Effect of triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000 on elderly patients with chronic constipation_West China Medical Journal

Authors：

HE Fuqian , LI Xiaoran ,  HUANG Xiaoli

Center of Gerontology and Geriatrics/National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

HUANG Xiaoli, Email: xiaoxiao334@sina.cn

Keywords：

Triple viable bifidobacterium lactobacillus tablets; Polyethylene glycol 4000; Elderly; Chronic constipation

DOI：

10.7507/1002-0179.201604244

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the effect of triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000 on elderly patients with chronic constipation. Methods This pilot study was conducted at the Center of Gerontology and Geriatrics, West China Hospital. A total of 120 patients with chronic constipation, aged 60 years or older, treated between April 2015 and April 2016 were enrolled, and randomly assigned into group A (polyethylene glycol 4000) and group B (triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000) with 60 patients in each. All the patients were estimated before and after the treatment with Bristol Stool Form Scale (BSFS), Patient Assessment of Constipation Symptom (PAC-SYM) and Constipation Related Disability (CRDS), and the adverse drug reactions were observed. Results In group A, before the treatment, the scores of BSFS, PAC-SYM and CRDS were 1.98±0.77, 37.87±4.12 and 31.03±3.19, respectively; while after the treatment, the scores were 3.87±0.82, 28.55±2.15 and 18.56±1.80, respectively, which were all significantly improved (P<0.05). In group B, before the treatment, the scores of BSFS, PAC-SYM and CRDS were 2.03±0.78, 36.25±4.98 and 30.28±3.56, respectively; while after the treatment, the scores were 4.80±0.75, 19.73±3.42 and 13.80±2.36, respectively, which were all significantly improved (P<0.05). The improvement of constipation in group B was significantly better than that in group A after treatment (P<0.05). There was no adverse drug reaction observed. Conclusion Triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000 may be an effective therapy for elderly patients with chronic constipation.

Citation： HE Fuqian, LI Xiaoran, HUANG Xiaoli. Effect of triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000 on elderly patients with chronic constipation. West China Medical Journal, 2017, 32(12): 1872-1875. doi: 10.7507/1002-0179.201604244 Copy

1.	De Giorgio R, Ruggeri E, Stanghellini V, et al. Chronic constipation in the elderly: a primer for the gastroenterologist. BMC Gastroenterol, 2015, 15:130.
2.	余英. 老年性便秘與腸道菌群失調的相關性及藥物干預性研究. 胃腸病學和肝病學雜志, 2010, 19(12): 1133-1135.
3.	翟力平, 王曉偉. 聚乙二醇 4000 治療老年習慣性便秘療效和安全性觀察. 中國誤診學雜志, 2011, 11(3): 604.
4.	羅馬委員會. 功能性胃腸病羅馬Ⅲ診斷標準. 胃腸病學, 2006, 11(12): 761-765.
5.	Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol, 1997, 32(9): 920-924.
6.	Frank L, Kleinman L, Farup C, et al. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol, 1999, 34(9): 870-877.
7.	Hart SL, Albiani JJ, Crangle CJ, et al. Development and assessment of the constipation-related disability scale. Aliment Pharmacol Ther, 2012, 35(1): 183-192.
8.	Lindberg G, Hamid SS, Malfertheiner PA, et al. World gastroenterology organisation global guideline Constipation. A global perspective. J Clin Gastroenterol, 2011, 45(6): 483-487.
9.	中華醫學會消化病學分會胃腸動力學組. 中華醫學會外科學分會結直腸肛門外科學組.中國慢性便秘診治指南. 胃腸病學, 2013, 18(10): 605-611.
10.	Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science, 2012, 336(686): 1268-1273.
11.	何馥倩, 黃曉麗, 高鳳嬌, 等. 枯草桿菌二聯活菌腸溶膠囊預防老年人抗生素相關性腸道菌群失調的臨床研究. 華西醫學, 2013, 28(1): 83-84.
12.	Holma R, Hongisto SM, Saxelin M, et al. Constipation is relieved more by rye bread than wheat bread or laxatives without increased adverse gastrointestinal effects. J Nutr, 2010, 140(3): 534-541.
13.	劉海寧. 腸道菌群與功能性便秘的研究進展. 復旦學報: 醫學版, 2015, 42(4): 564-568.
14.	Zhao X, Suo HY, Qian Y, et al. Therapeutic effects of Lactobacillus casei Qian treatment in activated carbon-induced constipated mice. Mol Med Rep, 2015, 12(2): 3191-3199.
15.	周思遠, 劉婷, 覃海知, 等. 臨床常用便秘診斷和療效評價量表的特征. 世界華人消化雜志, 2013, 21(25): 2611-2616.

1. De Giorgio R, Ruggeri E, Stanghellini V, et al. Chronic constipation in the elderly: a primer for the gastroenterologist. BMC Gastroenterol, 2015, 15:130.
2. 余英. 老年性便秘與腸道菌群失調的相關性及藥物干預性研究. 胃腸病學和肝病學雜志, 2010, 19(12): 1133-1135.
3. 翟力平, 王曉偉. 聚乙二醇 4000 治療老年習慣性便秘療效和安全性觀察. 中國誤診學雜志, 2011, 11(3): 604.
4. 羅馬委員會. 功能性胃腸病羅馬Ⅲ診斷標準. 胃腸病學, 2006, 11(12): 761-765.
5. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol, 1997, 32(9): 920-924.
6. Frank L, Kleinman L, Farup C, et al. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol, 1999, 34(9): 870-877.
7. Hart SL, Albiani JJ, Crangle CJ, et al. Development and assessment of the constipation-related disability scale. Aliment Pharmacol Ther, 2012, 35(1): 183-192.
8. Lindberg G, Hamid SS, Malfertheiner PA, et al. World gastroenterology organisation global guideline Constipation. A global perspective. J Clin Gastroenterol, 2011, 45(6): 483-487.
9. 中華醫學會消化病學分會胃腸動力學組. 中華醫學會外科學分會結直腸肛門外科學組.中國慢性便秘診治指南. 胃腸病學, 2013, 18(10): 605-611.
10. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science, 2012, 336(686): 1268-1273.
11. 何馥倩, 黃曉麗, 高鳳嬌, 等. 枯草桿菌二聯活菌腸溶膠囊預防老年人抗生素相關性腸道菌群失調的臨床研究. 華西醫學, 2013, 28(1): 83-84.
12. Holma R, Hongisto SM, Saxelin M, et al. Constipation is relieved more by rye bread than wheat bread or laxatives without increased adverse gastrointestinal effects. J Nutr, 2010, 140(3): 534-541.
13. 劉海寧. 腸道菌群與功能性便秘的研究進展. 復旦學報: 醫學版, 2015, 42(4): 564-568.
14. Zhao X, Suo HY, Qian Y, et al. Therapeutic effects of Lactobacillus casei Qian treatment in activated carbon-induced constipated mice. Mol Med Rep, 2015, 12(2): 3191-3199.
15. 周思遠, 劉婷, 覃海知, 等. 臨床常用便秘診斷和療效評價量表的特征. 世界華人消化雜志, 2013, 21(25): 2611-2616.

West China Medical Journal

Effect of triple viable bifidobacterium lactobacillus tablets combined with polyethylene glycol 4000 on elderly patients with chronic constipation

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