Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee_West China Medical Journal

Authors：

 LiMin ¹ ,  WuXiaohui ² , YiWeien ³ , LiangYi ¹ , TangLiugang ² , YuWenjing ¹ , ShaHu ¹ , WuJia ¹ , WangCuiping ¹

1. Department of Rheumatology and Osteoarthritis, Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041,P. R. China;
2. Department of Sinew Injury, Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041,P. R. China;
3. Department of Rehabilitation, TCM Hospital of Yuechi County, Guang’an, Sichuan 638300, P. R. China;

Corresponding?author：

WuXiaohui, Email: noll777@qq.com

Keywords：

Osteoarthritis, knee; Cold pain of knee; Glucosamine hydrochloride; Risedronate

DOI：

10.7507/1002-0179.201600230

Video：

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Objective To evaluate the efficacy of the glucosamine hydrochloride combined with risedronate in the treatment of knee osteoarthritis (KOA) associated with cold pain of knee. Methods The clinical data of 50 KOA patients including 25 with cold pain and 25 without cold pain, treated in the Department of Rheumatology between January and December 2015 were collected. The clinical symptoms, Western Ontario and McMater Universities (WOMAC) index of osteoarthritis score, knee cold pain score, knee joint therml texture maps (TTM) score, serum osteoprotegerin (OPG), Dickkopf-1 (DKK-1) , and sclerostin levels (SO) were recorded for comparison between patients with and without cold pain in order to investigate the correlation between these indicators and cold pain degree. Patients in the cold pain group were treated with glucosamine hydrochloride combined with risedronate. Follow-up lasted for six months, and the improvement of above indexes and the treatment safety were analyzed. Results There were significant differences between the two groups in the disease course, TTM score of knee front and popliteal fossa, ΔTTM, DKK-1 and SO (P ＜ 0.05) . After 6 months of treatment, patients in the cold pain group improved significantly in WOMAC score, knee cold pain score, TTM score of knee front and popliteal fossa, ΔTTM, OPG, DKK-1 and SO (P ＜ 0.05) . Conclusions As one of the main complaints of patients with advanced OA, knee cold pain is associated with the metabolic activity of osteoclasts. It can be alleviated by the treatment with risedronate combined with glucosamine.

Citation： LiMin, WuXiaohui, YiWeien, LiangYi, TangLiugang, YuWenjing, ShaHu, WuJia, WangCuiping. Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee. West China Medical Journal, 2016, 31(5): 841-844. doi: 10.7507/1002-0179.201600230 Copy

1.	中華醫學會風濕病學分會. 骨關節炎診斷及治療指南[J]. 中華風濕病學雜志, 2010, 14(6) : 416-419.
2.	李敏, 伊偉恩, 吳曉惠, 等. 類風濕關節炎伴膝冷痛的相關因素分析[J]. 四川大學學報: 醫學版, 2015, 46(2) : 293-295.
3.	樊秋貴, 郭鈞, 楊民. OPG RANKL RANK等因子在類風濕關節炎患者血清及滑膜液中的變化及意義[J]. 中華風濕病學雜志, 2007, 11(1) : 38-40.
4.	Uderhardt S, Diarra D, Katzenbeisser J, et al. Blockade of dickkopf (DKK)-1 induces fusion of sacroiliac joints[J]. Ann Rheum Dis, 2010, 69(3) : 592-597.
5.	趙鳳儀, 王莉. 硬骨素在骨生成中的作用[J]. 中國骨質疏松雜志, 2009, 15(6) : 460-462, 472.
6.	黃勝光, 陳輝, 周汝云, 等. 蜂針療法對風濕寒性關節痛患者中醫證候評分及血液流變學的影響[J]. 中醫藥導報, 2012, 9(9) : 16-18.
7.	李敏, 梁翼, 余文景, 等. 鹽酸氨基葡萄糖聯合雙醋瑞因在伴骨髓水腫的膝骨關節炎的療效評估[J]. 華西醫學, 2012, 12(12) : 1764- 1767.
8.	劉湘源, 趙金霞, 姚中強, 等. 圖表式臨床風濕病學[M]. 北京: 中國醫藥科技出版社, 2013: 468-470.
9.	劉孟宇, 李勇, 韓慶森. 膝骨關節炎與風濕寒性關節痛的TTM鑒別診斷[J]. 中國中西醫結合影像學雜志, 2008, 6(2) : 111-113.
10.	Rachner TD, G?bel A, Benad-Mehner P, et al. Dickkopf-1 as a mediator and novel target in malignant bone disease[J]. Cancer Lett, 2014, 346(2) : 172-177.
11.	陳枝瓊, 李向培, 厲小梅, 等. 強直性脊柱炎患者外周血中 Dickkopf-1和硬骨素的表達及臨床意義[J]. 安徽醫科大學學報, 2013, 48(6) : 671-674.
12.	Pazianas M, Cooper C, Ebetino FH, et al. Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis[J]. Ther Clin Risk Manag, 2010, 6(1) : 325-343.
13.	曲新華, 郝永強. 雙膦酸鹽在骨科相關疾病治療中的地位及再認識[J]. 中華骨科雜志, 2014, 34(1) : 78-80.
14.	吳曉惠, 趙琛, 鐘義蘭, 等. 鹽酸氨基葡萄糖聯合抗骨增生片治療不同類型膝骨關節炎療效比較[J]. 華西醫學, 2012, 12(12) : 1792- 1795.
15.	戴燚, 楊歡, 張漢慶, 等. 鹽酸氨基葡萄糖聯合降鈣素對絕經后膝骨關節炎基質金屬蛋白酶3和骨橋蛋白表達的影響[J]. 華西醫學, 2012, 12(12) : 1772-1775.

1. 中華醫學會風濕病學分會. 骨關節炎診斷及治療指南[J]. 中華風濕病學雜志, 2010, 14(6) : 416-419.
2. 李敏, 伊偉恩, 吳曉惠, 等. 類風濕關節炎伴膝冷痛的相關因素分析[J]. 四川大學學報: 醫學版, 2015, 46(2) : 293-295.
3. 樊秋貴, 郭鈞, 楊民. OPG RANKL RANK等因子在類風濕關節炎患者血清及滑膜液中的變化及意義[J]. 中華風濕病學雜志, 2007, 11(1) : 38-40.
4. Uderhardt S, Diarra D, Katzenbeisser J, et al. Blockade of dickkopf (DKK)-1 induces fusion of sacroiliac joints[J]. Ann Rheum Dis, 2010, 69(3) : 592-597.
5. 趙鳳儀, 王莉. 硬骨素在骨生成中的作用[J]. 中國骨質疏松雜志, 2009, 15(6) : 460-462, 472.
6. 黃勝光, 陳輝, 周汝云, 等. 蜂針療法對風濕寒性關節痛患者中醫證候評分及血液流變學的影響[J]. 中醫藥導報, 2012, 9(9) : 16-18.
7. 李敏, 梁翼, 余文景, 等. 鹽酸氨基葡萄糖聯合雙醋瑞因在伴骨髓水腫的膝骨關節炎的療效評估[J]. 華西醫學, 2012, 12(12) : 1764- 1767.
8. 劉湘源, 趙金霞, 姚中強, 等. 圖表式臨床風濕病學[M]. 北京: 中國醫藥科技出版社, 2013: 468-470.
9. 劉孟宇, 李勇, 韓慶森. 膝骨關節炎與風濕寒性關節痛的TTM鑒別診斷[J]. 中國中西醫結合影像學雜志, 2008, 6(2) : 111-113.
10. Rachner TD, G?bel A, Benad-Mehner P, et al. Dickkopf-1 as a mediator and novel target in malignant bone disease[J]. Cancer Lett, 2014, 346(2) : 172-177.
11. 陳枝瓊, 李向培, 厲小梅, 等. 強直性脊柱炎患者外周血中 Dickkopf-1和硬骨素的表達及臨床意義[J]. 安徽醫科大學學報, 2013, 48(6) : 671-674.
12. Pazianas M, Cooper C, Ebetino FH, et al. Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis[J]. Ther Clin Risk Manag, 2010, 6(1) : 325-343.
13. 曲新華, 郝永強. 雙膦酸鹽在骨科相關疾病治療中的地位及再認識[J]. 中華骨科雜志, 2014, 34(1) : 78-80.
14. 吳曉惠, 趙琛, 鐘義蘭, 等. 鹽酸氨基葡萄糖聯合抗骨增生片治療不同類型膝骨關節炎療效比較[J]. 華西醫學, 2012, 12(12) : 1792- 1795.
15. 戴燚, 楊歡, 張漢慶, 等. 鹽酸氨基葡萄糖聯合降鈣素對絕經后膝骨關節炎基質金屬蛋白酶3和骨橋蛋白表達的影響[J]. 華西醫學, 2012, 12(12) : 1772-1775.

West China Medical Journal

Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee

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