Research on the Correlation between Nonalcoholic Fatty Liver Disease and Helicobacter pylori_West China Medical Journal

Authors：

 GuoLilin , LuMengjie , HeMin , WuQinqin ,  WangYoujuan

Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

WangYoujuan, Email: yjwang1963@163.com

Keywords：

Nonalcoholic fatty liver disease; Helicobacter pylori; Correlation

DOI：

10.7507/1002-0179.201600458

Video：

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Objective To investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and Helicobacter pylori (HP) infection. Methods Medical examination data of healthy physical examination participates who underwent carbon 14 urea breath test for detection of HP and abdominal ultrasound examination between March and June 2015 were analyzed. Cross sectional analysis was carried out. Based on the diagnostic criteria of NAFLD, the subjects were divided into two groups: NAFLD group and normal control group. HP infection was compared between the two groups. Logistics regression analysis was performed to analyze the relationship between HP infection and NAFLD. Results The proportion of men, age, weight, body mass index (BMI), waistline, alanine aminotransferase (ALT), aspartate aminotransferase, glutamyl transferase, albumin, fasting blood-glucose (GLU), total cholesterol triacylglycerol (TG), low density lipoprotein-cholesterol, and blood pressure were all significantly higher in the NAFLD group than the control group (P < 0.05), while height and high density lipoprotein-cholesterol were significantly lower in the NAFLD group (P < 0.05). The detection rate of NAFLD in males was higher than that in females. The detection rates of NAFLD in different age groups were significantly different, and the highest detection rate of NAFLD was in the age group of 50-59 years old (P < 0.05). The rate of HP infection was not significantly different in subjects of different ages and genders (P > 0.05). The rate of HP infection in the NAFLD group was significantly higher than those of the control group in age groups of 18-29, 30-39, 40-49, 50-59, and 70-79 years old (P < 0.05). The logistic regression analysis revealed that age, HP infection, TG, ALT, BMI, GLU, and diastolic pressure were correlated with NAFLD (P < 0.05). Conclusion HP infection may be a risk factor in the development of NAFLD.

Citation： GuoLilin, LuMengjie, HeMin, WuQinqin, WangYoujuan. Research on the Correlation between Nonalcoholic Fatty Liver Disease and Helicobacter pylori. West China Medical Journal, 2016, 31(10): 1667-1670. doi: 10.7507/1002-0179.201600458 Copy

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2.	Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association[J]. Hepatology, 2012, 55(6): 2005-2023.
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7.	中華醫學會肝病學分會脂肪肝和酒精性肝病學組.非酒精性脂肪性肝病診療指南[J].肝臟, 2006, 11(1): 68-70.
8.	中華醫學會消化病學分會幽門螺桿菌學組/全國幽門螺桿菌研究協作組, 劉文忠, 謝勇, 等.第四次全國幽門螺桿菌感染處理共識報告[J].中華消化雜志, 2012, 32(10): 655-661.
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10.	Suzuki H, Franceschi F, Nishizawa T, et al. Extragastric manifestations of Helicobacter pylori infection[J]. Helicobacter, 2011, 16(Suppl 1): 65-69.
11.	Huang B, Chen Y, Xie Q, et al. CagA-positive Helicobacter pylori strains enhanced coronary atherosclerosis by increasing serum OxLDL and HsCRP in patients with coronary heart disease[J]. Dig Dis Sci, 2011, 56(1): 109-114.
12.	Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoimmune diseases[J]. Oral Dis, 2011, 17(7): 621-627.
13.	Gen R, Demir M, Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation[J]. South Med J, 2010, 103(3): 190-196.
14.	Park MJ, Choi SH, Kim D, et al. Association between Helicobacter pylori seropositivity and the coronary artery calcium score in a screening population[J]. Gut Liver, 2011, 5(3): 321-327.
15.	Kucukazman M, Yavuz B, Sacikara M, et al. The relationship between updated Sydney System score and LDL cholesterol levels in patients infected with Helicobacter pylori[J]. Dig Dis Sci, 2009, 54(3): 604-607.

1. Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace[J]. J Hepatol, 2012, 56(6): 1384-1391.
2. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association[J]. Hepatology, 2012, 55(6): 2005-2023.
3. 陳燕凌, 葉敬文, 佘菲菲, 等.原發性肝細胞癌病人肝組織中螺桿菌的檢測與分析[J].中華肝膽外科雜志, 2007, 13(10): 667-671.
4. Polyzos SA, Kountouras J, Zavos C. Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines[J]. Curr Mol Med, 2009, 9(3): 299-314.
5. Takuma Y. Helicobacter pylori infection and liver diseases[J]. Gan To Kagaku Ryoho, 2011, 38(3): 362-364.
6. Polyzos SA, Kountouras J, Papatheodorou A, et al. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease[J]. Metabolism, 2013, 62(1): 121-126.
7. 中華醫學會肝病學分會脂肪肝和酒精性肝病學組.非酒精性脂肪性肝病診療指南[J].肝臟, 2006, 11(1): 68-70.
8. 中華醫學會消化病學分會幽門螺桿菌學組/全國幽門螺桿菌研究協作組, 劉文忠, 謝勇, 等.第四次全國幽門螺桿菌感染處理共識報告[J].中華消化雜志, 2012, 32(10): 655-661.
9. Figura N, Franceschi F, Santucci A, et al. Extragastric manifestations of Helicobacter pylori infection[J]. Helicobacter, 2010, 15(Suppl 1): 60-68.
10. Suzuki H, Franceschi F, Nishizawa T, et al. Extragastric manifestations of Helicobacter pylori infection[J]. Helicobacter, 2011, 16(Suppl 1): 65-69.
11. Huang B, Chen Y, Xie Q, et al. CagA-positive Helicobacter pylori strains enhanced coronary atherosclerosis by increasing serum OxLDL and HsCRP in patients with coronary heart disease[J]. Dig Dis Sci, 2011, 56(1): 109-114.
12. Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoimmune diseases[J]. Oral Dis, 2011, 17(7): 621-627.
13. Gen R, Demir M, Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation[J]. South Med J, 2010, 103(3): 190-196.
14. Park MJ, Choi SH, Kim D, et al. Association between Helicobacter pylori seropositivity and the coronary artery calcium score in a screening population[J]. Gut Liver, 2011, 5(3): 321-327.
15. Kucukazman M, Yavuz B, Sacikara M, et al. The relationship between updated Sydney System score and LDL cholesterol levels in patients infected with Helicobacter pylori[J]. Dig Dis Sci, 2009, 54(3): 604-607.

West China Medical Journal

Research on the Correlation between Nonalcoholic Fatty Liver Disease and Helicobacter pylori

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