Research progress of three-dimensional printing technology for clinical application in intervertebral fusion region_West China Medical Journal

Authors：

WANG Linnan , YANG Xi ,  SONG Yueming

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

SONG Yueming, Email: hx_sym@163.com

Keywords：

Three-dimensional printing technology; Intervertebral fusion; Clinical application; Research progress

DOI：

10.7507/1002-0179.201809010

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the development of three-dimensional (3D) printing technology, more and more researches have focused on its application in the region of intervertebral fusion materials; the prospects are worth looking forward to. This article reviews the researches about 3D printing technology in spinal implants, and summarizes the materials and printing technology applied in the field of spinal interbody fusion, and the shortcomings in the current research and application. With the rapid development of 3D printing technology and new materials, more and more 3D printing spinal interbodies will be developed and used clinically.

Citation： WANG Linnan, YANG Xi, SONG Yueming. Research progress of three-dimensional printing technology for clinical application in intervertebral fusion region. West China Medical Journal, 2018, 33(9): 1061-1067. doi: 10.7507/1002-0179.201809010 Copy

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1. Cavanaugh PK, Mounts T, Vaccaro AR. Use of 3-dimensional printing in spine care. Contemp Spine Surg, 2015, 16(1): 1-5.
2. Kuehn BM. Clinicians embrace 3D printers to solve unique clinical challenges. JAMA, 2016, 315(4): 333-335.
3. 程文俊, 勘武生, 鄭瓊, 等. 3D 打印鈦合金骨小梁金屬臼杯全髖關節置換術的短期療效. 中華骨科雜志, 2014, 34(8): 816-823.
4. 王臻, 滕勇, 李滌塵, 等. 基于快速成型的個體化人工半膝關節的研制-計算機輔助設計與制造. 中國修復重建外科雜志, 2004, 18(5): 347-351.
5. Xu N, Wei F, Liu X, et al. Reconstruction of the upper cervical spine using a personalized 3D-printed vertebral body in an adolescent with ewing sarcoma. Spine (Phila Pa 1976), 2016, 41(1): E50-E54.
6. Wu SH, Li Y, Zhang YQ, et al. Porous titanium-6 aluminum-4 vanadium cage has better osseointegration and less micromotion than a poly-ether-ether-ketone cage in sheep vertebral fusion. Artif Organs, 2013, 37(12): E191-E201.
7. Murr LE, Gaytan SM, Ramirez DA, et al. Metal fabrication by additive manufacturing using laser and electron beam melting technologies. J Mater Sci Technol, 2012, 28(1): 1-14.
8. Parthasarathy J, Starly B, Raman S, et al. Mechanical evaluation of porous titanium (Ti6A14V) structures with electron beam melting (EBM). J Mech Behav Biomed Mater, 2010, 3(3): 249-259.
9. Lethaus B, Poort L, B?ckmann R, et al. Additive manufacturing for microvascular reconstruction of the mandible in 20 patients. J Cranio Maxill Surg, 2012, 40: 43-46.
10. Su XB, Yang YQ, Yu P, et al. Development of porous medical implant scaffolds via laser additive manufacturing. Trans Nonferrous Met Soc China, 2012, 22(Suppl 1): S181-S187.
11. 盧祺, 于濱生. 脊柱內植物的 3D 打印技術研究進展. 中國修復重建外科雜志, 2016, 30(9): 1160-1165.
12. 吳天順, 陳揚, 藍濤, 等. 脊柱 3D 打印椎間融合器材料的初步展望. 生物骨科材料與臨床研究, 2018, 15(1): 58-63.
13. Eisenbarth E, Velten D, Müller M, et al. Biocompatibility of beta-stabilizing elements of titanium alloys. Biomaterials, 2004, 25(26): 5705-5713.
14. Pattanayak DK, Fukuda A, Matsushita T, et al. Bioactive Ti metal analogous to human cancellous bone: fabrication by selective laser melting and chemical treatments. Acta Biomater, 2011, 7(3): 1398-1406.
15. Olivares-Navarrete R, Gittens RA, Schneider JM, et al. Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic protein production on titanium alloy substrates than on poly-ether-ether-ketone. Spine J, 2012, 12(3): 265-272.
16. 羅麗娟, 余森, 于振濤, 等. 3D 打印鈦及鈦合金醫療器械的優勢及臨床應用現狀. 生物骨科材料與臨床研究, 2015, 12(6): 72-75.
17. Castellvi AE, Castellvi A, Clabeaux DH. Corpectomy with titanium cage reconstruction in the cervical spine. J Clin Neurosci, 2012, 19(4): 517-521.
18. Song ZL, Feng CK, Chiu FY, et al. The clinical significance of rapid prototyping technique in complex spinal deformity surgery-case sharing and literature review. Formosan J Musculoskeletal Disord, 2013, 4(3): 88-93.
19. Butscher A, Bohner M, Hofmann S, et al. Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. Acta Biomater, 2011, 7(3): 907-920.
20. Bertollo N, Da Assuncao R, Hancock NJ, et al. Influence of electron beam melting manufactured implants on ingrowth and shear strength in an ovine model. J Arthroplasty, 2012, 27(8): 1429-1436.
21. Fukuda A, Takemoto M, Saito T, et al. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater, 2011, 7(5): 2327-2336.
22. Chen Y, Chen D, Guo Y, et al. Subsidence of titanium mesh cage: a study based on 300 cases. J Spinal Disord Tech, 2008, 21(7): 489-492.
23. Lee YS, Kim YB, Park SW. Risk factors for postoperative subsidence of single-level anterior cervical discectomy and fusion: the significance of the preoperative cervical alignment. Spine (Phila Pa 1976), 2014, 39(16): 1280-1287.
24. Jiang W, Shi J, Li W, et al. Three dimensional melt-deposition of polycaprolactone/bio-derived hydroxyapatite composite into scaffold for bone repair. J Biomater Sci Polym Ed, 2013, 24(5): 539-550.
25. 郭敏, 鄭玉峰. 多孔鉭材料制備及其骨科植入物臨床應用現狀. 中國骨科臨床與基礎研究雜志, 2013, 5(1): 47-54.
26. Veillette CJ, Mehdian H, Schemitsch EH, et al. Survivorship analysis and radiographic outcome following tantalum rod insertion for osteonecrosis of the femoral head. J Bone Joint Surg Am, 2006, 88(Suppl 3): 48-55.
27. Zardiackas LD, Parsell DE, Dillon LD, et al. Structure, metallurgy, and mechanical properties of a porous Tantalum foam. J Biomed Mater Res, 2001, 58(2): 180-187.
28. Aldegheri R, Taglialavoro G, Berizzi A, et al. The tantalun screw for treating femoral head necrosis: rationale and results. Strategies Trauma Limb Reconstr, 2007, 2(2/3): 63-68.
29. Malloy JP, Beutler W, Peppelman W, et al. Clinical outcomes with porous tantalum in lumbar interbody fusion. Spine J, 2010, 10(9): S147-S148.
30. 李洋. 激光增材制造(3D 打印)制備生物醫用多孔金屬工藝及組織性能研究. 江蘇: 蘇州大學, 2015.
31. Saris NE, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta, 2000, 294(1/2): 1-26.
32. Staiger MP, Pietak AM, Huadmai J, et al. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials, 2006, 27(9): 1728-1734.
33. 許灝鋮, 張帆, 呂飛舟, 等. 金屬鎂及其合金植入材料在脊柱外科中的應用. 國際骨科學雜志, 2016, 37(5): 269-273.
34. Simon JL, Roy TD, Parsons JR, et al. Engineered cellular response to scaffold architecture in a rabbit trephine defect. J Biomed Mater Res A, 2003, 66(2): 275-282.
35. Witte F, Reifenrath J, Müeller PP, et al. Cartilage repair on magnesium scaffolds used as a subchondral bone replacement. Materwiss Werksttech, 2006, 37(6): 504-508.
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