Analysis of Risk Factors of Diabetic Retinopathy_West China Medical Journal

Authors：

 WangHan ,  WangHaoyue

Department of Ophthalmology, the People’s Hospital of Tengzhou, Tengzhou, Shandong 277500, P. R. China;

Corresponding?author：

WangHaoyue, Email: whyyk@126.com

Keywords：

Diabetes mellitus; Retinopathy; Risk factors

DOI：

10.7507/1002-0179.201600241

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the risk factors of diabetic retinopathy. Methods We retrospectively analyzed the clinical data of 137 patients with diabetes mellitus (DM) from July 2012 to July 2015. According to the situation of retinopathy, the patients were divided into three groups. Forty-three patients without retinopathy were regarded as the control group, 46 non-proliferative retinopathy patients as the observation group, and 48 patients with proliferative retinopathy as the trial group. DM blood pressure, blood glucose, glycosylated hemoglobin, blood lipid, albumin creatinine ratio and other indicators were collected and analyzed, and multiple-factor non-conditional logistic regression analysis was carried out. Results Glycosylated hemoglobin, total cholesterol, triglyceride, low density lipoproteincholesterol, high density lipoprotein cholesterol, body mass index, postprandial 2-hour blood glucose and fasting blood glucose were not significantly different among the three groups (P ＞ 0.05) , but the duration of diabetes, vascular endothelial growth factor and urinary albumin creatinine ratio were significantly different (P ＜ 0.05) . The diabetic duration, glycosylated hemoglobin, systolic blood pressure, urinary albumin creatinine ratio and vascular endothelial growth factor were independently associated with diabetic retinopathy (P ＜ 0.05) . Conclusion The prolonged disease course of diabetic patients, unstable status of blood glucose and blood pressure, and the increase of blood vessel growth factor and vascular endothelial growth factor can cause the development of diabetic retinopathy.

Citation： WangHan, WangHaoyue. Analysis of Risk Factors of Diabetic Retinopathy. West China Medical Journal, 2016, 31(5): 889-892. doi: 10.7507/1002-0179.201600241 Copy

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11.	胡利, 李東豪, 陳慧. 糖尿病患者血糖控制相關因素與糖尿病視網膜病變發生的關系[J]. 中華眼底病雜志, 2011, 27(3) : 210-213.
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14.	尤巧英, 朱麒錢, 斯徐偉. 等血管生成素及其Tie-2受體與不同分級的2型糖尿病視網膜病變的相關性研究[J]. 中華內分泌代謝雜志, 2011, 27(8) : 561-563.
15.	Pfister F, Wang Y, Schreiter K, et al. Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia[J]. Acta Diabetol, 2010, 47(1) : 59-64.
16.	張振華, 耿燕, 孫清秀, 等. 438名眼科醫師糖尿病視網膜病變相關知識的認知度調查與影響因素分析[J]. 中國實用眼科雜志, 2011, 29(7) : 735-738.
17.	王曉梅, 金成吉, 張弢, 等. 血管內皮生長因子基因多態性與糖尿病視網膜病變的相關性[J]. 中國糖尿病雜志,2008,16(8) :462-464.
18.	Feghhi M, Nikzamir A, Esteghamati A, et al. Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes[J]. Transl Res, 2011, 158(2) : 85-91.

1. 羅潔, 趙菊蓮, 游志鵬, 等. 糖尿病視網膜病變危險因素的研究現狀[J]. 中國實用眼科雜志, 2011, 29(1) : 14-17.
2. 彭曉燕,張永鵬. 糖尿病視網膜病變的治療趨勢[J]. 眼科, 2011, 20(4) : 217-221.
3. 胡安娣娜. 李濤, 羅燕, 等. 增殖性糖尿病視網膜病變的危險因素分析[J]. 中國實用眼科雜志, 2011, 29(9) : 925-928.
4. 李豐, 游志鵬, 謝琳, 等. 糖尿病視網膜病變危險因素及基因多態性研究進展[J]. 中國實用眼科雜志, 2015, 33(1) : 6-8.
5. 錢榮立. 關于糖尿病新診斷標準與分型的意義[J]. 臨床內科雜志, 2000, 17(3) : 133.
6. 于湄, 蘇志燕, 劉向祎, 等. 2型糖尿病視網膜病變的相關因素分析 [J]. 中國實驗診斷學, 2010, 14(9) : 1434-1436.
7. Wilkinson CP, Ferris FL 3rd, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales[J]. Ophthalmology, 2003, 110(9) : 1677-1682.
8. Stratton IM, Kohner EM, Aldington SJ, et al. UKPDS 50: risk factors for incidence and progression of retinopathy in Type Ⅱ diabetes over 6 years from diagnosis[J]. Diabetologia, 2001, 44(2) : 156-163.
9. 王芳, 王春芳, 閆建林, 等. 45歲以上糖尿病患者中糖尿病視網膜病變的患病率調查及相關危險因素分析[J]. 中華實驗眼科雜志, 2013, 31(8) : 783-787.
10. Hayes AJ, Leal J, Gray AM, et al. UKPDS outcomes model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year united kingdom prospective diabetes study: UKPDS 82[J]. Diabetologia, 2013, 56(9) : 1925-1933.
11. 胡利, 李東豪, 陳慧. 糖尿病患者血糖控制相關因素與糖尿病視網膜病變發生的關系[J]. 中華眼底病雜志, 2011, 27(3) : 210-213.
12. Sayin N, Kara N, Pekel G. Ocular complications of diabetes mellitus[J]. World J Diabetes, 2015, 6(1) : 92-108.
13. Janghorbani M, Amini M, Ghanbari H, et al. Incidence of and risk factors for diabetic retinopathy in Isfahan, Iran[J]. Ophthalmic Epidemiol, 2003, 10(2) : 81-95.
14. 尤巧英, 朱麒錢, 斯徐偉. 等血管生成素及其Tie-2受體與不同分級的2型糖尿病視網膜病變的相關性研究[J]. 中華內分泌代謝雜志, 2011, 27(8) : 561-563.
15. Pfister F, Wang Y, Schreiter K, et al. Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia[J]. Acta Diabetol, 2010, 47(1) : 59-64.
16. 張振華, 耿燕, 孫清秀, 等. 438名眼科醫師糖尿病視網膜病變相關知識的認知度調查與影響因素分析[J]. 中國實用眼科雜志, 2011, 29(7) : 735-738.
17. 王曉梅, 金成吉, 張弢, 等. 血管內皮生長因子基因多態性與糖尿病視網膜病變的相關性[J]. 中國糖尿病雜志,2008,16(8) :462-464.
18. Feghhi M, Nikzamir A, Esteghamati A, et al. Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes[J]. Transl Res, 2011, 158(2) : 85-91.

West China Medical Journal

Analysis of Risk Factors of Diabetic Retinopathy

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