Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sj?ren Syndrome_West China Medical Journal

Authors：

 WuTong ,  ZhouBin , LongLi , ZhangJing

Department of Rheumatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

ZhouBin, Email: bingb2917@163.com

Keywords：

Primary Sj?; gren syndrome; Thrombocytopenia; Thrombopoietin; Anti-thrombopoietin antibody

DOI：

10.7507/1002-0179.201600237

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Objective To analyze the correlation of thrombopoietin (TPO) and anti-TPO antibody with thrombocytopenia in patients with primary Sj?gren syndrome (PSS). Methods We included in our study 40 PSS patients with thrombocytopenia (group A), 22 PSS patients who once had thrombocytopenia and returned to normal (group B), 40 PSS patients with normal platelet counts (group C) and 40 healthy controls (group D) between September 2013 and October 2014. Anti-TPO antibody was detected by indirect enzyme-linked immunosorbent assay (ELISA), and serum TPO levels were measured by ELISA. We analyzed the relationship between the assay results and the clinical manifestations and parameters. Results The serum TPO levels in groups A, B, and C were (129.74±17.47) , (330.23±18.07) and (364.19±12.25) pg/mL, respectively, and they were significantly higher than that in group D [(54.04±10.71) pg/mL] (P ＜ 0.05) . The serum level of TPO was positively correlated with CRP and IgA (r_s=0.224, P=0.039; r_s=0.239, P=0.033) , and was negatively correlated with C4 level (r_s=?0.220, P=0.041) , but it was not significantly correlated with platelet count, erythrocyte sedimentation rate, the level of antiphospholipid antibodies and the titer of antinuclear antibodies (P ＞ 0.05) . The positive rate of PSS patients was 20.59% (21/102) and the rate in groups A, B, and C was respectively 17.5% (7/40) , 22.72% (5/22) , and 22.5% (9/40) . There was no statistically significant difference between the positive and negative groups in various clinical indexes (P ＞ 0.05) . Conclusion AntiTPO antibody may not be the main mechanism of thrombocytopenia in PSS patients, and there is a certain correlation between TPO and inflammatory factors.

Citation： WuTong, ZhouBin, LongLi, ZhangJing. Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sj?ren Syndrome. West China Medical Journal, 2016, 31(5): 871-874. doi: 10.7507/1002-0179.201600237 Copy

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1. 青玉鳳, 周京國, 楊明輝, 等. 原發性干燥綜合征伴血液系統損害的臨床分析[J]. 中華風濕病學雜志, 2009, 13(2) :117-119.
2. 蘭麗敏. 原發性干燥綜合征血液系統損害臨床分析[J]. 河北中醫, 2011, 33(9) : 1421-1423.
3. 王景, 宣磊, 董振華. 原發性干燥綜合征合并血液系統損害研究概況[J]. 醫學研究雜志, 2015, 44(3) : 169-171.
4. 蘇江, 朱靜, 周彬. 原發性干燥綜合征血液系統損害與免疫學指標的相關性分析[J]. 西部醫學, 2009, 21(11) : 1943-1944.
5. 謝雯. 原發性干燥綜合征血液系統損害臨床特點[J]. 現代實用醫學, 2002, 14(8) : 409-410.
6. 程永靜, 王芳, 張春媚, 等. 干燥綜合征血液系統損害與免疫學及各臨床指標的相關性分析[J]. 中國臨床保健雜志, 2011, 14(3) : 230-231.
7. 任立敏, 何菁. 韓聚方, 等. 原發性干燥綜合征合并血細胞減少臨床分析[C]//首屆全國中青年風濕病學學術大會論文匯編. 北京: 中華醫學會風濕病學分會, 2004: 10.
8. 董怡. 論2002年干燥綜合征分類(診斷)標準[J]. 中華風濕病學雜志, 2003, 7(1) : 1-2.
9. Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies[J]. Blood, 2002, 100(10) : 3457-3469.
10. Kaushansky K. Molecular mechanisms of thrombopoietin signaling[J]. Thromb Haemost, 2009, 7(Suppl 1) : 235-238.
11. 徐亮, 王元, 陳順樂, 等. 系統性紅斑狼瘡血小板減少患者巨核祖細胞分化障礙[J]. 上海醫學, 2004, 27(10) : 739-742, 791.
12. 羅雄燕, 武麗君, 吳鳳霞, 等. 巨核細胞增殖與分化障礙在系統性紅斑狼瘡伴發血小板減少中的作用[J]. 中華臨床醫師雜志: 電子版, 2010, 4(2) : 150-153.
13. Vadhan-Raj S. Clinical experience with recombinant human thrombopoietin in chemotherapy-induced thrombocytopenia[J]. Semin Hematol, 2000, 37(2, 4) : 28-34.
14. 華寶來, 趙永強, 朱鐵楠, 等. 血小板減少患者皮下注射重組人血小板生成素后抗體生成的動態監測[J]. 血栓與止血學, 2005, 11(2) : 59-61.
15. Füreder W, Firbas U, Nichol JL, et al. Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus[J]. Lupus, 2002, 11(4) : 221-226.
16. Ziakas PD, Routsias JG, Giannouli S, et al. Suspects in the tale of lupus-associated thrombocytopenia[J]. Clin Exp Immunol, 2006, 65(2) : 363.
17. Ziakas PD, Papadaki H, Psyllaki M, et al. Anti-thrombopoietin anti-bodies suppress megakaryocytic colony formation in vitro in patients with systemic lupus erythaematosus[J]. Ann Rheum Dis, 2008, 67(11) : 1643-1644.
18. 吳侗, 周彬, 龍麗, 等. 干燥綜合征患者抗血小板生成素受體抗體與血小板減少的相關性研究[J]. 實用醫院臨床雜志, 2014, 11(2) : 63-66.
19. Lu C, Nossent J. Thrombopoietin levels in systemic lupus erythematosus are linked to inflammatory cytokines, but unrelated to thrombocytopenia or thrombosis[J]. Lupus, 2015, 24(1) : 18-24.

West China Medical Journal

Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sj?ren Syndrome

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