Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs_West China Medical Journal

Authors：

 ZhaoRuiting ^1,2 ,  FengPing ¹ , ZongZhiyong ¹ , ChenLiyu ¹

1. Infectious Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Gastroenterology, PLA 452 Hospital, Chengdu, Sichuan 610065, P. R. China;

Corresponding?author：

FengPing, Email: fengp_62@163.com

Keywords：

Staphylococcus; Septicemia; Drug-resistance

DOI：

10.7507/1002-0179.201600187

Video：

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Objective To survey and analyze the drug resistance of clinical isolated strains of bloodborne infectious staphylococci, in order to provide references for clinical diagnosis of aureus septicemia and rational use of antimicrobial agents. Methods We retrospectively studied the clinical data of 496 patients with staphylococcal septicemia confirmed by blood culture between June 2008 and May 2015 in West China Hospital of Sichuan University. The microbiological characteristics of the disease were analyzed. Results In the included 496 cases, there were 216 (43.55%) cases of coagulase-positive Staphylococcus (CPS) septicemia and 280 (56.45%) of coagulase-negative Staphylococcus (CNS) septicemia; 85 (17.14%) cases were caused by community infection, while the other 411 (82.86%) resulted from hospital infection. The drug resistance rate of CPS and CNS toward oxacillin was respectively 27.78% (60/216) and 87.50% (245/280), with a significant difference (P < 0.05). In al l the clinical isolated strains of CPS, the drug resistance rate of community infected strains and hospital infected strains toward oxacillin was respectively 9.67% (6/62) and 35.06% (54/154), with a significant difference (P < 0.05). For the clinical isolated strains of CNS, the drug resistance rate of community infected strains and hospital infected strains toward oxacillin was respectively 69.57% (16/23) and 89.11% (229/257), also with a significant difference (P < 0.05). Conclusions The drug resistance of hospital infected staphylococcal strains is stronger than community infected strains. The CNS strains are more drug-resistant than CPS strains.

Citation： ZhaoRuiting, FengPing, ZongZhiyong, ChenLiyu. Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs. West China Medical Journal, 2016, 31(4): 683-687. doi: 10.7507/1002-0179.201600187 Copy

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12.	梁冰, 王軍, 姜美娟, 等. 凝固酶陰性葡萄球菌生物膜標志物3種檢測方法比較[J]. 臨床檢驗雜志, 2010, 28(6): 410-412.
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14.	Torma MA, Marti M, Valle J, et al. sar A is an essential positive regulator of Staphylococcus epidermidis biofilm development[J]. J Bacterial, 2005, 187(7): 2348-2356.
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16.	Gu J, Li H, Li M, et al. Bacterial insertion sequence IS256 as a protention molecular maker to discriminate invasive strains from commensal strains of Straphylococcus epidermids[J]. J Hosp Infect, 2005, 61(4): 342-348.
17.	Novotna G, Adamkova V, Janata J, et al. Prevalence of resistance mechanisms against macrolides and linsosamids in the Czech Repulic and occurrence of an undefined mechanism of resistance to lincosamides[J]. Antimicrob Agents Chemother, 2005, 49(8): 3586-3589.
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1. ?Gould SW, Cuschieri P, Rollason J, et al. The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta[J]. Ann Clin Microbiol Antinicrob, 2010, 21(9): 20.
2. Stefani S. Evolution in the antibiotic susceptibity and resistance[J].Infez Med, 2009, 17(2): 5-12.
3. Wang L, Barrett JF. Control and prevention of MRSA infections[J].Methods Mol Biol, 2007, 391(4): 209-225.
4. 馬筱玲, 王敬華, 李華, 等. 異質性萬古霉素耐藥葡萄球菌分離及生物學特性觀察[J]. 中華微生物學和免疫學雜志, 2004, 24(7): 583-586.
5. 余方友, 李美蘭, 林曉梅, 等. 萬古霉素對金黃色葡萄球菌體外抗菌活性研究[J]. 中國微生態學雜志, 2006, 18(3): 240-242.
6. 廖康, 陳冬梅, 曾燕, 等. 異質性萬古霉素中介金黃色葡萄球菌的檢測與分析[J]. 中國臨床實用醫學, 2008, 2(12): 4-5.
7. 中華人民共和國衛生部. 醫院感染診斷標準(試行)[J]. 現代實用醫學, 2003, 81(7): 460-465.
8. 馬序竹, 李湘燕, 侯芳, 等.成人敗血癥249例回顧性臨床分析[J]. 中華醫院感染學雜志, 2010, 20(5): 648-650.
9. 江應安, 胡亞華, 楊麗華, 等. 55例葡萄球菌敗血癥臨床生物學分型及耐藥性分析[J]. 中國實用內科雜志, 2002, 22(4): 233-234.
10. 李石好, 唐正運. 45例葡萄球菌敗血癥臨床生物學分型及藥敏分析[J]. 廣東醫學, 2007, 28(9): 1501-1502.
11. 饒希, 呂曉菊, 劉焱斌, 等. 金黃色葡萄球菌敗血癥55例臨床分析[J]. 四川大學學報: 醫學版, 2009, 40(2): 347-349, 360.
12. 梁冰, 王軍, 姜美娟, 等. 凝固酶陰性葡萄球菌生物膜標志物3種檢測方法比較[J]. 臨床檢驗雜志, 2010, 28(6): 410-412.
13. Rogers KL, Ruoo ME, Fey PD. The presence of ica ADBC is detrimental to the colonization of human skin by Staphylococcus epidermidis[J]. Appl Environ Microbiol, 2008, 74(19): 6155-6157.
14. Torma MA, Marti M, Valle J, et al. sar A is an essential positive regulator of Staphylococcus epidermidis biofilm development[J]. J Bacterial, 2005, 187(7): 2348-2356.
15. Rachid S, Cho S, Ohlesn K, et al. Induction of Staphylococcus epidermidis biofilm formation by environmental factors: the possible involvement of the alternative transcription factor sig B[J].Adv Exp Med Biol, 2000, 485(2): 159-166.
16. Gu J, Li H, Li M, et al. Bacterial insertion sequence IS256 as a protention molecular maker to discriminate invasive strains from commensal strains of Straphylococcus epidermids[J]. J Hosp Infect, 2005, 61(4): 342-348.
17. Novotna G, Adamkova V, Janata J, et al. Prevalence of resistance mechanisms against macrolides and linsosamids in the Czech Repulic and occurrence of an undefined mechanism of resistance to lincosamides[J]. Antimicrob Agents Chemother, 2005, 49(8): 3586-3589.
18. Correa JE, De Paulis A, Predari S, et al. First report of qac G, qac H and qac J genes in Staphylococcus haemolyticus human clinical isolates[J]. J Antimicrob Chemother, 2008, 62(5): 956-960.

West China Medical Journal

Analysis on the Sensitivity of 496 Clinical Isolated Strains of Bloodborne Infectious Staphylococci to Antibacterial Drugs

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