Research status of the relationship between telomeres and cardiovascular and cerebrovascular diseases_West China Medical Journal

Authors：

TANG Yifang ¹ , TANG Qin ¹ , WANG Xiaoqing ¹ , LIN Yapeng ¹ , GUO Yijia ¹ , HAO Junli ¹ , ZHANG Xiao ² ,  YANG Jie ¹

1. Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;
2. School of Basic Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding?author：

YANG Jie, Email: yangjie1126@163.com

Keywords：

Telomeres; Atherosclerosis; Cardiovascular and cerebrovascular diseases; Biomarkers

DOI：

10.7507/1002-0179.201907164

Video：

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Abstract Full text Figures/Tables Video References Cited by

Telomeres play an important role in maintaining genomic stability and cell life. Accumulating studies show that telomeres are closely related to human aging, cardiovascular diseases and cerebrovascular diseases. There are a series of researches about telomeres and atherosclerosis across the world, including studies on the relationship between atherosclerosis, cardiovascular diseases, cerebrovascular diseases and telomere length, and on telomere-targeted treatments for cardiovascular and cerebrovascular diseases. Telomeres may be a risk predictor or a new therapeutic target for atherosclerosis and cardiovascular diseases. This article reviews the relationship between telomeres and cardiovascular and cerebrovascular diseases, introduces the research progress of telomere length and cardiovascular diseases, cerebrovascular diseases, and the possible mechanisms of their association, aiming to provide a theoretical basis for exploring new therapeutic targets for atherosclerosis.

Citation： TANG Yifang, TANG Qin, WANG Xiaoqing, LIN Yapeng, GUO Yijia, HAO Junli, ZHANG Xiao, YANG Jie. Research status of the relationship between telomeres and cardiovascular and cerebrovascular diseases. West China Medical Journal, 2019, 34(10): 1170-1174. doi: 10.7507/1002-0179.201907164 Copy

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5.	Doksani Y, Wu JY, de Lange T, et al. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell, 2013, 155(2): 345-356.
6.	Hayashi MT. Telomere biology in aging and cancer: early history and perspectives. Genes Genet Syst, 2018, 92(3): 107-118.
7.	de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev, 2005, 19(18): 2100-2110.
8.	Li JS, Miralles Fusté J, Simavorian T, et al. TZAP: a telomere-associated protein involved in telomere length control. Science, 2017, 355(6325): 638-641.
9.	Zhang W, Hui R, Yang S. Telomeres, cardiovascular aging, and potential intervention for cellular senescence. Sci China Life Sci, 2014, 57(8): 858-862.
10.	陳宇, 劉繼斌, 劉鵬, 等. 人頸動脈粥樣硬化斑塊組織及外周血白細胞相對端粒長度的檢測及相關性分析. 中國分子心臟病學雜志, 2012, 12(1): 27-31.
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13.	Tian R, Zhang LN, Zhang TT, et al. Association between oxidative stress and peripheral leukocyte telomere length in patients with premature coronary artery disease. Med Sci Monit, 2017, 23: 4382-4390.
14.	劉龍梅, 王仲朝, 李保, 等. 外周血白細胞端粒長度與早發冠心病的相關性研究. 實用檢驗醫師雜志, 2015, 7(2): 70-72.
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30.	李丹青. 外周血白細胞端粒長度與大動脈粥樣硬化性腦梗死及頸動脈粥樣硬化斑塊穩定性的相關研究. 合肥: 安徽醫科大學, 2017.
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32.	吳奇, 韓東陽, 李昕. 外周血白細胞DNA相對端粒長度與進展性腦梗死患病風險的關聯性. 東南國防醫藥, 2019, 21(2): 135-140.
33.	Martin-Ruiz C, Dickinson HO, Keys B, et al. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol, 2006, 60(2): 174-180.
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36.	Jin X, Pan B, Dang X, et al. Relationship between short telomere length and stroke: a meta-analysis. Medicine (Baltimore), 2018, 97(39): e12489.
37.	Gao D, Zhang R, Ji G, et al. Relative telomere length and stroke risk in a Chinese han population. J Mol Neurosci, 2018, 66(4): 475-481.
38.	Maeda T, Oyama JI, Higuchi Y, et al. The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders. J Nutr Health Aging, 2010, 14(9): 793-797.
39.	Zhang D, Wen X, Wu W, et al. Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis. Atherosclerosis, 2013, 231(1): 173-179.
40.	肖健豪, 袁倩, 張斯淼, 等. 外周血PON1基因高甲基化、端粒長度變短與腦梗死發病相關. 臨床與病理雜志, 2019, 39(5): 1002-1009.
41.	Borghini A, Cervelli T, Galli A, et al. DNA modifications in atherosclerosis: from the past to the future. Atherosclerosis, 2013, 230(2): 202-209.
42.	Yin H, Pickering JG. Cellular senescence and vascular disease: novel routes to better understanding and therapy. Can J Cardiol, 2016, 32(5): 612-623.
43.	Erusalimsky JD, Kurz DJ. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp Gerontol, 2005, 40(8/9): 634-642.
44.	Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985), 2009, 106(1): 326-332.
45.	李燕, 段君, 王玉瑤. 端粒、端粒酶在動脈粥樣硬化中的研究進展. 生命的化學, 2018, 38(3): 473-477.
46.	雷江, 田衛峰, 劉毅龍. 端粒與心血管疾病的關系. 現代醫學與健康研究電子雜志, 2018, 2(15): 180-183.
47.	黃四春, 姜昕, 郭毅. 端粒長度與心腦血管疾病. 實用醫學雜志, 2011, 27(16): 3066-3068.
48.	呂濤, 郭文怡. 端粒長度與心血管疾病危險因素關系的研究進展. 心臟雜志, 2018, 30(5): 575-579, 593.
49.	肖濱, 黃小波. 衰老與動脈粥樣硬化關系的研究進展. 中華老年多器官疾病雜志, 2018, 17(11): 866-869.
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1. GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol, 2019, 18(5): 439-458.
2. Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet, 2019.
3. 《中國腦卒中防治報告2018》編寫組. 我國腦卒中防治仍面臨巨大挑戰——《中國腦卒中防治報告2018》概要. 中國循環雜志, 2019, 34(2): 105-119.
4. 李梅, 趙雪芹, 王同兆, 等. 動脈粥樣硬化的發病機制及治療的綜述. 科技視界, 2017(26): 35-36, 52.
5. Doksani Y, Wu JY, de Lange T, et al. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell, 2013, 155(2): 345-356.
6. Hayashi MT. Telomere biology in aging and cancer: early history and perspectives. Genes Genet Syst, 2018, 92(3): 107-118.
7. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev, 2005, 19(18): 2100-2110.
8. Li JS, Miralles Fusté J, Simavorian T, et al. TZAP: a telomere-associated protein involved in telomere length control. Science, 2017, 355(6325): 638-641.
9. Zhang W, Hui R, Yang S. Telomeres, cardiovascular aging, and potential intervention for cellular senescence. Sci China Life Sci, 2014, 57(8): 858-862.
10. 陳宇, 劉繼斌, 劉鵬, 等. 人頸動脈粥樣硬化斑塊組織及外周血白細胞相對端粒長度的檢測及相關性分析. 中國分子心臟病學雜志, 2012, 12(1): 27-31.
11. 葉興, 黃河浪. 端粒長度檢測技術與方法進展及其優缺點比較. 廣東醫學, 2018, 39(1): 148-150, 155.
12. Haycock PC, Heydon EE, Kaptoge S, et al. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ, 2014, 349: g4227.
13. Tian R, Zhang LN, Zhang TT, et al. Association between oxidative stress and peripheral leukocyte telomere length in patients with premature coronary artery disease. Med Sci Monit, 2017, 23: 4382-4390.
14. 劉龍梅, 王仲朝, 李保, 等. 外周血白細胞端粒長度與早發冠心病的相關性研究. 實用檢驗醫師雜志, 2015, 7(2): 70-72.
15. 田然, 張磊楠, 張婷婷, 等. 外周血白細胞端粒長度與早發冠心病的相關性及其影響因素分析. 中國循環雜志, 2016, 31(6): 541-545.
16. Zhan Y, Karlsson IK, Karlsson R, et al. Exploring the causal pathway from telomere length to coronary heart disease: a network mendelian randomization study. Circ Res, 2017, 121(3): 214-219.
17. Hunt SC, Kimura M, Hopkins PN, et al. Leukocyte telomere length and coronary artery calcium. Am J Cardiol, 2015, 116(2): 214-218.
18. Carty CL, Kooperberg C, Liu J, et al. Leukocyte telomere length and risks of incident coronary heart disease and mortality in a racially diverse population of postmenopausal women. Arterioscler Thromb Vasc Biol, 2015, 35(10): 2225-2231.
19. Huang S, Ding R, Lin Y, et al. Reduced T-cell thymic export reflected by sj-TREC in patients with coronary artery disease. J Atheroscler Thromb, 2016, 23(5): 632-643.
20. Satoh M, Nasu T, Takahashi Y, et al. Expression of miR-23a induces telomere shortening and is associated with poor clinical outcomes in patients with coronary artery disease. Clin Sci (Lond), 2017, 131(15): 2007-2017.
21. Satoh M, Minami Y, Takahashi Y, et al. Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease. Clin Sci (Lond), 2009, 116(11): 827-835.
22. Satoh M, Takahashi Y, Tabuchi T, et al. Cellular and molecular mechanisms of statins: an update on pleiotropic effects. Clin Sci (Lond), 2015, 129(2): 93-105.
23. Zhang W, Chen Y, Wang Y, et al. Short telomere length in blood leucocytes contributes to the presence of atherothrombotic stroke and haemorrhagic stroke and risk of post-stroke death. Clin Sci (Lond), 2013, 125(1): 27-36.
24. Ding H, Chen C, Shaffer JR, et al. Telomere length and risk of stroke in Chinese. Stroke, 2012, 43(3): 658-663.
25. Li J, Feng C, Li L, et al. The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis. Sci Rep, 2018, 8(1): 2290.
26. Xiao J, Yuan Q, Zhang S, et al. The telomere length of peripheral blood cells is associated with the risk of ischemic stroke in han population of northern China. Medicine (Baltimore), 2019, 98(7): e14593.
27. Zee RY, Castonguay AJ, Barton NS, et al. Relative leukocyte telomere length and risk of incident ischemic stroke in men: a prospective, nested case-control approach. Rejuvenation Res, 2010, 13(4): 411-414.
28. 李靜, 張梅, 余傳慶, 等. 外周血白細胞相對端粒長度與腦卒中的相關研究. 中國分子心臟病學雜志, 2015, 15(6): 1529-1533.
29. 陳宇, 王玉瑤, 范靖堯, 等. 外周血白細胞端粒長度與初發卒中患者心腦血管死亡風險的關系. 中國卒中雜志, 2013, 8(5): 368-374.
30. 李丹青. 外周血白細胞端粒長度與大動脈粥樣硬化性腦梗死及頸動脈粥樣硬化斑塊穩定性的相關研究. 合肥: 安徽醫科大學, 2017.
31. 李靜. 動脈粥樣硬化性腦梗死患者外周血白細胞相對端粒長度的相關性研究. 蚌埠: 蚌埠醫學院, 2017.
32. 吳奇, 韓東陽, 李昕. 外周血白細胞DNA相對端粒長度與進展性腦梗死患病風險的關聯性. 東南國防醫藥, 2019, 21(2): 135-140.
33. Martin-Ruiz C, Dickinson HO, Keys B, et al. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol, 2006, 60(2): 174-180.
34. 周亞飛. 急性腦梗死患者認知功能障礙相關影響因素研究. 濟南: 濟南大學, 2015.
35. D’Mello MJ, Ross SA, Briel M, et al. Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis. Circ Cardiovasc Genet, 2015, 8(1): 82-90.
36. Jin X, Pan B, Dang X, et al. Relationship between short telomere length and stroke: a meta-analysis. Medicine (Baltimore), 2018, 97(39): e12489.
37. Gao D, Zhang R, Ji G, et al. Relative telomere length and stroke risk in a Chinese han population. J Mol Neurosci, 2018, 66(4): 475-481.
38. Maeda T, Oyama JI, Higuchi Y, et al. The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders. J Nutr Health Aging, 2010, 14(9): 793-797.
39. Zhang D, Wen X, Wu W, et al. Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis. Atherosclerosis, 2013, 231(1): 173-179.
40. 肖健豪, 袁倩, 張斯淼, 等. 外周血PON1基因高甲基化、端粒長度變短與腦梗死發病相關. 臨床與病理雜志, 2019, 39(5): 1002-1009.
41. Borghini A, Cervelli T, Galli A, et al. DNA modifications in atherosclerosis: from the past to the future. Atherosclerosis, 2013, 230(2): 202-209.
42. Yin H, Pickering JG. Cellular senescence and vascular disease: novel routes to better understanding and therapy. Can J Cardiol, 2016, 32(5): 612-623.
43. Erusalimsky JD, Kurz DJ. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp Gerontol, 2005, 40(8/9): 634-642.
44. Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985), 2009, 106(1): 326-332.
45. 李燕, 段君, 王玉瑤. 端粒、端粒酶在動脈粥樣硬化中的研究進展. 生命的化學, 2018, 38(3): 473-477.
46. 雷江, 田衛峰, 劉毅龍. 端粒與心血管疾病的關系. 現代醫學與健康研究電子雜志, 2018, 2(15): 180-183.
47. 黃四春, 姜昕, 郭毅. 端粒長度與心腦血管疾病. 實用醫學雜志, 2011, 27(16): 3066-3068.
48. 呂濤, 郭文怡. 端粒長度與心血管疾病危險因素關系的研究進展. 心臟雜志, 2018, 30(5): 575-579, 593.
49. 肖濱, 黃小波. 衰老與動脈粥樣硬化關系的研究進展. 中華老年多器官疾病雜志, 2018, 17(11): 866-869.
50. Scheller Madrid A, Rode L, Nordestgaard BG, et al. Short telomere length and ischemic heart disease: observational and genetic studies in 290022 individuals. Clin Chem, 2016, 62(8): 1140-1149.
51. Telomeres Mendelian Randomization Collaboration. Association between telomere length and risk of cancer and non-neoplastic diseases: a mendelian randomization study. JAMA Oncol, 2017, 3(5): 636-651.
52. Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet, 2013, 45(4): 422-427.
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