Study of neural mechanisms underlying anisometropic amblyopia with event-related potential_West China Medical Journal

Authors：

WU Ye ¹ , WANG Shoujing ² , WANG Chunhui ³ , ZHANG Wenqiu ⁴ , ZHENG Zhong ⁵ ,  LIU Longqian ¹

1. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Medical Engineering Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Ophthalmology, Aviation General Hospital, Beijing 100012, P. R. China;
4. Research Laboratory of Ophthalmology and Vision Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
5. Neurobiological Laboratory Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIU Longqian, Email: b.q15651@hotmail.com

Keywords：

Amblyopia; Event-related potential; Neural mechanisms

DOI：

10.7507/1002-0179.201904151

Video：

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Objective To investigate the neural mechanisms of subjects with anisometropic amblyopia using event-related potential (ERP) technology.Methods Nineteen subjects diagnosed with anisometropic amblyopia were consecutively recruited from the outpatients of the West China Hospital of Sichuan University from June 2013 to February 2014, and twenty normal subjects were recruited as control subjects. All subjects were given different orientation Gabor stimuli with three spatial frequencies (1, 2, 8 cpd) and their ERP was recorded. The differences of P3b, including amplitude and latency, were compared between amblyopic eye and fellow or control eye.Results Among the three groups of amblyopic eye and fellow or control eye, there was no statistically significant difference in accuracy or response time at three spatial frequencies (P>0.05), in latency or amplitude of P3b at low spatial frequencies (1, 2 cpd) ((P>0.05), or in amplitude of P3b at high spatial frequency (8 cpd) (P>0.05). P3b latency of amblyopic eye extended at high spatial frequency (8 cpd), compared to fellow or control eye. Amblyopic eye was most significantly weakened in Brodmann area 17 at the P3b wave of each spatial frequency (1, 2, 8 cpd), and there was most significantly weakened in high spatial frequency (8 cpd).Conclusion The P3b latency of amblyopic eye extended at high spatial frequency suggests that the cognitive function of amblyopia is impaired, at an extent, in the late visual processing stage.

Citation： WU Ye, WANG Shoujing, WANG Chunhui, ZHANG Wenqiu, ZHENG Zhong, LIU Longqian. Study of neural mechanisms underlying anisometropic amblyopia with event-related potential. West China Medical Journal, 2019, 34(11): 1279-1284. doi: 10.7507/1002-0179.201904151 Copy

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2.	Wu JF, Bi HS, Wang SM, et al. Refractive error, visual acuity and causes of vision loss in children in Shandong, China. The shandong children eye study. PloS one, 2013, 8(12): e82763.
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6.	Hosseinmenni S, Talebnejad MR, Jafarzadehpur E, et al. P100 wave latency in anisometropic and esotropic amblyopia versus normal eyes. J Ophthalmic Vis Res, 2015, 10(3): 268-273.
7.	Hou C, Good WV, Norcia AM. Detection of amblyopia using sweep VEP vernier and grating acuity. Invest Ophthalmol Vis Sci, 2018, 59(3): 1435-1442.
8.	伍葉, 劉隴黔. 弱視患者大腦功能與結構異常的研究進展. 中華眼科雜志, 2017, 53(5): 392-395.
9.	Hamilton HK, Perez VB, Ford JM, et al. Mismatch negativity but not P300 is associated with functional disability in schizophrenia. Schizophr Bull, 2018, 44(3): 492-504.
10.	Dejanovi? M, Iveti? V, Nestorovi? V, et al. The value of P3B event related potentials in the assessment of cognitive function in subclinical hypothyroidism. Minerva Endocrinol, 2017, 42(1): 15-23.
11.	Han SH, Jeong HB, Park KY, et al. P300 latency changes in patients with mild cognitive impairment after taking choline alphoscerate; a preliminary study. eNeurologicalSci, 2018, 11: 5-8.
12.	Bankó éM, K?rtvélyes J, Németh J, et al. Amblyopic deficits in the timing and strength of visual cortical responses to faces. Cortex, 2013, 49(4): 1013-1024.
13.	Bankó éM, K?rtvélyes J, Weiss B, et al. How the visual cortex handles stimulus noise: insights from amblyopia. PloS One, 2013, 8(6): e66583.
14.	K?rtvélyes J, Bankó EM, Andics A, et al. Visual cortical responses to the input from the amblyopic eye are suppressed during binocular viewing. Acta Biol Hung, 2012, 63(Suppl 1): 65-79.
15.	Zhao J, Yang XB, Wang JL, et al. Amblyopic-related frontal changes in an orientation discrimination task: a research of P3a event-related potentials in anisometropic amblyopia. Hippokratia, 2016, 20(1): 60-66.
16.	潘映幅. 臨床誘發電位學. 2 版. 北京: 人民衛生出版社, 2000: 13-16.
17.	Andrade EP, Berezovsky A, Sacai PY, et al. Dysfunction in the fellow eyes of strabismic and anisometropic amblyopic children assessed by visually evoked potentials. Arq Bras Oftalmol, 2016, 79(5): 294-298.

1. Pi LH, Chen L, Liu Q, et al. Prevalence of eye diseases and causes of visual impairment in school-aged children in Western China. J Epidemiol, 2012, 22(1): 37-44.
2. Wu JF, Bi HS, Wang SM, et al. Refractive error, visual acuity and causes of vision loss in children in Shandong, China. The shandong children eye study. PloS one, 2013, 8(12): e82763.
3. Greenwood JA, Tailor VK, Sloper JJ, et al. Visual acuity, crowding, and stereo-vision are linked in children with and without amblyopia. Invest Ophthalmol Vis Sci, 2012, 53(12): 7655-7665.
4. Richards MD, Goltz HC, Wong AMF. Audiovisual perception in amblyopia: a review and synthesis. Exp Eye Res, 2019, 183: 68-75.
5. Kiorpes L, Daw N. Cortical correlates of amblyopia. Vis Neurosci, 2018, 35: E016.
6. Hosseinmenni S, Talebnejad MR, Jafarzadehpur E, et al. P100 wave latency in anisometropic and esotropic amblyopia versus normal eyes. J Ophthalmic Vis Res, 2015, 10(3): 268-273.
7. Hou C, Good WV, Norcia AM. Detection of amblyopia using sweep VEP vernier and grating acuity. Invest Ophthalmol Vis Sci, 2018, 59(3): 1435-1442.
8. 伍葉, 劉隴黔. 弱視患者大腦功能與結構異常的研究進展. 中華眼科雜志, 2017, 53(5): 392-395.
9. Hamilton HK, Perez VB, Ford JM, et al. Mismatch negativity but not P300 is associated with functional disability in schizophrenia. Schizophr Bull, 2018, 44(3): 492-504.
10. Dejanovi? M, Iveti? V, Nestorovi? V, et al. The value of P3B event related potentials in the assessment of cognitive function in subclinical hypothyroidism. Minerva Endocrinol, 2017, 42(1): 15-23.
11. Han SH, Jeong HB, Park KY, et al. P300 latency changes in patients with mild cognitive impairment after taking choline alphoscerate; a preliminary study. eNeurologicalSci, 2018, 11: 5-8.
12. Bankó éM, K?rtvélyes J, Németh J, et al. Amblyopic deficits in the timing and strength of visual cortical responses to faces. Cortex, 2013, 49(4): 1013-1024.
13. Bankó éM, K?rtvélyes J, Weiss B, et al. How the visual cortex handles stimulus noise: insights from amblyopia. PloS One, 2013, 8(6): e66583.
14. K?rtvélyes J, Bankó EM, Andics A, et al. Visual cortical responses to the input from the amblyopic eye are suppressed during binocular viewing. Acta Biol Hung, 2012, 63(Suppl 1): 65-79.
15. Zhao J, Yang XB, Wang JL, et al. Amblyopic-related frontal changes in an orientation discrimination task: a research of P3a event-related potentials in anisometropic amblyopia. Hippokratia, 2016, 20(1): 60-66.
16. 潘映幅. 臨床誘發電位學. 2 版. 北京: 人民衛生出版社, 2000: 13-16.
17. Andrade EP, Berezovsky A, Sacai PY, et al. Dysfunction in the fellow eyes of strabismic and anisometropic amblyopic children assessed by visually evoked potentials. Arq Bras Oftalmol, 2016, 79(5): 294-298.

West China Medical Journal

Study of neural mechanisms underlying anisometropic amblyopia with event-related potential

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