Key issues and strategies in the construction of biobank_West China Medical Journal

Authors：

XU Yan , FAN Ping ,  HU Xun

Biobank, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

HU Xun, Email: hxxhu99@163.com

Keywords：

Biobank; Construction; Key issue; Strategy

DOI：

10.7507/1002-0179.201803211

Video：

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Biobank is an important platform for translational medicine, precision medicine and drug development. In the past 10 years, although the construction of biobank in China has made great progress, it still faces many challenges. This article analyzes the key issues and also puts forward specific suggestions in the management of biobank from the aspects of ethics issues, quality control of biospecimens, information management, sample and data sharing, so as to provide reference for the construction and development of a high standard biobank.

Citation： XU Yan, FAN Ping, HU Xun. Key issues and strategies in the construction of biobank. West China Medical Journal, 2018, 33(6): 651-654. doi: 10.7507/1002-0179.201803211 Copy

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12.	周一峰, 閔偉勇, 張小燕, 等. 中國生物樣本庫質量達標檢查結果分析. 實用器官移植電子雜志, 2017, 5(6): 444-447.
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14.	劉世建, 傅啟華, 王偉, 等. 臨床生物樣本庫發展的機遇與挑戰. 第二軍醫大學學報, 2017, 38(3): 265-269.

1. 賀晶, 白楊, 池慧, 等. 我國生物樣本庫建設管理中存在的問題及規范化管理策略. 醫學信息學雜志, 2017, 38(1): 53-58.
2. 錢開宇, 朱源, 曹馨月, 等. 加強倫理委員會建設, 促進生物樣本庫發展. 轉化醫學雜志, 2018, 7(1): 14-16, 41.
3. Sun HY, Sun R, Hao M, et al. Effect of duration of ex vivo ischemia time and storage period on RNA quality in biobanked human renal cell carcinoma tissue. Ann Surg Oncol, 2016, 23(1): 297-304.
4. Pieragostino D, Petrucci F, Del Boccio PA, et al. Pre-analytical factors in clinical proteomics investigations: impact of ex vivo protein modifications for multiple sclerosis biomarker discovery. J Proteomics, 2010, 73(3, SI): 579-592.
5. Plebani M, Sciacovelli L, Aita A, et al. Harmonization of pre-analytical quality indicators. Biochem Med (Zagreb), 2014, 24(1): 105-113.
6. Imbeaud S, Graudens E, Boulanger V, et al. Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces. Nucleic Acids Res, 2005, 33(6): e56.
7. Caixeiro NJ, Lai K, Lee CS. Quality assessment and preservation of RNA from biobank tissue specimens: a systematic review. J Clin Pathol, 2016, 69(3): 260-265.
8. Faltas BM. Designing and managing modern biobanks. Genet Eng Biotechn N, 2013, 33(16): 38, 40.
9. del Campo M, Mollenhauer B, Bertolotto A, et al. Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Parkinson’s disease cerebrospinal fluid biomarkers: an update. Biomark Med, 2012, 6(4): 419-430.
10. Nanni U, Betsou F, Riondino S, et al. SPRECware: software tools for Standard PREanalytical Code (SPREC) labeling - effective exchange and search of stored biospecimens. Int J Biol Markers, 2012, 27(3): e272-e279.
11. 翟培軍, 李軍燕, 胡冬梅, 等. 生物樣本庫國際認可和標準化發展與前景. 中華臨床實驗室管理電子雜志, 2017, 5(1): 6-8.
12. 周一峰, 閔偉勇, 張小燕, 等. 中國生物樣本庫質量達標檢查結果分析. 實用器官移植電子雜志, 2017, 5(6): 444-447.
13. Somiari SB, Somiari RI. The future of biobanking: a conceptual look at how biobanks can respond to the growing human biospecimen needs of researchers. Adv Exp Med Biol, 2015, 864: 11-27.
14. 劉世建, 傅啟華, 王偉, 等. 臨床生物樣本庫發展的機遇與挑戰. 第二軍醫大學學報, 2017, 38(3): 265-269.

West China Medical Journal

Key issues and strategies in the construction of biobank

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