The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

 FanWenjiang ¹ ,  LiuQing ²

1. Department of Pain, The First People’s Hospital of Neijiang, Neijiang, Sichuan 641000, P. R. China;
2. Department of Pain, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P. R. China;

Corresponding?author：

LiuQing, Email: 1105859368@qq.com

Keywords：

Ozone; Glucosamine; Osteoarthritis, knee

DOI：

10.7507/1002-0179.201600225

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the efficacy and safety of the joint application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection in the treatment of knee osteoarthritis. Methods From January 2014 to January 2015, 72 patients who matched the criteria of moderate knee osteoarthritis were randomly divided into two groups according to the table of random number: oral glucosamine hydrochloride tablet and knee joint cavity ozone injection group (group G+O) and ozone group (group O). Patients of group G+O orally took glucosamine hydrochloride tablets (0.48 g, 3 times/day) for twelve weeks, and ozone was injected into the patients’ knee joint once a week for the first four weeks. The treatment for group O patients was the same with Group G+O, except that the glucosamine hydrochloride tablets were replaced by glucosamine hydrochloride placebo (2 tablets, 3 times/day, taking orally). We recorded the Visual Analogue Scale (VAS) score, Western Ontario & McMaster University (WOMAC) osteoarthritis index score and the adverse reactions before treatment and in the first, third and sixth month after treatment. Results Patients’ VAS scores and WOMAC scores of both the two groups in the first, third and sixth month after treatment were significantly different from those before the treatment (P ＜ 0.05) . In the first month after treatment, there were no significant difference in patients’ VAS scores and WOMAC scores between the two groups (P ＞ 0.05) . In the third and sixth month after treatment, there were significant differences in patients’ VAS scores and WOMAC scores between the two groups (P ＜ 0.05) . There was no obvious adverse reactions during the treatment. Conclusions The combined application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection and the ozone treatment for moderate knee osteoarthritis are both effective, without any adverse reaction. The combined treatment of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection on moderate knee osteoarthritis has better long-term efficacy, and it is worth spreading.

Citation： FanWenjiang, LiuQing. The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2016, 31(5): 823-826. doi: 10.7507/1002-0179.201600225 Copy

1.	李寧華. 中老年人群骨關節炎的流行病學特征[J]. 中國臨床康復, 2005, 9(38) : 133-135.
2.	陳明生, 張毅, 唐曉蘭, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療退行性骨性膝關節炎的臨床觀察[J]. 臨床軍醫雜志, 2012, 40(5) : 1082-1084.
3.	Laba TL, Brien JA, Fransen M, et al. Patient preferences for adherence to treatment for osteoarthritis: the MEdication Decisions in Osteoarthritis Study (MEDOS)[J]. BMC Musculoskelet Disord, 2013, 14(1) : 1-9.
4.	曾廣南, 馮沃軍, 胡永祥, 等. 膝關節退行性骨關節炎常見壓痛點的臨床觀察[J]. 中國中醫骨傷雜志, 2007, 15(11) : 18-20.
5.	何文革, 閆冬梅, 李瑞陽. 臭氧聯合鹽酸氨基葡萄糖用于膝關節股性關節炎治療的療效[J]. 中國康復醫學雜志, 2014, 29(7) : 675-676.
6.	高越, 王飛, 范宇, 等. 臭氧治療骨關節炎研究進展[J]. 中國疼痛醫學雜志, 2014, 20(6) : 427-429.
7.	唐令. 不同藥物治療膝骨性關節炎綜合癥狀的效果[J]. 中國醫藥導報, 2015, 12(15) : 132-135.
8.	李英. 鹽酸氨基葡萄糖治療骨關節炎的臨床研究[J]. 醫藥, 2015 (1) : 71.
9.	余素君, 胡鈺鑌, 魏薇. 鹽酸氨基葡萄糖治療骨關節炎的療效與安全性觀察[J]. 醫學信息, 2014, 27(9) : 228.
10.	向成浩, 蔣從斌, 楊萬波, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2012, 27(12) : 1796-1799.
11.	葉楊, 高曉梅, 楊南萍. 雙盲雙模擬藥物治療中重度膝骨關節炎的安全性和療效分析評價[J]. 中國現代醫學雜志, 2015, 25(13) : 73-77.
12.	Kapur N, Kamel IR, HerlichA. Oral and craniofacil pain: diagnosis, pathophysiology, and treatment[J]. Int Anesthesiol Clin, 2003, 41(3) : 115-150.
13.	Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patientrelevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee [J]. J Rheumatol 1988, 15(12) : 1833-1840.
14.	曾偉南, 周宗科, 李海, 等. 氨基葡萄糖聯合布洛芬與單用布洛芬治療髖關節骨關節炎前瞻性隨機對照臨床研究[J]. 華西醫學, 2012, 27(12) : 1805-1808.
15.	陳潔, 蘭由玉, 劉偉, 等. 鹽酸氨基葡萄糖與雙醋瑞因治療骨關節炎的臨床對照研究[J].華西醫學, 2014, 29(6) : 1111-1114.
16.	陳瑤, 俞泳, 何成奇. 膝骨關節炎患者本體感覺、肌力及關節功能的相關性研究[J]. 四川大學學報: 醫學版, 2015, 46(6) : 880-884.
17.	Ruane R, Griffiths P. Glucosamine therapy compared to ibuprofen for joint pain[J]. Br J Community Nurs, 2002, 7(3) : 148-152.
18.	王大壽, 王林, 安裕文. 臭氧對兔膝骨性關節炎關節沖洗液中細胞因子含量影響的實驗研究[J]. 中國疼痛醫學雜志, 2011, 17(1) : 59-60.
19.	Moretti M. Effectiveness of Oxygen-Ozone and Hyaluronic Acid Injections in De Quervain’s Syndrome[J]. Intern J Ozone Ther, 2012, 11 (1) : 31-33.
20.	何曉峰. 臭氧治療的臨床應用[M]. 北京: 科學出版社, 2009: 99-103.
21.	Scott JL, Gabrielides C, Davidson RK, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease[J]. Ann Rheum Dis, 2010, 69(8) : 1502-1510.

1. 李寧華. 中老年人群骨關節炎的流行病學特征[J]. 中國臨床康復, 2005, 9(38) : 133-135.
2. 陳明生, 張毅, 唐曉蘭, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療退行性骨性膝關節炎的臨床觀察[J]. 臨床軍醫雜志, 2012, 40(5) : 1082-1084.
3. Laba TL, Brien JA, Fransen M, et al. Patient preferences for adherence to treatment for osteoarthritis: the MEdication Decisions in Osteoarthritis Study (MEDOS)[J]. BMC Musculoskelet Disord, 2013, 14(1) : 1-9.
4. 曾廣南, 馮沃軍, 胡永祥, 等. 膝關節退行性骨關節炎常見壓痛點的臨床觀察[J]. 中國中醫骨傷雜志, 2007, 15(11) : 18-20.
5. 何文革, 閆冬梅, 李瑞陽. 臭氧聯合鹽酸氨基葡萄糖用于膝關節股性關節炎治療的療效[J]. 中國康復醫學雜志, 2014, 29(7) : 675-676.
6. 高越, 王飛, 范宇, 等. 臭氧治療骨關節炎研究進展[J]. 中國疼痛醫學雜志, 2014, 20(6) : 427-429.
7. 唐令. 不同藥物治療膝骨性關節炎綜合癥狀的效果[J]. 中國醫藥導報, 2015, 12(15) : 132-135.
8. 李英. 鹽酸氨基葡萄糖治療骨關節炎的臨床研究[J]. 醫藥, 2015 (1) : 71.
9. 余素君, 胡鈺鑌, 魏薇. 鹽酸氨基葡萄糖治療骨關節炎的療效與安全性觀察[J]. 醫學信息, 2014, 27(9) : 228.
10. 向成浩, 蔣從斌, 楊萬波, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2012, 27(12) : 1796-1799.
11. 葉楊, 高曉梅, 楊南萍. 雙盲雙模擬藥物治療中重度膝骨關節炎的安全性和療效分析評價[J]. 中國現代醫學雜志, 2015, 25(13) : 73-77.
12. Kapur N, Kamel IR, HerlichA. Oral and craniofacil pain: diagnosis, pathophysiology, and treatment[J]. Int Anesthesiol Clin, 2003, 41(3) : 115-150.
13. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patientrelevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee [J]. J Rheumatol 1988, 15(12) : 1833-1840.
14. 曾偉南, 周宗科, 李海, 等. 氨基葡萄糖聯合布洛芬與單用布洛芬治療髖關節骨關節炎前瞻性隨機對照臨床研究[J]. 華西醫學, 2012, 27(12) : 1805-1808.
15. 陳潔, 蘭由玉, 劉偉, 等. 鹽酸氨基葡萄糖與雙醋瑞因治療骨關節炎的臨床對照研究[J].華西醫學, 2014, 29(6) : 1111-1114.
16. 陳瑤, 俞泳, 何成奇. 膝骨關節炎患者本體感覺、肌力及關節功能的相關性研究[J]. 四川大學學報: 醫學版, 2015, 46(6) : 880-884.
17. Ruane R, Griffiths P. Glucosamine therapy compared to ibuprofen for joint pain[J]. Br J Community Nurs, 2002, 7(3) : 148-152.
18. 王大壽, 王林, 安裕文. 臭氧對兔膝骨性關節炎關節沖洗液中細胞因子含量影響的實驗研究[J]. 中國疼痛醫學雜志, 2011, 17(1) : 59-60.
19. Moretti M. Effectiveness of Oxygen-Ozone and Hyaluronic Acid Injections in De Quervain’s Syndrome[J]. Intern J Ozone Ther, 2012, 11 (1) : 31-33.
20. 何曉峰. 臭氧治療的臨床應用[M]. 北京: 科學出版社, 2009: 99-103.
21. Scott JL, Gabrielides C, Davidson RK, et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease[J]. Ann Rheum Dis, 2010, 69(8) : 1502-1510.

West China Medical Journal

The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content