胚胎皮膚無瘢痕愈合的研究進展_West China Medical Journal

Authors：

 胡華 ,  岑瑛

四川大學華西醫院燒傷整形外科（成都 610041）;

Corresponding?author：

岑瑛, Email: cenying0141@163.com

Keywords：

胚胎; 創傷; 無瘢痕愈合

DOI：

10.7507/1002-0179.20160051

Video：

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Abstract Full text Figures/Tables Video References Cited by

早期胚胎皮膚的創傷愈合時間短，傷后無瘢痕遺留，探索其愈合機制對臨床防治瘢痕具有重要意義。盡管無瘢痕愈合的發生機制仍不明確，但近年來隨著研究的深入，成體與胚胎皮膚創傷愈合過程中所表現出的差異逐漸被發現。現就胚胎成長環境、炎癥、細胞因子、細胞外基質、基因表達等方面對胚胎無瘢痕愈合的可能機制作出闡述。

Citation： 胡華, 岑瑛. 胚胎皮膚無瘢痕愈合的研究進展. West China Medical Journal, 2016, 31(1): 184-187. doi: 10.7507/1002-0179.20160051 Copy

1.	Burrington JD. Wound healing in the fetal lamb[J]. J Pediatr Surg, 1971, 6(5):523-528.
2.	Longaker MT, Whitby DJ, Ferguson MW, et al. Adult skin wounds in the fetal environment heal with scar formation[J]. Ann Surg, 1994, 219(1):65-72.
3.	夏揚, 張敏, 徐光, 等. 有關瘢痕形成機制研究:不同皮膚成纖維細胞對羊水的反應[J]. 中國臨床康復, 2004, 8(32):7190-7191.
4.	李鵬, 王志國. 機械張力參與病理性瘢痕形成的研究進展[J]. 中國美容整形外科雜志, 2013, 24(11):655-657.
5.	Frantz FW, Bettinger DA, Haynes JH, et al. Biology of fetal repair:the presence of bacteria in fetal wounds induces an adult-like healing response[J]. J Pediatr Surg, 1993, 28(3):428-433; discussion 433-434.
6.	Ashcroft GS, Yang X, Glick AB, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response[J]. Nat Cell Biol, 1999, 1(5):260-266.
7.	Thomas BL, Krummel TM, Melang M, et al. Collagen synthesis and type expression by fetal fibroblasts in vitro[J]. Surg Forum, 1988, 39:642.
8.	Clark RAF. Wound repair:overview and general considerations[M]//Clark RAF. The molecular and cellular biology of wound repair. 2nd ed. New York:Plenum Press, 1996:3-50.
9.	章伏生, 陸樹良. 肌成纖維細胞在皮膚瘢痕形成過程中的作用[J]. 中華創傷雜志, 2009, 25(12):1106-1109.
10.	Akita S, Akino K, Hirano A. Basic fibroblast growth factor in scarless wound healing[J]. Adv Wound Care (New Rochelle), 2013, 2(2): 44-49.
11.	Abe M, Yokoyama Y, Ishikawa O. A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing:the induction of myofibroblast apoptosis[J]. Eur J Dermatol, 2012, 22(1):46-53.
12.	宋慧鋒, 柴家科, 林子豪, 等. 胎兒和成人皮膚及其創面愈合過程中堿性成纖維細胞生長因子的表達及意義[J]. 中國修復重建外科雜志, 2003, 17(4):298-300.
13.	Krummel TM, Michna BA, Thomas BL, et al. Transforming growth factor beta (TGF-beta) induces fibrosis in a fetal wound model[J]. J Pediatr Surg, 1988, 23(7):647-652.
14.	Liechty KW, Adzick NS, Crombleholme TM. Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair[J]. Cytokine, 2000, 12(6):671-676.
15.	Expert Dyslipidemia Panel, Grundy SM. An international atherosclerosis society position paper:global recommendations for the management of dyslipidemia[J]. J Clin Lipidol, 2013, 7(6): 561-565.
16.	Bouabe H, Liu Y, Moser M, et al. Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo[J]. J Immunol, 2011, 187(6):3165-3176.
17.	Liechty KW, Kim HB, Adzick NS, et al. Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair[J]. J Pediatr Surg, 2000, 35(6):866-872; discussion 872-873.
18.	Leung A, Balaji S, Le LD, et al. Interleukin-10 and hyaluronan are essential to the fetal fibroblast functional phenotype[J]. J Surg Res, 2013, 179(2):257-258.
19.	Antoniades HN, Galanopoulos T, Neville-Golden J, et al. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts[J]. Proc Natl Acad Sci USA, 1991, 88(2):565-569.
20.	石慧娟, 程基焱. 細胞因子與胚胎皮膚無瘢痕愈合[J]. 四川解剖學雜志, 2008, 16(1):38-41.
21.	Longaker MT, Chiu ES, Adzick NS, et al. Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid[J]. Ann Surg, 1991, 213(4):292-296.
22.	Mast BA, Flood LC, Haynes JH, et al. Hyaluronic acid is a major component of the matrix of fetal rabbit skin and wounds:implications for healing by regeneration[J]. Matrix, 1991, 11(1): 63-68.
23.	Mast BA, Diegelmann RF, Krummel TM, et al. Hyaluronic acid modulates proliferation, collagen and protein synthesis of cultured fetal fibroblasts[J]. Matrix, 1993, 13(6):441-446.
24.	Longaker MT, Whitby DJ, Jennings RW, et al. Fetal diaphragmatic wounds heal with scar formation[J]. J Surg Res, 1991, 50(4): 375-385.
25.	Whitby DJ, Longaker MT, Harrison MR, et al. Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin[J]. J Cell Sci, 1991, 99(Pt 3):583-586.
26.	Smith LT, Holbrook KA, Madri JA. Collagen types Ⅰ, Ⅲ, and Ⅴ in human embryonic and fetal skin[J]. Am J Anat, 1986, 175(4):507-521.
27.	Cheng J, Yu H, Deng S, et al. MicroRNA profiling in mid- and late-gestational fetal skin:implication for scarless wound healing[J]. Tohoku J Exp Med, 2010, 221(3):203-209.
28.	Suárez Y, Wang C, Manes TD, et al. Cutting edge:TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells:feedback control of inflammation[J]. J Immunol, 2010, 184(1): 21-25.
29.	Colwell AS, Longaker MT, Peter Lorenz H. Identification of differentially regulated genes in fetal wounds during regenerative repair[J]. Wound Repair Regen, 2008, 16(3):450-459.
30.	Lo DD, Zimmermann AS, Nauta A, et al. Scarless fetal skin wound healing update[J]. Birth Defects Res C Embryo Today, 2012, 96(3):237-247.
31.	Stelnicki EJ, Arbeit J, Cass DL, et al. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds[J]. J Invest Dermatol, 1998, 111(1):57-63.
32.	Mack JA, Abramson SR, Ben Y, et al. Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing[J]. FASEB J, 2003, 17(10):1352-1354.
33.	吳志遠, 郭曉瑞, 黃海華, 等. 胎兒和成人皮膚相關基因的差異表達[J]. 中國組織工程研究與臨床康復, 2011, 15(2):286-289.
34.	Wang ZL, Inokuchi T, Ikeda H, et al. Collagen-binding heat shock protein HSP47 expression during healing of fetal skin wounds[J]. Int J Oral Maxillofac Surg, 2002, 31(2):179-184.
35.	Jantschitsch C, Kindas-Mügge I, Metze D, et al. Expression of the small heat shock protein HSP 27 in developing human skin[J]. Br J Dermatol, 1998, 139(2):247-253.

1. Burrington JD. Wound healing in the fetal lamb[J]. J Pediatr Surg, 1971, 6(5):523-528.
2. Longaker MT, Whitby DJ, Ferguson MW, et al. Adult skin wounds in the fetal environment heal with scar formation[J]. Ann Surg, 1994, 219(1):65-72.
3. 夏揚, 張敏, 徐光, 等. 有關瘢痕形成機制研究:不同皮膚成纖維細胞對羊水的反應[J]. 中國臨床康復, 2004, 8(32):7190-7191.
4. 李鵬, 王志國. 機械張力參與病理性瘢痕形成的研究進展[J]. 中國美容整形外科雜志, 2013, 24(11):655-657.
5. Frantz FW, Bettinger DA, Haynes JH, et al. Biology of fetal repair:the presence of bacteria in fetal wounds induces an adult-like healing response[J]. J Pediatr Surg, 1993, 28(3):428-433; discussion 433-434.
6. Ashcroft GS, Yang X, Glick AB, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response[J]. Nat Cell Biol, 1999, 1(5):260-266.
7. Thomas BL, Krummel TM, Melang M, et al. Collagen synthesis and type expression by fetal fibroblasts in vitro[J]. Surg Forum, 1988, 39:642.
8. Clark RAF. Wound repair:overview and general considerations[M]//Clark RAF. The molecular and cellular biology of wound repair. 2nd ed. New York:Plenum Press, 1996:3-50.
9. 章伏生, 陸樹良. 肌成纖維細胞在皮膚瘢痕形成過程中的作用[J]. 中華創傷雜志, 2009, 25(12):1106-1109.
10. Akita S, Akino K, Hirano A. Basic fibroblast growth factor in scarless wound healing[J]. Adv Wound Care (New Rochelle), 2013, 2(2): 44-49.
11. Abe M, Yokoyama Y, Ishikawa O. A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing:the induction of myofibroblast apoptosis[J]. Eur J Dermatol, 2012, 22(1):46-53.
12. 宋慧鋒, 柴家科, 林子豪, 等. 胎兒和成人皮膚及其創面愈合過程中堿性成纖維細胞生長因子的表達及意義[J]. 中國修復重建外科雜志, 2003, 17(4):298-300.
13. Krummel TM, Michna BA, Thomas BL, et al. Transforming growth factor beta (TGF-beta) induces fibrosis in a fetal wound model[J]. J Pediatr Surg, 1988, 23(7):647-652.
14. Liechty KW, Adzick NS, Crombleholme TM. Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair[J]. Cytokine, 2000, 12(6):671-676.
15. Expert Dyslipidemia Panel, Grundy SM. An international atherosclerosis society position paper:global recommendations for the management of dyslipidemia[J]. J Clin Lipidol, 2013, 7(6): 561-565.
16. Bouabe H, Liu Y, Moser M, et al. Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo[J]. J Immunol, 2011, 187(6):3165-3176.
17. Liechty KW, Kim HB, Adzick NS, et al. Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair[J]. J Pediatr Surg, 2000, 35(6):866-872; discussion 872-873.
18. Leung A, Balaji S, Le LD, et al. Interleukin-10 and hyaluronan are essential to the fetal fibroblast functional phenotype[J]. J Surg Res, 2013, 179(2):257-258.
19. Antoniades HN, Galanopoulos T, Neville-Golden J, et al. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts[J]. Proc Natl Acad Sci USA, 1991, 88(2):565-569.
20. 石慧娟, 程基焱. 細胞因子與胚胎皮膚無瘢痕愈合[J]. 四川解剖學雜志, 2008, 16(1):38-41.
21. Longaker MT, Chiu ES, Adzick NS, et al. Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid[J]. Ann Surg, 1991, 213(4):292-296.
22. Mast BA, Flood LC, Haynes JH, et al. Hyaluronic acid is a major component of the matrix of fetal rabbit skin and wounds:implications for healing by regeneration[J]. Matrix, 1991, 11(1): 63-68.
23. Mast BA, Diegelmann RF, Krummel TM, et al. Hyaluronic acid modulates proliferation, collagen and protein synthesis of cultured fetal fibroblasts[J]. Matrix, 1993, 13(6):441-446.
24. Longaker MT, Whitby DJ, Jennings RW, et al. Fetal diaphragmatic wounds heal with scar formation[J]. J Surg Res, 1991, 50(4): 375-385.
25. Whitby DJ, Longaker MT, Harrison MR, et al. Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin[J]. J Cell Sci, 1991, 99(Pt 3):583-586.
26. Smith LT, Holbrook KA, Madri JA. Collagen types Ⅰ, Ⅲ, and Ⅴ in human embryonic and fetal skin[J]. Am J Anat, 1986, 175(4):507-521.
27. Cheng J, Yu H, Deng S, et al. MicroRNA profiling in mid- and late-gestational fetal skin:implication for scarless wound healing[J]. Tohoku J Exp Med, 2010, 221(3):203-209.
28. Suárez Y, Wang C, Manes TD, et al. Cutting edge:TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells:feedback control of inflammation[J]. J Immunol, 2010, 184(1): 21-25.
29. Colwell AS, Longaker MT, Peter Lorenz H. Identification of differentially regulated genes in fetal wounds during regenerative repair[J]. Wound Repair Regen, 2008, 16(3):450-459.
30. Lo DD, Zimmermann AS, Nauta A, et al. Scarless fetal skin wound healing update[J]. Birth Defects Res C Embryo Today, 2012, 96(3):237-247.
31. Stelnicki EJ, Arbeit J, Cass DL, et al. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds[J]. J Invest Dermatol, 1998, 111(1):57-63.
32. Mack JA, Abramson SR, Ben Y, et al. Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing[J]. FASEB J, 2003, 17(10):1352-1354.
33. 吳志遠, 郭曉瑞, 黃海華, 等. 胎兒和成人皮膚相關基因的差異表達[J]. 中國組織工程研究與臨床康復, 2011, 15(2):286-289.
34. Wang ZL, Inokuchi T, Ikeda H, et al. Collagen-binding heat shock protein HSP47 expression during healing of fetal skin wounds[J]. Int J Oral Maxillofac Surg, 2002, 31(2):179-184.
35. Jantschitsch C, Kindas-Mügge I, Metze D, et al. Expression of the small heat shock protein HSP 27 in developing human skin[J]. Br J Dermatol, 1998, 139(2):247-253.

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