Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis_West China Medical Journal

Authors：

 ZhongChao , YeHua , TuYujian

Department of Traditional Chinese Medicine Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Tenghuangjiangu tablets

DOI：

10.7507/1002-0179.201600322

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Objective To evaluate the therapeutic effect of glucosamine hydrochloride combined with Tenghuangjiangu tablets on knee osteoarthritis. Methods From August 2012 to February 2014, 180 patients with knee osteoarthritis were randomly divided into three groups with 60 in each. Patients in group A were treated with glucosamine hydrochloride; patients in group B were treated with Tenghuangjiangu tablets; and patients in group C were treated with the combination of glucosamine hydrochloride and Tenghuangjiangu tablets. After the 12-week treatment, clinical efficacy and safety of the treatment were observed and compared with those before the treatment. Results The twenty-meter walking pain, Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and the joint tenderness in the three groups 12 weeks after the treatment and 4 weeks after withdrawal improved obviously compared with those before the treatment (P<0.05), and the difference between the results of 12 weeks after treatment and 4 weeks after withdrawal was not significant (P>0.05). The improvement in group C was better than both group A and B with significant differences (P<0.05), while the difference between group A and B was not significant (P>0.05). There was no obvious abnormal routine blood and urine test result or damage of liver and lung functions during the treatment in all the three groups. Twelve weeks after treatment, six patients with abdominal ache were found in group A with an incidence of 10.0%; 5 abdominal ache and 2 diarrhea were in group B with a rate of 12.5%; and 4 abdominal ache and 3 diarrhea were in group C with a rate of 12.5%. All the patients completed the treatment. No significant difference in the incidence of adverse reactions was found among the three groups (P>0.05). Conclusion The therapeutic effect of combined glucosamine hydrochloride and Tenghuangjiangu tablets is obvious on knee osteoarthritis with low incidence of adverse reactions.

Citation： ZhongChao, YeHua, TuYujian. Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1181-1184. doi: 10.7507/1002-0179.201600322 Copy

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1. 中華醫學會風濕病學分會. 骨關節炎診斷及診治指南[J]. 中華風濕病學雜志, 2010, 14(6):416-419.
2. Loeser RC. Osteoarthritis:a disease of the joint as an organ[J]. Arthritis Rheum, 2012, 64(6):1697-1707.
3. Arnold EL, Arnold WJ. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis[J]. J Am Acad Orthop Surg, 2001, 9(5):352-353.
4. Zhao HY, Huang YZ, Zhang J, et al. Clinical observation of compound recipe Rhizoma Corydalis Decumbentis for the treatment of knee osteoarthritis[J]. Strait Pharm J, 2011, 23(6):101-103.
5. 中華醫學會骨科分會. 骨關節炎診治指南(2007年版)[J]. 中華骨科雜志, 2007, 27(10):793-796.
6. 鄭莜萸. 中藥新藥臨床研究指導原則[M]. 北京:中國醫藥科技出版社, 2005:349-353.
7. 國家中醫藥管理局. 中醫病證診斷療效標準[M]. 南京:南京大學出版社, 1994:30-31.
8. Lawrence JS. Rheumatism in population[M]. London:William Heinemann Med Book LTD, 1997:153.
9. 蔣協遠, 王大偉. 骨科臨床療效評價標準[M]. 北京:人民衛生出版社, 2005:275-277.
10. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Ⅰ. Conceptual framework and item selection[J]. Med Care, 1992, 30(6):473-483.
11. van den Berg WB. Osteoarthritis year 2010 in review:pathomechanisms[J]. Osteoarthritis Cartilage, 2011, 19(4):338-341.
12. Mahendira D, Towheed TE. Systematic review of non-surgical therapies for osteoarthritis of the hand:an update[J]. Osteoarthritis Cartilage, 2009, 17(10):1263-1268.
13. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
14. Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3):293-299.
15. 李方, 龐學豐. 三痹湯治療類風濕性關節炎30例[J]. 陜西中醫, 2008, 29(8):996-997.
16. 張波, 盧敏, 唐盾. 藤黃健骨片治療椎動脈型頸椎病臨床療效觀察[J]. 中國現代藥物應用, 2010, 4(16):171-172.
17. 張波, 盧敏, 唐盾. 藤黃健骨片、玻璃酸鈉聯用與單用玻璃酸鈉治療骨性關節炎療效比較[J]. 中國當代醫藥, 2010, 17(17):67-68.
18. 周洪保, 張曦, 呂正祥. 膝關節骨性關節炎治療進展[J]. 中醫藥導報, 2012, 18(2):87-89.

West China Medical Journal

Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis

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