Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area_West China Medical Journal

Authors：

LIANG Xinying ,  LI Yao , LI Ting , QIU Ping , MEI Xi

Department of Endocrinology and Metabolic Disease, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding?author：

LI Yao, Email: 240877508@qq.com

Keywords：

Beckman reagent; Pregnancy; Thyroid function index; Normal reference value

DOI：

10.7507/1002-0179.201804042

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo establish a normal reference value range of specific thyroid function in pregnant women corresponding to Beckman reagent in Chengdu.MethodsWe randomly selected 120 non-pregnant women and 445 pregnant women who underwent routine examinations at the First Affiliated Hospital of Chengdu Medical College from November 2016 to June 2017; tested for free triiodothyronine (FT₃), free thyroxine (FT₄), and thyroid stimulating hormone (TSH) in serum; used SPSS 24.0 to calculate the bilateral limit of each index (Section 2.5, 97. 5 Quot); established the normal range of Beckman reagent.ResultsThe reference ranges of FT₃, FT₄, and TSH in the first, second, and third trimester of pregnancy were 4.41–6.33, 4.17–6.12, and 3.86–6.39 pmol/L; 7.64–14.63, 6.62–13.69, and 6.62–12.51 pmol/L; 0.21–3.62, 0.16–4.35, and 0.89–4.88 mU/L; respectively. There was no significant difference in serum TSH between the first and second trimester (P>0.05), and neither between the first and second trimesters and the controls in serum FT₃ (P>0.05). The differences in serum FT₃, FT₄, and TSH among the rest of trimesters, and between each trimester and the normal control group were statistically significant (P<0.05). There was a significant correlation between TSH and FT₄ in the early and middle stages of pregnancy (r=–0.277, –0.392, P<0.01).ConclusionThe reference value of FT₃, FT₄, and TSH in pregnant women with Beckman reagent was significantly different from that in non-pregnant women.

Citation： LIANG Xinying, LI Yao, LI Ting, QIU Ping, MEI Xi. Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area. West China Medical Journal, 2018, 33(5): 527-531. doi: 10.7507/1002-0179.201804042 Copy

1.	Shan ZY, Chen YY, Teng WP, et al. A study for maternal thyroid hormone deficiency during the first half of pregnancy in China. Eur J Clin Invest, 2009, 39(1): 37-42.
2.	關海霞, 李晨陽, 李玉姝, 等. 妊娠晚期婦女甲狀腺疾病特點及甲狀腺自身抗體變化的研究. 中華婦產科雜志, 2006, 41(8): 529-532.
3.	史娜娜, 馬莉, 黃亞娟, 等. 建立特異性甲狀腺功能參考值在評價妊娠晚期甲狀腺功能減退中的意義. 中國婦幼保健, 2015(29): 4964-4967.
4.	中華醫學會內分泌學分會, 中華醫學會圍產醫學分會. 妊娠和產后甲狀腺疾病診治指南. 中華內分泌代謝雜志, 2012, 28(5): 354-371.
5.	Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid, 2017, 27(3): 315-389.
6.	張春艷. 成都地區妊娠婦女甲狀腺激素正常參考值范圍的建立及甲狀腺疾病的篩查. 南充: 川北醫學院, 2014.
7.	楊建波, 甘西倫, 王明霜, 等. 川南地區各孕期甲狀腺激素變化及參考范圍. 標記免疫分析與臨床, 2016, 23(5): 498-500.
8.	陳玉敏, 曾菁, 嚴悅溶, 等. 成都地區妊娠婦女甲狀腺激素正常參考值建立及甲狀腺自身抗體對孕婦甲狀腺功能的影響. 四川大學學報: 醫學版, 2017, 48(3): 450-454.
9.	Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev, 1997, 18(3): 404-433.
10.	Soldin OP, Tractenberg RE, Hollowell JG, et al. Treimester-specific changes in maternal throid hormorne, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid, 2004, 14: 1084-1090.
11.	Haddow JE, Palomaki GE, Allan WC, et al. Maternal thvroid deficiency during pregnancy and subsequent neuropsyehological development of the child. N Engl Med, 1999, 341(8): 549-555.
12.	Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf), 2010, 72(6): 825-829.
13.	李佳, 滕衛平, 單忠艷, 等. 中國漢族碘適量地區月份特異性TSH和T4的正常參考范圍. 中華內分泌代謝雜志, 2008, 12(24): 605-608.
14.	Korevaar TIM, Medici M, Visser TJ, et al. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol, 2017, 13(10): 610-622.
15.	Knight BA, Shields BM, Hattersley AT, et al. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. J Endocrinol, 2016, 174(1): 51-57.
16.	舒小雨, 漆洪波, 蔣利華, 等. BECKMAN試劑檢測妊娠各期特異性甲狀腺功能指標正常值范圍研究. 中國實用內科雜志, 2013(11): 881-884.
17.	陳巧巧, 王志成. 寧波市妊娠期婦女甲狀腺功能指標參考區間的建立. 中華全科醫學, 2016, 14(6): 1013-1016.
18.	陳喬彬, 李維, 皇甫英, 等. 妊娠婦女促甲狀腺素和游離甲狀腺素參考區間初步建立. 臨床檢驗雜志, 2013, 31(12): 948-950.
19.	王瑜. 蘭州地區妊娠期甲狀腺激素參考值范圍探討. 蘭州: 蘭州大學, 2017.
20.	韓銳, 魯穎, 吳琳, 等. 撫順地區婦女妊娠期特異性甲狀腺功能參考區間的建立與評價. 大連醫科大學學報, 2016, 38(2): 168-171.
21.	黃璐, 羅丹, 王利民, 等. 成都地區妊娠期特異性甲狀腺激素水平參考值范圍的探討及臨床分析. 現代婦產科進展, 2016, 25(4): 269-272.
22.	馬瑞婷, 黃慧, 嚴悅溶, 等. 正常成人甲狀腺激素水平影響因素探討. 四川大學學報: 醫學版, 2015, 46(4): 611-614.

1. Shan ZY, Chen YY, Teng WP, et al. A study for maternal thyroid hormone deficiency during the first half of pregnancy in China. Eur J Clin Invest, 2009, 39(1): 37-42.
2. 關海霞, 李晨陽, 李玉姝, 等. 妊娠晚期婦女甲狀腺疾病特點及甲狀腺自身抗體變化的研究. 中華婦產科雜志, 2006, 41(8): 529-532.
3. 史娜娜, 馬莉, 黃亞娟, 等. 建立特異性甲狀腺功能參考值在評價妊娠晚期甲狀腺功能減退中的意義. 中國婦幼保健, 2015(29): 4964-4967.
4. 中華醫學會內分泌學分會, 中華醫學會圍產醫學分會. 妊娠和產后甲狀腺疾病診治指南. 中華內分泌代謝雜志, 2012, 28(5): 354-371.
5. Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid, 2017, 27(3): 315-389.
6. 張春艷. 成都地區妊娠婦女甲狀腺激素正常參考值范圍的建立及甲狀腺疾病的篩查. 南充: 川北醫學院, 2014.
7. 楊建波, 甘西倫, 王明霜, 等. 川南地區各孕期甲狀腺激素變化及參考范圍. 標記免疫分析與臨床, 2016, 23(5): 498-500.
8. 陳玉敏, 曾菁, 嚴悅溶, 等. 成都地區妊娠婦女甲狀腺激素正常參考值建立及甲狀腺自身抗體對孕婦甲狀腺功能的影響. 四川大學學報: 醫學版, 2017, 48(3): 450-454.
9. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev, 1997, 18(3): 404-433.
10. Soldin OP, Tractenberg RE, Hollowell JG, et al. Treimester-specific changes in maternal throid hormorne, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid, 2004, 14: 1084-1090.
11. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thvroid deficiency during pregnancy and subsequent neuropsyehological development of the child. N Engl Med, 1999, 341(8): 549-555.
12. Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf), 2010, 72(6): 825-829.
13. 李佳, 滕衛平, 單忠艷, 等. 中國漢族碘適量地區月份特異性TSH和T4的正常參考范圍. 中華內分泌代謝雜志, 2008, 12(24): 605-608.
14. Korevaar TIM, Medici M, Visser TJ, et al. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol, 2017, 13(10): 610-622.
15. Knight BA, Shields BM, Hattersley AT, et al. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. J Endocrinol, 2016, 174(1): 51-57.
16. 舒小雨, 漆洪波, 蔣利華, 等. BECKMAN試劑檢測妊娠各期特異性甲狀腺功能指標正常值范圍研究. 中國實用內科雜志, 2013(11): 881-884.
17. 陳巧巧, 王志成. 寧波市妊娠期婦女甲狀腺功能指標參考區間的建立. 中華全科醫學, 2016, 14(6): 1013-1016.
18. 陳喬彬, 李維, 皇甫英, 等. 妊娠婦女促甲狀腺素和游離甲狀腺素參考區間初步建立. 臨床檢驗雜志, 2013, 31(12): 948-950.
19. 王瑜. 蘭州地區妊娠期甲狀腺激素參考值范圍探討. 蘭州: 蘭州大學, 2017.
20. 韓銳, 魯穎, 吳琳, 等. 撫順地區婦女妊娠期特異性甲狀腺功能參考區間的建立與評價. 大連醫科大學學報, 2016, 38(2): 168-171.
21. 黃璐, 羅丹, 王利民, 等. 成都地區妊娠期特異性甲狀腺激素水平參考值范圍的探討及臨床分析. 現代婦產科進展, 2016, 25(4): 269-272.
22. 馬瑞婷, 黃慧, 嚴悅溶, 等. 正常成人甲狀腺激素水平影響因素探討. 四川大學學報: 醫學版, 2015, 46(4): 611-614.

West China Medical Journal

Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content