pneumoniae</italic> serotype K1 causing pyogenic liver abscess. J Med Microbiol, 2017, 66(1): 1-7.
5.	Manneh-Roussel J, Haycocks JRJ, Magán A, <italic>et al</italic>. cAMP receptor protein controls vibrio cholerae gene expression in response to host colonization. mBio, 2018, 9(4): e00966-18.
6.	Almblad H, Rybtke M, Hendiani S, <italic>et al</italic>. High levels of cAMP inhibit <italic>Pseudomonas aeruginosa</italic> biofilm formation through reduction of the c-di-GMP content. Microbiology, 2019, 165(3): 324-333.
7.	Green J, Stapleton MR, Smith LJ, <italic>et al</italic>. Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches. Curr Opin Microbiol, 2014, 18(100): 1-7.
8.	Durai L, Vijayalakshmi R, Karunagaran D. A novel reporter system for cyclic AMP mediated gene expression in mammalian cells based on synthetic transgene expression system. Eur J Pharmacol, 2019, 855: 56-64.
9.	Liu B, Hong C, Huang RK, <italic>et al</italic>. Structural basis of bacterial transcription activation. Science, 2017, 358(6365): 947-951.
10.	Feng Y, Zhang Y, Ebright RH. Structural basis of transcription activation. Science, 2016, 352(6291): 1330-1333.
11.	Paczosa MK, Mecsas J. <italic>Klebsiella pneumoniae</italic>: going on the offense with a strong defense. Microbiol Mol Biol Rev, 2016, 80(3): 629-661.
12.	豐雯詩, 王逸群, 陳旭巖. 肺炎克雷伯菌毒力影響因素和耐藥機制研究進展. 北京醫學, 2019, 41(7): 588-591.
13.	Lam MMC, Wyres KL, Judd LM, <italic>et al</italic>. Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in <italic>Klebsiella pneumoniae</italic>. Genome Med, 2018, 10(1): 77.
14.	Russo TA, Olson R, Macdonald U, <italic>et al</italic>. <italic>Aerobactin</italic> mediates virulence and accounts for increased siderophore production underiron-limiting conditions by hypervirulent (hypermucoviscous)<italic>Klebsiella pneumoniae</italic>. Infect Immun, 2014, 82(6): 2356-2367.
15.	Arabaghian H, Salloum T, Alousi S, <italic>et al</italic>. Molecular characterization of carbapenem resistant <italic>Klebsiella pneumoniae</italic> and <italic>Klebsiella quasipneumoniae</italic> isolated from Lebanon. Sci Rep, 2019, 9(1): 531.
16.	Shankar C, Veeraraghavan B, Nabarro LEB, <italic>et al</italic>. Whole genome analysis of hypervirulent <italic>Klebsiella pneumoniae</italic> isolates from community and hospital acquired bloodstream infection. BMC Microbiol, 2018, 18(1): 6.
17.	楊世亞. cAMP受體蛋白調控肺炎克雷伯菌kfuABC操縱子的研究. 重慶: 重慶醫科大學, 2014: 1-63.
18.	高倩倩, 殷杏, 祝俊英, 等. 碳青霉烯類耐藥肺炎克雷伯菌的分子特征. 中國感染與化療雜志, 2018, 18(1): 53-57.
19.	Fetherston JD, Kirillina O, Bobrov AG, <italic>et al</italic>. The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. Infect Immun, 2010, 78(5): 2045-2052.
20.	Pechous RD, Sivaraman V, Stasulli NM, <italic>et al</italic>. Pneumonic plague: the darker side of <italic>Yersinia pestis</italic>. Trends Microbiol, 2016, 24(3): 190-197.
21.	Ritzert JT, Minasov G, Embry R, <italic>et al</italic>. The cyclic AMP receptor protein regulates quorum sensing and global gene expression in <italic>Yersinia pestis</italic> during planktonic growth and growth in biofilms. mBio, 2019, 10(6): e02613-19.
22.	Bobrov AG, Kirillina O, Fosso MY, <italic>et al</italic>. Zinc transporters YbtX and ZnuABC are required for the virulence of <italic>Yersinia pestis</italic> in bubonic and pneumonic plague in mice. Metallomics, 2017, 9(6): 757-772.
23.	Caulfield AJ, Walker ME, Gielda LM, <italic>et al</italic>. The Pla protease of <italic>Yersinia pestis</italic> degrades fas ligand to manipulate host cell death and inflammation. Cell Host Microbe, 2014, 15(4): 424-434.
24.	Ritzert JT, Lathem WW. Depletion of glucose activates catabolite repression during pneumonic plague. J Bacteriol, 2018, 200(11): e00737-17.
25.	于明明, 張康, 王曉威, 等. 創傷弧菌致病機制、抗生素耐藥及污染現狀. 社區醫學雜志, 2018, 16(8): 83-86.
26.	Kim JA, Lee MA, Jung YC, <italic>et al</italic>. Repression of VvpM protease expression by quorum sensing and the cAMP-cAMP receptor protein complex in <italic>Vibrio vulnificus</italic>. J Bacteriol, 2018, 200(7): e00526-17.
27.	Kim CM, Ahn YJ, Kim SJ, <italic>et al</italic>. Temperature change induces the expression of vuuA encoding <italic>Vulnibactin</italic> receptor and crp encoding cyclic AMP receptor protein in <italic>Vibrio vulnificus</italic>. Curr Microbiol, 2016, 73(1): 54-64.
28.	Oh MH, Lee SM, Lee DH, <italic>et al</italic>. Regulation of the <italic>Vibrio vulnificus hupA</italic> gene by temperature alteration and cyclic AMP receptor protein and evaluation of its role in virulence. Infect Immun, 2009, 77(3): 1208-1215.
29.	Kim CM, Kim SJ, Shin SH. Cyclic AMP-receptor protein activates aerobactin receptor IutA expression in <italic>Vibrio vulnificus</italic>. J Microbiol, 2012, 50(2): 320-325.
30.	Zhang Z, Gosset G, Barabote R, <italic>et al</italic>. Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in <italic>Escherichia coli</italic>. J Bacteriol, 2005, 187(3): 980-990.
31.	Huang TP, Wong AC. A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in <italic>Stenotrophomonas maltophilia</italic>. Appl Environ Microbiol, 2007, 73(15): 5034-5040.
32.	Choi J, Jung WH, Kronstad JW. The cAMP/protein kinaseA signaling pathway in pathogenic basidiomycete fungi: connections with iron homeostasis. J Microbiol, 2015, 53(9): 579-587.

1. Lamb AL. Breaking a pathogen’s iron will: Inhibiting siderophore production as an antimicrobial strategy. Biochim Biophys Acta, 2015, 1854(8): 1054-1070.
2. Kramer J, ?zkaya ?, Kümmerli R. Bacterial siderophores in community and host interactions. Nat Rev Microbiol, 2020, 18(3): 152-163.
3. 陳辭言, 杜艷. 高毒力肺炎克雷伯菌研究進展. 中華實驗和臨床感染病雜志(電子版), 2019, 13(2): 89-92.
4. Ou Q, Fan J, Duan D, <italic>et al</italic>. Involvement of cAMP receptor protein in biofilm formation, fimbria production, capsular polysaccharide biosynthesis and lethality in mouse of <italic>Klebsiella pneumoniae</italic> serotype K1 causing pyogenic liver abscess. J Med Microbiol, 2017, 66(1): 1-7.
5. Manneh-Roussel J, Haycocks JRJ, Magán A, <italic>et al</italic>. cAMP receptor protein controls vibrio cholerae gene expression in response to host colonization. mBio, 2018, 9(4): e00966-18.
6. Almblad H, Rybtke M, Hendiani S, <italic>et al</italic>. High levels of cAMP inhibit <italic>Pseudomonas aeruginosa</italic> biofilm formation through reduction of the c-di-GMP content. Microbiology, 2019, 165(3): 324-333.
7. Green J, Stapleton MR, Smith LJ, <italic>et al</italic>. Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches. Curr Opin Microbiol, 2014, 18(100): 1-7.
8. Durai L, Vijayalakshmi R, Karunagaran D. A novel reporter system for cyclic AMP mediated gene expression in mammalian cells based on synthetic transgene expression system. Eur J Pharmacol, 2019, 855: 56-64.
9. Liu B, Hong C, Huang RK, <italic>et al</italic>. Structural basis of bacterial transcription activation. Science, 2017, 358(6365): 947-951.
10. Feng Y, Zhang Y, Ebright RH. Structural basis of transcription activation. Science, 2016, 352(6291): 1330-1333.
11. Paczosa MK, Mecsas J. <italic>Klebsiella pneumoniae</italic>: going on the offense with a strong defense. Microbiol Mol Biol Rev, 2016, 80(3): 629-661.
12. 豐雯詩, 王逸群, 陳旭巖. 肺炎克雷伯菌毒力影響因素和耐藥機制研究進展. 北京醫學, 2019, 41(7): 588-591.
13. Lam MMC, Wyres KL, Judd LM, <italic>et al</italic>. Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in <italic>Klebsiella pneumoniae</italic>. Genome Med, 2018, 10(1): 77.
14. Russo TA, Olson R, Macdonald U, <italic>et al</italic>. <italic>Aerobactin</italic> mediates virulence and accounts for increased siderophore production underiron-limiting conditions by hypervirulent (hypermucoviscous)<italic>Klebsiella pneumoniae</italic>. Infect Immun, 2014, 82(6): 2356-2367.
15. Arabaghian H, Salloum T, Alousi S, <italic>et al</italic>. Molecular characterization of carbapenem resistant <italic>Klebsiella pneumoniae</italic> and <italic>Klebsiella quasipneumoniae</italic> isolated from Lebanon. Sci Rep, 2019, 9(1): 531.
16. Shankar C, Veeraraghavan B, Nabarro LEB, <italic>et al</italic>. Whole genome analysis of hypervirulent <italic>Klebsiella pneumoniae</italic> isolates from community and hospital acquired bloodstream infection. BMC Microbiol, 2018, 18(1): 6.
17. 楊世亞. cAMP受體蛋白調控肺炎克雷伯菌kfuABC操縱子的研究. 重慶: 重慶醫科大學, 2014: 1-63.
18. 高倩倩, 殷杏, 祝俊英, 等. 碳青霉烯類耐藥肺炎克雷伯菌的分子特征. 中國感染與化療雜志, 2018, 18(1): 53-57.
19. Fetherston JD, Kirillina O, Bobrov AG, <italic>et al</italic>. The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. Infect Immun, 2010, 78(5): 2045-2052.
20. Pechous RD, Sivaraman V, Stasulli NM, <italic>et al</italic>. Pneumonic plague: the darker side of <italic>Yersinia pestis</italic>. Trends Microbiol, 2016, 24(3): 190-197.
21. Ritzert JT, Minasov G, Embry R, <italic>et al</italic>. The cyclic AMP receptor protein regulates quorum sensing and global gene expression in <italic>Yersinia pestis</italic> during planktonic growth and growth in biofilms. mBio, 2019, 10(6): e02613-19.
22. Bobrov AG, Kirillina O, Fosso MY, <italic>et al</italic>. Zinc transporters YbtX and ZnuABC are required for the virulence of <italic>Yersinia pestis</italic> in bubonic and pneumonic plague in mice. Metallomics, 2017, 9(6): 757-772.
23. Caulfield AJ, Walker ME, Gielda LM, <italic>et al</italic>. The Pla protease of <italic>Yersinia pestis</italic> degrades fas ligand to manipulate host cell death and inflammation. Cell Host Microbe, 2014, 15(4): 424-434.
24. Ritzert JT, Lathem WW. Depletion of glucose activates catabolite repression during pneumonic plague. J Bacteriol, 2018, 200(11): e00737-17.
25. 于明明, 張康, 王曉威, 等. 創傷弧菌致病機制、抗生素耐藥及污染現狀. 社區醫學雜志, 2018, 16(8): 83-86.
26. Kim JA, Lee MA, Jung YC, <italic>et al</italic>. Repression of VvpM protease expression by quorum sensing and the cAMP-cAMP receptor protein complex in <italic>Vibrio vulnificus</italic>. J Bacteriol, 2018, 200(7): e00526-17.
27. Kim CM, Ahn YJ, Kim SJ, <italic>et al</italic>. Temperature change induces the expression of vuuA encoding <italic>Vulnibactin</italic> receptor and crp encoding cyclic AMP receptor protein in <italic>Vibrio vulnificus</italic>. Curr Microbiol, 2016, 73(1): 54-64.
28. Oh MH, Lee SM, Lee DH, <italic>et al</italic>. Regulation of the <italic>Vibrio vulnificus hupA</italic> gene by temperature alteration and cyclic AMP receptor protein and evaluation of its role in virulence. Infect Immun, 2009, 77(3): 1208-1215.
29. Kim CM, Kim SJ, Shin SH. Cyclic AMP-receptor protein activates aerobactin receptor IutA expression in <italic>Vibrio vulnificus</italic>. J Microbiol, 2012, 50(2): 320-325.
30. Zhang Z, Gosset G, Barabote R, <italic>et al</italic>. Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in <italic>Escherichia coli</italic>. J Bacteriol, 2005, 187(3): 980-990.
31. Huang TP, Wong AC. A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in <italic>Stenotrophomonas maltophilia</italic>. Appl Environ Microbiol, 2007, 73(15): 5034-5040.
32. Choi J, Jung WH, Kronstad JW. The cAMP/protein kinaseA signaling pathway in pathogenic basidiomycete fungi: connections with iron homeostasis. J Microbiol, 2015, 53(9): 579-587.

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