Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction_West China Medical Journal

Authors：

 HuangJiajun ,  Dulin , WangYongqiang , Wangwei

Department of Neurology, the Second People's Hospital of Neijiang, Neijiang, Sichuan 644100, P. R. China;

Corresponding?author：

Dulin, Email: njyydulin@126.com

Keywords：

Inflammatory factors; Acute cerebral infarction; Multiple linear regression model

DOI：

10.7507/1002-0179.201600542

Video：

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Objective To observe the relationship between the serum level changes of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-18, intercellular adhesion molecule-1(ICAM1), matrix metalloproteinase (MMP)-9 and lipoprotein-associated phospholipase A2(Lp-PLA2), and the multiple factors of acute cerebral infarction (ACI). Methods We chose 76 patients with ACI treated between July 2012 and June 2014 as our study subjects.On the second day (acute phase) and the 15th day (recovery phase) after onset, we checked the patients for their serum levels of hsCRP, IL-18, ICAM1, MMP-9 and Lp-PLA2.Then, multiple linear regression analysis was performed to observe the correlation of the serum level change degree of inflammatory factors with hypertension, diabetes, coronary heart disease, smoking history, carotid atherosclerotic plaque, lipid levels, infarct size and National Institute of Health Stroke Scale (NIHSS) score. Results The changes of all the inflammatory factors in the acute phase and the recovery phase of cerebral infarction were not significantly related to smoking history, hypertension, coronary heart disease, low-density lipoprotein and NIHSS scores (P > 0.05).The changes of hsCRP and ICAM1 had significant correlation with cerebral infarct size, diabetes mellitus and carotid atherosclerotic plaque (P < 0.05), and the change level of Lp-PLA2 was related to diabetes mellitus, and carotid atherosclerotic plaque (P < 0.05).MMP-9 serum level change had correlation with only cerebral infarct size (P < 0.05). Conclusions Serum level changes of inflammatory factors are related to various factors of cerebral infarction.The main factors that affecting the serum level changes are cerebral infarction area, diabetes mellitus and carotid atherosclerosis.

Citation： HuangJiajun, Dulin, WangYongqiang, Wangwei. Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction. West China Medical Journal, 2016, 31(12): 1971-1974. doi: 10.7507/1002-0179.201600542 Copy

1.	Wang PY, Kao CH, Mui MY, et al. Leukocyte infiltration in acute hemispheric ischemic stroke[J]. Stroke, 1993, 24(2):236-240.
2.	Kogure K, Yamasaki Y, Matsuo Y, et al. Inflammation of thebrain after ischemic[J]. Acta Neurochir Suppl, 1996, 66:40-43.
3.	朱春麗, 彭一鵬, 歐陽存, 等.遠端缺血后適應處理對急性腦梗死患者血清促炎因子和抗炎因子的影響及其臨床意義[J].疑難病雜志, 2016, 15(3):241-244.
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8.	畢顯梅, 王永久, 劉坤, 等.急性腦梗死患者頸動脈斑塊穩定性與血漿IL-18、MMP-9的相關性研究[J].中國神經免疫學和神經病學雜志, 2013, 20(4):256-259.
9.	陳線茹, 豆志偉.基質金屬蛋白酶與動脈粥樣硬化病變的關系.心血管病學進展[J]. 2012, 33(3):314-317.
10.	李冰, 姜雪松.腦梗死血清基質金屬蛋白酶-2, 基質金屬蛋白酶-9的動態變化及臨床意義[J].華西醫學, 2015, 30(11):2009-2012.
11.	陶晶, 李志, 劉卉萍.急性腦梗死患者血清基質金屬蛋白酶-9檢測的臨床意義[J].實用醫技雜志, 2011, 18(12):1243-1245.
12.	Kemp EH, Waterman EA, Gawkrodger DJ, et al. Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay[J]. Br J Dermato1, 1998, 139(5):798-805.
13.	劉春燕.血清脂蛋白相關磷脂酶A2及C反應蛋白與頸動脈粥樣硬化斑塊易損性的關系.中華實用診斷與治療雜志, 2014, 28(4):350-352.
14.	Zaremba J, Losy J. Interleukin-18 in acute ischemic stroke patients[J]. Neurol Sci, 2003, 24(3):117-124.
15.	劉勇, 楊國銘.糖尿病合并腦梗死患者超敏C反應蛋白水平與頸動脈粥樣硬化及預后的關系[J].現代中西醫結合雜志, 2012, 21(16):1745-1746.
16.	Mucalo I, Jovanovski E, Rahelic D, et al. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension[J]. J Ethnopharmacol, 2013, 150(1):148-153.

1. Wang PY, Kao CH, Mui MY, et al. Leukocyte infiltration in acute hemispheric ischemic stroke[J]. Stroke, 1993, 24(2):236-240.
2. Kogure K, Yamasaki Y, Matsuo Y, et al. Inflammation of thebrain after ischemic[J]. Acta Neurochir Suppl, 1996, 66:40-43.
3. 朱春麗, 彭一鵬, 歐陽存, 等.遠端缺血后適應處理對急性腦梗死患者血清促炎因子和抗炎因子的影響及其臨床意義[J].疑難病雜志, 2016, 15(3):241-244.
4. 蔣正強, 高金霞.彩色多普勒超聲檢查頸動脈粥樣硬化斑塊與腦梗死的相關性研究[J].臨床醫學, 2010, 30(8):89-90.
5. 黎紅華, 汪志忠, 吳非, 等.腦梗死危險因素與頸動脈粥樣硬化斑塊穩定性及炎性反應因子的關系[J].中國神經免疫學和神經病學雜志, 2011, 18(5):375-376.
6. 王大力, 張江, 張文彥, 等.急性腦梗死患者血清hs-CRP濃度的變化及其臨床意義[J].放射免疫學雜志, 2006, 19(3):241-243.
7. 曲欣, 張競文, 常越, 等.糖尿病高血糖腦缺血再灌注梗死區周圍微小血管病理變化[J].神經解剖學雜志, 2015, 31(4):433-438.
8. 畢顯梅, 王永久, 劉坤, 等.急性腦梗死患者頸動脈斑塊穩定性與血漿IL-18、MMP-9的相關性研究[J].中國神經免疫學和神經病學雜志, 2013, 20(4):256-259.
9. 陳線茹, 豆志偉.基質金屬蛋白酶與動脈粥樣硬化病變的關系.心血管病學進展[J]. 2012, 33(3):314-317.
10. 李冰, 姜雪松.腦梗死血清基質金屬蛋白酶-2, 基質金屬蛋白酶-9的動態變化及臨床意義[J].華西醫學, 2015, 30(11):2009-2012.
11. 陶晶, 李志, 劉卉萍.急性腦梗死患者血清基質金屬蛋白酶-9檢測的臨床意義[J].實用醫技雜志, 2011, 18(12):1243-1245.
12. Kemp EH, Waterman EA, Gawkrodger DJ, et al. Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay[J]. Br J Dermato1, 1998, 139(5):798-805.
13. 劉春燕.血清脂蛋白相關磷脂酶A2及C反應蛋白與頸動脈粥樣硬化斑塊易損性的關系.中華實用診斷與治療雜志, 2014, 28(4):350-352.
14. Zaremba J, Losy J. Interleukin-18 in acute ischemic stroke patients[J]. Neurol Sci, 2003, 24(3):117-124.
15. 劉勇, 楊國銘.糖尿病合并腦梗死患者超敏C反應蛋白水平與頸動脈粥樣硬化及預后的關系[J].現代中西醫結合雜志, 2012, 21(16):1745-1746.
16. Mucalo I, Jovanovski E, Rahelic D, et al. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension[J]. J Ethnopharmacol, 2013, 150(1):148-153.

West China Medical Journal

Study of Correlation between Inflammatory Factors and Multiple Factors of Acute Cerebral Infarction

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