Research progress of microRNA-215 gene_West China Medical Journal

Authors：

YAN Qiong ,  XU Anshu

Surgery of North City, Qujing Hospital, Kunming Medical University, Qujing, Yunnan 655000, P. R. China;

Corresponding?author：

XU Anshu, Email: 315000722@qq.com

Keywords：

MicroRNA-215 gene; oncogene; tumor suppressor gene

DOI：

10.7507/1002-0179.202002138

Video：

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At present, there are relatively many clinical gene studies. microRNA -215 (miR-215) is a miRNA induced by p53. It exists in animals and humans. miR-215 can exist not only in tumor tissues, but also in blood, urine and feces. miR-215 is abnormally expressed in a variety of tumors and plays a role in promoting and inhibiting cancer. Therefore, miR-215 may provide a new research direction for tumor diagnosis, treatment and prognosis. This paper reviews the expression of miR-215 as a oncogene and tumor suppressor gene in tumors and in non tumors.

Citation： YAN Qiong, XU Anshu. Research progress of microRNA-215 gene. West China Medical Journal, 2022, 37(1): 151-155. doi: 10.7507/1002-0179.202002138 Copy

1.	Boni V, Bitarte N, Cristobal I, et al. miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther, 2010, 9(8): 2265-2275.
2.	婁杰, 劉華, 毛濤, 等. 結直腸腫瘤組織 miR-215 表達及臨床意義. 齊魯醫學雜志, 2015, 30(6): 631-634.
3.	To KK, Tong CW, Wu M, et al. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside. World J Gastroenterol, 2018, 24(27): 2949-2973.
4.	晏玥, 王乙安, 陳芳, 等. 尿外泌體 microRNA 與腎臟疾病相關性的研究進展. 實用醫學雜志, 2019, 35(4): 673-676.
5.	余綺荷, 張文. MicroRNA 與結直腸癌化療關系的研究進展. 中國癌癥雜志, 2014, 24(1): 62-68.
6.	Vychytilova-Faltejskova P, Merhautova J, Machackova T, et al. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis, 2017, 6(11): 399.
7.	吳旭波, 曹奕鷗, 浦文蘭, 等. miR-215 在進展期結腸直腸癌中的表達及其臨床意義. 外科理論與實踐, 2013, 18(3): 247-251.
8.	宋敏, 宋志超, 王鎮, 等. miR-215-3p 通過調控 CXCR4 逆轉結腸癌 HCT8 細胞 5-FU 耐藥的實驗研究. 臨床腫瘤學雜志, 2019, 24(6): 513-517.
9.	張永鋒, 郭長軍, 譚永港, 等. 潰瘍性結腸炎相關性結腸癌差異表達的 miRNA 的篩選研究. 中國中西醫結合消化雜志, 2014, 22(2): 65-68.
10.	Tan YG, Zhang YF, Guo CJ, et al. Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer. Asian Pac J Trop Med, 2013, 6(12): 972-976.
11.	李勇, 徐麗瑤, 付碧琪, 等. miR-192、miR-215 及 ERCC3 在 NSCLC 細胞系 A549 放療后的表達變化及意義. 實用臨床醫學, 2011, 12(12): 1-3.
12.	Cai X, Peng D, Wei H, et al. miR-215 suppresses proliferation and migration of non-small cell lung cancer cells. Oncol lett, 2017, 13(4): 2349-2353.
13.	劉銳, 董文剛, 王飛, 等. miR-215 抑制骨肉瘤細胞生長及其分子機制. 現代腫瘤醫學, 2019, 27(9): 1472-1476.
14.	Han J, Zhang M, Nie C, et al. miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1. Cell Death Dis, 2019, 10(3): 195.
15.	Li M, Zou X, Xia T, et al. A five-miRNA panel in plasma was identified for breast cancer diagnosis. Cancer Med, 2019, 8(16): 7006-7017.
16.	Gao JB, Zhu MN, Zhu XL. miRNA-215-5p suppresses the aggressiveness of breast cancer cells by targeting Sox9. FEBS Open Bio, 2019, 9(11): 1957-1967.
17.	龐琦, 牟嬌, 郭艷紅, 等. microRNA-215 在糖尿病腎病小鼠腎組織中的表達及意義. 中華腎臟病雜志, 2012, 28(4): 305-311.
18.	崔勝金, 陳澤衍, 郭偉權, 等. microRNA 在肥胖相關腎病發生的臨床應用. 數理醫藥學雜志, 2018, 31(8): 1118-1120.
19.	楊夢戈, 張曉潔, 肇玉明. MicroRNA 對缺血性腦卒中自噬調控作用的研究進展. 生命的化學, 2019, 39(2): 338-352.
20.	侯靜芳, 楊華, 趙世民, 等. 慢病毒介導 miR-215 過表達對克羅恩病的影響及作用機制. 國際消化病雜志, 2019, 39(5): 347-351.
21.	林振呂, 張琳, 鄭建濤. miR-215 對胃癌細胞侵襲轉移能力的影響及機制. 中國老年學雜志, 2015, 35(21): 6064-6067.
22.	刁卓, 劉曉超, 唐玉虎, 等. 胃癌組織 miR-215 表達變化及其與患者預后的關系. 山東醫藥, 2017, 57(8): 80-82.
23.	張軍, 陳兆峰, 劉曉光, 等. 微小 RNA-215 在胃癌中的表達及其臨床意義. 蘭州大學學報(醫學版), 2013, 39(4): 13-16,20.
24.	李良平, 龍思澤, 高采平. 胃癌患者血清 microRNA-192 和 microRNA-215 的表達及臨床意義. 中華臨床醫師雜志(電子版), 2013, 7(12): 5223-5227.
25.	Deng Y, Huang Z, Xu Y, et al. MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett, 2014, 342(1): 27-35.
26.	楊林聲, 王理論, 杜青衛. microRNA-215 對人視網膜母細胞瘤細胞生長及抑癌基因 Rb1 表達的調控作用. 海南醫學, 2015, 26(24): 3592-3597.
27.	符小林, 李謨漢, 符密. MiR-215 和 RUNX1 在視網膜母細胞瘤中的表達水平及臨床意義. 中國醫師雜志, 2018, 20(9): 1310-1315.
28.	Agostini A, Brunetti M, Davidson B, et al. The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. Sci Rep, 2018, 8(1): 11069.
29.	裴穎皓, 鐘勇, 王俊, 等. 穩定型心絞痛患者血清 microRNA 的表達差異. 臨床心血管病雜志, 2014, 30(1): 18-23.
30.	杜偉, 郭麗娜, 龐席寧. 下調 miR-215-5p 對 TGF-β誘導的人肺成纖維細胞 IMR-90 增殖抑制作用觀察. 山東醫藥, 2018, 58(40): 15-19.
31.	Tian H, He Z. miR-215 enhances HCV replication by targeting TRIM22 and inactivating NF-κB signaling. Yonsei Med J, 2018, 59(4): 511-518.
32.	Liang H, Li Y, Luo RY, et al. MicroRNA-215 is a potential prognostic marker for cervical cancer. J Huazhong Univ Sci Technology Med Sci, 2014, 34(2): 207-212.
33.	Liu CQ, Chen Y, Xie BF, et al. MicroRNA-215-3p suppresses the growth and metastasis of cervical cancer cell via targeting SOX9. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5628-5639.
34.	楊慶輝, 李偉偉, 王瑾, 等. 肝內膽管癌上皮組織 miR-215 表達與病理特征的相關性. 現代消化及介入診療, 2019, 24(5): 529-532.
35.	孫嘉玲, 文彬, 孫海濤, 等. 不同轉移潛能肝癌細胞株 miRNAs 表達譜的差異性研究. 中國藥理學通報, 2018, 34(5): 656-663.
36.	周原世, 李響, 姜興明, 等. 前列腺癌相關轉錄因子 1 在惡性腫瘤中的研究進展. 中國臨床醫學, 2019, 26(1): 126-131.
37.	Ali LH, Higazi AM, Moness HM, et al. Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma. Clin Exp Gastroenterol, 2019, 12: 51-66.
38.	Mamdouh S, Khorshed F, Aboushousha T, et al. Evaluation of mir-224, mir-215 and mir-143 as serum biomarkers for HCV associated hepatocellular carcinoma. Asian Pac J Cancer Prev, 2017, 18(11): 3167-3171.
39.	Ren Y, Shang J, Li J, et al. The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma. J Boil Chem, 2017, 292(43): 17939-17949.

1. Boni V, Bitarte N, Cristobal I, et al. miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther, 2010, 9(8): 2265-2275.
2. 婁杰, 劉華, 毛濤, 等. 結直腸腫瘤組織 miR-215 表達及臨床意義. 齊魯醫學雜志, 2015, 30(6): 631-634.
3. To KK, Tong CW, Wu M, et al. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside. World J Gastroenterol, 2018, 24(27): 2949-2973.
4. 晏玥, 王乙安, 陳芳, 等. 尿外泌體 microRNA 與腎臟疾病相關性的研究進展. 實用醫學雜志, 2019, 35(4): 673-676.
5. 余綺荷, 張文. MicroRNA 與結直腸癌化療關系的研究進展. 中國癌癥雜志, 2014, 24(1): 62-68.
6. Vychytilova-Faltejskova P, Merhautova J, Machackova T, et al. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis, 2017, 6(11): 399.
7. 吳旭波, 曹奕鷗, 浦文蘭, 等. miR-215 在進展期結腸直腸癌中的表達及其臨床意義. 外科理論與實踐, 2013, 18(3): 247-251.
8. 宋敏, 宋志超, 王鎮, 等. miR-215-3p 通過調控 CXCR4 逆轉結腸癌 HCT8 細胞 5-FU 耐藥的實驗研究. 臨床腫瘤學雜志, 2019, 24(6): 513-517.
9. 張永鋒, 郭長軍, 譚永港, 等. 潰瘍性結腸炎相關性結腸癌差異表達的 miRNA 的篩選研究. 中國中西醫結合消化雜志, 2014, 22(2): 65-68.
10. Tan YG, Zhang YF, Guo CJ, et al. Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer. Asian Pac J Trop Med, 2013, 6(12): 972-976.
11. 李勇, 徐麗瑤, 付碧琪, 等. miR-192、miR-215 及 ERCC3 在 NSCLC 細胞系 A549 放療后的表達變化及意義. 實用臨床醫學, 2011, 12(12): 1-3.
12. Cai X, Peng D, Wei H, et al. miR-215 suppresses proliferation and migration of non-small cell lung cancer cells. Oncol lett, 2017, 13(4): 2349-2353.
13. 劉銳, 董文剛, 王飛, 等. miR-215 抑制骨肉瘤細胞生長及其分子機制. 現代腫瘤醫學, 2019, 27(9): 1472-1476.
14. Han J, Zhang M, Nie C, et al. miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1. Cell Death Dis, 2019, 10(3): 195.
15. Li M, Zou X, Xia T, et al. A five-miRNA panel in plasma was identified for breast cancer diagnosis. Cancer Med, 2019, 8(16): 7006-7017.
16. Gao JB, Zhu MN, Zhu XL. miRNA-215-5p suppresses the aggressiveness of breast cancer cells by targeting Sox9. FEBS Open Bio, 2019, 9(11): 1957-1967.
17. 龐琦, 牟嬌, 郭艷紅, 等. microRNA-215 在糖尿病腎病小鼠腎組織中的表達及意義. 中華腎臟病雜志, 2012, 28(4): 305-311.
18. 崔勝金, 陳澤衍, 郭偉權, 等. microRNA 在肥胖相關腎病發生的臨床應用. 數理醫藥學雜志, 2018, 31(8): 1118-1120.
19. 楊夢戈, 張曉潔, 肇玉明. MicroRNA 對缺血性腦卒中自噬調控作用的研究進展. 生命的化學, 2019, 39(2): 338-352.
20. 侯靜芳, 楊華, 趙世民, 等. 慢病毒介導 miR-215 過表達對克羅恩病的影響及作用機制. 國際消化病雜志, 2019, 39(5): 347-351.
21. 林振呂, 張琳, 鄭建濤. miR-215 對胃癌細胞侵襲轉移能力的影響及機制. 中國老年學雜志, 2015, 35(21): 6064-6067.
22. 刁卓, 劉曉超, 唐玉虎, 等. 胃癌組織 miR-215 表達變化及其與患者預后的關系. 山東醫藥, 2017, 57(8): 80-82.
23. 張軍, 陳兆峰, 劉曉光, 等. 微小 RNA-215 在胃癌中的表達及其臨床意義. 蘭州大學學報(醫學版), 2013, 39(4): 13-16,20.
24. 李良平, 龍思澤, 高采平. 胃癌患者血清 microRNA-192 和 microRNA-215 的表達及臨床意義. 中華臨床醫師雜志(電子版), 2013, 7(12): 5223-5227.
25. Deng Y, Huang Z, Xu Y, et al. MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett, 2014, 342(1): 27-35.
26. 楊林聲, 王理論, 杜青衛. microRNA-215 對人視網膜母細胞瘤細胞生長及抑癌基因 Rb1 表達的調控作用. 海南醫學, 2015, 26(24): 3592-3597.
27. 符小林, 李謨漢, 符密. MiR-215 和 RUNX1 在視網膜母細胞瘤中的表達水平及臨床意義. 中國醫師雜志, 2018, 20(9): 1310-1315.
28. Agostini A, Brunetti M, Davidson B, et al. The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. Sci Rep, 2018, 8(1): 11069.
29. 裴穎皓, 鐘勇, 王俊, 等. 穩定型心絞痛患者血清 microRNA 的表達差異. 臨床心血管病雜志, 2014, 30(1): 18-23.
30. 杜偉, 郭麗娜, 龐席寧. 下調 miR-215-5p 對 TGF-β誘導的人肺成纖維細胞 IMR-90 增殖抑制作用觀察. 山東醫藥, 2018, 58(40): 15-19.
31. Tian H, He Z. miR-215 enhances HCV replication by targeting TRIM22 and inactivating NF-κB signaling. Yonsei Med J, 2018, 59(4): 511-518.
32. Liang H, Li Y, Luo RY, et al. MicroRNA-215 is a potential prognostic marker for cervical cancer. J Huazhong Univ Sci Technology Med Sci, 2014, 34(2): 207-212.
33. Liu CQ, Chen Y, Xie BF, et al. MicroRNA-215-3p suppresses the growth and metastasis of cervical cancer cell via targeting SOX9. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5628-5639.
34. 楊慶輝, 李偉偉, 王瑾, 等. 肝內膽管癌上皮組織 miR-215 表達與病理特征的相關性. 現代消化及介入診療, 2019, 24(5): 529-532.
35. 孫嘉玲, 文彬, 孫海濤, 等. 不同轉移潛能肝癌細胞株 miRNAs 表達譜的差異性研究. 中國藥理學通報, 2018, 34(5): 656-663.
36. 周原世, 李響, 姜興明, 等. 前列腺癌相關轉錄因子 1 在惡性腫瘤中的研究進展. 中國臨床醫學, 2019, 26(1): 126-131.
37. Ali LH, Higazi AM, Moness HM, et al. Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma. Clin Exp Gastroenterol, 2019, 12: 51-66.
38. Mamdouh S, Khorshed F, Aboushousha T, et al. Evaluation of mir-224, mir-215 and mir-143 as serum biomarkers for HCV associated hepatocellular carcinoma. Asian Pac J Cancer Prev, 2017, 18(11): 3167-3171.
39. Ren Y, Shang J, Li J, et al. The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma. J Boil Chem, 2017, 292(43): 17939-17949.

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