The effect of combined aerobic and resistance training on exercise capacity and quality of life in patients with severe or very severe chronic obstructive pulmonary disease_West China Medical Journal

Authors：

LIU Sa , LIU Yuan , ZHANG Wenliang , XIE Kangling ,  LIU Suixin

Department of Rehabilition, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P. R. China;

Corresponding?author：

LIU Suixin, Email: 2278359828@qq.com

Keywords：

Chronic obstructive pulmonary disease; Pulmonary rehabilitation; Exercise capacity; Quality of life

DOI：

10.7507/1002-0179.201805002

Video：

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Objective To investigate the effect of aerobic combined with resistance training on exercise capacity and quality of life in patients with severe or very severe chronic obstructive pulmonary disease (COPD). Methods Thirty patients with severe or very severe COPD were randomly divided into the control group (n=15) and the exercise group (n=15) from January 2011 to January 2013. The control group was given health education and routine drug treatment. The exercise group was given muscle relaxation and 6-week aerobic combined resistance exercise training on the basis of the control group. Pulmonary function, 6-minute walk test (6MWT), 30-second sit-to-stand (30-STS), 30-second arm curl test (30-ACT), Medical Research Council Dyspnea Scale (MRC), COPD Assessment Test (CAT), Beck Anxiety and Depression Scale were performed before and after intervention in both groups. Results After intervention, compared with those in the control group, the 6MWT, 30-STS and 30-ACT in the exercise group increased significantly [(518.44±84.62) vs. (412.93±82.53) m, (24.53±3.98) vs. (16.87±3.91) times, (26.07±3.41) vs. (17.93±3.39) times, P<0.05], while the CAT score, Beck anxiety and depression scores decreased significantly (4.87±3.68vs. 26.10±10.18, 2.47±1.81 vs. 11.50±4.89, 2.27±2.49 vs. 12.20±6.35, P<0.05), and MRC score also decreased significantly [1.0 (1.0, 2.0)vs. 2.0 (2.0, 4.0), P<0.05]. There was no statistical difference in pulmonary function between the two groups before or after intervention (P>0.05). Conclusion Exercise-based pulmonary rehabilitation can significantly improve the treatment outcomes in Chinese patients with severe or very severe COPD.

Citation： LIU Sa, LIU Yuan, ZHANG Wenliang, XIE Kangling, LIU Suixin. The effect of combined aerobic and resistance training on exercise capacity and quality of life in patients with severe or very severe chronic obstructive pulmonary disease. West China Medical Journal, 2018, 33(10): 1252-1256. doi: 10.7507/1002-0179.201805002 Copy

1.	中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2013 年修訂版). 中國醫學前沿雜志: 電子版, 2014, 6(2): 67-80.
2.	GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary Disease (Revised 2015). (2016-3-18)[2018-04-20]. http.//www.goldcopd.com.
3.	Vogiatzis I. Strategies of muscle training in very severe COPD patients. Eur Respir J, 2011, 38(4): 971-975.
4.	GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (Revised 2011). www.Goldcopd.com.
5.	Foster C, Porcari JP, Gibson M, et al. Translation of submaximal exercise test responses to exercise prescription using the Talk Test. J Strength Cond Res, 2009, 23(9): 2425-2429.
6.	Williams MA, Haskell WL, Ades PA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation, 2007, 116(5): 572-584.
7.	Ross R, Blair SN, Arena R, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation, 2016, 134(24): e653-e699.
8.	盛艦輝, 譚薇, 王曉麗. 肺康復訓練對老年重度慢性阻塞性肺病的影響. 濰坊醫學院學報, 2016, 38(2): 103-106.
9.	劉漢坤, 周明, 吳志強. 肺康復聯合布地奈德/福莫特羅和噻托溴銨治療重度和極重度穩定期 COPD 的效果. 中國當代醫藥, 2016, 23(15): 23-25.
10.	劉景新, 劉曉丹, 吳衛兵, 等. 高強度間歇訓練對 COPD 患者的康復效果及作用機制. 中國康復醫學雜志, 2017, 32(12): 1441-1444.
11.	孟申. 從肺康復指南的更新看肺康復研究的進展. 中華結核和呼吸雜志, 2010, 33(3): 216-218.
12.	COPD Working Group. Pulmonary rehabilitation for patients with chronic pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser, 2012, 12(6): 1-75.
13.	汪立新, 顧曉燕, 沈素娥, 等. 運動及漸進性肌肉放松訓練對緩解期 COPD 患者運動耐力、日常生活能力及情緒的影響. 臨床肺科雜志, 2014, 19(8): 1377-1380.
14.	Puhan MA, Siebeling L, Zoller M, et al. Simple functional performance tests and mortality in COPD. Eur Respir J, 2013, 42(4): 956-963.
15.	Eisner MD, Blanc PD, Yelin EH, et al. Influence of anxiety on health outcomes in COPD. Thorax, 2010, 65(3): 229-234.
16.	李毅, 李月川. 不同時期施行肺康復對 COPD 患者抑郁及焦慮的改善效果比較. 天津醫藥, 2016, 44(8): 1010-1014.
17.	Ries AL. ACCP/AACVPR evidence-based guidelines for pulmonary rehabilitation. Round 3: another step forward. J Cardiopulm Rehabil Prev, 2007, 27(4): 233-236.
18.	吳海燕, 錢鈞, 李樹雯, 等. 心肺康復運動訓練對 COPD 穩定期患者肺功能的影響. 中國康復醫學雜志, 2016, 31(3): 351-353.
19.	Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.

1. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2013 年修訂版). 中國醫學前沿雜志: 電子版, 2014, 6(2): 67-80.
2. GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary Disease (Revised 2015). (2016-3-18)[2018-04-20]. http.//www.goldcopd.com.
3. Vogiatzis I. Strategies of muscle training in very severe COPD patients. Eur Respir J, 2011, 38(4): 971-975.
4. GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (Revised 2011). www.Goldcopd.com.
5. Foster C, Porcari JP, Gibson M, et al. Translation of submaximal exercise test responses to exercise prescription using the Talk Test. J Strength Cond Res, 2009, 23(9): 2425-2429.
6. Williams MA, Haskell WL, Ades PA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation, 2007, 116(5): 572-584.
7. Ross R, Blair SN, Arena R, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation, 2016, 134(24): e653-e699.
8. 盛艦輝, 譚薇, 王曉麗. 肺康復訓練對老年重度慢性阻塞性肺病的影響. 濰坊醫學院學報, 2016, 38(2): 103-106.
9. 劉漢坤, 周明, 吳志強. 肺康復聯合布地奈德/福莫特羅和噻托溴銨治療重度和極重度穩定期 COPD 的效果. 中國當代醫藥, 2016, 23(15): 23-25.
10. 劉景新, 劉曉丹, 吳衛兵, 等. 高強度間歇訓練對 COPD 患者的康復效果及作用機制. 中國康復醫學雜志, 2017, 32(12): 1441-1444.
11. 孟申. 從肺康復指南的更新看肺康復研究的進展. 中華結核和呼吸雜志, 2010, 33(3): 216-218.
12. COPD Working Group. Pulmonary rehabilitation for patients with chronic pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser, 2012, 12(6): 1-75.
13. 汪立新, 顧曉燕, 沈素娥, 等. 運動及漸進性肌肉放松訓練對緩解期 COPD 患者運動耐力、日常生活能力及情緒的影響. 臨床肺科雜志, 2014, 19(8): 1377-1380.
14. Puhan MA, Siebeling L, Zoller M, et al. Simple functional performance tests and mortality in COPD. Eur Respir J, 2013, 42(4): 956-963.
15. Eisner MD, Blanc PD, Yelin EH, et al. Influence of anxiety on health outcomes in COPD. Thorax, 2010, 65(3): 229-234.
16. 李毅, 李月川. 不同時期施行肺康復對 COPD 患者抑郁及焦慮的改善效果比較. 天津醫藥, 2016, 44(8): 1010-1014.
17. Ries AL. ACCP/AACVPR evidence-based guidelines for pulmonary rehabilitation. Round 3: another step forward. J Cardiopulm Rehabil Prev, 2007, 27(4): 233-236.
18. 吳海燕, 錢鈞, 李樹雯, 等. 心肺康復運動訓練對 COPD 穩定期患者肺功能的影響. 中國康復醫學雜志, 2016, 31(3): 351-353.
19. Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.

West China Medical Journal

The effect of combined aerobic and resistance training on exercise capacity and quality of life in patients with severe or very severe chronic obstructive pulmonary disease

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