Research on the value of ultrasonography in the diagnosis of primary testicular lymphoma and the differential diagnosis_West China Medical Journal

Authors：

JING Wenli ¹ , SHA Xiaoxi ² , WANG Dongmei ¹ ,  LI Yongzhong ¹

1. Department of Ultrasonography, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Ultrasonography, Affiliated Hospital of Chengdu University of TCM, Chengdu, Sichuan 610075, P. R. China;

Corresponding?author：

LI Yongzhong, Email: ly917@126.com

Keywords：

Lymphoma; Testicular; Ultrasonography

DOI：

10.7507/1002-0179.201508103

Video：

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Objective To discuss the diagnostic and differential diagnostic value of ultrasonography for primary testicular lymphoma (PTL) by studying the ultrasonographical image characteristics. Methods Thirty-one patients with PTL confirmed by postoperative histopathology between 2005 and 2015 were chosen to be the study subjects. We retrospectively analyzed their ultrasonographical features and clinical data. Results Most PTL patients were elderly men, and the initial symptom was mainly painless testis enlargement. Thirty-nine testicles were involved in the primary testicular lymphoma, including 23 unilateral and 8 bilateral. In the 31 patients, 22 had diffuse lesions and 9 nodal. Ultrasonography showed that most tumors were hypoechoic lesions, and part of them were hyperechoic linearly. The lesions had abundant blood flow signals with a low resistance index. Conclusions In elderly patients with painless testicular enlargement, the possibility of primary testicular lymphoma must be fist considered. Manifestations of primary testicular lymphoma have some distinctive characteristics, and combined with clinical history, they are helpful for the diagnosis and differential diagnosis of PTL.

Citation： JING Wenli, SHA Xiaoxi, WANG Dongmei, LI Yongzhong. Research on the value of ultrasonography in the diagnosis of primary testicular lymphoma and the differential diagnosis. West China Medical Journal, 2017, 32(4): 567-570. doi: 10.7507/1002-0179.201508103 Copy

1.	?婁麗麗, 岑溪南, 歐晉平, 等. 236例原發性結外淋巴瘤臨床和病理分析. 中國實驗血液學雜志, 2014, 22(1): 85-92.
2.	Zucca E, Conconi A, Mughal TI, et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol, 2003, 21(1): 20-27.
3.	Shahab N, Doll DC. Testicular lymphoma. Semin Oncol, 1999, 26(3): 259-269.
4.	Cheah CY, Wirth A, Seymour JF. Primary testicular lymphoma. Blood, 2014, 123(4): 486-493.
5.	Vitolo U, Ferreri AJ, Zucca E, et al. Primary testicular lymphoma. Crit Rev Oncol Hematol, 2008, 65(2): 183-189.
6.	Tondini C, Ferreri AJ, Siracusano L, et al. Diffuse large-cell lymphoma of the testis. J Clin Oncol, 1999, 17(9): 2854-2858.
7.	朱一辰, 肖荊, 郭宇文, 等. 原發性睪丸淋巴瘤 17 例的診治體會. 國際外科學雜志, 2012, 39(6): 377-379.
8.	Zouhair A, Weber D, Belkacé mi Y, et al. Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys, 2002, 52(3): 652-656.
9.	Lagrange JL, Ramaioli A, Theodore CH, et al. Non-Hodgkin’s lymphoma of the testis: a retrospective study of 84 patients treated in the French anticancer centres. Ann Oncol, 2001, 12(9): 1313-1319.
10.	何川, 蔡迪明, 劉霆. 睪丸淋巴瘤的超聲影像學和臨床特點及文獻復習. 中國醫學影像技術, 2007, 23(4): 592-594.
11.	聶寶, 黃欣, 劉校龍, 等. 65 例睪丸非霍奇金淋巴瘤的臨床病理學特征. 中華血液學雜志, 2015, 36(9): 765-769.
12.	Zicherman JM, Weissman D, Gribbin C, et al. Best cases from the AFIP: primary diffuse large B-cell lymphoma of the epididymis and testis. Radiographics, 2005, 25(1): 243-248.
13.	Booman M, Douwes J, Glas AM, et al. Primary testicular diffuse large B-cell lymphomas have activated B-cell-like subtype characteristics. J Pathol, 2006, 210(2): 163-171.
14.	趙海軍, 姚福生, 鐘龍. 原發睪丸彌漫大 B 細胞淋巴瘤心臟侵犯一例. 中華血液學雜志, 2014, 35(8): 770.
15.	王振華, 楮雯, 寇育紅, 等. 高頻彩色多普勒超聲對原發性睪丸淋巴瘤的診斷價值及誤診分析. 中國男科學雜志, 2015, 29(9): 46-48, 52.
16.	Dogra VS, Gottlieb RH, Oka M, et al. Sonography of the scrotum. Radiology, 2003, 227(1): 18-36.
17.	陳舜, 薛恩生, 林禮務, 等. 彩色多普勒超聲在睪丸生殖細胞瘤診斷中的價值. 中華醫學超聲雜志: 電子版, 2006, 3(4): 229-231.
18.	Mazzu D, Jeffrey RB, Ralls PW. Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol, 1995, 164(3): 645-647.

1. ?婁麗麗, 岑溪南, 歐晉平, 等. 236例原發性結外淋巴瘤臨床和病理分析. 中國實驗血液學雜志, 2014, 22(1): 85-92.
2. Zucca E, Conconi A, Mughal TI, et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol, 2003, 21(1): 20-27.
3. Shahab N, Doll DC. Testicular lymphoma. Semin Oncol, 1999, 26(3): 259-269.
4. Cheah CY, Wirth A, Seymour JF. Primary testicular lymphoma. Blood, 2014, 123(4): 486-493.
5. Vitolo U, Ferreri AJ, Zucca E, et al. Primary testicular lymphoma. Crit Rev Oncol Hematol, 2008, 65(2): 183-189.
6. Tondini C, Ferreri AJ, Siracusano L, et al. Diffuse large-cell lymphoma of the testis. J Clin Oncol, 1999, 17(9): 2854-2858.
7. 朱一辰, 肖荊, 郭宇文, 等. 原發性睪丸淋巴瘤 17 例的診治體會. 國際外科學雜志, 2012, 39(6): 377-379.
8. Zouhair A, Weber D, Belkacé mi Y, et al. Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys, 2002, 52(3): 652-656.
9. Lagrange JL, Ramaioli A, Theodore CH, et al. Non-Hodgkin’s lymphoma of the testis: a retrospective study of 84 patients treated in the French anticancer centres. Ann Oncol, 2001, 12(9): 1313-1319.
10. 何川, 蔡迪明, 劉霆. 睪丸淋巴瘤的超聲影像學和臨床特點及文獻復習. 中國醫學影像技術, 2007, 23(4): 592-594.
11. 聶寶, 黃欣, 劉校龍, 等. 65 例睪丸非霍奇金淋巴瘤的臨床病理學特征. 中華血液學雜志, 2015, 36(9): 765-769.
12. Zicherman JM, Weissman D, Gribbin C, et al. Best cases from the AFIP: primary diffuse large B-cell lymphoma of the epididymis and testis. Radiographics, 2005, 25(1): 243-248.
13. Booman M, Douwes J, Glas AM, et al. Primary testicular diffuse large B-cell lymphomas have activated B-cell-like subtype characteristics. J Pathol, 2006, 210(2): 163-171.
14. 趙海軍, 姚福生, 鐘龍. 原發睪丸彌漫大 B 細胞淋巴瘤心臟侵犯一例. 中華血液學雜志, 2014, 35(8): 770.
15. 王振華, 楮雯, 寇育紅, 等. 高頻彩色多普勒超聲對原發性睪丸淋巴瘤的診斷價值及誤診分析. 中國男科學雜志, 2015, 29(9): 46-48, 52.
16. Dogra VS, Gottlieb RH, Oka M, et al. Sonography of the scrotum. Radiology, 2003, 227(1): 18-36.
17. 陳舜, 薛恩生, 林禮務, 等. 彩色多普勒超聲在睪丸生殖細胞瘤診斷中的價值. 中華醫學超聲雜志: 電子版, 2006, 3(4): 229-231.
18. Mazzu D, Jeffrey RB, Ralls PW. Lymphoma and leukemia involving the testicles: findings on gray-scale and color Doppler sonography. AJR Am J Roentgenol, 1995, 164(3): 645-647.

West China Medical Journal

Research on the value of ultrasonography in the diagnosis of primary testicular lymphoma and the differential diagnosis

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