Study on the treatment effect of early enteral nutrition on severe acute pancreatitis_West China Medical Journal

Authors：

LIANGGang , TANDong , HEMengguo , ZHANGTianzheng ,  DUANHongliang

Department of Hepatobiliary Surgery, No.215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi 712000, P. R. China;

Corresponding?author：

DUANHongliang, Email: duanhongliang180@qq.com

Keywords：

Severe acute pancreatitis; Enteral nutrition; Nutrition therapy

DOI：

10.7507/1002-0179.201512086

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the effect of early enteral nutrition in the clinical treatment of severe acute pancreatitis (SAP). Methods Forty-two SAP patients who improved with non-surgical treatments between January 2012 and December 2014 were selected and randomly divided into control group and study group with 21 patients in each. Patients in the control group accepted whole venous nutrition, while those in the study group had early enteral nutrition. Nutrition indexes, blood biological indexes, and Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score on day 7 and 14 after treatment, and average hospital stay of the two groups of patients were recorded and compared. Results No differences in body weight reduction, lymphocytes, serum albumin, calcium, glucose, APACHE Ⅱ score between the two groups after 7 days of treatment were observed (P>0.05). But there were significant differences in body weight, lymphocytes, serum albumin, and APACHE Ⅱ score between these two groups after 14 days of treatment (P<0.05). Hospital stay of the study group was obviously shorter (P<0.01). Conclusions Early enteral nutrition support for patients with severe acute pancreatitis can improve nutritional status and shorten hospital stay. It is worthy of wider clinical application.

Citation： LIANGGang, TANDong, HEMengguo, ZHANGTianzheng, DUANHongliang. Study on the treatment effect of early enteral nutrition on severe acute pancreatitis. West China Medical Journal, 2017, 32(1): 8-11. doi: 10.7507/1002-0179.201512086 Copy

1.	?費改順. 急性胰腺炎營養支持研究進展. 西北國防醫學雜志, 2015, 36(7): 462-465.
2.	Hynninen M, Vahonen M, Markkanen H, et al. Intramucosal pH and endotoxin and cytokine release in severe acute panereatitis. Shock, 2000, 13(1): 79.
3.	冷凱, 羅燕青, 曾鵬飛. 腸內營養支持治療重癥急性胰腺炎的臨床研究. 中國普通外科雜志, 2014, 23(3): 392-395.
4.	中華醫學會外科學分會胰腺外科學組. 急性胰腺炎診治指南(2014). 中華普通外科學文獻: 電子版, 2015, 14(2): 86-89.
5.	Brisinda G, Vanella S, Crocco A, et al. Severe acute pancreatitis: advances and insights in assessment of severity and management. Eur J Gastroenterol Hepatol, 2011, 23(7): 541-551.
6.	Mounzor R, Langmead CJ, Wu B, et al. Comparison of existing clinical scoring system to predict persistent organ failure in patients with actue pancreatitis. Gastroenterology, 2012, 142(7): 1476-1482.
7.	Raraty MG, Halloran CM, Dodd S, et al. Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Ann Surg, 2010, 251(5): 787-793.
8.	李維勤. 重癥急性胰腺炎早期腸內營養管支持治療. 中國實用外科雜志, 2012, 32(7): 533-535.
9.	苗毅. 重癥急性胰腺炎診斷及治療的難點與爭議. 中國實用外科雜志, 2012, 32(7): 520-522.
10.	Pezzilli R, Fantini L, Morselli-Labate AM. New approaches for the treatment of acute pancreatitis. JOP, 2006, 7(1): 79-91.
11.	Dervenis C. Enteral nutrition in severe acute pancreatitis: future development. JOP, 2004, 5(2): 60-63.
12.	Mirtallo JM, Forbes A, Mcclave SA, et al. International consensus guidelines for nutrition therapy in pancreatitis. J Parenter Enteral Nutr, 2012, 36(3): 284-291.
13.	溫怡洪, 李國偉, 方海星. 早期腸內營養治療對急性重癥胰腺炎所致 SRIS 轉歸的影響. 中國普通外科雜志, 2015, 24(3): 446-448.
14.	石志敬. 腸內營養啟動時機對重癥急性胰腺炎預后影響的臨床研究. 山西醫科大學, 2009(21): 3633-3641.
15.	梁紅亮, 楊曦, 陳旭平, 等. 經胃鏡放置空腸營養管對急性重癥胰腺炎的營養支持和預防感染價值. 華西醫學, 2012, 27(11): 1617-1620.
16.	劉瀟. 急性重癥胰腺炎腸內場外營養的療效對比. 臨床急診雜志, 2015, 16(6): 425-427.
17.	姚紅兵, 曾榮城, 文明波, 等. 早期腸內營養與延遲腸內營養治療重癥急性胰腺炎的臨床療效比較. 實用醫學雜志, 2014(14): 2231-2233.
18.	胡毅, 博濤, 高文彪. 早期腸內營養支持對重癥急性胰腺炎患者炎癥反應和免疫功能的影響.中國老年學雜志, 2015, 35(8): 2083-2084.
19.	付云輝, 文劍波, 王桂良, 等. 早期腸內營養對重癥急性胰腺炎患者細胞因子水平及內毒素的影響. 世界華人消化雜志, 2015, 23(7): 1174-1179.
20.	Sun JK, Mu XW, Li WQ, et al. Effects of enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol, 2013, 19(6): 917-922.

1. ?費改順. 急性胰腺炎營養支持研究進展. 西北國防醫學雜志, 2015, 36(7): 462-465.
2. Hynninen M, Vahonen M, Markkanen H, et al. Intramucosal pH and endotoxin and cytokine release in severe acute panereatitis. Shock, 2000, 13(1): 79.
3. 冷凱, 羅燕青, 曾鵬飛. 腸內營養支持治療重癥急性胰腺炎的臨床研究. 中國普通外科雜志, 2014, 23(3): 392-395.
4. 中華醫學會外科學分會胰腺外科學組. 急性胰腺炎診治指南(2014). 中華普通外科學文獻: 電子版, 2015, 14(2): 86-89.
5. Brisinda G, Vanella S, Crocco A, et al. Severe acute pancreatitis: advances and insights in assessment of severity and management. Eur J Gastroenterol Hepatol, 2011, 23(7): 541-551.
6. Mounzor R, Langmead CJ, Wu B, et al. Comparison of existing clinical scoring system to predict persistent organ failure in patients with actue pancreatitis. Gastroenterology, 2012, 142(7): 1476-1482.
7. Raraty MG, Halloran CM, Dodd S, et al. Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Ann Surg, 2010, 251(5): 787-793.
8. 李維勤. 重癥急性胰腺炎早期腸內營養管支持治療. 中國實用外科雜志, 2012, 32(7): 533-535.
9. 苗毅. 重癥急性胰腺炎診斷及治療的難點與爭議. 中國實用外科雜志, 2012, 32(7): 520-522.
10. Pezzilli R, Fantini L, Morselli-Labate AM. New approaches for the treatment of acute pancreatitis. JOP, 2006, 7(1): 79-91.
11. Dervenis C. Enteral nutrition in severe acute pancreatitis: future development. JOP, 2004, 5(2): 60-63.
12. Mirtallo JM, Forbes A, Mcclave SA, et al. International consensus guidelines for nutrition therapy in pancreatitis. J Parenter Enteral Nutr, 2012, 36(3): 284-291.
13. 溫怡洪, 李國偉, 方海星. 早期腸內營養治療對急性重癥胰腺炎所致 SRIS 轉歸的影響. 中國普通外科雜志, 2015, 24(3): 446-448.
14. 石志敬. 腸內營養啟動時機對重癥急性胰腺炎預后影響的臨床研究. 山西醫科大學, 2009(21): 3633-3641.
15. 梁紅亮, 楊曦, 陳旭平, 等. 經胃鏡放置空腸營養管對急性重癥胰腺炎的營養支持和預防感染價值. 華西醫學, 2012, 27(11): 1617-1620.
16. 劉瀟. 急性重癥胰腺炎腸內場外營養的療效對比. 臨床急診雜志, 2015, 16(6): 425-427.
17. 姚紅兵, 曾榮城, 文明波, 等. 早期腸內營養與延遲腸內營養治療重癥急性胰腺炎的臨床療效比較. 實用醫學雜志, 2014(14): 2231-2233.
18. 胡毅, 博濤, 高文彪. 早期腸內營養支持對重癥急性胰腺炎患者炎癥反應和免疫功能的影響.中國老年學雜志, 2015, 35(8): 2083-2084.
19. 付云輝, 文劍波, 王桂良, 等. 早期腸內營養對重癥急性胰腺炎患者細胞因子水平及內毒素的影響. 世界華人消化雜志, 2015, 23(7): 1174-1179.
20. Sun JK, Mu XW, Li WQ, et al. Effects of enteral nutrition on immune function of severe acute pancreatitis patients. World J Gastroenterol, 2013, 19(6): 917-922.

West China Medical Journal

Study on the treatment effect of early enteral nutrition on severe acute pancreatitis

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