Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children_West China Medical Journal

Authors：

 LI Ruizhen , ZHANG Yuerong , ZENG Jiawei , LI Shuixia

Department of Clinical Laboratory, the People’s Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding?author：

LI Ruizhen, Email: 604641161@qq.com

Keywords：

Reticulocyte parameters; Children with different types of anemia; Automatic blood cell analyzer

DOI：

10.7507/1002-0179.201511115

Video：

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Objective To investigate the diagnostic value of the series parameters of reticulocyte in children with different types of anemia. Methods From January to August 2015, the reticulocyte parameters of 150 children with different types of anemia treated in the People’s Hospital of Dujiangyan were retrospectively analyzed. Another 150 healthy children aged 1-10 years examined in the same hospital at the same period were as the control group. Mindray BC-6900 automatic blood cell analyzer and suited reagent were used to determine the absolute value of reticulocyte (RET#), percentage of reticulocyte (RET%), immature reticulocyte ratio (IRF), low fluorescent intensity reticulocyte percentage (LFR%), moderate fluorescent intensity reticulocyte percentage (MFR%), and height fluorescent intensity reticulocyte percentage (HFR%). The data were statistically analyzed. Results Compared with the control group, RET%, RET# and IRF results in iron deficiency anemia group, hemolytic anemia group, aplastic anemia group, recent hemorrhagic anemia group, renal anemia group, leukemia and chemotherapy group had statistical difference (P<0.05). Compared with the control group, LFR%, MFR%, HFR% results in hemolytic anemia group and aplastic anemia group had statistical difference (P<0.05). LFR%, MFR% and HFR% results of other types of anemia had no statistical differences (P>0.05). Conclusion The series parameters of the reticulocyte, having an important reference value, can be used in the diagnosis of children with different types of anemia as a reference index, early diagnosis and early treatment of children with different anemia, which also can be used as a method to diagnose different types of anemia.

Citation： LI Ruizhen, ZHANG Yuerong, ZENG Jiawei, LI Shuixia. Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children. West China Medical Journal, 2017, 32(7): 1033-1036. doi: 10.7507/1002-0179.201511115 Copy

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2. 王德琴. 網織紅細胞參數 IRF 的臨床應用價值. 國際檢驗醫學雜志, 2012, 33(22): 2745-2746.
3. 陳志奇. 骨髓細胞學檢查在小兒貧血病因診斷中的臨床價值分析. 中國實用醫藥, 2015, 10(14): 66.
4. 劉洋子, 宋金霞, 孫桂霞. 新生兒貧血相關因素分析及防治進展. 齊魯護理雜志, 2013, 19(19): 62-64.
5. 陳灝珠. 實用內科學(上) . 11 版. 北京: 人民衛生出版社, 2003: 1221-1253.
6. 戈建軍, 王曉衛, 戈萱. 兒童網織紅細胞參考范圍調查及臨床應用. 中國實驗診斷學, 2006,10(10): 1213-1215.
7. Harris N, Kunicka J, Kratz A. The ADVIA 2120 hematology system: flow cytometry-based analysis of blood and body fluids in the routine hematology laboratory. Lab Hematol, 2005, 11(1): 47-61.
8. 施澤瑜. 探討血液檢驗在貧血鑒別診斷中的臨床意義. 吉林醫學, 2012, 33(30): 6626.
9. 譚維賢. 貧血鑒別診斷中血液檢驗的臨床作用. 華夏醫學, 2013, 26(1): 148-150.
10. 熊立凡. 劉成玉臨床檢驗基礎. 4 版. 北京: 人民衛生出版社, 2007: 37, 124.
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12. 韓平, 楊延敏. 回顧網織紅細胞及網織紅細胞參數的臨床意義. 大家健康: 學術版, 2014, 6(11): 14-15.
13. 王曉賢. 網織紅細胞多參數分析對貧血患者診療的意義. 齊齊哈爾醫學院學報, 2011, 32(15): 2460-2461.
14. 劉錫范, 常洪軍, 尋蕊蕊, 等. 未成熟網織紅細胞在小兒貧血中的應用價值, 濰坊醫學院學報, 2007, 29(6): 441-442.

West China Medical Journal

Analysis of the clinical application of the reticulocyte parameters and different types of anemia in children

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