Clinical characteristics of 41 cases of primary salivary glandtype lung cancer_West China Medical Journal

Authors：

YANG Liqing ^1,2 ,  YANG Xiaodong ¹ , ZHANG Yi ¹ , HU Qiufang ^1,3 , WANG Yan ¹ , CHEN Xuping ¹ , ZHOU Zhenxing ¹

1. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Respiratory Medicine, the East Rigon of the People’s Hospital of Sichuan, Chengdu, Sichuan 610100, P. R. China;
3. Department of Nursing, Leshan Vocational and Technical College, Leshan, Sichuan 614000, P. R. China;

Corresponding?author：

YANG Xiaodong, Email: yang-xiaodong@163.com

Keywords：

Primary salivary glandtype lung cancer; Clinical features; Rare low-grade malignancy

DOI：

10.7507/1002-0179.201604032

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Objective To enhance the understanding of the primary salivary glandtype lung cancer (PSGLC) and improve the diagnostic rate of the disease. Methods The clinical data of 41 patients with PSGLC pathologically confirmed in West China Hospital between October 2009 and October 2015 were analyzed in terms of clinical features, therapy and prognosis. Results All the 41 patients (21 males and 20 females) accounted for 0.22% (41/18 738) of the primary malignant lung tumor diagnosed in the same period. The patients aged from 16 to 72 with the median age of 43.6. The disease course was 1 month to 6 years, and 12 had smoking history. There were 23 cases of adenoid cystic carcinoma, 15 of mucoepidermoid carcinoma and 3 of acinic cell carcinoma. The symptoms, chest-computed tomography and fiberbronchoscopy examination had no specificity. There were 34 patients who had undergone surgery, in whom 3 had fiberbronchoscopy, 4 had oral traditional Chinese medicine treatment, 5 had chemotherapy and radiotherapy at the same time, 9 received chemotherapy only, and 4 recived radiotherapy only. Follow-up period lasted for 2-65 months, with the median time of 38 months. Two patients had recrudescence, 6 patients had distant metastasis and 1 patient died. Conclusions PSGLC have no specific clinical features; its diagnosis basically rely on pathological examination. After comprehensive treatment mainly on surgery, the prognosis of the disease is better than other malignant lung cancers.

Citation： YANG Liqing, YANG Xiaodong, ZHANG Yi, HU Qiufang, WANG Yan, CHEN Xuping, ZHOU Zhenxing. Clinical characteristics of 41 cases of primary salivary glandtype lung cancer. West China Medical Journal, 2017, 32(6): 857-861. doi: 10.7507/1002-0179.201604032 Copy

1.	楊朝暉, 王建軍, 何燕, 等. 青年人肺原發性涎腺型腫瘤的臨床病理特征及預后. 臨床與實驗病理學雜志, 2015, 31(3): 264-267.
2.	鄭智, 潘鐵成, 趙金平, 等. 涎腺型肺癌的診斷及治療. 中國腫瘤臨床, 2005, 32(12): 694-696.
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5.	吳堅, 趙紹宏, 郭愛桃, 等. 原發涎腺型肺癌的 CT 診斷. 中華腫瘤雜志, 2011, 33(4): 313-316.
6.	Elnayal A, Moran CA, Fox PS, et al. Primary salivary gland-type lung cancer:imagingand clinical. AJR Am J Roentgenol, 2013, 201(1): W57-W63.
7.	陳昊, 王紅霞, 閆蓉, 等. 3 種惡性涎腺上皮性腫瘤 EGFR 和 HER-2 表達的差異及意義. 廣東醫學, 2013, 34(21): 3255-3258.
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9.	Kanematsu T, Yohena T, Uehara T, et al. Treatment outcome of resected and nonresected primary adenoid cystic carcinoma of the lung. Ann Thorac Cardiovasc Surg, 2002, 8(2): 74-77.
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11.	Chopra A, Shim C, Sharma N, et al. Primary salivary type lung tumor: Mucoepidermoid carcinoma. Respir Med Case Rep, 2013, 9(4): 18-20.
12.	Chin CH, Huang CC, Lin MC, et al. Prognostic factors of tracheobronchial mucoepidermoid carcinoma--15 years experience. Respirology, 2008, 13(2): 275-280.
13.	Rivera MP. Lung cancer in women:differences in epidemiology,biology,histology,and treatment outcomes.Semin Respir Crit Care Med, 1994, 34(6): 51-52.
14.	Teo YK. Bronchial mucoepidermoid carcinoma: an unusual cause of complex cystic lung mass in a young man. J Bronchology Interv Pulmonol, 2010, 17(1): 73-75.
15.	Monaco SE, Khalbuss WE, Ustinova E, et al. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: a report of 16 patients. Diagn Cytopathol, 2012, 40(12): 1062-1070.
16.	Brassesco MS, Valera ET, Lira RC, et al. Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings. Pediatr Blood Cancer, 2011, 56(2): 311-313.

1. 楊朝暉, 王建軍, 何燕, 等. 青年人肺原發性涎腺型腫瘤的臨床病理特征及預后. 臨床與實驗病理學雜志, 2015, 31(3): 264-267.
2. 鄭智, 潘鐵成, 趙金平, 等. 涎腺型肺癌的診斷及治療. 中國腫瘤臨床, 2005, 32(12): 694-696.
3. 陸鳴, 柳瑋華. 原發性肺涎腺腫瘤臨床病理特點. 心肺血管病雜志, 2011, 30(5): 420-423.
4. Triantafillidou K, Dimitrakopoulos J, Iordanidis F, et al. Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature. Oral Dis, 2006, 12(4): 364-370.
5. 吳堅, 趙紹宏, 郭愛桃, 等. 原發涎腺型肺癌的 CT 診斷. 中華腫瘤雜志, 2011, 33(4): 313-316.
6. Elnayal A, Moran CA, Fox PS, et al. Primary salivary gland-type lung cancer:imagingand clinical. AJR Am J Roentgenol, 2013, 201(1): W57-W63.
7. 陳昊, 王紅霞, 閆蓉, 等. 3 種惡性涎腺上皮性腫瘤 EGFR 和 HER-2 表達的差異及意義. 廣東醫學, 2013, 34(21): 3255-3258.
8. Molina R, Aubry M, Christine L, et al. Primary salivary glang-type lung cancer-spectrum of clinical presentation histopathologic and factors. Cancer, 2007, 15(11): 2253-2259.
9. Kanematsu T, Yohena T, Uehara T, et al. Treatment outcome of resected and nonresected primary adenoid cystic carcinoma of the lung. Ann Thorac Cardiovasc Surg, 2002, 8(2): 74-77.
10. Zhu F, Liu Z, Hou Y, et al. Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China. J Thorac Oncol, 2013, 8(12): 1578-1584.
11. Chopra A, Shim C, Sharma N, et al. Primary salivary type lung tumor: Mucoepidermoid carcinoma. Respir Med Case Rep, 2013, 9(4): 18-20.
12. Chin CH, Huang CC, Lin MC, et al. Prognostic factors of tracheobronchial mucoepidermoid carcinoma--15 years experience. Respirology, 2008, 13(2): 275-280.
13. Rivera MP. Lung cancer in women:differences in epidemiology,biology,histology,and treatment outcomes.Semin Respir Crit Care Med, 1994, 34(6): 51-52.
14. Teo YK. Bronchial mucoepidermoid carcinoma: an unusual cause of complex cystic lung mass in a young man. J Bronchology Interv Pulmonol, 2010, 17(1): 73-75.
15. Monaco SE, Khalbuss WE, Ustinova E, et al. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: a report of 16 patients. Diagn Cytopathol, 2012, 40(12): 1062-1070.
16. Brassesco MS, Valera ET, Lira RC, et al. Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings. Pediatr Blood Cancer, 2011, 56(2): 311-313.

West China Medical Journal

Clinical characteristics of 41 cases of primary salivary glandtype lung cancer

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