Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis_West China Medical Journal

Authors：

 WangWenzhi ¹ , XuJian ¹ , WangLu ¹ , LiuZhonghua ²

1. Department of Osteoporosis, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Geriatrics, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Vitamin D; Calcium; Medication

DOI：

10.7507/1002-0179.201600321

Video：

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Objective To explore the therapeutic effect of glucosamine hydrochloride combined with calcium and vitamin D on knee osteoarthritis. Methods A total of 120 female outpatients with knee osteoarthritis from January 2014 to January 2015 were selected. The patients were randomly divided into study group and control group (60 patients in each group) according to their treatment sequence. The patients in the study group were given oral calcium citrate, alfacalcidol and glucosamine hydrochloride while those in the control group were given glucosamine hydrochloride only. Both groups were investigated and scored by Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire before and three and six months after treatment. Results Three and six months after the treatment, WOMAC scores of both groups were lower than those before the treatment with significant differences (P<0.05). Three months after the treatment, WOMAC scores between the two groups didn't differ much (P>0.05), while the difference between the two groups was significant 6 months after the treatment (P<0.05). Three months after the treatment, the difference of total effective rate in the study group (43.3%) and control group (41.7%) was not significant (P>0.05), while the rate in the study group (65.0%) was obviously higher than that in the control group (46.7%) 6 months after the treatment (P<0.05). Conclusion Glucosamine hydrochloride has exact effect on knee osteoarthritis. There are differences in the therapeutic effect on knee osteoarthritis between glucosamine hydrochloride combined with calcium and vitamin D and glucosamine hydrochloride alone after six-month treatment.

Citation： WangWenzhi, XuJian, WangLu, LiuZhonghua. Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1178-1180. doi: 10.7507/1002-0179.201600321 Copy

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2.	余衛, 徐苓, 秦明偉, 等. 北京市城區老年人膝關節骨關節炎流行病學調查——與美國白種人膝關節骨關節炎的臨床和X線比較分析[J]. 中華放射學雜志, 2005, 39(1):67-71.
3.	高萬里, 吳立生, 訾金花, 等. 女性膝骨性關節與雌二醇及其代謝產物的關系[J]. 中華實驗外科雜志, 2014, 31(3):662-665.
4.	Pendleton A, Arden N, Dougados M, et al. EULAR recommendations for the management of knee osteoarthritis:report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)[J]. Ann Rheum Dis, 2000, 59(12):936-944.
5.	趙鑒非, Fornasier VL. 組織形態計量學方法測定骨性關節炎股骨頭骨密度[J]. 中華外科雜志, 2003, 41(5):354-358.
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7.	Kanis JA, Melton L, Christiansen C, et al. The diagnosis of osteoporosis[J]. J Bone Miner Res, 1994, 9(8):1137-1141.
8.	Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J]. J Rheumatol, 1988, 15(12):1833-1840.
9.	Langley GB, Sheppeard H. Problems associated with pain measurement in arthritis:comparison of the visual analogue and verbal rating scales[J]. Clin Exp Rheumatol, 1985, 2(3):231-234.
10.	Reginster JY, Bruyere O, Neuprez A. Current role of glucosamine in the treatment of osteoarthritis[J]. Rheumatology (Oxford), 2007, 46(5):731-735.
11.	羅群英, 廖燕群, 葉虹. 氨基葡萄糖聯合醋氯酸腸溶膠囊治療骨關節炎的療效觀察[J]. 國際醫藥衛生導報, 2010, 16(3):319-320.
12.	高山, 劉少楠, 王傳林, 等. 鹽酸氨基葡萄糖膠囊聯合氯諾昔康片治療膝骨關節炎的臨床研究[J]. 國際醫藥衛生導報, 2013, 19(17):2728-2731.
13.	楊雪生. 硫酸氨基葡萄糖聯合仙靈骨葆治療骨關節炎臨床觀察[J]. 中國基層醫藥, 2013, 20(9):1371-1373.
14.	王昆, 朱蕾, 劉斌, 等. 硫酸氨基葡萄糖和透明質酸鈉治療髕股關節骨關節炎的研究[J]. 解剖與臨床, 2008, 13(6):418-420.
15.	馬哲, 馮浩, 梁佳慧. 中西醫結合治療膝關節骨性關節炎療效觀察[J]. 中國醫藥, 2011, 6(8):970-971.
16.	Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis:a longitudinal study[J]. Arthritis Rheum, 1999, 42(5):854-860.
17.	Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee:a randomized controlled pilot trial[J]. Clin Orthop Relat Res, 2013, 471(11):3556-3562.
18.	Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults:a 5-year longitudinal study[J]. Ann Rheum Dis, 2014, 73(4):697-703.
19.	Solovieva S, Hirvonen A, Siivola P, et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women[J]. Arthritis Res Ther, 2006, 8(1):R20.
20.	Khodyrev VN, Beketova NA, Kodentsova VM, et al. The influence of the vitamin-mineral complex upon the blood vitamin, calcium and phosphorus of patients with ostreoarthrosis[J]. Vopr Pitan, 2006, 75(2):44-47.

1. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee:2000 update[J]. Arthritis Rheum, 2000, 43(9):1905-1915.
2. 余衛, 徐苓, 秦明偉, 等. 北京市城區老年人膝關節骨關節炎流行病學調查——與美國白種人膝關節骨關節炎的臨床和X線比較分析[J]. 中華放射學雜志, 2005, 39(1):67-71.
3. 高萬里, 吳立生, 訾金花, 等. 女性膝骨性關節與雌二醇及其代謝產物的關系[J]. 中華實驗外科雜志, 2014, 31(3):662-665.
4. Pendleton A, Arden N, Dougados M, et al. EULAR recommendations for the management of knee osteoarthritis:report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)[J]. Ann Rheum Dis, 2000, 59(12):936-944.
5. 趙鑒非, Fornasier VL. 組織形態計量學方法測定骨性關節炎股骨頭骨密度[J]. 中華外科雜志, 2003, 41(5):354-358.
6. 邱貴興. 骨關節炎診治指南(2007年版)[J]. 中國臨床醫生雜志, 2007, 27(10):793.
7. Kanis JA, Melton L, Christiansen C, et al. The diagnosis of osteoporosis[J]. J Bone Miner Res, 1994, 9(8):1137-1141.
8. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J]. J Rheumatol, 1988, 15(12):1833-1840.
9. Langley GB, Sheppeard H. Problems associated with pain measurement in arthritis:comparison of the visual analogue and verbal rating scales[J]. Clin Exp Rheumatol, 1985, 2(3):231-234.
10. Reginster JY, Bruyere O, Neuprez A. Current role of glucosamine in the treatment of osteoarthritis[J]. Rheumatology (Oxford), 2007, 46(5):731-735.
11. 羅群英, 廖燕群, 葉虹. 氨基葡萄糖聯合醋氯酸腸溶膠囊治療骨關節炎的療效觀察[J]. 國際醫藥衛生導報, 2010, 16(3):319-320.
12. 高山, 劉少楠, 王傳林, 等. 鹽酸氨基葡萄糖膠囊聯合氯諾昔康片治療膝骨關節炎的臨床研究[J]. 國際醫藥衛生導報, 2013, 19(17):2728-2731.
13. 楊雪生. 硫酸氨基葡萄糖聯合仙靈骨葆治療骨關節炎臨床觀察[J]. 中國基層醫藥, 2013, 20(9):1371-1373.
14. 王昆, 朱蕾, 劉斌, 等. 硫酸氨基葡萄糖和透明質酸鈉治療髕股關節骨關節炎的研究[J]. 解剖與臨床, 2008, 13(6):418-420.
15. 馬哲, 馮浩, 梁佳慧. 中西醫結合治療膝關節骨性關節炎療效觀察[J]. 中國醫藥, 2011, 6(8):970-971.
16. Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis:a longitudinal study[J]. Arthritis Rheum, 1999, 42(5):854-860.
17. Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee:a randomized controlled pilot trial[J]. Clin Orthop Relat Res, 2013, 471(11):3556-3562.
18. Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults:a 5-year longitudinal study[J]. Ann Rheum Dis, 2014, 73(4):697-703.
19. Solovieva S, Hirvonen A, Siivola P, et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women[J]. Arthritis Res Ther, 2006, 8(1):R20.
20. Khodyrev VN, Beketova NA, Kodentsova VM, et al. The influence of the vitamin-mineral complex upon the blood vitamin, calcium and phosphorus of patients with ostreoarthrosis[J]. Vopr Pitan, 2006, 75(2):44-47.

West China Medical Journal

Therapeutic Effect of Glucosamine Hydrochloride Combined with Calcium and Vitamin D on Knee Osteoarthritis

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