Analysis of Maternal and Infant Outcomes of Pregnant Women with Gestational Diabetes Mellitus_West China Medical Journal

Authors：

 JingXiaofan ¹ , LiuYuan ¹ , RaoZhiyong ¹ , DaiTingting ¹ , LiXuemei ¹ , PuFangfang ¹ ,  HuWen ¹ , QiaoRong ²

1. Department of Clinical Nutrition, West China Hospital;
2. Nutrition Room, West China Second University Hospital;Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

HuWen, Email: wendy_nutrition@163.com

Keywords：

Gestational diabetes mellitus; Diet during pregnancy; Weight gain during the pregnancy; Pregnant outcomes

DOI：

10.7507/1002-0179.20160080

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the relationship between the diet during pregnancy and gestational diabetes mellitus (GDM), and analyze the effect of GDM on weight gain, outcome and complication of mother and infant. Methods We selected 128 GDM pregnant women and 267 non-GDM pregnant women who were investigated by semi-quantitative food frequency method during September 2009 to March 2011. Then, we collected relevant information and the data were analyzed by t-test and chi-square test. Results There were statistically significant differences between the two groups in total calorie, carbohydrate, fat and protein intakes per day (P<0.05). In general, the rates of insufficient weight gain and excessive weight gain during pregnancy in the GDM group were significantly higher than the non-GDM group (P<0.05), while proper weight gain rate was significantly lower (P<0.01). The risk of hydramnion, intrahepatic cholestasis and pregnancy-induced hypertension in the GDM group was significantly higher than the non-GDM group (P<0.05), while there was no significant difference between the two groups in premature delivery, cesarean section or premature membrane ruptures (P>0.05). Apgar scores were significantly different at minute 1 and 5 between the infants in the two groups (P<0.05). The incidence of fetal death, malformation, mild neonatal asphyxia and fetal macrosomia in the GDM group was significantly higher than the non-GDM group (P<0.05). No significant differences between the two groups in low birth weight infant, cord entanglement and fetal distress were detected (P>0.05). Conclusion GDM can lead to high incidence of poor outcome and complication. It is vital to strengthen the examination and keep balanced dietary structure, in order to reduce the complication and improve the health of mother and child.

Citation： JingXiaofan, LiuYuan, RaoZhiyong, DaiTingting, LiXuemei, PuFangfang, HuWen, QiaoRong. Analysis of Maternal and Infant Outcomes of Pregnant Women with Gestational Diabetes Mellitus. West China Medical Journal, 2016, 31(2): 301-305. doi: 10.7507/1002-0179.20160080 Copy

1.	Zhang F, Dong L, Zhang CP, et al. Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008[J]. Diabet Med, 2011, 28(6):652-657.
2.	尹玉竹, 諶小衛, 李小毛, 等. 孕前體重、孕期增重與妊高征及新生兒出生體重的關系[J]. 第一軍醫大學學報, 2005, 25(2):226-228.
3.	武潔姝, 蔭士安. 孕期體重增長與妊娠結局[J]. 中華圍產醫學雜志, 2005, 8(4):282-284.
4.	樂杰. 婦產科學[M]. 7版. 北京:人民衛生出版社, 2008.
5.	周敏, 章小維, 渠川琰, 等. 妊娠期適宜增重范圍與出生體重的關系研究[J]. 中國實用婦科與產科雜志, 2007, 23(4):275-277.
6.	Reece EA. The fetal and maternal consequences of gestational diabetes mellitus[J]. J Matern-Fetal Neonatal Med, 2010, 25(3):199-203.
7.	楊月欣. 中國食物成分表2004[M]. 北京:北京大學醫學出版社, 2005.
8.	李艷平, 何宇納, 翟鳳英, 等. 稱重法、回顧法和食物頻率法評估人群食物攝入量的比較[J]. 中華預防醫學雜志, 2006, 40(4):273-280.
9.	Institute of Medicine. Nutrition during pregnancy:partⅠ:weight gain, partⅡ:Nutrient supplements[M]. Washington DC:National Academy Press, 1990.
10.	Rosenberg TJ, Garbers S, Lipkind H, et al. Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes:differences among 4 racial/etbnic groups[J]. Am J Public Health, 2005, 95(9):1545-1551.
11.	Dennedy MC, Dunne F. The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome[J]. Best Pract Res Clin Endocrinol Metab, 2010, 24(4):573-589.
12.	Stuebe AM, Forman MR, Michels KB. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter[J]. Int J Obes, 2009, 33(7):743-752.
13.	劉鄭潔. 妊娠期糖代謝異常對妊娠結局的影響[J]. 中國婦幼保健, 2010, 25(17):2345-2346.
14.	Yogev Y, Xenakis EM, Langer O. The association between preeclampsia and the severity of gestational diabetes:the impact of glycemic control[J]. Am J Obstet Gynecol, 2004, 191(5):1655-1660.
15.	Vambergue A, Nuttens MC, Goeusse P, et al. Pregnancy induced hypertension in women with gestational carbohydrate intolerance:the diagest study[J]. Eur J Obstet Gynecol Reprod Biol, 2002, 102(1):31-35.
16.	何冰, 李書琴, 王偉, 等. 妊娠期糖尿病患者妊娠晚期血脂水平變化與新生兒出生體重的關系[J]. 中華婦產科雜志, 2004, 39(10):675-677.
17.	Setji TL, Brown AJ, Feinglos MN. Gestational diabetemellitus[J].Clin Diabet[J], 2005, 23(1):17-24.
18.	楊慧霞. 妊娠合并糖尿病對孕婦和圍產兒的影響[J]. 中華醫學信息導報, 2005, 20(3):14-15.
19.	馬向東, 陳必良, 辛曉燕, 等. 妊娠合并糖尿病誘發胚胎先天性神經管缺陷的MAP激酶及細胞凋亡信號傳導機制[J]. 現代婦產科進展, 2003, 12(5):324-326, 335.
20.	Barahona MJ, Sucunza N, García-Patterson A, et al. Period of gestational diabetes mellitus diagnosis and maternal and fetal morbidity[J]. Acta Obstet Gynecol Scand, 2005, 84(7):622-627.
21.	Melamed N, Hod M. Perinatal mortality in pregestational diabetes[J]. Int J Gynaecol Obstet, 2009, 104 (Suppl 1):S20-S24.
22.	杜曉紅, 羅紅權, 常軍. 控制血糖對改善妊娠期糖尿病孕婦妊娠結局的意義[J]. 實用婦產科雜志, 2008, 24(8):501-503.
23.	Greene MF, Solomon CG. Gestational diabetes mellitus-time to treat[J]. N Engl J Med, 2005, 352(24):2544-2546.
24.	李娟, 李和江. 孕期心理干預對妊娠結局的影響[J]. 中國婦幼保健, 2010, 25(16):2199-2200.

1. Zhang F, Dong L, Zhang CP, et al. Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008[J]. Diabet Med, 2011, 28(6):652-657.
2. 尹玉竹, 諶小衛, 李小毛, 等. 孕前體重、孕期增重與妊高征及新生兒出生體重的關系[J]. 第一軍醫大學學報, 2005, 25(2):226-228.
3. 武潔姝, 蔭士安. 孕期體重增長與妊娠結局[J]. 中華圍產醫學雜志, 2005, 8(4):282-284.
4. 樂杰. 婦產科學[M]. 7版. 北京:人民衛生出版社, 2008.
5. 周敏, 章小維, 渠川琰, 等. 妊娠期適宜增重范圍與出生體重的關系研究[J]. 中國實用婦科與產科雜志, 2007, 23(4):275-277.
6. Reece EA. The fetal and maternal consequences of gestational diabetes mellitus[J]. J Matern-Fetal Neonatal Med, 2010, 25(3):199-203.
7. 楊月欣. 中國食物成分表2004[M]. 北京:北京大學醫學出版社, 2005.
8. 李艷平, 何宇納, 翟鳳英, 等. 稱重法、回顧法和食物頻率法評估人群食物攝入量的比較[J]. 中華預防醫學雜志, 2006, 40(4):273-280.
9. Institute of Medicine. Nutrition during pregnancy:partⅠ:weight gain, partⅡ:Nutrient supplements[M]. Washington DC:National Academy Press, 1990.
10. Rosenberg TJ, Garbers S, Lipkind H, et al. Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes:differences among 4 racial/etbnic groups[J]. Am J Public Health, 2005, 95(9):1545-1551.
11. Dennedy MC, Dunne F. The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome[J]. Best Pract Res Clin Endocrinol Metab, 2010, 24(4):573-589.
12. Stuebe AM, Forman MR, Michels KB. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter[J]. Int J Obes, 2009, 33(7):743-752.
13. 劉鄭潔. 妊娠期糖代謝異常對妊娠結局的影響[J]. 中國婦幼保健, 2010, 25(17):2345-2346.
14. Yogev Y, Xenakis EM, Langer O. The association between preeclampsia and the severity of gestational diabetes:the impact of glycemic control[J]. Am J Obstet Gynecol, 2004, 191(5):1655-1660.
15. Vambergue A, Nuttens MC, Goeusse P, et al. Pregnancy induced hypertension in women with gestational carbohydrate intolerance:the diagest study[J]. Eur J Obstet Gynecol Reprod Biol, 2002, 102(1):31-35.
16. 何冰, 李書琴, 王偉, 等. 妊娠期糖尿病患者妊娠晚期血脂水平變化與新生兒出生體重的關系[J]. 中華婦產科雜志, 2004, 39(10):675-677.
17. Setji TL, Brown AJ, Feinglos MN. Gestational diabetemellitus[J].Clin Diabet[J], 2005, 23(1):17-24.
18. 楊慧霞. 妊娠合并糖尿病對孕婦和圍產兒的影響[J]. 中華醫學信息導報, 2005, 20(3):14-15.
19. 馬向東, 陳必良, 辛曉燕, 等. 妊娠合并糖尿病誘發胚胎先天性神經管缺陷的MAP激酶及細胞凋亡信號傳導機制[J]. 現代婦產科進展, 2003, 12(5):324-326, 335.
20. Barahona MJ, Sucunza N, García-Patterson A, et al. Period of gestational diabetes mellitus diagnosis and maternal and fetal morbidity[J]. Acta Obstet Gynecol Scand, 2005, 84(7):622-627.
21. Melamed N, Hod M. Perinatal mortality in pregestational diabetes[J]. Int J Gynaecol Obstet, 2009, 104 (Suppl 1):S20-S24.
22. 杜曉紅, 羅紅權, 常軍. 控制血糖對改善妊娠期糖尿病孕婦妊娠結局的意義[J]. 實用婦產科雜志, 2008, 24(8):501-503.
23. Greene MF, Solomon CG. Gestational diabetes mellitus-time to treat[J]. N Engl J Med, 2005, 352(24):2544-2546.
24. 李娟, 李和江. 孕期心理干預對妊娠結局的影響[J]. 中國婦幼保健, 2010, 25(16):2199-2200.

West China Medical Journal

Analysis of Maternal and Infant Outcomes of Pregnant Women with Gestational Diabetes Mellitus

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content