The disinfection effect of peracetic acid <b><i>versus</i></b> glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis _West China Medical Journal

Authors：

 XIE Jing ¹ , CHEN Min ² , LUO Xuefeng ²

1. Operation Management Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

XIE Jing, Email: 1207328440@qq.com

Keywords：

Peracetic acid; Glutaraldehyde; Endoscope; Disinfection; Meta-analysis

DOI：

10.7507/1002-0179.201710179

Video：

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ObjectiveTo compare the disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope, and provide suggestions for choosing endoscopic disinfectant.MethodsWe searched literatures in PubMed, Embase, Cochrane Central Library, China National Knowledge Infrastructure, Wanfang database and VIP database, with the retrieval time from the establishment of each database to July 2017, screening and comparing the disinfection qualification rate of peroxyacetic acid versus glutaraldehyde in immersion disinfection of flexible endoscope. The number of flexible endoscopies after disinfection was the main effect index, and a fixed effect model analysis was performed.ResultsSix comparative studies were enrolled in this Meta-analysis, with a total of 786 flexible endoscopes. The result of Meta-analysis showed that the qualification rate of disinfection of peracetic acid was higher than that of glutaraldehyde with the same disinfection time [relative risk=1.09, 95% confidence interval (1.06, 1.13), P<0.000 01].ConclusionThe disinfection effect of peroxyacetic acid immersion method is better than that of glutaraldehyde.

Citation： XIE Jing, CHEN Min, LUO Xuefeng. The disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis . West China Medical Journal, 2018, 33(3): 302-306. doi: 10.7507/1002-0179.201710179 Copy

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2.	Beilenhoff U, Neumann CS, Rey JF, et al. European society of gastrointestinal endoscopy; European society of gastroenterology and endoscopy nurses and associates. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endoscopy. Endoscopy, 2008, 40(11): 939.
3.	Vizcaino-Alcaide MJ. Herruzo-Cabrera R, Fernandez-Ace?ero M J.comparison of the disinfectant efficacy of perasafe and 2% glutaraldehyde in in vitro tests. J Hosp Infect, 2003, 53(2): 124-128.
4.	Petersen BT, Chennat J, Cohen J, et al. Multisociety guideline on reprocessing flexible gastrointestinal endoscopes: 2011. Gastrointest Endosc, 2011, 73(6): 1075-1084.
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12.	徐勇. 內鏡消毒劑的選擇. 中國內鏡雜志, 2002, 8(7): 28-30.
13.	張艷紅. 消化內鏡消毒劑選擇. 中華醫院感染學雜志, 2006, 16(9): 1078-1080.
14.	劉運喜, 邢玉斌, 鞏玉秀. 軟式內鏡清洗消毒技術規范 WS 507－2016. 中國感染控制雜志, 2017, 16(6): 587-592.
15.	Chenjiao W, Hongyan Z, Qing G, et al. In-use evaluation of peracetic acid for high-level disinfection of endoscopes. Gastroenterol Nurs, 2016, 39(2): 116-120.
16.	Herruzo R, Vizcaino MJ, Herruzo I. Efficacy of a new peracetic acid-based disinfectant agent (" Adaspor ready to use”). J Hosp Infect, 2010, 74(2): 192-193.
17.	吳忱姣, 張弘炎, 顧青, 等. 過氧乙酸消毒劑對胃鏡污染枯草桿菌黑色變種芽孢的消毒研究. 護理與康復, 2015, 14(10): 903-904, 908.
18.	陸燁, 胡國慶, 陸龍喜, 等. 新型消毒劑對內鏡消毒效果的研究. 中華醫院感染學雜志, 2012, 22(12): 2598-2600.
19.	周曉, 李鵬, 韋鍵, 等. 兩種消毒劑對消化內鏡現場消毒效果的比較研究. 中國消毒學雜志, 2013, 30(2): 114-115.
20.	周曉, 李鵬, 韋鍵, 等. 過氧乙酸對消化內鏡消毒效果研究. 中國消毒學雜志, 2013, 30(1): 11-12.

1. Park S, Jang JY, Koo JS, et al. A review of current disinfectants for gastrointestinal endoscopic reprocessing. Clin Endosc, 2013, 46(4): 337-341.
2. Beilenhoff U, Neumann CS, Rey JF, et al. European society of gastrointestinal endoscopy; European society of gastroenterology and endoscopy nurses and associates. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endoscopy. Endoscopy, 2008, 40(11): 939.
3. Vizcaino-Alcaide MJ. Herruzo-Cabrera R, Fernandez-Ace?ero M J.comparison of the disinfectant efficacy of perasafe and 2% glutaraldehyde in in vitro tests. J Hosp Infect, 2003, 53(2): 124-128.
4. Petersen BT, Chennat J, Cohen J, et al. Multisociety guideline on reprocessing flexible gastrointestinal endoscopes: 2011. Gastrointest Endosc, 2011, 73(6): 1075-1084.
5. 馬春麗, 李武平, 宋向陽, 等. 三種消毒劑對消化內鏡消毒效果比較觀察. 中國消毒學雜志, 2013, 30(5): 414-415, 419.
6. 羅淑君. 新型過氧乙酸溶液應用于消化內鏡消毒 50 例. 吉林醫學, 2013, 34(30): 6332-6333.
7. 劉倩雯, 李練, 葉婉華, 等. 新型過氧乙酸對軟式內鏡消毒效果的評價. 中國藥物經濟學, 2016, 11(8): 69-72.
8. 吳仁培, 方愛喬, 劉建強, 等. 新型過氧乙酸溶液消毒消化內鏡的效果評價. 中華消化內鏡雜志, 2012, 29(3): 159-162.
9. 于泳, 崔靜, 劉霞, 等. 新型過氧乙酸溶液消毒消化內鏡的效果評價. 中國傷殘醫學, 2014(18): 24-25.
10. 王澤瓊. 過氧乙酸型內鏡消毒機對纖維支氣管鏡消毒的應用觀察. 當代護士: 專科版, 2012(11): 9-10.
11. 鐘昱文, 翁濤華, 黃美卿, 等. 四種全自動內鏡消毒機對內鏡消毒效果的比對觀察. 中國消毒學雜志, 2008, 25(4): 359-362.
12. 徐勇. 內鏡消毒劑的選擇. 中國內鏡雜志, 2002, 8(7): 28-30.
13. 張艷紅. 消化內鏡消毒劑選擇. 中華醫院感染學雜志, 2006, 16(9): 1078-1080.
14. 劉運喜, 邢玉斌, 鞏玉秀. 軟式內鏡清洗消毒技術規范 WS 507－2016. 中國感染控制雜志, 2017, 16(6): 587-592.
15. Chenjiao W, Hongyan Z, Qing G, et al. In-use evaluation of peracetic acid for high-level disinfection of endoscopes. Gastroenterol Nurs, 2016, 39(2): 116-120.
16. Herruzo R, Vizcaino MJ, Herruzo I. Efficacy of a new peracetic acid-based disinfectant agent (" Adaspor ready to use”). J Hosp Infect, 2010, 74(2): 192-193.
17. 吳忱姣, 張弘炎, 顧青, 等. 過氧乙酸消毒劑對胃鏡污染枯草桿菌黑色變種芽孢的消毒研究. 護理與康復, 2015, 14(10): 903-904, 908.
18. 陸燁, 胡國慶, 陸龍喜, 等. 新型消毒劑對內鏡消毒效果的研究. 中華醫院感染學雜志, 2012, 22(12): 2598-2600.
19. 周曉, 李鵬, 韋鍵, 等. 兩種消毒劑對消化內鏡現場消毒效果的比較研究. 中國消毒學雜志, 2013, 30(2): 114-115.
20. 周曉, 李鵬, 韋鍵, 等. 過氧乙酸對消化內鏡消毒效果研究. 中國消毒學雜志, 2013, 30(1): 11-12.

West China Medical Journal

The disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis

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