Research on the Correlation between Lipid Accumulation Product and the Risk of Ischemic Cardiovascular Disease in Middle-aged and Elderly People of Chengdu Area_West China Medical Journal

Authors：

 ZhaoWanyan ^1,2 , WangYong ¹ ,  ChenXiaoping ¹

1. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Jinyang Community Health Services Center, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

ChenXiaoping, Email: chenxp13@aliyun.com

Keywords：

Lipid accumulation product; Risk factors; Vascular damage; Cardiovascular disease

DOI：

10.7507/1002-0179.201600283

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the correlation between lipid accumulation product (LAP) and risk of ischemic cardiovascular disease (ICVD). Methods This cross-sectional study was performed among community residents from an urban community in Chengdu area between September 2011 and June 2012. Questionnaire survey was carried out. Each individual underwent biochemistry analysis and physical examination. In addition, brachial-ankle pulse wave velocity (BaPWV) and augmentation index (AI) were detected. Pearson correlation analysis was performed to explore the relationship between LAP and each cardiovascular risk factor. Liner regression model was used to analyze the relationship between LAP and ICVD. Results A total of 780 individuals with complete data were included in the analysis. LAP was correlated with blood pressure, total cholesterol, high density lipoprotein cholesterol, fasting blood glucose, and BaPWV (P＜0.05). LAP was associated with the risk of ICVD (r=0.253, P＜0.001). After being adjusted with sex, age and other cardiovascular risk factors, LAP was also correlated with the risk of ICVD (r=0.050, P＜0.001). Conclusions High LAP is associated with elevated cardiovascular risks and subclinical vascular damage. In addition, LAP is correlated with ICVD risk, thus it may be used to predict the incidence of ICVD to some extent. However, as the correlation is weak, our study does not support the direct use of this indicator to predict ICVD. Large-sample studies based on different races and ages are needed.

Citation： ZhaoWanyan, WangYong, ChenXiaoping. Research on the Correlation between Lipid Accumulation Product and the Risk of Ischemic Cardiovascular Disease in Middle-aged and Elderly People of Chengdu Area. West China Medical Journal, 2016, 31(6): 1053-1056. doi: 10.7507/1002-0179.201600283 Copy

1.	Kahn HS. The “lipid accumulation product” performs better than the body mass index for recognizing cardiovascular risk: a populationbased comparison[J]. BMC Cardiovasc Disord, 2005(5): 26.
2.	Chiang JK, Koo M. Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in Taiwanese People aged 50 and over[J]. BMC Cardiovasc Disord, 2012(12): 78.
3.	Bozorgmanesh M, Hadaegh F, Azizi F. Diabetes prediction, lipid accumulation product, and adiposity measures; 6-year follow-up: Tehran lipid and glucose study [J]. Lipids Health Dis, 2010(9): 45.
4.	劉圣好, 潘文博, 鐘萬生, 等. 原發性高血壓患者脈搏波傳導速度的影響因素[J]. 中華高血壓雜志, 2011, 19(3): 283-285.
5.	Holewijn S, Den Heijer M, Swinkels DW, et al. The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis[J]. J Clin Endocrinol Metab, 2009, 94(8): 2893-2899.
6.	王勇, 阿利曼·巴生, 幸露, 等. 成都市武侯區自然人群肥胖與大動脈僵硬度的關系[J]. 中華高血壓雜志, 2014, 22(7): 675-679.
7.	Wang X, Xie J, Zhang LJ, et al. Reference values of brachial-ankle pulse wave velocity for Northern Chinese[J]. Chin Med J (Engl), 2009, 122(18): 2103-2106.
8.	黃榮杰, 郭玉冰, 鄭云香. 依普利酮與氯沙坦對輕中度原發性高血壓患者動脈僵硬度及中心動脈壓的影響[J]. 中華高血壓雜志, 2012, 20(8): 776-780.
9.	Martin JS, Beck DT, Gurovich AN, et al. The acute effects of smokeless tobacco on central aortic blood pressure and wave reflection characteristics[J]. Exp Biol Med (Maywood), 2010, 235(10): 1263-1268.
10.	Wu YF, Liu XQ, Li X, et al. Estimation of 10-year risk of fatal and nonfatal ischemic cardiovascular diseases in Chinese adults[J]. Circulation, 2006, 114(21): 2217-2225.
11.	Rosito GA, Massaro JM, Hoffmann U, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study[J]. Circulation, 2008, 117(5): 605-613.
12.	Freedland ES. Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review[J]. Nutr Metab (Lond), 2004, 1(1): 12.
13.	Taverna MJ, Martínez-Larrad MT, Frechtel GD, et al. Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population[J]. Eur J Endocrinol, 2011, 164(4): 559-567.
14.	Xia C, Li R, Zhang S, et al. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals[J]. Eur J Clin Nutr, 2012, 66(9): 1035-1038.
15.	Iglseder B, Cip P, Malaimare L, et al. The metabolic syndrome is a stronger risk factor for early carotid atherosclerosis in women than in men[J]. Stroke, 2005, 36(6): 1212-1217.
16.	Maple-Brown L, Cunningham J, Celermajer DS, et al. Increased carotid intima-media thickness in remote and urban Indigenous Australians: impact of diabetes and components of the metabolic syndrome[J]. Clin Endocrinol (Oxf), 2007, 66(3): 419-425.
17.	Tellechea ML, Aranguren F, Martínez-Larrad MT, et al. Ability of lipid accumulation product to identify metabolic syndrome in healthy men from Buenos Aires[J]. Diabetes Care, 2009, 32(7): e85.
18.	Henrichot E, Juge-Aubry CE, Pernin A, et al. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis?[J]. Arterioscler Thromb Vasc Biol, 2005, 25(12): 2594-2599.
19.	Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity[J]. Am J Physiol Heart Circ Physiol, 2005, 289(5): H1807-H1813.
20.	Ioachimescu AG, Brennan DM, Hoar BM, et al. The lipid accumulation product and all-cause mortality in patients at high cardiovascular risk: a PreCIS database study[J]. Obesity (Silver Spring), 2010, 18(9): 1836-1844.
21.	Bozorgmanesh M, Hadaegh F, Azizi F. Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran lipid and glucose study[J]. Lipids Health Dis, 2010(9): 100.

1. Kahn HS. The “lipid accumulation product” performs better than the body mass index for recognizing cardiovascular risk: a populationbased comparison[J]. BMC Cardiovasc Disord, 2005(5): 26.
2. Chiang JK, Koo M. Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in Taiwanese People aged 50 and over[J]. BMC Cardiovasc Disord, 2012(12): 78.
3. Bozorgmanesh M, Hadaegh F, Azizi F. Diabetes prediction, lipid accumulation product, and adiposity measures; 6-year follow-up: Tehran lipid and glucose study [J]. Lipids Health Dis, 2010(9): 45.
4. 劉圣好, 潘文博, 鐘萬生, 等. 原發性高血壓患者脈搏波傳導速度的影響因素[J]. 中華高血壓雜志, 2011, 19(3): 283-285.
5. Holewijn S, Den Heijer M, Swinkels DW, et al. The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis[J]. J Clin Endocrinol Metab, 2009, 94(8): 2893-2899.
6. 王勇, 阿利曼·巴生, 幸露, 等. 成都市武侯區自然人群肥胖與大動脈僵硬度的關系[J]. 中華高血壓雜志, 2014, 22(7): 675-679.
7. Wang X, Xie J, Zhang LJ, et al. Reference values of brachial-ankle pulse wave velocity for Northern Chinese[J]. Chin Med J (Engl), 2009, 122(18): 2103-2106.
8. 黃榮杰, 郭玉冰, 鄭云香. 依普利酮與氯沙坦對輕中度原發性高血壓患者動脈僵硬度及中心動脈壓的影響[J]. 中華高血壓雜志, 2012, 20(8): 776-780.
9. Martin JS, Beck DT, Gurovich AN, et al. The acute effects of smokeless tobacco on central aortic blood pressure and wave reflection characteristics[J]. Exp Biol Med (Maywood), 2010, 235(10): 1263-1268.
10. Wu YF, Liu XQ, Li X, et al. Estimation of 10-year risk of fatal and nonfatal ischemic cardiovascular diseases in Chinese adults[J]. Circulation, 2006, 114(21): 2217-2225.
11. Rosito GA, Massaro JM, Hoffmann U, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study[J]. Circulation, 2008, 117(5): 605-613.
12. Freedland ES. Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review[J]. Nutr Metab (Lond), 2004, 1(1): 12.
13. Taverna MJ, Martínez-Larrad MT, Frechtel GD, et al. Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population[J]. Eur J Endocrinol, 2011, 164(4): 559-567.
14. Xia C, Li R, Zhang S, et al. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals[J]. Eur J Clin Nutr, 2012, 66(9): 1035-1038.
15. Iglseder B, Cip P, Malaimare L, et al. The metabolic syndrome is a stronger risk factor for early carotid atherosclerosis in women than in men[J]. Stroke, 2005, 36(6): 1212-1217.
16. Maple-Brown L, Cunningham J, Celermajer DS, et al. Increased carotid intima-media thickness in remote and urban Indigenous Australians: impact of diabetes and components of the metabolic syndrome[J]. Clin Endocrinol (Oxf), 2007, 66(3): 419-425.
17. Tellechea ML, Aranguren F, Martínez-Larrad MT, et al. Ability of lipid accumulation product to identify metabolic syndrome in healthy men from Buenos Aires[J]. Diabetes Care, 2009, 32(7): e85.
18. Henrichot E, Juge-Aubry CE, Pernin A, et al. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis?[J]. Arterioscler Thromb Vasc Biol, 2005, 25(12): 2594-2599.
19. Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity[J]. Am J Physiol Heart Circ Physiol, 2005, 289(5): H1807-H1813.
20. Ioachimescu AG, Brennan DM, Hoar BM, et al. The lipid accumulation product and all-cause mortality in patients at high cardiovascular risk: a PreCIS database study[J]. Obesity (Silver Spring), 2010, 18(9): 1836-1844.
21. Bozorgmanesh M, Hadaegh F, Azizi F. Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran lipid and glucose study[J]. Lipids Health Dis, 2010(9): 100.

Previous Article
腦梗死患者腸內營養腹瀉護理一例
Next Article
Arthroscopic Treatment for Obsolete Posterolateral Rotatory Dislocation of Knee Joint

West China Medical Journal

Research on the Correlation between Lipid Accumulation Product and the Risk of Ischemic Cardiovascular Disease in Middle-aged and Elderly People of Chengdu Area

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content