Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses_West China Medical Journal

Authors：

 KangMin ¹ ,  QiYana ^2,3 , ShaoJianbo ⁴ , MaHuijing ⁴ , ZhengNannan ⁴

1. Department of Radiology, Women and Children's Hospital of Sichuan Province, Chengdu, Sichuan 610042, P. R. China;
2. West China School of Public Health;
3. Continuing Education Department, West China Hospital;Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. Women and Children Health Care Center of Wuhan City, Wuhan, Hubei 430016, P. R. China;

Corresponding?author：

QiYana, Email: qiyana2012@163.com

Keywords：

Fetal thymus; Volume; Model; Magnetic resonance imaging

DOI：

10.7507/1002-0179.20160024

Video：

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Objective To study the model to predict thymus volume with two-dimensional section diameters among fetuses. Methods From September 2010 to March 2012, 210 singleton pregnant women suspected with fetal abnormality by prenatal ultrasonic testing were confirmed using MRI technology. Three two-dimensional section diameters of thymus were measured and the volume was calculated. No abnormal fetuses regarded as the standard, theoretical normal volume of fetal thymus was calculated. Paired t-test was used to compare the actual thymus volume with its corresponding theoretical normal value, and thus the fetuses were divided into two groups of normal and dysplasia so as to establish predictive model respectively. With two-dimensional section diameters as independent variables and thymus volume as dependent variable, the linear regression model was established. According to the model, the thymus volume was predicted and the error rate was calculated by formula: error rate=(predicted value-actual value) /actual value×100%. The Pearson correlation coefficient of error rate and fetal gestational age was calculated. Results The models of normal and dysplasia groups to predict thymus volume were lnV=0.016d₁+0.030d₂+0.086d₃+5.707+ε (R₂=0.510) and lnV=0.048d₁+0.036d₂+0.016d₃+6.011+ε (R₂=0.447). The average absolute values of predicted error rate were 4.34% and 5.34% and decreased with fetal gestational age (normal r=-0.264, P=0.007; dysplasia r=-0.182, P=0.060). Conclusion The prediction effects of above models are not so good and the model accuracy increases with fetal gestational age. Normal fetuses' model of different gestational age should be established to predict thymus volume by conducting large sample size study in the future. The modeling approach has certain practicability and clinical value and can be applied in ultrasonic technique.

Citation： KangMin, QiYana, ShaoJianbo, MaHuijing, ZhengNannan. Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses. West China Medical Journal, 2016, 31(1): 94-97. doi: 10.7507/1002-0179.20160024 Copy

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1. Zalel Y, Gamzu R, Mashiach S, et al. The development of the fetal thymus:an in utero sonographic evaluation[J]. Prenat Diagn, 2002, 22(2):114-117.
2. 凌樂文, 呂國榮. 產前超聲檢測胎兒胸腺[J]. 中國介入影像與治療學, 2012, 9(2):133-135.
3. El-Haieg DO, Zidan AA, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes[J]. BJOG, 2008, 115(7):836-841.
4. Cromi A, Ghezzi F, Raffaelli R, et al. Ultrasonographic measurement of thymus size in IUGR fetuses:a marker of the fetal immunoendocrine response to malnutrition[J]. Ultrasound Obstet Gynecol, 2009, 33(4):421-426.
5. 紀偉英, 鄭名芳, 陳常佩, 等. 胎兒胸腺發育的超聲測量[J]. 中國醫學影像學雜志, 2010, 18(1):80-81.
6. 李凌. 二維、三維超聲檢測胎兒胸腺及胎兒先心病與22q11微缺失關聯性探討[D]. 長沙:中南大學, 2010.
7. 李凌, 周啟昌, 鄒琳, 等. 二維、三維超聲技術檢測正常胎兒胸腺的研究[J]. 中華超聲影像學雜志, 2011, 20(1):53-57.
8. 玄英華. 胎兒胸腺的超聲研究[D]. 北京:北京協和醫學院, 2012.
9. 鄭建國, 景玉萍, 康照昌, 等. 幾種先天畸形胎兒胸腺的解剖及組織觀察[J]. 湖北職業技術學院學報, 2006, 9(2):82-84.
10. 楊文娟, 吳青青. 胎兒畸形與22q11微缺失相關性的研究進展[J]. 中國婦產科臨床雜志, 2011, 12(2):151-153.
11. 呂國榮, 李伯義, 李麗雅, 等. 超聲評估心臟畸形及感染胎兒的胸腺發育[J]. 中國超聲醫學雜志, 2011, 27(5):451-454.
12. 李建斌, 劉學敏, 李德明, 等. 胎兒胸腺的觀察和測量[J]. 長治醫學院學報, 2003, 17(3):163-164.
13. 楊瑞琦, 郭鳳軍, 劉學娟, 等. 二維和三維超聲測量胎兒胸腺在胎兒宮內生長遲緩時的應用[J]. 中華醫學雜志, 2014, 94(33): 2607-2609.
14. 陳靜, 劉彩霞, 尹少尉. 磁共振成像在胎兒異常中的臨床應用研究[J]. 中國醫科大學學報, 2008, 37(5):670-672, 678.
15. 朱銘. 胎兒磁共振——磁共振檢查的新領域[J]. 磁共振成像, 2011, 2(1):7-12.

West China Medical Journal

Study on the Model to Predict Thymus Volume with Two-dimensional Section Diameters among Fetuses

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