微RNA在脊髓損傷中的作用及研究進展_West China Medical Journal

Authors：

 賀琴琴 ,  王廷華 , 羅朝志

四川大學華西醫院麻醉科（成都 610041）;

Corresponding?author：

王廷華, Email: tinghua_neuron@263.net

Keywords：

微RNA; 脊髓損傷; 調控

DOI：

10.7507/1002-0179.201600490

Video：

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Abstract Full text Figures/Tables Video References Cited by

脊髓損傷是一種全球高發病率、高致殘性和高死亡率的中樞神經系統疾病，不僅嚴重降低患者的生存質量，還給家庭、社會帶來巨大的負擔。脊髓損傷后的細胞應答和生物化學紊亂等病理改變主要依賴于特異性基因的表達或抑制。而微RNA（miRNA）在脊髓損傷后基因表達起著重要的開關作用。miRNA是真核生物中的一類由內源基因編碼的長度為18～25個核苷酸的非編碼RNA。它們在轉錄后水平調控基因表達，在脊椎動物脊髓損傷后病理調控中起重要作用。miRNA能成為調控細胞狀態和分子機制，提高脊髓損傷后功能恢復的有效治療工具。該文主要就miRNA在脊髓損傷后的表達變化及其在脊髓損傷后病理改變過程中的作用予以綜述，探討基于miRNA治療脊髓損傷的可行性，以期改善脊髓損傷的臨床預后。

Citation： 賀琴琴, 王廷華, 羅朝志. 微RNA在脊髓損傷中的作用及研究進展. West China Medical Journal, 2016, 31(10): 1782-1789. doi: 10.7507/1002-0179.201600490 Copy

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