Analysis of current status of immunonutrition research in China based on Chinese databases_West China Medical Journal

Authors：

ZHANG Xingxia ¹ , CHEN Xinrong ² , HU Yanjie ² ,  LI Ka ²

1. Organization Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LI Ka, Email: lika127@126.com

Keywords：

Immunonutrition; bibliometrics; Chinese databases

DOI：

10.7507/1002-0179.202006122

Video：

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Objective To analyze the research status of immunonutrition in China based on Chinese databases, and to provide a reference for clinical practice and future research. Methods Literatures about the application of immunonutrition in nutrition support were searched in China National Knowledge Infrastructure, SinoMed, Chongqing VIP and Wanfang databases using bibliometrics methods. The retrieval time was up to August 2022, and the document characteristics such as the number of publications, the institutions and the citation frequency and other features were analyzed. Results A total of 725 literatures were included, with the highest number of literatures issued in 2015 and 2020, both 62. The areas with the most published literatures were Jiangsu (10.6%) and Guangdong (8.4%). The institutions with the most published literatures were General Hospital of Eastern Theater Command (4.8%) and West China Hospital of Sichuan University (3.9%). There were 78 dissertations and 647 journal articles in total. The most published journal was Parenteral & Enteral Nutrition (6.5%). The top three citations were all reviews. The degree of cooperation was 2.7, and the co-authorship rate was 70.1%. A total of 121 articles reported the supporting funds and projects. The research types included 499 original studies (68.8%) and 226 secondary studies (31.2%). The analysis of the subjects showed that immunonutrition was mostly applied to gastrointestinal diseases, especially gastrointestinal cancer patients, accounting for 42.5%. Nutritional support was divided into enteral nutrition and parenteral nutrition. Enteral nutrition was adopted in most literatures, accounting for 88.4%. Conclusions The research content of immunonutrition in Chinese database in China is relatively simple. Most of them focus on the comparison between immunonutrition and general nutrition support. The selection of immune nutrients and the application of immunonutrition in critically ill patients such as sepsis need further research.

Citation： ZHANG Xingxia, CHEN Xinrong, HU Yanjie, LI Ka. Analysis of current status of immunonutrition research in China based on Chinese databases. West China Medical Journal, 2023, 38(1): 65-71. doi: 10.7507/1002-0179.202006122 Copy

1.	Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr, 2007, 98(Suppl 1): S133-S139.
2.	崔久嵬, 卓文磊, 黃嵐, 等. 腫瘤免疫營養治療指南. 腫瘤代謝與營養電子雜志, 2020, 7(2): 160-168.
3.	Cheng Y, Zhang J, Zhang L, et al. Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis. BMC Gastroenterol, 2018, 18(1): 11.
4.	Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery, 1992, 112(1): 56-67.
5.	Pilotto S, Agustoni F, Morelli AM, et al. Nutritional support in lung cancer: time to combine immunonutrition with immunotherapy?. Nutrition, 2022, 98: 111637.
6.	Probst P, Ohmann S, Klaiber U, et al. Meta-analysis of immunonutrition in major abdominal surgery. Br J Surg, 2017, 104(12): 1594-1608.
7.	Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA, 2001, 286(8): 944-953.
8.	彭俊生, 王吉甫, 王頎. 精氨酸強化全腸外營養的免疫恢復作用研究. 中國臨床營養雜志, 1997(3): 112-115.
9.	黎介壽. 臨床營養支持的發展趨勢. 腸外與腸內營養, 2010, 17(1): 1-4.
10.	黎介壽. 危重病人與免疫營養. 腸外與腸內營養, 2001(3): 127-128.
11.	李寧, 黎介壽. 外科營養近 20 年的進展與展望. 中國實用外科雜志, 2002, 22(1): 6-8.
12.	江志偉, 李寧, 劉福坤, 等. 腸內免疫營養對胃癌手術病人免疫功能和急性炎性反應的調理作用. 腸外與腸內營養, 2000, 7(4): 200-203.
13.	李寧. 臨床營養的新概念: 免疫營養. 中國實用外科雜志, 2001, 21(1): 7-9.
14.	李小好, 尚桂蓮, 周志斌, 等. 早期免疫腸內營養支持對重癥腦卒中患者營養狀況和免疫功能以及預后的影響. 中國全科醫學, 2012, 15(26): 3006-3008.
15.	李幼生, 黎介壽. 圍手術期腸內營養支持. 實用臨床醫藥雜志, 2004, 8(5): 1-5.
16.	陳亞軍, 齊玉梅. 精氨酸免疫營養作用的研究進展. 中國臨床營養雜志, 2007, 15(5): 310-314.
17.	許劍民, 何連齊, 吳新華, 等. 胃腸道腫瘤患者術前腸內免疫營養支持. 中華消化雜志, 2005, 25(1): 19-22.
18.	蔣小華, 李寧, 朱維銘, 等. 腸內免疫營養對手術創傷后機體免疫、炎癥反應及預后的影響. 中國實用外科雜志, 2004, 24(1): 43-46.
19.	崔久嵬, 卓文磊, 黃嵐, 等. 腫瘤免疫營養治療指南. 腫瘤代謝與營養電子雜志, 2016, 3(4): 224-228.
20.	Fan M, Wang Q, Fang W, et al. Early enteral combined with parenteral nutrition treatment for severe traumatic brain injury: effects on immune function, nutritional status and outcomes. Chin Med Sci J, 2016, 31(4): 213-220.
21.	Ka?mierczak-Siedlecka K, Daca A, Folwarski M, et al. Immunonutritional support as an important part of multidisciplinary anti-cancer therapy. Cent Eur J Immunol, 2020, 45(4): 454-460.
22.	龐增粉, 劉玉萍, 李靈娟. 腸內免疫營養與全素營養療法在胃腸道腫瘤患者術后護理中的應用. 齊魯護理雜志, 2019, 25(2): 58-60.
23.	熊睿, 汪曉泊, 殷生芝, 等. 免疫營養素強化的腸內營養治療對創傷危重患者免疫功能及臨床結局的影響. 中國醫藥, 2018, 13(1): 99-103.
24.	馬春劍. 早期免疫腸內營養對重癥急性胰腺炎患者免疫功能及炎性反應的影響. 中國醫學前沿雜志(電子版), 2018, 10(6): 151-155.
25.	范士元. 腸內免疫營養與全素營養療法在胃腸道腫瘤患者術后護理中的應用效果對比. 中國當代醫藥, 2016, 23(33): 174-176.
26.	Slim K, Badon F, Vacheron CH, et al. Umbrella review of the efficacy of perioperative immunonutrition in visceral surgery. Clin Nutr ESPEN, 2022, 48: 99-108.
27.	王蕾, 張穎, 王立彬, 等. 腸內免疫營養在胃腸道腫瘤圍手術期的臨床應用. 中華臨床醫師雜志(電子版), 2020, 14(6): 465-468.
28.	林勇軍, 熊濱, 林忠文. 免疫營養支持治療對早期膿毒癥患者的作用研究. 廣西醫學, 2017, 39(8): 1242-1245.
29.	Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr, 2017, 36(1): 11-48.
30.	Weimann A, Braga M, Carli F, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
31.	郭志學, 葛長青, 劉博, 等. 肝癌術后早期不同免疫增強型營養支持方式的治療效果比較. 河北醫藥, 2017, 39(17): 2589-2592, 2596.
32.	謝琦, 金慧成, 賈忠, 等. 胃癌全胃切除患者圍術期兩種免疫營養支持治療的臨床比較. 浙江醫學, 2015, 34(6): 484-487.
33.	邱小文. 腸內免疫增強型營養對肺癌化療患者的影響及護理. 解放軍護理雜志, 2004, 21(3): 14-16.
34.	Yang J, Zhang X, Li K, et al. Effects of EN combined with PN enriched with n-3 polyunsaturated fatty acids on immune related indicators and early rehabilitation of patients with gastric cancer: a randomized controlled trial. Clin Nutr, 2022, 41(6): 1163-1170.
35.	劉邦倫, 田旭, 陳偉慶. 不同腸內免疫營養方案對胃癌術后患者臨床結局影響的網狀 Meta 分析. 臨床與病理雜志, 2018, 38(9): 1921-1934.
36.	Prieto I, Montemui?o S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr, 2017, 36(6): 1457-1464.
37.	Belsky JB, Wira CR, Jacob V, et al. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutr Res Rev, 2018, 31(2): 281-290.
38.	Boisramé-Helms J, Meyer G, Degirmenci SE, et al. “Immunonutrition” has failed to improve peritonitis-induced septic shock in rodents. PLoS One, 2016, 11(1): e0147644.

1. Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr, 2007, 98(Suppl 1): S133-S139.
2. 崔久嵬, 卓文磊, 黃嵐, 等. 腫瘤免疫營養治療指南. 腫瘤代謝與營養電子雜志, 2020, 7(2): 160-168.
3. Cheng Y, Zhang J, Zhang L, et al. Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis. BMC Gastroenterol, 2018, 18(1): 11.
4. Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery, 1992, 112(1): 56-67.
5. Pilotto S, Agustoni F, Morelli AM, et al. Nutritional support in lung cancer: time to combine immunonutrition with immunotherapy?. Nutrition, 2022, 98: 111637.
6. Probst P, Ohmann S, Klaiber U, et al. Meta-analysis of immunonutrition in major abdominal surgery. Br J Surg, 2017, 104(12): 1594-1608.
7. Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA, 2001, 286(8): 944-953.
8. 彭俊生, 王吉甫, 王頎. 精氨酸強化全腸外營養的免疫恢復作用研究. 中國臨床營養雜志, 1997(3): 112-115.
9. 黎介壽. 臨床營養支持的發展趨勢. 腸外與腸內營養, 2010, 17(1): 1-4.
10. 黎介壽. 危重病人與免疫營養. 腸外與腸內營養, 2001(3): 127-128.
11. 李寧, 黎介壽. 外科營養近 20 年的進展與展望. 中國實用外科雜志, 2002, 22(1): 6-8.
12. 江志偉, 李寧, 劉福坤, 等. 腸內免疫營養對胃癌手術病人免疫功能和急性炎性反應的調理作用. 腸外與腸內營養, 2000, 7(4): 200-203.
13. 李寧. 臨床營養的新概念: 免疫營養. 中國實用外科雜志, 2001, 21(1): 7-9.
14. 李小好, 尚桂蓮, 周志斌, 等. 早期免疫腸內營養支持對重癥腦卒中患者營養狀況和免疫功能以及預后的影響. 中國全科醫學, 2012, 15(26): 3006-3008.
15. 李幼生, 黎介壽. 圍手術期腸內營養支持. 實用臨床醫藥雜志, 2004, 8(5): 1-5.
16. 陳亞軍, 齊玉梅. 精氨酸免疫營養作用的研究進展. 中國臨床營養雜志, 2007, 15(5): 310-314.
17. 許劍民, 何連齊, 吳新華, 等. 胃腸道腫瘤患者術前腸內免疫營養支持. 中華消化雜志, 2005, 25(1): 19-22.
18. 蔣小華, 李寧, 朱維銘, 等. 腸內免疫營養對手術創傷后機體免疫、炎癥反應及預后的影響. 中國實用外科雜志, 2004, 24(1): 43-46.
19. 崔久嵬, 卓文磊, 黃嵐, 等. 腫瘤免疫營養治療指南. 腫瘤代謝與營養電子雜志, 2016, 3(4): 224-228.
20. Fan M, Wang Q, Fang W, et al. Early enteral combined with parenteral nutrition treatment for severe traumatic brain injury: effects on immune function, nutritional status and outcomes. Chin Med Sci J, 2016, 31(4): 213-220.
21. Ka?mierczak-Siedlecka K, Daca A, Folwarski M, et al. Immunonutritional support as an important part of multidisciplinary anti-cancer therapy. Cent Eur J Immunol, 2020, 45(4): 454-460.
22. 龐增粉, 劉玉萍, 李靈娟. 腸內免疫營養與全素營養療法在胃腸道腫瘤患者術后護理中的應用. 齊魯護理雜志, 2019, 25(2): 58-60.
23. 熊睿, 汪曉泊, 殷生芝, 等. 免疫營養素強化的腸內營養治療對創傷危重患者免疫功能及臨床結局的影響. 中國醫藥, 2018, 13(1): 99-103.
24. 馬春劍. 早期免疫腸內營養對重癥急性胰腺炎患者免疫功能及炎性反應的影響. 中國醫學前沿雜志(電子版), 2018, 10(6): 151-155.
25. 范士元. 腸內免疫營養與全素營養療法在胃腸道腫瘤患者術后護理中的應用效果對比. 中國當代醫藥, 2016, 23(33): 174-176.
26. Slim K, Badon F, Vacheron CH, et al. Umbrella review of the efficacy of perioperative immunonutrition in visceral surgery. Clin Nutr ESPEN, 2022, 48: 99-108.
27. 王蕾, 張穎, 王立彬, 等. 腸內免疫營養在胃腸道腫瘤圍手術期的臨床應用. 中華臨床醫師雜志(電子版), 2020, 14(6): 465-468.
28. 林勇軍, 熊濱, 林忠文. 免疫營養支持治療對早期膿毒癥患者的作用研究. 廣西醫學, 2017, 39(8): 1242-1245.
29. Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr, 2017, 36(1): 11-48.
30. Weimann A, Braga M, Carli F, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
31. 郭志學, 葛長青, 劉博, 等. 肝癌術后早期不同免疫增強型營養支持方式的治療效果比較. 河北醫藥, 2017, 39(17): 2589-2592, 2596.
32. 謝琦, 金慧成, 賈忠, 等. 胃癌全胃切除患者圍術期兩種免疫營養支持治療的臨床比較. 浙江醫學, 2015, 34(6): 484-487.
33. 邱小文. 腸內免疫增強型營養對肺癌化療患者的影響及護理. 解放軍護理雜志, 2004, 21(3): 14-16.
34. Yang J, Zhang X, Li K, et al. Effects of EN combined with PN enriched with n-3 polyunsaturated fatty acids on immune related indicators and early rehabilitation of patients with gastric cancer: a randomized controlled trial. Clin Nutr, 2022, 41(6): 1163-1170.
35. 劉邦倫, 田旭, 陳偉慶. 不同腸內免疫營養方案對胃癌術后患者臨床結局影響的網狀 Meta 分析. 臨床與病理雜志, 2018, 38(9): 1921-1934.
36. Prieto I, Montemui?o S, Luna J, et al. The role of immunonutritional support in cancer treatment: Current evidence. Clin Nutr, 2017, 36(6): 1457-1464.
37. Belsky JB, Wira CR, Jacob V, et al. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutr Res Rev, 2018, 31(2): 281-290.
38. Boisramé-Helms J, Meyer G, Degirmenci SE, et al. “Immunonutrition” has failed to improve peritonitis-induced septic shock in rodents. PLoS One, 2016, 11(1): e0147644.

West China Medical Journal

Analysis of current status of immunonutrition research in China based on Chinese databases

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