The research progress of Caveolin-1 protein in the field of Alzheimer’s disease_West China Medical Journal

Authors：

ZHANG Xi ¹ ,  YUAN Depei ¹ , ZENG Chuhua ² , MAO Jianqin ²

1. School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P. R. China;
2. Medical School, Hubei University for Nationalities, Enshi, Hubei 445000, P. R. China;

Corresponding?author：

YUAN Depei, Email: ydp7880@163.com

Keywords：

Caveolin-1; Alzheimer’s disease; Review

DOI：

10.7507/1002-0179.201812022

Video：

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Caveolin-1 (Cav-1) protein plays a very important role in the central nervous system, and is closely related to Alzheimer’s disease (AD). Through literature review, this article summarizes the present research status of Cav-1 protein in the field of AD from three aspects: the relationship between Cav-1 gene and AD; the relationship of Cav-1 protein with learning and memory; the relationship of Cav-1 protein with amyloid β-protein and Tau protein. And the aim of this paper is to provide a new thought and evidence for exploring the mechanism of AD via Cav-1 protein.

Citation： ZHANG Xi, YUAN Depei, ZENG Chuhua, MAO Jianqin. The research progress of Caveolin-1 protein in the field of Alzheimer’s disease. West China Medical Journal, 2019, 34(3): 338-342. doi: 10.7507/1002-0179.201812022 Copy

1.	張玫瑩, 朱鐵年, 趙瑞景, 等. 小凹蛋白-1 調控表皮生長因子受體活化對惡性黑色素瘤細胞生物學行為的影響. 解放軍醫藥雜志, 2018, 30(4): 46-50.
2.	楊娟麗. Caveolin-1 調控表皮生長因子受體活化對結直腸癌細胞增殖和轉移的影響. 石家莊: 河北醫科大學, 2018.
3.	于衛民, 姬建勝, 王冬冬. RNA 干擾 Caveolin-1 基因表達抑制食管癌細胞增殖侵襲及 PI3K/AKT 信號通路的研究. 中國地方病防治雜志, 2018, 33(3): 357.
4.	鐘義良, 張融融, 黃思源, 等. 急性腦梗死患者血清陷窩蛋白 1 水平與早期神經功能惡化的關系. 上海交通大學學報(醫學版), 2017, 37(12): 1678-1681.
5.	鄭慶玲. Caveolin-1 的生物學結構及在腫瘤研究中的進展. 現代醫藥衛生, 2007, 23(24): 3710-3711.
6.	Ohadi M, Heshmati Y, Mirabzadeh A. P01-99 Extreme alleles at the human caveolin 1 gene novel purine complex and risk of Alzheimer’s disease. Eur Psychiatry, 2009, 24(Suppl 1): S487.
7.	Heshmati Y, Mirabzadeh A, Feizzade G, et al. A novel polymorphic purine complex at the 1.5 kb upstream region of the human caveolin-1 gene and risk of Alzheimer’s disease; extra-short alleles and accumulated allele homozygosity. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(2): 248-253.
8.	Zarif Yeganeh M, Mirabzadeh A, Khorram Khorshid HR, et al. Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet, 2010, 153B(1): 347-349.
9.	Heidari A, Behmanesh M, Sahraian MA, et al. The human caveolin 1 gene upstream purine complex and neurodegeneration-a common signature. J Neuroimmunol, 2011, 236(1/2): 106-110.
10.	Heidari A, Hosseinkhani S, Talebi S, et al. Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: implication in neurodegenerative disorders. Gene, 2012, 505(1): 186-189.
11.	吳平. ApoE 基因多態性和cav-1 基因上游 PPC 長度多態性與 AD、MCI 和 VD 的相關性研究. 上海: 復旦大學, 2009.
12.	Gioiosa L, Raggi C, Ricceri LJ, et al. Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res, 2008, 188(2): 255-262.
13.	王紅霞. 不同年齡大鼠腦內 Caveolin-1 蛋白的表達及其與學習記憶關系研究. 大連: 遼寧師范大學, 2006.
14.	鄒偉, 王紅霞, 劉晶, 等. 大鼠腦內 caveolin-1 蛋白的表達及其在分辨學習中的作用. 生理學報, 2006, 58(5): 429-434.
15.	嵇志紅, 鄒偉. 空間學習記憶訓練對大鼠海馬 Caveolin-1 蛋白表達的影響. 大連大學學報, 2013(6): 35-37, 43.
16.	王璐. Caveolin-1 蛋白在空間學習記憶中的作用及其信號轉導機制的研究. 大連: 遼寧師范大學, 2008.
17.	Egawa J, Schilling JM, Cui W, et al. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J, 2017, 31(8): 3403-3411.
18.	袁林. 固本健腦法對 MCI 大鼠學習記憶能力及海馬 Caveolin-1 的影響. 武漢: 湖北中醫藥大學, 2011.
19.	陳冬冬. 新型釩氧配合物對糖尿病小鼠學習記憶功能損傷的干預及與 Caveolin-1 表達的關系. 大連: 遼寧師范大學, 2009.
20.	姜梅. 基于腎藏志理論的腎虛質大鼠海馬區學習記憶蛋白 ERK1 及 Caveolin-1 表達研究. 咸陽: 陜西中醫藥大學, 2017.
21.	Ikezu T, Trapp BD, Song KS, et al. Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J Biol Chem, 1998, 273(17): 10485-10495.
22.	Hattori C, Asai M, Onishi H, et al. BACE1 interacts with lipid raft proteins. J Neurosci Res, 2006, 84(4): 912-917.
23.	Head BP, Peart JN, Panneerselvam M, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One, 2010, 5(12): e15697.
24.	Jang SK, Yu JM, Kim ST, et al. An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and a beta-degrading enzymes in microglia. Eur J Pharmacol, 2015, 758: 1-10.
25.	Pietri M, Dakowski C, Hannaoui SA, et al. PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nat Med, 2013, 19(9): 1124-1131.
26.	Hashimoto M, Hossain S, Katakura M, et al. The binding of Aβ_1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: implicates to Alzheimer’s disease. Biochimica et Biophysica Acta, 2015, 1848(6): 1402-1409.
27.	Zhu DH, Su YC, Fu BM, et al. Magnesium reduces blood-brain barrier permeability and regulates amyloid-beta transcytosis. Mol Neurobiol, 2018, 55(9): 7118-7131.
28.	András IE, Eum SY, Toborek M. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. Biochem Biophys Res Commun, 2012, 421(2): 177-183.
29.	Van Helmond ZK, Miners JS, Bednall E, et al. Caveolin-1 and-2 and their relationship to cerebral amyloid angiopathy in Alzheimer’s disease. Neuropathol Appl Neurobiol, 2007, 33(3): 317-327.
30.	Kang QM, Xiang YE, Li D, et al. MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3 beta pathway in N2a/APP695swe cells. Oncotarget, 2017, 8(15): 24314-24326.
31.	Wu J, Zhou SL, Pi LH, et al. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: a potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget, 2017, 8(25): 40843-40856.
32.	Zhao YL, Song JN, Ma XD, et al. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res, 2016, 11(6): 944-950.
33.	朱耀乾. 固本健腦法對 AD 模型大鼠海馬區 Caveolin-1、樹突棘、P-tau 的影響. 恩施: 湖北民族學院, 2015.
34.	胡玉萍, 王平, 袁德培, 等. 固本健腦法對 Alzheimer 病模型大鼠海馬區樹突棘及 P-tau 的影響. 世界科學技術-中醫藥現代化, 2016, 18(1): 53-59.
35.	陳謙峰. 固本健腦法對 AD 細胞模型的作用及 Caveolin-1、P-tau 影響的研究. 武漢: 湖北中醫藥大學, 2015.
36.	Sun J, Zhang X, Wang C, et al. Curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/GSK-3β in N2a/APP695swe cells and APP/PS1 double transgenic Alzheimer’s disease mice. Am J Chin Med, 2017, 45(8): 1667-1682.
37.	孫潔蕓. 姜黃素通過 Caveolin-1 在 AD 中發揮神經保護作用的分子機制. 重慶: 重慶醫科大學, 2014.
38.	向月, 張雄, 楊軍, 等. miR-124-3p 通過負調控 Caveolin-1 表達降低 N2a/APPswe 細胞內 Tau 蛋白磷酸化水平. 基礎醫學與臨床, 2015, 35(5): 579-584.

1. 張玫瑩, 朱鐵年, 趙瑞景, 等. 小凹蛋白-1 調控表皮生長因子受體活化對惡性黑色素瘤細胞生物學行為的影響. 解放軍醫藥雜志, 2018, 30(4): 46-50.
2. 楊娟麗. Caveolin-1 調控表皮生長因子受體活化對結直腸癌細胞增殖和轉移的影響. 石家莊: 河北醫科大學, 2018.
3. 于衛民, 姬建勝, 王冬冬. RNA 干擾 Caveolin-1 基因表達抑制食管癌細胞增殖侵襲及 PI3K/AKT 信號通路的研究. 中國地方病防治雜志, 2018, 33(3): 357.
4. 鐘義良, 張融融, 黃思源, 等. 急性腦梗死患者血清陷窩蛋白 1 水平與早期神經功能惡化的關系. 上海交通大學學報(醫學版), 2017, 37(12): 1678-1681.
5. 鄭慶玲. Caveolin-1 的生物學結構及在腫瘤研究中的進展. 現代醫藥衛生, 2007, 23(24): 3710-3711.
6. Ohadi M, Heshmati Y, Mirabzadeh A. P01-99 Extreme alleles at the human caveolin 1 gene novel purine complex and risk of Alzheimer’s disease. Eur Psychiatry, 2009, 24(Suppl 1): S487.
7. Heshmati Y, Mirabzadeh A, Feizzade G, et al. A novel polymorphic purine complex at the 1.5 kb upstream region of the human caveolin-1 gene and risk of Alzheimer’s disease; extra-short alleles and accumulated allele homozygosity. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(2): 248-253.
8. Zarif Yeganeh M, Mirabzadeh A, Khorram Khorshid HR, et al. Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet, 2010, 153B(1): 347-349.
9. Heidari A, Behmanesh M, Sahraian MA, et al. The human caveolin 1 gene upstream purine complex and neurodegeneration-a common signature. J Neuroimmunol, 2011, 236(1/2): 106-110.
10. Heidari A, Hosseinkhani S, Talebi S, et al. Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: implication in neurodegenerative disorders. Gene, 2012, 505(1): 186-189.
11. 吳平. ApoE 基因多態性和cav-1 基因上游 PPC 長度多態性與 AD、MCI 和 VD 的相關性研究. 上海: 復旦大學, 2009.
12. Gioiosa L, Raggi C, Ricceri LJ, et al. Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res, 2008, 188(2): 255-262.
13. 王紅霞. 不同年齡大鼠腦內 Caveolin-1 蛋白的表達及其與學習記憶關系研究. 大連: 遼寧師范大學, 2006.
14. 鄒偉, 王紅霞, 劉晶, 等. 大鼠腦內 caveolin-1 蛋白的表達及其在分辨學習中的作用. 生理學報, 2006, 58(5): 429-434.
15. 嵇志紅, 鄒偉. 空間學習記憶訓練對大鼠海馬 Caveolin-1 蛋白表達的影響. 大連大學學報, 2013(6): 35-37, 43.
16. 王璐. Caveolin-1 蛋白在空間學習記憶中的作用及其信號轉導機制的研究. 大連: 遼寧師范大學, 2008.
17. Egawa J, Schilling JM, Cui W, et al. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J, 2017, 31(8): 3403-3411.
18. 袁林. 固本健腦法對 MCI 大鼠學習記憶能力及海馬 Caveolin-1 的影響. 武漢: 湖北中醫藥大學, 2011.
19. 陳冬冬. 新型釩氧配合物對糖尿病小鼠學習記憶功能損傷的干預及與 Caveolin-1 表達的關系. 大連: 遼寧師范大學, 2009.
20. 姜梅. 基于腎藏志理論的腎虛質大鼠海馬區學習記憶蛋白 ERK1 及 Caveolin-1 表達研究. 咸陽: 陜西中醫藥大學, 2017.
21. Ikezu T, Trapp BD, Song KS, et al. Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J Biol Chem, 1998, 273(17): 10485-10495.
22. Hattori C, Asai M, Onishi H, et al. BACE1 interacts with lipid raft proteins. J Neurosci Res, 2006, 84(4): 912-917.
23. Head BP, Peart JN, Panneerselvam M, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One, 2010, 5(12): e15697.
24. Jang SK, Yu JM, Kim ST, et al. An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and a beta-degrading enzymes in microglia. Eur J Pharmacol, 2015, 758: 1-10.
25. Pietri M, Dakowski C, Hannaoui SA, et al. PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nat Med, 2013, 19(9): 1124-1131.
26. Hashimoto M, Hossain S, Katakura M, et al. The binding of Aβ_1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: implicates to Alzheimer’s disease. Biochimica et Biophysica Acta, 2015, 1848(6): 1402-1409.
27. Zhu DH, Su YC, Fu BM, et al. Magnesium reduces blood-brain barrier permeability and regulates amyloid-beta transcytosis. Mol Neurobiol, 2018, 55(9): 7118-7131.
28. András IE, Eum SY, Toborek M. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. Biochem Biophys Res Commun, 2012, 421(2): 177-183.
29. Van Helmond ZK, Miners JS, Bednall E, et al. Caveolin-1 and-2 and their relationship to cerebral amyloid angiopathy in Alzheimer’s disease. Neuropathol Appl Neurobiol, 2007, 33(3): 317-327.
30. Kang QM, Xiang YE, Li D, et al. MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3 beta pathway in N2a/APP695swe cells. Oncotarget, 2017, 8(15): 24314-24326.
31. Wu J, Zhou SL, Pi LH, et al. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: a potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget, 2017, 8(25): 40843-40856.
32. Zhao YL, Song JN, Ma XD, et al. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res, 2016, 11(6): 944-950.
33. 朱耀乾. 固本健腦法對 AD 模型大鼠海馬區 Caveolin-1、樹突棘、P-tau 的影響. 恩施: 湖北民族學院, 2015.
34. 胡玉萍, 王平, 袁德培, 等. 固本健腦法對 Alzheimer 病模型大鼠海馬區樹突棘及 P-tau 的影響. 世界科學技術-中醫藥現代化, 2016, 18(1): 53-59.
35. 陳謙峰. 固本健腦法對 AD 細胞模型的作用及 Caveolin-1、P-tau 影響的研究. 武漢: 湖北中醫藥大學, 2015.
36. Sun J, Zhang X, Wang C, et al. Curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/GSK-3β in N2a/APP695swe cells and APP/PS1 double transgenic Alzheimer’s disease mice. Am J Chin Med, 2017, 45(8): 1667-1682.
37. 孫潔蕓. 姜黃素通過 Caveolin-1 在 AD 中發揮神經保護作用的分子機制. 重慶: 重慶醫科大學, 2014.
38. 向月, 張雄, 楊軍, 等. miR-124-3p 通過負調控 Caveolin-1 表達降低 N2a/APPswe 細胞內 Tau 蛋白磷酸化水平. 基礎醫學與臨床, 2015, 35(5): 579-584.

West China Medical Journal

The research progress of Caveolin-1 protein in the field of Alzheimer’s disease

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